The association between telomere length and cancer prognosis: Evidence from a meta-analysis

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Zhang, Chunli ^a,b   Chen, Xiaohua ^c   Li, Lu ^d   Zhou, Ying ^a   Wang, Chao ^d   Hou, Shuxun ^a,b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b Chinese People's Liberation Army Postgraduate Medical School   (China)

^c The People's Liberation Army 161 Hospital   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; AMERICAN; ARTICLE; ASIAN; CANCER GROWTH; CANCER MORTALITY; CANCER PROGNOSIS; CANCER SURVIVAL; CELLULAR PARAMETERS; CHRONIC LYMPHATIC LEUKEMIA; COLORECTAL CANCER; ESOPHAGUS CANCER; ETHNIC DIFFERENCE; EVIDENCE BASED MEDICINE; FLUORESCENCE IN SITU HYBRIDIZATION; HIGH RISK POPULATION; HUMAN; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PUBLISHING; SOUTHERN BLOTTING; TELOMERE; TELOMERE LENGTH; DISEASE COURSE; META ANALYSIS; NEOPLASMS; PATHOLOGY; PROGNOSIS; SURVIVAL ANALYSIS; TELOMERE HOMEOSTASIS;

DISEASE PROGRESSION; HUMANS; NEOPLASMS; PROGNOSIS; PUBLICATION BIAS; SURVIVAL ANALYSIS; TELOMERE HOMEOSTASIS;

EID: 84941278028     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133174     Document Type: Article

References (74)

1. Blackburn EH. Structure and function of telomeres. Nature 1991; 350: 569-573. PMID: 1708110
2. Blackburn EH. Switching and signaling at the telomere. Cell 2001; 106: 661-673. PMID: 11572773
3. Huffman KE, Levene SD, Tesmer VM, Shay JW, Wright WE. Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. J Biol Chem. 2000; 275: 19719-19722. PMID: 10787419
4. Harley CB. Telomere loss: mitotic clock or genetic time bomb? Mutat Res. 1991; 256: 271-282. PMID: 1722017
5. Martinez P, Blasco MA. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 2011; 11: 161-176. doi: 10.1038/nrc3025 PMID: 21346783
6. Sanders JL, Newman AB. Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither? Epidemiol Rev. 2013; 35: 112-131. doi: 10.1093/epirev/mxs008 PMID: 23302541
7. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, et al. Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice. Nature 2000; 406: 641-645. PMID: 10949306
8. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91: 25-34. PMID: 9335332
9. Engelhardt M, Drullinsky P, Guillem J, Moore MA. Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin Cancer Res. 1997; 3: 1931-1941. PMID: 9815582
10. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990; 346: 866-868. PMID: 2392154
11. Rampazzo E, Bertorelle R, Serra L, Terrin L, Candiotto C, Pucciarelli S, et al. Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers. Br J Cancer 2010; 102: 1300-1305. doi: 10.1038/sj.bjc.6605644 PMID: 20386541
12. D'Mello MJ, Ross SA, Briel M, Anand SS, Gerstein H, Paré G. Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis. Circ Cardiovasc Genet. 2015; 8: 82-90. doi: 10.1161/CIRCGENETICS.113.000485 PMID: 25406241
13. Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 2014; 349: g4227-g4227. doi: 10.1136/bmj.g4227 PMID: 25006006
14. Wentzensen IM, Mirabello L, Pfeiffer RM, Savage SA. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011; 20: 1238-1250. doi: 10.1158/1055-9965. EPI-11-0005 PMID: 21467229
15. Ma H, Zhou Z, Wei S, Liu Z, Pooley KA, Dunning AM, et al. Shortened telomere length is associated with increased risk of cancer: a meta-analysis. PLoS One 2011; 6: e20466. doi: 10.1371/journal.pone. 0020466 PMID: 21695195
16. Chen Y, Qu F, He X, Bao G, Liu X, Wan S, et al. Short leukocyte telomere length predicts poor prognosis and indicates altered immune functions in colorectal cancer patients. Ann Oncol. 2014; 25: 869-876. doi: 10.1093/annonc/mdu016 PMID: 24608194
17. Garcia-Aranda C, de Juan C, Diaz-Lopez A, Sanchez-Pernaute A, Torres A-J, Diaz-Rubio E, et al. Correlations of telomere length, telomerase activity, and telomeric-repeat binding factor 1 expression in colorectal carcinoma. Cancer 2006; 106: 541-551. PMID: 16388518
18. Svenson U, Nordfjall K, Stegmayr B, Manjer J, Nilsson P, Tavelin B, et al. Breast cancer survival is associated with telomere length in peripheral blood cells. Cancer Res. 2008; 68: 3618-3623. doi: 10. 1158/0008-5472.CAN-07-6497 PMID: 18483243
19. Duggan C, Risques R, Alfano C, Prunkard D, Imayama I, Holte S, et al. Change in peripheral blood leukocyte telomere length and mortality in breast cancer survivors. J Natl Cancer Inst. 2014; 106: dju035. doi: 10.1093/jnci/dju035 PMID: 24627273
20. Lu L, Zhang C, Zhu G, Irwin M, Risch H, Menato G, et al. Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome. Breast Cancer Res. 2011; 13: R56. doi: 10.1186/bcr2893 PMID: 21645396
21. Shen J, Gammon MD, Terry MB, Bradshaw PT, Wang Q, Teitelbaum SL, et al. Genetic polymorphisms in telomere pathway genes, telomere length, and breast cancer survival. Breast Cancer Res Treat. 2012; 134: 393-400. doi: 10.1007/s10549-012-2058-9 PMID: 22527105
22. Wells G, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in metaanalyses. Ottawa Health Research Institute. Available: http://www.ohri.ca/programs/clinical-epidemiology/oxford.asp.
23. Zhang D-H, Chen J-Y, Hong C-Q, Yi D-Q, Wang F, Cui W. High-risk human papillomavirus infection associated with telomere elongation in patients with esophageal squamous cell carcinoma with poor prognosis. Cancer 2014; 120: 2673-2683. doi: 10.1002/cncr.28797 PMID: 24840723
24. Yan S, Han B, Wu Y, Zhou D, Zhao Y. Telomerase gene mutation screening and telomere overhang detection in Chinese patients with acute myeloid leukemia. Leuk Lymphoma 2013; 54: 1437-1441. doi: 10.3109/10428194.2012.729834 PMID: 23157242
25. Weischer M, Nordestgaard BG, Cawthon RM, Freiberg JJ, Tybjaerg-Hansen A, Bojesen SE. Short telomere length, cancer survival, and cancer risk in 47102 individuals. J Natl Cancer Inst. 2013; 105: 459-468. doi: 10.1093/jnci/djt016 PMID: 23468462
26. Svenson U, Ljungberg B, Roos G. Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma. Cancer Res. 2009; 69: 2896-2901. doi: 10.1158/0008-5472.CAN-08-3513 PMID: 19318563
27. Spanoudakis E, Bazdiara I, Pantelidou D, Kotsianidis I, Papadopoulos V, Margaritis D, et al. Dynamics of telomere's length and telomerase activity in Philadelphia chromosome negative myeloproliferative neoplasms. Leuk Res. 2011; 35: 459-464. doi: 10.1016/j.leukres.2010.07.042 PMID: 20828816
28. Russo A, Modica F, Guarrera S, Fiorito G, Pardini B, Viberti C, et al. Shorter leukocyte telomere length is independently associated with poor survival in patients with bladder cancer. Cancer Epidemiol Biomarkers Prev. 2014; 23: 2439-2446. doi: 10.1158/1055-9965.EPI-14-0228 PMID: 25234236
29. Rossi D, Lobetti Bodoni C, Genuardi E, Monitillo L, Drandi D, Cerri M, et al. Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia. Leukemia 2009; 23: 1062-1072. doi: 10.1038/leu.2008.399 PMID: 19340005
30. Rampazzo E, Bonaldi L, Trentin L, Visco C, Keppel S, Giunco S, et al. Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes. Haematologica. 2011; 97: 56-63. doi: 10.3324/haematol.2011.049874 PMID: 21933855
31. Mansouri L, Grabowski P, Degerman S, Svenson U, Gunnarsson R, Cahill N, et al. Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients. Am J Hematol. 2013; 88: 647-651. doi: 10.1002/ajh.23466 PMID: 23620080
32. Lotsch D, Ghanim B, Laaber M, Wurm G, Weis S, Lenz S, et al. Prognostic significance of telomeraseassociated parameters in glioblastoma: effect of patient age. Neuro Oncol. 2013; 15: 423-432. doi: 10. 1093/neuonc/nos329 PMID: 23393205
33. Liu HQ, An JZ, Liu J, Yang YF, Zhang HX, Zhao BY, et al. Leukocyte telomere length predicts overall survival in hepatocellular carcinoma treated with transarterial chemoembolization. Carcinogenesis 2012; 33: 1040-1045. doi: 10.1093/carcin/bgs098 PMID: 22318909
34. Lin J, Blalock JA, Chen M, Ye Y, Gu J, Cohen L, et al. Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients. Cancer Epidemiol Biomarkers Prev. 2015; 24: 336-343. doi: 10.1158/1055-9965.EPI-14-0992 PMID: 25416716
35. Kotsopoulos J, Prescott J, De Vivo I, Fan I, Mclaughlin J, Rosen B, et al. Telomere length and mortality following a diagnosis of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2014; 23: 2603-2606. doi: 10.1158/1055-9965.EPI-14-0885 PMID: 25159293
36. Jeon H-S, Choi YY, Choi JE, Lee WK, Lee E, Yoo SS, et al. Telomere length of tumor tissues and survival in patients with early stage non-small cell lung cancer. Mol Carcinog. 2014; 53: 272-279. doi: 10. 1002/mc.21972 PMID: 23065897
37. Hultdin M, Rosenquist R, Thunberg U, Tobin G, Norrback KF, Johnson A, et al. Association between telomere length and VH gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications. Br J Cancer 2003; 88: 593-598. PMID: 12592375
38. Heaphy CM, Yoon GS, Peskoe SB, Joshu CE, Lee TK, Giovannucci E, et al. Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death. Cancer Discov. 2013; 3: 1130-1141. doi: 10.1158/2159-8290.CD-13-0135 PMID: 23779129
39. Gertler R, Doll D, Maak M, Feith M, Rosenberg R. Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma. Cancer 2008; 112: 2173-2180. doi: 10.1002/cncr.23419 PMID: 18348304
40. Gertler R. Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. J Clin Oncol. 2004; 22: 1807-1814. PMID: 15143073
41. Borssén M, Cullman I, Norén-Nyström U, Sundström C, Porwit A, Forestier E, et al. hTERT promoter methylation and telomere length in childhood acute lymphoblastic leukemia-associations with immunophenotype and cytogenetic subgroup. Exp Hematol. 2011; 39: 1144-1151. doi: 10.1016/j.exphem. 2011.08.014 PMID: 21914494
42. Willeit P, Willeit J, Kloss-Brandstatter A, Kronenberg F, Kiechl S. Fifteen-year follow-up of association between telomere length and incident cancer and cancer mortality. JAMA 2011; 306: 42-44. doi: 10. 1001/jama.2011.901 PMID: 21730239
43. Roos G, Kröber A, Grabowski P, Kienle D, Bühler A, Döhner H, et al. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood 2008; 111: 2246-2252. PMID: 18045969
44. Bechter OE, Eisterer W, Pall G, Hilbe W, Kühr T, Thaler J, et al. Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia. Cancer Res. 1998; 58: 4918-4922. PMID: 9810000
45. Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, et al. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. Br J Cancer 2015; 112: 313-318. doi: 10.1038/bjc.2014.561 PMID: 25412235
46. Pezzolo A, Pistorio A, Gambini C, Haupt R, Ferraro M, Erminio G, et al. Intratumoral diversity of telomere length in individual neuroblastoma tumors. Oncotarget 2015; 6: 7493-7503. PMID: 25595889
47. Chen Y, Wu Y, Huang X, Qu P, Li G, Jin T, et al. Leukocyte telomere length: a novel biomarker to predict the prognosis of glioma patients. J Cancer Res Clin Oncol. 2015; In press.
48. Qu F, Li R, He X, Li Q, Xie S, Gong L, et al. Short telomere length in peripheral blood leukocyte predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients. Mol Oncol. 2015; 9: 727-739. doi: 10.1016/j.molonc.2014.11.008 PMID: 25515040
49. Boscolo-Rizzo P, Rampazzo E, Perissinotto E, Piano MA, Giunco S, Baboci L, et al. Telomere shortening in mucosa surrounding the tumor: biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell carcinoma. Oral Oncol. 2015; 51: 500-507. doi: 10.1016/j. oraloncology.2015.02.100 PMID: 25771075
50. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015. PMID: 7605428
51. Tahara H, Kuniyasu H, Yokozaki H, Yasui W, Shay JW, Ide T, et al. Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions. Clin Cancer Res. 1995; 1: 1245-1251. PMID: 9815918
52. Bertorelle R, Briarava M, Rampazzo E, Biasini L, Agostini M, Maretto I, et al. Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer. Br J Cancer 2013; 108: 278-284. doi: 10.1038/bjc.2012.602 PMID: 23322193
53. Gertler R, Rosenberg R, Stricker D, Friederichs J, Hoos A, Werner M, et al. Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. J Clin Oncol. 2004; 22: 1807-1814. PMID: 15143073
54. Haiman CA, Chen GK, Vachon CM, Canzian F, Dunning A, Millikan RC, et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011; 43: 1210-1214. doi: 10.1038/ng.985 PMID: 22037553
55. Kinnersley B, Migliorini G, Broderick P, Whiffin N, Dobbins SE, Casey G, et al. The TERT variant rs2736100 is associated with colorectal cancer risk. Br J Cancer 2012; 107: 1001-1008. doi: 10.1038/bjc.2012.329 PMID: 22878375
56. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, et al. Lung cancer susceptibility locus at 5p15.33. Nat Genet. 2008; 40: 1404-1406. doi: 10.1038/ng.254 PMID: 18978790
57. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010; 42: 224-228. doi: 10.1038/ng.522 PMID: 20101243
58. Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet. 2009; 41: 899-904. doi: 10.1038/ng. 407 PMID: 19578367
59. Zhong R, Liu L, Zou L, Zhu Y, Chen W, Zhu B, et al. Genetic variations in TERT-CLPTM1L locus are associated with risk of lung cancer in Chinese population. Mol Carcinog. 2013; 52 Suppl 1: E118-126. doi: 10.1002/mc.22043 PMID: 23908149
60. Rachakonda PS, Hosen I, de Verdier PJ, Fallah M, Heidenreich B, Ryk C, et al. TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism. Proc Natl Acad Sci U S A 2013; 110: 17426-17431. doi: 10.1073/pnas. 1310522110 PMID: 24101484
61. Codd V, Nelson CP, Albrecht E, Mangino M, Deelen J, Buxton JL, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013; 45: 422-427, e421-422. doi: 10.1038/ng.2528 PMID: 23535734
62. de Lange T. How telomeres solve the end-protection problem. Science 2009; 326: 948-952. doi: 10. 1126/science.1170633 PMID: 19965504
63. Günes C, Rudolph KL. The role of telomeres in stem cells and cancer. Cell 2013; 152: 390-393. doi: 10.1016/j.cell.2013.01.010 PMID: 23374336
64. Nelson HD, Zakher B, Cantor A, Fu R, Griffin J, O'Meara ES, et al. Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis. Ann Intern Med. 2012; 156: 635-648. doi: 10.7326/0003-4819-156-9-201205010-00006 PMID: 22547473
65. Zhu B, Tian J, Zhong R, Tian Y, Chen W, Qian J, et al. Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population. Mol Carcinog. 2014; In press.
66. Li J, Zou L, Chen W, Zhu B, Shen N, Ke J, et al. Dietary mushroom intake may reduce the risk of breast cancer: evidence from a meta-analysis of observational studies. PLoS One 2014; 9: e93437. doi: 10. 1371/journal.pone.0093437 PMID: 24691133
67. Zhu B, Zou L, Qi L, Zhong R, Miao X. Allium vegetables and garlic supplements do not reduce risk of colorectal cancer, based on meta-analysis of prospective studies. Clin Gastroenterol Hepatol. 2014; 12: 1991-2001, e1-4. doi: 10.1016/j.cgh.2014.03.019 PMID: 24681077
68. Burke LS, Hyland PL, Pfeiffer RM, Prescott J, Wheeler W, Mirabello L, et al. Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. PLoS One 2013; 8: e71121. doi: 10.1371/journal.pone.0071121 PMID: 23990928
69. Nan H, Du M, De Vivo I, Manson JE, Liu S, McTiernan A, et al. Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res. 2011; 71: 6758-6763. doi: 10.1158/0008-5472. CAN-11-1988 PMID: 22028319
70. Xie H, Wu X, Wang S, Chang D, Pollock RE, Lev D, et al. Long telomeres in peripheral blood leukocytes are associated with an increased risk of soft tissue sarcoma. Cancer 2013; 119: 1885-1891. doi: 10. 1002/cncr.27984 PMID: 23408253
71. Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M, et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun. 2013; 4: 1597. doi: 10.1038/ncomms2602 PMID: 23511462
72. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393-395. PMID: 12573379
73. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2003; 30: e47.
74. Valls-Bautista C, Piñol-Felis C, Reñé-Espinet JM, Buenestado-García J, Viñas-Salas J. In colon cancer, normal colon tissue and blood cells have altered telomere lengths. J Surg Oncol. 2015; 111: 899-904. doi: 10.1002/jso.23894 PMID: 25873347