Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 36, 2015, Pages E5078-E5087

  Prieto, G Aleph ^a   Snigdha, Shikha ^a   Baglietto Vargas, David ^a   Smith, Erica D ^a   Berchtold, Nicole C ^a   Tong, Liqi ^a   Ajami, Dariush ^b   Laferla, Frank M ^a   Rebek, Julius ^b,c   Cotman, Carl W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

AcP; AcPb; LTP; Neuroinflammation; Receptor sensitivity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN;

ADULT; AGED; AGING; ANIMAL CELL; ARTICLE; ASTROCYTE; BINDING SITE; BRAIN HOMOGENATE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; INFLAMMATION; LONG TERM POTENTIATION; MEMORY; MEMORY DISORDER; MICROGLIA; MIDDLE AGED; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; POSTSYNAPTIC DENSITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC TRANSMISSION; SYNAPTOSOME; UPREGULATION; WESTERN BLOTTING; 129 MOUSE; AGE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; RNA INTERFERENCE; SPRAGUE DAWLEY RAT;

AGE FACTORS; ANIMALS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN-1BETA; LONG-TERM POTENTIATION; MICE, 129 STRAIN; MICE, INBRED C57BL; NEURONAL PLASTICITY; NEURONS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-1 TYPE I; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SYNAPSES; SYNAPTOSOMES;

EID: 84941236952     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514486112     Document Type: Article

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