Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages

Molecular Immunology

Volumn 49, Issue 1-2, 2011, Pages 311-316

  Carlson, Bradley A ^a   Yoo, Min Hyuk ^a   Conrad, Marcus ^b   Gladyshev, Vadim N ^c   Hatfield, Dolph L ^a   Park, Jin Mo ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Lipopolysaccharide; Macrophage; Selenoprotein; Thioredoxin reductase; VSIG4

Indexed keywords

B7 ANTIGEN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; SELENIUM; SELENOPROTEIN; THIOREDOXIN REDUCTASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; MACROPHAGE; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; GENE EXPRESSION; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SELENOPROTEINS; SIGNAL TRANSDUCTION; THIOREDOXIN REDUCTASE 1;

MUS;

EID: 82455195081     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.09.001     Document Type: Article

References (22)

1. Carlson B.A., Yoo M.H., Sano Y., Sengupta A., Kim J.Y., Irons R., Gladyshev V.N., Hatfield D.L., Park J.M. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol. 2009, 10:57.
2. Clausen B.E., Burkhardt C., Reith W., Renkawitz R., Förster I. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 1999, 8:265-277.
3. Coulthard L.R., White D.E., Jones D.L., McDermott M.F., Burchill S.A. p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol. Med. 2009, 15:369-379.
4. Gladyshev V.N., Stadtman T.C., Hatfield D.L., Jeang K.T. Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:835-839.
5. Hatfield D.L., Berry M.L., Gladyshev V.N. Selenium: Its Molecular Biology and Role in Human Health 2006, Springer, NewYork. second ed.
6. Hatfield D.L., Carlson B.A., Xu X.M., Mix H., Gladyshev V.N. Selenocysteine incorporation machinery and the role of selenoproteins in development and health. Prog. Nucleic Acid Res. Mol. Biol. 2006, 81:97-142.
7. Hoffmann P.R., Berry M.J. The influence of selenium on immune responses. Mol. Nutr. Food Res. 2008, 52:1273-1280.
8. Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid. Redox Signal. 2000, 2:811-820.
9. Jakupoglu C., Przemeck G.K., Schneider M., Moreno S.G., Mayr N., Hatzopoulos A.K., de Angelis M.H., Wurst W., Bornkamm G.W., Brielmeier M., Conrad M. Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol. Cell. Biol. 2005, 25:1980-1988.
10. Kawai T., Akira S. Signaling to NF-κB by toll-like receptors. Trends Mol. Med. 2007, 13:460-469.
11. Kim C., Sano Y., Todorova K., Carlson B.A., Arpa L., Celada A., Lawrence T., Otsu K., Brissette J.L., Arthur J.S., Park J.M. The kinase p38α serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat. Immunol. 2008, 9:1019-1027.
12. Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O., Guigó R., Gladyshev V.N. Characterization of mammalian selenoproteomes. Science 2003, 300:1439-1443.
13. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8:958-969.
14. Park J.M., Greten F.R., Li Z.W., Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 2002, 297:2048-2051.
15. Park J.M., Greten F.R., Wong A., Westrick R.J., Arthur J.S., Otsu K., Hoffmann A., Montminy M., Karin M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis-CREB and NF-kappaB as key regulators. Immunity 2005, 23:319-329.
16. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998, 282:2085-2088.
17. Ricciardi-Castagnoli P., Granucci F. Interpretation of the complexity of innate immune responses by functional genomics. Nat. Rev. Immunol. 2002, 2:881-889.
18. Shrimali R.K., Irons R.D., Carlson B.A., Sano Y., Gladyshev V.N., Park J.M., Hatfield D.L. Selenoproteins mediate T cell immunity through an antioxidant mechanism. J. Biol. Chem. 2008, 283:20181-20185.
19. Strnad J., Burke J.R. IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges. Trends Pharmacol. Sci. 2007, 28:142-148.
20. Sun Q.A., Wu Y., Zappacosta F., Jeang K.T., Lee B.J., Hatfield D.L., Gladyshev V.N. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J. Biol. Chem. 1999, 274:24522-24530.
21. Vogt L., Schmitz N., Kurrer M.O., Bauer M., Hinton H.I., Behnke S., Gatto D., Sebbel P., Beerli R.R., Sonderegger I., Kopf M., Saudan P., Bachmann M.F. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. J. Clin. Invest. 2006, 116:2817-2826.
22. Xu X.M., Carlson B.A., Mix H., Zhang Y., Saira K., Glass R.S., Berry M.J., Gladyshev V.N., Hatfield D.L. Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 2006, 5:96-105.