Role of Autophagy in Capsaicin-Induced Apoptosis in U251 Glioma Cells

Cellular and Molecular Neurobiology

Volumn 36, Issue 5, 2016, Pages 737-743

  Liu, Ya Ping ^a   Dong, Fu Xing ^a   Chai, Xiang ^a   Zhu, Shuang ^a   Zhang, Bao Le ^a   Gao, Dian Shuai ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Capsaicin; Glioma

Indexed keywords

3 METHYLADENINE; BECLIN 1; CAPSAICIN; LACTATE DEHYDROGENASE; LC3II PROTEIN; PHOSPHATIDYLETHANOLAMINE; PROCASPASE 3; PROTEIN; PROTEIN P53; PROTEIN P62; PUMA ALPHA PROTEIN; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; CASP3 PROTEIN, HUMAN; CASPASE 3; PIFITHRIN; TOLUENE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; GLIOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GLIOMA; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; BENZOTHIAZOLES; CAPSAICIN; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; GLIOMA; HUMANS; SIGNAL TRANSDUCTION; TOLUENE;

EID: 84941346829     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-015-0254-y     Document Type: Article

References (27)

1. Amaravadi RK, Yu D, Lum JJ et al (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326–336
2. Ashford TP, Porter KR (1962) Cytoplasmic components in hepatic cell lysosomes. J Cell Biol 12:198–202
3. Budanov AV, Karin M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134:451–460
4. Chow J, Norng M, Zhang J et al (2007) TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells: mechanisms behind a possible new “hot” cancer treatment. Biochim Biophys Acta 1773:565–576
5. Devesa I, Planells-Cases R, Fernández-Ballester G et al (2011) Role of the transient receptor potential vanilloid 1 in inflammation and sepsis. J Inflamm Res 4:67–81
6. Fan QW, Weiss WA (2011) Autophagy and Akt promote survival in glioma. Autophagy 7:536–538
7. Feng Z, Zhang H, Levine AJ et al (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci 102:8204–8209
8. Hassan MH, Edfawy M, Mansour A et al (2012) Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats. Toxicol Ind Health 28:428–438
9. Huang SP, Chen JC, Wu CC et al (2009) Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res 29:165–174
10. Huang X, Bai H-M, Chen L et al (2010) Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors. J Clin Neurosci 17:1515–1519
11. Jun HS, Park T, Lee CK et al (2007) Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2. Food Chem Toxicol 45:708–715
12. Kim JY, Kim EH, Kim SU et al (2010) Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation. Carcinogenesis 31:367–375
13. Klionsky DJ, Abeliovich H, Agostinis P (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151–175
14. Lau JK, Brown KC, Dom AM et al (2014) Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway. Apoptosis 19:1190–1201
15. Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27–42
16. Li J, Qin Z, Liang Z (2009) The prosurvival role of autophagy in Resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer 9:215
17. Liao HT, Lee HJ, Ho YC et al (2011) Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. Br J Pharmacol 163:330–345
18. Mah LY, O’Prey J, Baudot AD et al (2012) DRAM-1 encodes multiple isoforms that regulate autophagy. Autophagy 8:18–28
19. Oh SH, Kim YS, Lim SC et al (2008) Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner. Autophagy 4:1009–1019
20. Reyes-Escogido MDL, Gonzalez-Mondragon EG, Vazquez-Tzompantzi E (2011) Chemical and pharmacological aspects of capsaicin. Molecules 16:1253–1270
21. Sekine R, Satoh T, Takaoka A et al (2012) Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp Dermatol 21:201–204
22. Singh P, Godbole M, Rao G et al (2011) Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors. Biochem Biophys Res Commun 415:181–186
23. Speidel D (2010) Transcription-independent p53 apoptosis: an alternative route to death. Trends Cell Biol 20:14–24
24. Tasdemir E, Chiara Maiuri M, Morselli E et al (2008) A dual role of p53 in the control of autophagy. Autophagy 4:810–814
25. Thoennissen NH, O’Kelly J, Lu D et al (2010) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and –negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene 29:285–296
26. Yue Z, Jin S, Yang C et al (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100:15077–15082
27. Ziglioli F, Frattini A, Maestroni U et al (2009) Vanilloid-mediated apoptosis in prostate cancer cells through a TRPV-1 dependent and a TRPV-1-independent mechanism. Acta Biomed 80:13–20