The Role of Iodine and Selenium in Autoimmune Thyroiditis

Hormone and Metabolic Research

Volumn 47, Issue 10, 2015, Pages 721-726

  Duntas, L H ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

autoimmune thyroiditis; iodine; selenium; TREG cells

Indexed keywords

IODINE; SELENIUM;

AUTOIMMUNE THYROIDITIS; DRUG MECHANISM; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SUPPLEMENTATION; ANIMAL; BIOLOGICAL MODEL; METABOLISM;

ANIMALS; HUMANS; IODINE; MODELS, BIOLOGICAL; SELENIUM; THYROIDITIS, AUTOIMMUNE;

EID: 84941561058     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0035-1559631     Document Type: Review

References (68)

1. Hollowell J. G., Staehling N. W., Flanders W. D., Hannon W. H., Gunter E. W., Spencer C. A., Braverman L. E. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab: 2002; 87 489 499
2. Lind P., Langsteger W., Molnar M., Gallowitsch H. J., Mikosch P., Gomez I. Epidemiology of thyroid diseases in iodine sufficiency. Thyroid: 1998; 8 1179 1183
3. Bülow Pedersen I., Knudsen N., Jorgensen T., Perrild H., Ovesen L., Laurberg P. Large differences in incidences of overt hyper- and hypothyroidism associated with a small difference in iodine intake: a prospective comparative register-based population survey. J Clin Endocrinol Metab: 2002; 87 4462 4469
4. Duntas L. H. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab: 2008; 4 454 460
5. Burek C. L., Talor M. V. Environmental triggers of autoimmune thyroiditis. J Autoimmun: 2009; 33 183 189
6. Rose N. R. The genetics of autoimmune thyroiditis: the first decade. J Autoimmun: 2011; 37 88 94
7. Duntas L. H. Environmental factors and thyroid autoimmunity. Ann Endocrinol (Paris): 2011; 72 108 113
8. Tanda M. L., Piantanida E., Lai A., Lombardi V., Dalle Mule I., Liparulo L., Pariani N., Bartalena L. Thyroid autoimmunity and environment. Horm Metab Res: 2009; 41 436 442
9. Eschler D. C., Hasham A., Tomer Y. Cutting edge: the etiology of autoimmune thyroid diseases. Clin Rev Allergy Immunol: 2011; 41 190 197
10. Miranda D. M., Massom J. N., Catarino R. M., Santos R. T., Toyoda S. S., Marone M. M., Tomimori E. K., Monte O. Impact of nutritional iodine optimization on rates of thyroid hypoechogenicity and autoimmune thyroiditis: a cross-sectional, comparative study. Thyroid: 2015; 25 118 124
11. Pedersen I. B., Knudsen N., Carlé A., Vejbjerg P., Jorgensen T., Perrild H., Ovesen L., Rasmussen L. B., Laurberg P. A cautious iodization programme bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population. Clin Endocrinol (Oxf): 2011; 75 120 126
12. Camargo R. Y., Tomimori E. K., Neves S. C., GS Rubio I., Galrão A. L., Knobel M., Medeiros-Neto G. Thyroid and the environment: exposure to excessive nutritional iodine increases the prevalence of thyroid disorders in Sao Paulo, Brazil. Eur J Endocrinol: 2008; 159 293 299
13. Vanderpump M. Thyroid autoimmunity following an iodization programme. Clin Endocrinol (Oxf) 201 75 10 11
14. Teng X., Shan Z., Chen Y., Lai Y., Yu J., Shan L., Bai X., Li Y., Li N., Li Z., Wang S., Xing Q., Xue H., Zhu L., Hou X., Fan C., Teng W. More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels. Eur J Endocrinol: 2011; 164 943 950
15. Aghini Lombardi F., Fiore E., Tonacchera M., Antonangeli L., Rago T., Frigeri M., Provenzale A. M., Montanelli L., Grasso L., Pinchera A., Vitti P. The effect of voluntary iodine prophylaxis in a small rural community: the Pescopagano survey 15 years later. J Clin Endocrinol Metab: 2013; 98 1031 1039
16. Laurberg P., Cerqueira C., Ovesen L., Rasmussen L. B., Perrild H., Andersen S., Pedersen I. B., Carlé A. Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab: 2010; 24 13 27
17. Allen E. M., Appel M. C., Braverman L. E. The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W rat. Endocrinology: 1986; 118 1977 1981
18. Rasooly L., Burek C. L., Rose N. R. Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. Clin Immunol Immunopathol: 1996; 81 287 292
19. Rose N. R., Witebsky E. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extract. J Immunol: 1956; 76 417 427
20. Carayanniotis G. Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis. Hormones: 2011; 10 27 35
21. Latrofa F., Fiore E., Rago T., Antonangeli L., Montanelli L., Ricci D., Provenzale M. A., Scutari M., Frigeri M., Tonacchera M., Vitti P. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin. J Clin Endocrinol Metab: 2013; 98 E1768 E1774
22. Rose N. R., Saboori A. M., Rasooly L., Burek C. L. The role of iodine in autoimmune thyroiditis. Crit Rev Immunol: 1997; 17 511 517
23. Kolypetri P., Noel N. A., Carayanniotis K. A., Carayanniotis G. Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. Hormones (Athens): 2010; 9 151 160
24. Weetman A. P., Cohen S., Makgoba M. W., Borysiewicz L. K. Expression of an intercellular adhesion molecule, ICAM-1, by human thyroid cells. J Endocrinol: 1989; 122 185 191
25. Burek C. L., Rose N. R. Autoimmune thyroiditis and ROS. Autoimmun Rev: 2008; 7 530 537
26. Colin I. M., Poncin S., Levêque P., Gallez B., Gérard A. C. Differential regulation of the production of reactive oxygen species in Th1 cytokine-treated thyroid cells. Thyroid: 2014; 24 441 452
27. Sharma R. B., Alegria J. D., Talor M. V., Rose N. R., Caturegli P., Burek C. L. Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes. J Immunol: 2005; 174 7740 7745
28. O'Shea J. J., Ma A., Lipsky P. Cytokines and autoimmunity. Nat Rev Immunol: 2002; 2 37 45
29. Barin J. G., Afanasyeva M., Talor M. V., Rose N. R., Burek C. L., Caturegli P. Thyroid-specific expression of IFN-limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes. J Immunol: 2003; 170 5523 5529
30. Gadina M. D., Hilton J. A., Johnston A., Morinobu A., Lighvani Y. J., Zhou R., Visconti J., O'Shea J. Signaling by type I and II cytokine receptors: ten years after. Curr Opin Immunol: 2001; 13 363 373
31. Horie I., Abiru N., Nagayama Y., Kuriya G., Saitoh O., Ichikawa T., Iwakura Y., Eguchi K. T helper type 17 immune response plays an indispensable role for development of iodine-induced autoimmune thyroiditis in nonobese diabetic-H2h4 mice. Endocrinology: 2009; 150 5135 5142
32. Ruffilli I., Ferrari S. M., Colaci M., Ferri C., Fallahi P., Antonelli A. IP-10 in autoimmune thyroiditis. Horm Metab Res: 2014; 46 597 602
33. Cui S. L., Yu J., Shoujun L. Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis. Int J Endocrinol: 2014; 2014 581069
34. Li D., Cai W., Gu R., Zhang Y., Zhang H., Tang K., Xu P., Katirai F., Shi W., Wang L., Huang T., Huang B. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol: 2013; 149 411 420
35. Yang X., Gao T., Shi R., Zhou X., Qu J., Xu J., Shan Z., Teng W. Effect of iodine excess on Th1, Th2, Th17, and Treg cell subpopulations in the thyroid of NOD.H-2h4 mice. Biol Trace Elem Res: 2014; 159 288 296
36. Kristensen B., Hegedüs L., Madsen H. O., Smith T. J., Nielsen C. H. Altered balance between self-reactive Th17 cells and Th10 cells and between full-length FOXP3 and FOXP3 splice variants in Hashimoto's thyroiditis. Clin Exp Immunol: 2015; 180 58 69
37. Ban Y., Tozaki T., Tobe T., Ban Y., Jacobson E. M., Concepcion E. S., Tomer Y. The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts. J Autoimmun: 2007; 28 201 207
38. Ehlers M., Thiel A., Papewalis C., Domröse A., Stenzel W., Bernecker C., Haase M., Allelein S., Schinner S., Willenberg H. S., Feldkamp J., Schott M. Enhanced iodine supplementation alters the immune process in a transgenic mouse model for autoimmune thyroiditis. Thyroid: 2014; 24 888 896
39. Kolypetri P., Carayanniotis G. Apoptosis of NOD.H2 h4 thyrocytes by low concentrations of iodide is associated with impaired control of oxidative stress. Thyroid: 2014; 24 1170 1178
40. Yu X., Li L., Li Q., Zang X., Liu Z. TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice. Biol Trace Elem Res: 2011; 143 1064 1076
41. Aaseth J., Frey H., Glattre E., Norheim G., Ringstad J., Thomassen Y. Selenium concentrations in the human thyroid gland. Biol Trace Elem Res: 1990; 24 147 152
42. Beckett G. J., Arthur J. R. Selenium and endocrine systems. J Endocrinol: 2005; 184 455 465
43. Duntas L. H. Selenium and the thyroid: a close-knit connection. J Clin Endocrinol Metab: 2010; 95 5180 5188
44. Toulis K. A., Anastasilakis A. D., Tzellos T. G., Goulis D. G., Kouvelas D. Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid: 2010; 20 1163 1173
45. Fan Y., Xu S., Zhang H., Cao W., Wang K., Chen G., Di H., Cao M., Liu C. Selenium supplementation for autoimmune thyroiditis: a systematic review and meta-analysis. Int J Endocrinol: 2014; 2014 904573
46. van Zuuren E. J., Albusta A. Y., Fedorowicz Z., Carter B., Pijl H. Selenium Supplementation for Hashimoto's Thyroiditis: Summary of a Cochrane Systematic Review. Eur Thyroid J: 2014; 3 25 31
47. Mao J., Pop V. J., Bath S. C., Vader H. L., Redman C. W., Rayman M. P. Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency. Eur J Nutr: 2014; [Epub ahead of print]
48. Duntas L. H., Benvenga S. Selenium: an element for life. Endocrine: 2015; 48 756 775
49. Wimmer I., Hartmann T., Brustbauer R., Minear G., Dam K. Selenium levels in patients with autoimmune thyroiditis and controls in lower Austria. Horm Metab Res: 2014; 46 707 709
50. Bülow Pedersen I., Knudsen N., Carlé A., Schomburg L., Köhrle J., Jorgensen T., Rasmussen L. B., Ovesen L., Laurberg P. Serum selenium is low in newly diagnosed Graves' disease: a population-based study. Clin Endocrinol (Oxf): 2013; 79 584 590
51. Wertenbruch T., Willenberg H. S., Sagert C., Nguyen T. B., Bahlo M., Feldkamp J., Groeger C., Hermsen D., Scherbaum W. A., Schott M. Serum selenium levels in patients with remission and relapse of graves' disease. Med Chem: 2007; 3 281 284
52. Khong J. J., Goldstein R. F., Sanders K. M., Schneider H., Pope J., Burdon K. P., Craig J. E., Ebeling P. R. Serum selenium status in Graves' disease with and without orbitopathy: a case-control study. Clin Endocrinol (Oxf): 2014; 80 905 910
53. Marcocci C., Kahaly G. J., Krassas G. E., Bartalena L., Prummel M., Stahl M., Altea M. A., Nardi M., Pitz S., Boboridis K., Sivelli P., von Arx G., Mourits M. P., Baldeschi L., Bencivelli W., Wiersinga W. Selenium and the course of mild Graves' orbitopathy. European Group on Graves' Orbitopathy. N Engl J Med: 2011; 364 1920 1931
54. Hoffmann F. W., Hashimoto A. C., Shafer L. A., Dow S., Berry M. J., Hoffmann P. R. Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr: 2010; 140 1155 1161
55. Hoffmann P. R. Mechanisms by which selenium influences immune responses. Arch Immunol Ther Exp (Warsz): 2007; 55 289 297
56. Carlson B. A., Yoo M. H., Sano Y., Sengupta A., Kim J. Y., Irons R., Gladyshev V. N., Hatfield D. L., Park J. M. Selenoproteins regulate macrophage invasiveness and extracellular matrix related gene expression. BMC Immunol: 2009; 10 57
57. Huang Z., Rose A. H., Hoffmann P. R. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal: 2012; 16 705 743
58. Fisfalen M. E. 1, Soltani K., Kaplan E., Palmer E. M., van Seventer G. A., Straus F. H., Diaz M., Ober C., DeGroot L. J. Evaluating the role of Th0 and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras. Clin Immunol Immunopathol: 1997; 85 253 264
59. Takahashi T., Sakaguchi S. Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease. Curr Mol Med: 2003; 3 693 706
60. Flynn J. C., Meroueh C., Snower D. P., David C. S., Kong Y. M. Depletion of CD4+CD25+ regulatory T cells exacerbates sodium iodide-induced experimental autoimmune thyroiditis in human leucocyte antigen DR3 (DRB1∗0301) transgenic class II-knock-out non-obese diabetic mice. Clin Exp Immunol: 2007; 147 547 554
61. Balázs C., Kaczur V. Effect of Selenium on HLA-DR expression of thyrocytes. Autoimmune Dis: 2012; 74635
62. Tan L., Sang Z. N., Shen J., Wu Y. T., Yao Z. X., Zhang J. X., Zhao N., Zhang W. Q. Selenium supplementation alleviates autoimmune thyroiditis by regulating expression of TH1/TH2 cytokines. Biomed Environ Sci: 2013; 26 920 925
63. Krysiak R., Okopien B. The effect of levothyroxine and selenomethionine on lymphocyte and monocyte cytokine release in women with Hashimoto's thyroiditis. J Clin Endocrinol Metab: 2011; 96 2206 2215
64. Gordon S., Taylor P. R. Monocyte and macrophage heterogeneity. Nat Rev Immunol: 2005; 5 953 964
65. Parnham M. J., Winkelmann J., Leyck S. Macrophage, lymphocyte and chronic inflammatory responses in selenium deficient rodents. Association with decreased glutathione peroxidase activity. Int J Immunopharmacol: 1983; 5455 5461
66. Carlson B. A., Yoo M. H., Conrad M., Gladyshev V. N., Hatfield D. L., Park J. M. Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol: 2011; 49 311 316
67. Santos L. R., Durães C., Mendes A., Prazeres H., Alvelos M. I., Moreira C. S., Canedo P., Esteves C., Neves C., Carvalho D., Sobrinho-Simões M., Soares P. A polymorphism in the promoter region of the selenoprotein S gene (SEPS1) contributes to Hashimoto's thyroiditis susceptibility. J Clin Endocrinol Metab: 2014; 99 E719 E723
68. Sutmuller R., Garritsen A., Adema G. J. Regulatory T cells and toll-like receptors: regulating the regulators. Ann Rheum Dis: 2007; 66 03 iii91 iii95