Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients

American Journal of Hematology

Volumn 88, Issue 8, 2013, Pages 647-651

  Mansouri, Larry ^a   Grabowski, Pawel ^b   Degerman, Sofie ^b   Svenson, Ulrika ^b   Gunnarsson, Rebeqa ^a   Cahill, Nicola ^a   Smedby, Karin Ekström ^c   Geisler, Christian ^d   Juliusson, Gunnar ^e   Roos, Göran ^b   Rosenquist, Richard ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d University of Copenhagen   (Denmark)

^e LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH1 RECEPTOR;

ADULT; ARTICLE; CANCER PROGNOSIS; CHRONIC LYMPHATIC LEUKEMIA; FEMALE; FOLLOW UP; GENE; GENETIC MARKER; HUMAN; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; SF3B1 GENE; TELOMERE; TIME TO TREATMENT; TP53 GENE; TREATMENT OUTCOME;

AGED; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; MUTATION; PHOSPHOPROTEINS; PREDICTIVE VALUE OF TESTS; RECEPTOR, NOTCH1; RETROSPECTIVE STUDIES; RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR; SURVIVAL RATE; TELOMERE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880817281     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23466     Document Type: Article

References (28)

1. Hackett JA, Greider CW. Balancing instability: Dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene 2002;21:619-626.
2. Augereau A, T'Kint de Roodenbeke C, Simonet T, et al. Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation. Blood 2011;118:1316-1322.
3. Lin TT, Letsolo BT, Jones RE, et al. Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: Evidence for a telomere crisis. Blood 2010;116:1899-1907.
4. Sevov M, Rosenquist R, Mansouri L. RNA-based markers as prognostic factors in chronic lymphocytic leukemia. Expert Rev Hematol 2012;5:69-79.
5. Gunnarsson R, Mansouri L, Rosenquist R. Exploring the genetic landscape in chronic lymphocytic leukemia using high-resolution technologies. Leuk Lymphoma 2013 Feb 28. [Epub ahead of print]
6. Rosenquist R, Cortese D, Bhoi S, et al. Prognostic markers and their clinical applicability in chronic lymphocytic leukemia-Where do we stand? Leuk Lymphoma 2013 Apr 30. [Epub ahead of print]
7. Van Bockstaele F, Verhasselt B, Philippe J. Prognostic markers in chronic lymphocytic leukemia: A comprehensive review. Blood Rev 2009;23:25-47.
8. Bechter OE, Eisterer W, Pall G, et al. Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia. Cancer Res 1998;58:4918-4922.
9. Hultdin M, Rosenquist R, Thunberg U, et al. Association between telomere length and V(H) gene mutation status in chronic lymphocytic leukaemia: Clinical and biological implications. Br J Cancer 2003;88:593-598.
10. Damle RN, Batliwalla FM, Ghiotto F, et al. Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations. Blood 2004;103:375-382.
11. Grabowski P, Hultdin M, Karlsson K, et al. Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status. Blood 2005;105:4807-4812.
12. Ricca I, Rocci A, Drandi D, et al. Telomere length identifies two different prognostic subgroups among VH-unmutated B-cell chronic lymphocytic leukemia patients. Leukemia 2007;21:697-705.
13. Roos G, Krober A, Grabowski P, et al. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood 2008;111:2246-2252.
14. Rossi D, Lobetti Bodoni C, Genuardi E, et al. Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia. Leukemia 2009;23:1062-1072.
15. Sellmann L, de Beer D, Bartels M, et al. Telomeres and prognosis in patients with chronic lymphocytic leukaemia. Int J Hematol 2011;93:74-82.
16. Aviv A, Chen W, Gardner JP, et al. Leukocyte telomere dynamics: Longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol 2009;169:323-329.
17. Nordfjall K, Svenson U, Norrback KF, et al. The individual blood cell telomere attrition rate is telomere length dependent. PLoS Genet 2009;5:e1000375.
18. Farzaneh-Far R, Lin J, Epel E, et al. Telomere length trajectory and its determinants in persons with coronary artery disease: Longitudinal findings from the heart and soul study. PLoS One 2010;5:e8612.
19. Gunnarsson R, Mansouri L, Isaksson A, et al. Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia. Haematologica 2011;96:1161-1169.
20. Smedby KE, Hjalgrim H, Melbye M, et al. Ultraviolet radiation exposure and risk of malignant lymphomas. J Natl Cancer Inst 2005;97:199-209.
21. Hallek M, Cheson BD, Catovsky D, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 2008;111:5446-5456.
22. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res 2002;30:e47.
23. Nordfjall K, Osterman P, Melander O, et al. hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood. Biochem Biophys Res Commun 2007;358:215-218.
24. Li AH, Rosenquist R, Forestier E, et al. Clonal rearrangements in childhood and adult precursor B acute lymphoblastic leukemia: A comparative polymerase chain reaction study using multiple sets of primers. Eur J Haematol 1999;63:211-218.
25. Giudicelli V, Chaume D, Lefranc MP. IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acids Res 2004;32:W435-W440.
26. Lefranc MP, Giudicelli V, Kaas Q, et al. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res 2005;33:D593-D597.
27. Gunnarsson R, Staaf J, Jansson M, et al. Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia-A comparative study of four differently designed, high resolution microarray platforms. Genes Chromosomes Cancer 2008;47:697-711.
28. Mansouri L, Cahill N, Gunnarsson R, et al. NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia. Leukemia 2013;27:512-514.