Foam cell formation in vivo converts macrophages to a pro-fibrotic phenotype

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Thomas, Anita C ^a   Eijgelaar, Wouter J ^b   Daemen, Mat J A P ^b,c   Newby, Andrew C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; LIVER X RECEPTOR; MESSENGER RNA; PROTEIN FOS; PROTEOGLYCAN; RETINOID X RECEPTOR; SMAD2 PROTEIN; TRANSCRIPTION FACTOR JUNB; TRANSFORMING GROWTH FACTOR BETA1; APOLIPOPROTEIN E;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROTIC PLAQUE; BIOACCUMULATION; CELL DIFFERENTIATION; CELL ISOLATION; CELL POLARITY; CONTROLLED STUDY; FIBROSIS; FOAM CELL; FOS GENE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; JUNB GENE; LXR GENE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RXR GENE; SKIN GRANULOMA; SMAD2 GENE; TGFBETA1 GENE; ANIMAL; ATHEROSCLEROSIS; DEFICIENCY; GENE EXPRESSION PROFILING; GENETICS; GRANULOMA; METABOLISM; PATHOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; SKIN DISEASE;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; FOAM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GRANULOMA; MALE; MICE; RETINOID X RECEPTORS; SIGNAL TRANSDUCTION; SKIN DISEASES;

EID: 84941307477     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128163     Document Type: Article

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