Genetic variants in the SWI/SNF complex and smoking collaborate to modify the risk of pancreatic cancer in a Chinese population

Molecular Carcinogenesis

Volumn 54, Issue 9, 2015, Pages 761-768

  Zhu, Beibei ^a   Tian, Jing ^b   Zhong, Rong ^a   Tian, Yao ^b   Chen, Wei ^a   Qian, Jiaming ^c   Zou, Li ^a   Xiao, Min ^b   Shen, Na ^a   Yang, Hong ^c   Lou, Jiao ^a   Qiu, Qian ^b   Ke, Juntao ^a   Lu, Xinghua ^c   Song, Wei ^b   Li, Hui ^b   Liu, Li ^d   Wang, Li ^b,e   Miao, Xiaoping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^d GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^e PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Gene environmental interactions; Genetic variants; Pancreatic cancer; Susceptibility; SWI SNF complex

Indexed keywords

ARID1 PROTEIN; ARID2 PROTEIN; BRD7 PROTEIN; BRG1 PROTEIN; PBRM1 PROTEIN; SMCRB1 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; ARID1A PROTEIN, HUMAN; ARID2 PROTEIN, HUMAN; BRD7 PROTEIN, HUMAN; DNA HELICASE; NONHISTONE PROTEIN; NUCLEAR PROTEIN; PBRM1 PROTEIN, HUMAN; SMARCA4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RISK; CANCER STAGING; CASE CONTROL STUDY; CHINESE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE MAP; HUMAN; MALE; PANCREAS CANCER; POPULATION RESEARCH; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SWITCH SUCROSE NON FERMENTABLE COMPLEX; VALIDATION STUDY; ADVERSE EFFECTS; CHINA; GENETICS; METABOLISM; MIDDLE AGED; PANCREAS; PANCREATIC NEOPLASMS; PATHOLOGY; RISK FACTOR;

ADULT; AGED; CASE-CONTROL STUDIES; CHINA; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA HELICASES; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PANCREAS; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMOKING; TRANSCRIPTION FACTORS;

EID: 84938962953     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22140     Document Type: Article

References (45)

1. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011. CA Cancer J Clin 2011; 61:212-236.
2. Welch HG, Schwartz LM, Woloshin S. Are increasing 5-year survival rates; Evidence of success against cancer? JAMA 2000; 283:2975-2978.
3. Raimondi S, Maisonneuve P, Lowenfels AB. Epidemiology of pancreatic cancer: An overview. Nat Rev Gastroenterol Hepatol 2009; 6:699-708.
4. Tersmette AC, Petersen GM, Offerhaus GJA, et al. Increased risk of incident. pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer. Clin Cancer Res 2001; 7:738-744.
5. Wu C, Miao X, Huang L, et al. Genome-wide association study identifies five loci. associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet 2011; 44:62-66.
6. Huang L, Wu C, Yu D, et al. Identification of common variants in BRCA2 and MAP2K4 for susceptibility to sporadic pancreatic cancer. Carcinogenesis 2013; 34:1001-1005.
7. Wray NR, Yang J, Goddard ME, Visscher PM. The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet 2010; 6:e1000864.
8. Wilson BG, Roberts CW. SWI/SNF nucleosome remodellers and cancer. Nat Rev Cancer 2011; 11:481-492.
9. Gallinari P, Di Marco S, Jones P, Pallaoro M, Steinkühler C. HDACs, histone deacetylation and gene transcription: From molecular biology to cancer therapeutics. Cell Res 2007; 17:195-211.
10. Jackson EM, Sievert AJ, Gai X, et al. Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors. Clin Cancer Res 2009; 15:1923-1930.
11. Xia W, Nagase S, Montia AG, et al. BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res 2008; 68:1667-1674.
12. Wang K, Kan J, Yuen ST, et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet 2011; 43:1219-1223.
13. Varela I, Tarpey P, Raine K, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011; 469:539-542.
14. Versteege I, Sévenet N, Lange J, et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 1998; 394:203-206.
15. Roberts CW, Leroux MM, Fleming MD, Orkin SH. Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell 2002; 2:415-425.
16. Shain AH, Giacomini CP, Matsukuma K, et al. Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci 2012; 109:E252-E259.
17. Biankin AV, Waddell N, Kassahn KS, et al. Pancreatic cancer genomes reveal. aberrations in axon guidance pathway genes. Nature 2012; 491:399-405.
18. Jones S, Li M, Parsons DW, et al. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat 2012; 33:100-103.
19. Nissenblatt M. Endometriosis-associated F ovarian S carcinomas. N Engl J Med 2011; 364:482-483.
20. Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-1806.
21. Wong AK, Shanahan F, Chen Y, et al. BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res 2000; 60:6171-6177.
22. Zhong R, Liu L, Zou L, et al. Genetic variations in the TGFbeta signaling pathway smoking and risk of colorectal cancer in a Chinese population. Carcinogenesis 2013; 34:936-942.
23. 2 tests. Biometrics 1954; 10:417-451.
24. Armitage P. Tests for linear trends in proportions and frequencies. Biometrics 1955; 11:375-386.
25. Barrett JC, Fry B, Maller J, Daly M. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
26. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
27. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001; 125:279-284.
28. Andersson T, Alfredsson L, Källberg H, Zdravkovic S, Ahlbom A. Calculating measures of biological interaction. Eur J Epidemiol 2005; 20:575-579.
29. Knol MJ, van der Tweel I, Grobbee DE, Numans ME, Geerlings MI. Estimating interaction on an additive scale between continuous determinants in a logistic regression model. Int J Epidemiol 2007; 36:1111-1118.
30. Lee PH, Shatkay H. F-SNP: Computationally predicted functional SNPs for disease association studies. Nucleic Acids Res 2008; 36:D820-D824.
31. Holm K, Melum E, Franke A, Karlsen T. SNPexp-A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels. BMC Bioinformatics 2010; 11:600.
32. Hendricks KB, Shanahan F, Lees E. Role for BRG1 in cell cycle control and tumor suppression. Mol Cell Biol 2004; 24:362-376.
33. Mantovani F, Drost J, Voorhoeve PM, Del Sal G, Agami R. Gene regulation and tumor suppression by the bromodomain-containing protein BRD7. Cell Cycle 2010; 9:2849-2853.
34. Bochar DA, Wang L, Beniya H, et al. BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer. Cell 2000; 102:257-265.
35. Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ. The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene 2009; 28:2492-2501.
36. Drost J, Mantovani F, Tocco F, et al. BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol 2010; 12:380-389.
37. Burrows AE, Smogorzewska A, Elledge SJ. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci 2010; 107:14280-14285.
38. Reisman DN, Sciarrotta J, Wang W, Funkhouser WK, Weissman BE. Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: Correlation with poor prognosis. Cancer Res 2003; 63:560-566.
39. Rosson GB, Bartlett C, Reed W, Weissman B. BRG1 loss in MiaPaCa2 cells induces an altered cellular morphology and disruption in the organization of the actin cytoskeleton. J Cell Physiol 2005; 205:286-294.
40. Dal Molin M, Hong S-M, Hebbar S, et al. Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas. Hum Pathol 2012; 43:585-591.
41. Strobeck MW, Knudsen KE, Fribourg AF, et al. BRG-1 is required for RB-mediated cell cycle arrest. Proc Natl Acad Sci 2000; 97:7748-7753.
42. Reisman D, Glaros S, Thompson E. The SWI/SNF complex and cancer. Oncogene 2009; 28:1653-1668.
43. Szulakowski P, Crowther AJ, Jiménez LA, et al. The effect of smoking on the transcriptional regulation of lung inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006; 174:41-50.
44. Ito K, Lim S, Caramori G, Chung K, Barnes P, Adcock I. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J 2001; 15:1110-1112.
45. Wu C, Kraft P, Stolzenberg-Solomon R, et al. Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut 2014; 63:152-160.