Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia

Cancer Research

Volumn 58, Issue 21, 1998, Pages 4918-4922

  Bechter, Oliver E ^a,b   Eisterer, Wolfgang ^a   Pall, Georg ^a   Hilbe, Wolfgang ^a   Kühr, Thomas ^a   Thaler, Josef ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA; TELOMERASE;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CANCER SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CORRELATION FUNCTION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TELOMERE;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; LEUKEMIA, B-CELL, CHRONIC; MALE; MIDDLE AGED; PROGNOSIS; SURVIVAL RATE; TELOMERASE; TELOMERE;

EID: 0032213488     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Blackburn, E. H. Structure and function of telomeres. Nature (Lond.), 350: 569-573, 1991.
2. Greider, C. W. Telomere length regulation. Annu. Rev. Biochem., 65: 337-365, 1996.
3. Watson, J. D. Origin of concatemeric T7 DNA. Nat. New Biol., 239: 197-201, 1972.
4. Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W., and Harley, C. B. Telomere end-replication problem and cell aging. J. Mol. Biol., 225: 951-960, 1992.
5. Harley, C. B., Futcher, A. B., and Greider, C. W. Telomeres shorten during aging of human fibroblasts. Nature (Lond.), 345: 458-460, 1990.
6. Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., and Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J., 11: 1921-1929, 1992.
7. Blackburn, E. H. Telomerases. Annu. Rev. Biochem., 61: 113-119, 1982.
8. Feng, J., Funk, W. D., Wang, S., Weinrich, S. L., Avilion, A. A., Chiu, C. P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., Le, S., West, M. D., Harley, C. B., Andrews, W. H., Greider, C. W., and Villeponteau, B. The RNA component of human telomerase. Science (Washington DC), 269: 1236-1241, 1995.
9. Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., and Weinberg, R. A. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell, 90: 785-795, 1997.
10. Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., and Cech, T. R. Telomerase catalytic subunit homologs from fission yeast and human. Science (Washington DC), 277: 955-959, 1997.
11. Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C. P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., and Wright W. E. Extension of life-span by introduction of telomerase into normal human cells. Science (Washington DC), 279: 349-352, 1998.
12. Hiyama, E., Yokoyama, T., Hiyama, K., Yamakido, M., Santo, T., Kodama, T., Ichikawa, T., and Matsuura, Y. Alteration of telomeric repeat length in adult and childhood solid neoplasia. Int. J. Oncol., 6: 13-16, 1995.
13. Nilsson, P., Mehle, C., Remes, K., and Roos, G. Telomerase activity in vivo in human malignant hematopoietic cells. Oncogene, 9: 3043-3048, 1994.
14. Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Washington DC), 266: 2011-2015, 1994.
15. Counter, C. M., Hirte, H. W., Bacchetti, S., and Harley, C. B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA, 91: 2900-2904, 1994.
16. Parkinson, E. K. Do telomerase antagonists represent a novel anti-cancer strategy? Br. J. Cancer, 73: 1-4, 1996.
17. Hiyama, E., Gollahon, L., Kataoka, T., Kuroi, K., Yokoyama, T., Gazdar, A. F., Hiyama, K., Piatyszek, M. A., and Shay, J. W. Telomerase activity in human breast tumors. J. Natl. Cancer Inst., 17: 116-122, 1996.
18. Morin, G. B. Telomerase a universal cancer target? J. Natl. Cancer Inst., 87: 859-861, 1995.
19. Shay, J. W., and Gazdar, A. F. Telomerase in the early detection of cancer. J. Clin. Pathol., 50: 106-109, 1997.
20. Rozman, C., and Montserrat, E. Chronic lymphocytic leukemia. N. Engl. J. Med., 333: 1052-1057, 1995.
21. Thaler, J., Denz, H., Gattringer, C., Glassl, H., Lechleitner, M., Dietze, O., and Huber, H. Diagnostic and prognostic value of immunohistological bone marrow examination: results in 212 patients with lymphoproliferative disorder. Blut, 54: 213-222, 1987.
22. Cheson, B. D., Bennett, J. M., Grever, M., Kay, N., Keating, M. J., O'Brien, S., and Rai, K. R. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood, 12: 4990-4997, 1996.
23. Rai, K. R., Sawitsky, A., Cronkite, E. P., Chanana, A. D., Levey, R. N., and Pasernack, B. S. Clinical staging of chronic lymphocytic leukemia. Blood, 46: 219-234, 1975.
24. Binet, J. L., Catovsky, D., Chandra, P., Dighiero, G., Montserrat, E., Rai, K. R., and Sawitsky, A. Chronic lymphocytic leukemia: proposal for a revised prognostic staging system. Br. J. Haematol., 48: 365-367, 1981.
25. Kaplan, E. L., and Meier, P. Nonparametric estimation for incomplete observations. J. Am. Stat. Assoc., 53: 457-481, 1958.
26. Cox, D. R. Regression models and life-tables. J. R. Stat. Soc., 34: 187-220, 1972.
27. Kilian, A., Bowtell, D. D. L., Abud, H. E., Hime, G. R., Venter, D. J., Keese, P. K., Duncan, E. L., Reddel, R. R., and Jefferson, R. A. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet., 6: 2011-2019, 1997.
28. Counter, C. M., Gupta, J., Harley, C. B., Leber, B., and Bacchetti, S. Telomerase activity in normal leukocytes and in hematologic malignancies. Blood, 85: 2315-2320, 1995.
29. Broccoli, D., Young, J. W., and de Lange, T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA, 92: 9082-9086, 1995.
30. Zhu, X., Kumar, R., Mandal, M., Sharma, N., Sharma, H. W., Dhingra, U., Sokoloski, J. A., Hsiao, R., and Narayanan, R. Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc. Natl. Acad. Sci. USA, 93: 6091-6095, 1996.
31. Chadeneau, C., Hay, K., Hirte, H. W., Gallinger, S., and Bacchetti, S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res., 55: 2533-2536, 1995.
32. Hiyama, E., Yokoyama, T., Tatsumoto, N., Hiyama, K., Imamura, Y., Murakami, Y., Kodama, T., Piatyszek, A., Shay, J. W., and Matsuura, Y. Telomerase activity in gastric cancer. Cancer Res., 55: 3258-3262, 1995.
33. Langford, L. A., Piatyszek, M. A., Xu, R., Schold, S. C., Wright, W. E., and Shay, J. W. Telomerase activity in ordinary meningiomas predicts poor outcome. Hum. Pathol., 28: 416-420, 1997.
34. Sugino, T., Yoshida, K., Bolodeoku, J., Tahara, H., Buley, I., Manek, S., Wells, C., Goodison, S., Ide, T., Suzuki, T., Tahara, E., and Tarin, D. Telomerase activity in human breast cancer and benign breast lesions: diagnostic applications in clinical specimens, including fine needle aspirates. Int. J. Cancer, 69: 301-306, 1996.
35. Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M. A., and Shay, J. W. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat. Med., 1: 249-255, 1995.
36. Zhang, W., Piatyszek, M. A., Kobayashi, T., Estey, E., Andreeff, M., Deisseroth, A. B., Wright, W. E., and Shay, J. W. Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin. Cancer Res., 2: 799-803, 1996.
37. Iwama, H., Ohyashiki, K., Ohyashiki, J. H., Hayashi, S., Kawakubo, K., Shay, J. W., and Toyama, K. The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myeloid leukemia. Cancer (Phila.), 79: 1552-1560, 1997.
38. Norrback, K. F., Dahlenborg, K., Carlsson, R., and Roos, G. Telomerase activation in normal B lymphocytes and non-Hodgkin's lymphomas. Blood, 88: 222-229, 1996.
39. Ohyashiki, K., Ohyashiki, J. H., Iwama, H., Hayashi, S., Shay, J. W., and Toyama, K. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia (Baltimore), 11: 190-194, 1996.
40. Autexier, C., and Greider, C. W. Telomerase and cancer: revisiting the telomere hypothesis. Trends Biochem. Sci., 21: 387-391, 1996.
41. Hiyama, K., Hiyama, E., Ishioka, S., Yamakido, M., Inai, K., Gazdar, A. F., Piatyszek, M. A., and Shay, J. W. Telomerase activity in small-cell and non-small-cell lung cancer. J. Natl. Cancer Inst., 87: 895-902, 1995.