Control of cell cycle progression in human natural killer cells through redox regulation of expression and phosphorylation of retinoblastoma gene product protein

Blood

Volumn 89, Issue 11, 1997, Pages 4092-4099

  Yamauchi, Akira ^a   Bloom, Eda T ^a  

^a Center for Biologics Evaluation/Res   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CYCLINE; GENE PRODUCT; GLUTATHIONE; INTERLEUKIN 2; PHOSPHOTRANSFERASE; THIOL DERIVATIVE;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CULTURE MEDIUM; DNA SYNTHESIS INHIBITION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NATURAL KILLER CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TUMOR SUPPRESSOR GENE;

EID: 0030970643     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.11.4092     Document Type: Article

References (36)

1. Yamauchi A, Bloom ET: Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells. J Immunol 151:5535, 1993
2. Staal FJT, Ela SW, Roederer M, Anderson MT, Herzenberg LA, Herzenberg L: Glutathione deficiency and human immunodeficiency virus infection. Lancet 339:909, 1992
3. Roederer M, Ela SW, Staal FJT, Herzenberg LA, Herzenberg L: N-Acetylcysteine: A new approach to anti-HIV therapy. AIDS Res Hum Retrovir 8:209, 1992
4. Staal FJT, Anderson MT, Staal GEJ, Herzenberg LA, Gitler C, Herzenberg L: Redox regulation of signal transduction: Tyrosine phosphorylation and calcium influx. Proc Natl Acad Sci USA 91:3619, 1994
5. + lymphocytes associated with distrubed intracellular redox balance in human immunodeficiency virus type 1 infection. Blood 86:258, 1995
6. + lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: Possible immunopathogenic role of oxidative stress. Blood 86:1383, 1995
7. Aoki T, Miyakoshi H, Usuda Y, Herberman RB: Low NK syndrome and its relationship to chronic fatigue syndrome. Clin Immunol Immunopathol 69:253, 1993
8. Buchkovich K, Duffy LA, Harlow E: The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097, 1989
9. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR: The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053, 1991
10. Evans GA, Wahl LM, Farrar WL: Interleukin-2-dependent phosphorylation of the retinoblastoma-susceptibility-gene product p110-115RB in human T-cells. Biochem J 282:759, 1992
11. Modiano JF, Domenico J, Szepesi A, Lucas JJ, Gelfand EW: Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells. J Biol Chem 269:32972, 1994
12. Lucas JJ, Szepesi A, Modiano JF, Domenico J, Gelfand EW: Regulation of synthesis and activity of the PLSTlRE protein (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated cdk4 homologue in normal human T lymphocytes. J Immunol 154:6275, 1995
13. Gu Y, Rosenblatt J, Morgan DO: Cell cycle regulation of CDK2 activated by phosphorylation of Thr160 and Tyr15. EMBO J 11:3995, 1992
14. cdc2 Cell 67:197, 1991
15. 1/S transition. EMBO J 13:4302, 1994
16. Dunphy WG, Kumagai A: The cdc25 protein contains an intrinsic phosphatase activity. Cell 67:189, 1991
17. Yamauchi A, Taga K, Mostowski HS, Bloom ET: Target cellinduced apoptosis of interleukin-2-activated human natural killer cells: Roles of cell surface molecules and intracellular events. Blood 87:5127, 1996
18. 1 cyclins in primary T cells is not blocked by rapamycin or cyclosporin A. Int Immunol 5:1199, 1993
19. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F: Features of apoptotic cells measured by flow cytometry. Cytometry 13:795, 1992
20. Anderson ME: Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113:548, 1985
21. Umehara H, Takashima A, Minami Y, Bloom ET: Signal transduction via phosphorylated adhesion molecule, LFA-1β (CD 18), is increased by culture of natural (NK) cells with interleukin (IL)-2 in the generation of lymphokine activated killer (LAK) cells. Int Immunol 5:19, 1993
22. Lin J-X, Migone T-S. Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ: The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331, 1995
23. Lin J-X. Bhat NK, John S, Queale WS, Leonard WJ: Characterization of the human interleukin-2 receptor β-chain gene promoter: Regulation of promoter activity by ets gene products. Mol Cell Biol 13:6201, 1993
24. Yu C-R, Lin J-X, Akira S, Bloom ET, Yamauchi A: Differential utilization of JAK-STAT signaling pathways in the stimulation of human NK cells by IL-2, IL-12, and IFN-α. J Immunol 157:126, 1996
25. Pearse RN, Feinman R, Ravetch JV: Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: Transcriptional induction by γ-interferon is mediated through common DNA response elements. Proc Natl Acad Sci USA 88:11305, 1991
26. Sadowski HB, Shuai K, Darnell JE Jr, Gilman MZ: A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science 261:1739, 1993
27. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680, 1970
28. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O: Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol 13:369, 1995
29. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M: Role of the ubiquitinproteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682, 1995
30. Kipl cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570, 1994
31. Jeoung DI, Tang B, Sonenberg M: Effects of tumor necrosis factor-α on antimitogenicity and cell cycle-related proteins in MCF-7 cells. J Biol Chem 270:18367, 1995
32. Ludlow JW, DeCaprio JA, Huang C-M, Lee W-H, Paucho E, Livingston DM: SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblstoma susceptibility gene product family. Cell 56:57, 1989
33. cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: Interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein. Oncogene 3:423, 1992
34. lck tyrosine kinase. Mol Immunol 31:623, 1994
35. Chittenden T, Livingston DM, Kaelin WG Jr: The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell 65:1073, 1991
36. Geng Y, Eaton EN, Picon M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA: Regulation of cyclin E transcription by E2Fs and retinoblastoma protein. Oncogene 12:1173, 1996