IL-2 Induces β2-Integrin Adhesion via a Wortmannin/LY294002-Sensitive, Rapamycin-Resistant Pathway: Phosphorylation of a 125-Kilodalton Protein Correlates with Induction of Adhesion, but Not Mitogenesis

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5350-5358

  Nielsen, Mette ^a   Svejgaard, Arne ^b   Skov, Søren ^a   Dobson, Pauline ^c   Bendtzen, Klaus ^b   Geisler, Carsten ^a   Ødum, Niels ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CD18 ANTIGEN; CELL ADHESION MOLECULE; CHROMONE DERIVATIVE; CYTOCHALASIN; CYTOCHALASIN E; ENZYME INHIBITOR; INTERLEUKIN 2; INTERLEUKIN 7; JAK3 PROTEIN, HUMAN; JANUS KINASE 3; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; POLYENE; PROTEIN TYROSINE KINASE; RAPAMYCIN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL ADHESION; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; MOLECULAR WEIGHT; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD18; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL ADHESION MOLECULES; CHROMONES; CYTOCHALASINS; ENZYME INHIBITORS; HUMANS; INTERLEUKIN-2; INTERLEUKIN-7; JANUS KINASE 3; MOLECULAR WEIGHT; MORPHOLINES; PHOSPHOPROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYENES; PROTEIN-TYROSINE KINASES; SIROLIMUS;

EID: 0030589286     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Minami, Y., T. Kono, T. Miyazaki, and T. Taniguchi. 1993. The IL2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11:245.
2. Kondo, S., M. Kinoshita, A. Shimizu, Y. Saito, M. Konishi, H. Sabe, and T. Honj. 1987. Expression and functional characterization of artificial mutants of interleukin-2 receptor. Nature 327:64.
3. Taniguchi, T., T. Miyazaki, Y. Minami, A. Kawahara, H. Fujii, Y. Nakagawa, M. Hatakeyama, and Z. J. Liu. 1995. IL-2 signaling involves recruitment and activation of multiple protein tyrosine kinases by the IL-2 receptor. Ann. NY Acad. Sci. 766:235.
4. Minami, M., and T. Taniguchi. 1995. IL-2 signaling: recruitment and activation of multiple protein tyrosine kinases by the components of the IL-2 receptor. Curr. Opin. Cell Biol. 7:156.
5. Nielsen, M., A. Svejgaard, S. Skov, and N. Ødum. 1994. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of Stat3 in human T lymphocytes. Eur. J. Immunol. 24:3082.
6. Hou, J., U. Schindler, W. J. Henzel, S. C. Wong, and S. L. McKnight. 1995. Identification and purification of human Stat proteins activated in response to interleukin-2. Immunity 2:321.
7. Lin, J. X., T-S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, and W. J. Leonard. 1995. The role of shared receptor motifs and common Stat proteins in generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331:39.
8. Nielsen, M., A. Svejgaard, C. Röpke, M. Nordahl, and N. Ødum. 1995. Staphyloccal enterotoxins modulate interleukin-2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins). Proc. Natl. Acad. Sci. USA 92:10995.
9. lck. Proc. Natl. Acad. Sci. USA 89:2789.
10. lck: identification of novel intermolecular association. Science 252:1523.
11. Ihle, J. N. 1995. Cytokine receptor signaling. Nature 377:591.
12. Russel, S. M., J. A. Johnston, M. Noguchi, M. Kawamura, C. M. Bacon, M. Friedmann, M. Berg, D. W. McVicar, B. A. Witthuhn, O. Silvennoinen, A. S. Goldman, F. C. Schmalstieg, J. N. Ihle, J. J. O'Shea, and W. J. Leonard. 1994. Interaction of IL-2Rβ and γ chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042.
13. Merida, I., E. Diez, and G. N. Gaulton. 1991. IL-2 binding activates a tyrosine phosphorylated phosphatidylinositol-3-kinase. J. Immunol. 147:2202.
14. Turner, B., U. Rapp, H. App, M. Greene, K. Dobashi, and J. Reed. 1991. Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T cell line. Proc. Natl. Acad. Sci. USA 88:1227.
15. Miyazaki, T., Z.-J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L. Barsoumian, R. M. Perlmutter, and T. Tanigushi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81:223.
16. Kornfeld, H., J. S. Berman, D. J. Beer, and D. M. Center. 1985. Induction of human T lymphocyte mobility by interleukin 2. J. Immunol. 134:3887.
17. Vyth-Dreese, F. A., Y. van Kooyk, T. A. M. Dellemijn, C. J. M. Melief, and C. G. Figdor. 1993. Regulatory effect of interleukin-4 (IL4) on the expression and function of lymphocyte adhesion receptors involved in IL2-induced cell aggregation. Immunology 78:244.
18. Vyth-Dreese, F. A., T. A. M. Dellemijn, A. Frijhoff, Y. van Kooyk, and C. G. Figdor. 1993. Role of LFA-1/ICAM-1 in interleukin-2 stimulated lymphocyte proliferation. Eur. J. Immunol. 23:3292.
19. Pankonin, G., B. Reipert, and A. Ager. 1992. Interactions between interleukin-2-activated lymphocytes and vascular endothelium: binding to and migration across specialized and non-specialized endothelia. Immunology 77:51.
20. Ødum, N., R. Hartzman, B. K. Jakobsen, N. Morling, P. Platz, F.-M. Robbins, L. P. Ryder, and A. Svejgaard. 1986. The HLA-DP polymorphism in Denmark investigated by local and international PLT reagents: definition of two new DP antigens. Tissue Antigens 28:105.
21. Nielsen, M., N. Ødum, K. Benutzen, L. P. Ryder, K. B. Jakobsen, and A. Svejgaard. 1994. MHC class II molecules regulate growth in human T cells. Exp. Clin. Immunogenet. 11:23.
22. Ødum, N., S. B. Kanner, J. A. Ledbetter, and A. Svejgaard. 1993. MHC class II molecules deliver costimulatory signals in human T cells through a functional linkage with IL2 receptors. J. Immunol. 150:5289.
23. Ødum, N., J. A. Ledbetter, P. Martin, D. Geraghty, T. Tsu, J. A. Hansen, and P. Gladstone. 1991. Homotypic aggregation of human cell lines by HLA class II, class Ia, and HLA-G-specific monoclonal antibodies. Eur. J. Immunol. 21:2121.
24. Arcaro, A., and M. P. Wymann. 1993. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses. Biochem. J. 296:297.
25. Uehara, Y., M. Hori, T. Takeuchi, and H. Umezawa. 1985. Screening of agents which convert transformed morphology of Rous sarcoma virus-infected rat kidney cells to normal morphology: identification of an active agent as herbimycin and its inhibition of intracellular src kinase. Jpn. J. Cancer Res. 76:672.
26. June, C. H., M. C. Fletcher, J. A. Ledbetter, G. L. Schieven, J. N. Siegel, A. F. Phillips, and L. E. Samelson. 1990. Inhibition of tyrosine phosphorylation prevents T cell receptor mediated signal transduction. Proc. Natl. Acad. Sci. USA 87:7722.
27. Ødum, N., P Martin, G. Schieven, N. A. Norris, L. S. Grosmaire, J. A. Hansen, and J. A. Ledbetter. 1991. Signal transduction by HLA-DR is mediated by tyrosine kinase(s) and regulated by CD45 in activated T cells. Hum. Immunol. 32:85.
28. Buckle, A.-M., and N. Hogg. 1990. Human memory T cells express intercellular adhesion molecule-1 which can be increased by interleukin 2 and interferon-γ. Eur. J. Immunol. 20:337.
29. Serve, H., N. S. Yee, G. Stella, L. Sepp-Lorenzino, J. C. Tan, and P. Besmer. 1995. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 14:473.
30. Vlahos, C. J., W. F. Matter, K. Y. Hui, and R. F. Brown. 1994. A specific inhibitor of phosphatidylinositol 3-kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-henzopyran-4-one (LY294002). J. Biol. Chem. 269:5241.
31. Vlahos, C. J., W. F. Matter, R. F. Brown, A. E. Traynor-Kaplan, P. G. Heyworth, E. R. Prossnitz, R. D. Ye, P. Marder, J. A. Schelm, K. J. Rothfuss, B. S. Serlin, and P. J. Simpson. 1995. Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J. Immunol. 154:2413.
32. Kuo, C. J., J. Chung, D. F. Fiorentino, W. M. Flanagan, J. Blenis, and G. R. Crabtree. 1992. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358:70.
33. Karnitz, L. M., L. A. Burns, S. L. Sutor, J. Blenis, and R. T. Abraham. 1995. Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Mol. Cel. Biol. 15:3049.
34. Monfar, M., K. P. Lemon, T. C. Grammer, L. Cheatham, J. Chung, C. J. Vlahos, and J. Blenis. 1995. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol. Cell. Biol. 15:326.
35. Dustin, M. L., and T. A. Springer. 1991. Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. Annu. Rev. Immunol. 9:27.
36. Geppert, T. D., and P. E. Lipsky. 1990. Regulatory role of microfilaments in the induction of T4 cell proliferation and interleukin-2 production. Cell. Immunol. 131:205.
37. Ulevitch, R. J., L. Kline, R. D. Schreiber, J. Pingel, I. Amaldi, W. Reith, and B. Mach. 1991. Hyperexpression of interferon-gamma-induced MHC class II genes associated with reorganization of the cytoskeleton. Am. J. Pathol. 139:287.
38. 1-integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cells. J. Exp. Med. 182:2079.
39. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251.
40. Rosales, C., V. O'Brien, L. Kornberg, and R. Juliano. 1995. Signal transduction by cell adhesion receptors. Biochem. Biophys. Acta 1242:77.
41. Ward, S. G., A. Wilson, L. Turner, J. Westwick, and D. M. Sansom. 1995. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol. 25:526.
42. Ghiotto-Ragueneau, M., M. Battifora, A. Truneh, M. D. Waterfield, and D. Olive. 1996. Comparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production. Eur. J. Immunol. 26:34.
43. Mookerjee, B. K., J. Cuppoketti, A. M. Rampal, and C. Y. Jung. 1981. The effects of cytochalasins on lymphocytes: identification of distinct cytochalasin-binding sites in relation to mitogenic response and hexose transport. J. Biol. Chem. 256: 1290.
44. src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation in polyomavirus middle-T-antigen-transformed cells. Mol. Cell. Biol. 11:713.
45. Kanner, S. B., A. Aruffo, and P.-Y. Chan. 1994. Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate. Proc. Natl. Acad. Sci. USA 91:10484.
46. Dummer, R., K. Miller, C. Eilles, and G. Burg. 1991. The skin: an immunoreactive target organ during interleukin-2 administration. Dermatologica 183:95.
47. Wilkinson, P. C., and I. Newman. 1994. Chemoattractant of IL-2 for human lymphocytes: a requirement for the IL-2 receptor beta chain. Immunology 82:134.