메뉴 건너뛰기




Volumn 167, Issue 2, 2015, Pages 251-258

Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals

Author keywords

ACAT 1; ApoE; Clusterin; Ketogenic diet; Seizure; Zinc transporter

Indexed keywords

ACETYL COENZYME A ACETYLTRANSFERASE; APOLIPOPROTEIN E; CLUSTERIN; FLUROTHYL; METALLOTHIONEIN III; PROTEIN ACAT 1; UNCLASSIFIED DRUG; ZINC TRANSPORTER; CARRIER PROTEIN; ZINC;

EID: 84941176728     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-015-0285-8     Document Type: Article
Times cited : (19)

References (44)
  • 1
    • 84868272893 scopus 로고    scopus 로고
    • Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure
    • COI: 1:CAS:528:DC%2BC38XhslWjsLjE, PID: 23119054
    • Kim JH, Jang BG, Choi BY et al (2012) Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure. PLoS One 7:e48543
    • (2012) PLoS One , vol.7 , pp. e48543
    • Kim, J.H.1    Jang, B.G.2    Choi, B.Y.3
  • 2
    • 85027942704 scopus 로고    scopus 로고
    • Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus
    • COI: 1:CAS:528:DC%2BC2cXhtlarsLvP, PID: 25200616
    • Choi BY, Kim JH, Kim HJ et al (2014) Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus. J Trace Elem Med Biol 28:474–481
    • (2014) J Trace Elem Med Biol , vol.28 , pp. 474-481
    • Choi, B.Y.1    Kim, J.H.2    Kim, H.J.3
  • 3
    • 69549112873 scopus 로고    scopus 로고
    • Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats
    • COI: 1:CAS:528:DC%2BD1MXhtVKnurrP, PID: 19536073
    • Suh SW, Won SJ, Hamby AM et al (2009) Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J Cereb Blood Flow Metab 29:1579–1588
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1579-1588
    • Suh, S.W.1    Won, S.J.2    Hamby, A.M.3
  • 4
    • 84892702866 scopus 로고    scopus 로고
    • Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders
    • PID: 24277719
    • Grabrucker S, Jannetti L, Eckert M et al (2014) Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain 137:137–152
    • (2014) Brain , vol.137 , pp. 137-152
    • Grabrucker, S.1    Jannetti, L.2    Eckert, M.3
  • 5
    • 84861391292 scopus 로고    scopus 로고
    • Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of epilepsy
    • PID: 22612814
    • Sanchez RM, Ribak CE, Shapiro LA (2012) Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of epilepsy. Epilepsia 53:98–108
    • (2012) Epilepsia , vol.53 , pp. 98-108
    • Sanchez, R.M.1    Ribak, C.E.2    Shapiro, L.A.3
  • 6
    • 37249070874 scopus 로고    scopus 로고
    • Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles
    • COI: 1:CAS:528:DC%2BD2sXhsVOrurfK, PID: 17712179
    • Linkous DH, Flinn JM, Koh JY et al (2008) Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles. J Histochem Cytochem 56:3–6
    • (2008) J Histochem Cytochem , vol.56 , pp. 3-6
    • Linkous, D.H.1    Flinn, J.M.2    Koh, J.Y.3
  • 7
    • 0033574071 scopus 로고    scopus 로고
    • Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene
    • COI: 1:CAS:528:DyaK1MXhsFSqsbs%3D, PID: 9990090
    • Cole TB, Wenzel HJ, Kafer KE et al (1999) Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci U S A 96:1716–1721
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 1716-1721
    • Cole, T.B.1    Wenzel, H.J.2    Kafer, K.E.3
  • 9
    • 84921472344 scopus 로고    scopus 로고
    • Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain
    • COI: 1:CAS:528:DC%2BC2MXhtFGjtb8%3D, PID: 25314677
    • Zhang Y, Zhang S, Marin-Valencia I et al (2015) Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. J Neurochem 132:301–312
    • (2015) J Neurochem , vol.132 , pp. 301-312
    • Zhang, Y.1    Zhang, S.2    Marin-Valencia, I.3
  • 10
    • 55349119933 scopus 로고    scopus 로고
    • Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet
    • PID: 19049599
    • Bough K (2008) Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet. Epilepsia 49:91–93
    • (2008) Epilepsia , vol.49 , pp. 91-93
    • Bough, K.1
  • 11
    • 23944442745 scopus 로고    scopus 로고
    • Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats
    • COI: 1:CAS:528:DC%2BD2MXpsVWkur4%3D, PID: 16125522
    • Taha AY, Ryan MA, Cunnane SC (2005) Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. Metabolism 54:1127–1132
    • (2005) Metabolism , vol.54 , pp. 1127-1132
    • Taha, A.Y.1    Ryan, M.A.2    Cunnane, S.C.3
  • 12
    • 84872658755 scopus 로고    scopus 로고
    • Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus
    • COI: 1:CAS:528:DC%2BC3sXhvFSmsLc%3D, PID: 23266720
    • Ni H, Ren SY, Zhang LL et al (2013) Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus. Toxicol Lett 217:162–169
    • (2013) Toxicol Lett , vol.217 , pp. 162-169
    • Ni, H.1    Ren, S.Y.2    Zhang, L.L.3
  • 13
    • 78349309559 scopus 로고    scopus 로고
    • Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain
    • COI: 1:CAS:528:DC%2BC3cXhtlyrsr3F, PID: 20556483
    • Lee JY, Cho E, Kim TY et al (2010) Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain. Biometals 23:1085–1095
    • (2010) Biometals , vol.23 , pp. 1085-1095
    • Lee, J.Y.1    Cho, E.2    Kim, T.Y.3
  • 14
    • 18044367746 scopus 로고    scopus 로고
    • c-Fos, N-methyl-d-aspartate receptor 2C, GABA-A-alpha1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat
    • COI: 1:CAS:528:DC%2BD2MXjs1Ghsbc%3D, PID: 15854768
    • Ni H, Jiang YW, Bo T et al (2005) c-Fos, N-methyl-d-aspartate receptor 2C, GABA-A-alpha1 immonoreactivity, seizure latency and neuronal injury following single or recurrent neonatal seizures in hippocampus of Wistar rat. Neurosci Lett 380:149–154
    • (2005) Neurosci Lett , vol.380 , pp. 149-154
    • Ni, H.1    Jiang, Y.W.2    Bo, T.3
  • 15
    • 0036198090 scopus 로고    scopus 로고
    • A ketogenic diet increases protein phosphorylation in brain slices of rats
    • COI: 1:CAS:528:DC%2BD38XitFSqt7o%3D, PID: 11880575
    • Ziegler DR, Araújo E, Rotta LN et al (2002) A ketogenic diet increases protein phosphorylation in brain slices of rats. J Nutr 132:483–487
    • (2002) J Nutr , vol.132 , pp. 483-487
    • Ziegler, D.R.1    Araújo, E.2    Rotta, L.N.3
  • 16
    • 41549092597 scopus 로고    scopus 로고
    • Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome
    • COI: 1:CAS:528:DC%2BD1cXksValsrk%3D, PID: 18329814
    • Rothstein S, Simkins T, Nuñez JL (2008) Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome. Neuroscience 152:959–969
    • (2008) Neuroscience , vol.152 , pp. 959-969
    • Rothstein, S.1    Simkins, T.2    Nuñez, J.L.3
  • 17
    • 84884235932 scopus 로고    scopus 로고
    • Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parkinson’s disease induced by unilateral stereotaxic injection of 6-ohda in rat
    • PID: 24023579
    • de Araújo DP, De Sousa CN, Araújo PV et al (2013) Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parkinson’s disease induced by unilateral stereotaxic injection of 6-ohda in rat. Evid Based Complement Alternat Med 2013:571378
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 571378
    • de Araújo, D.P.1    De Sousa, C.N.2    Araújo, P.V.3
  • 18
    • 84908322099 scopus 로고    scopus 로고
    • Diet, age, and prior injury status differentially alter behavioral outcomes following concussion in rats
    • Mychasiuk R, Hehar H, van Waes L et al (2014) Diet, age, and prior injury status differentially alter behavioral outcomes following concussion in rats. Neurobiol Dis 73C:1–11
    • (2014) Neurobiol Dis , vol.73C , pp. 1-11
    • Mychasiuk, R.1    Hehar, H.2    van Waes, L.3
  • 19
    • 84856251253 scopus 로고    scopus 로고
    • Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of cathepsin B
    • COI: 1:CAS:528:DC%2BC3MXhtVWisrvP, PID: 21842268
    • Ni H, Yan JZ, Zhang LL et al (2012) Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of cathepsin B. Neurochem Res 37:31–39
    • (2012) Neurochem Res , vol.37 , pp. 31-39
    • Ni, H.1    Yan, J.Z.2    Zhang, L.L.3
  • 20
    • 84856372774 scopus 로고    scopus 로고
    • Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
    • COI: 1:CAS:528:DC%2BC38XhvVGgtro%3D, PID: 22227620
    • Sliwa A, Plucinska G, Bednarczyk J et al (2012) Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Neurosci Lett 509:105–109
    • (2012) Neurosci Lett , vol.509 , pp. 105-109
    • Sliwa, A.1    Plucinska, G.2    Bednarczyk, J.3
  • 21
    • 84855997690 scopus 로고    scopus 로고
    • The effect of the classical and medium chain triglyceride ketogenic diet on vitamin and mineral levels
    • COI: 1:STN:280:DC%2BC387ltVyluw%3D%3D, PID: 21615805
    • Christodoulides SS, Neal EG, Fitzsimmons G et al (2012) The effect of the classical and medium chain triglyceride ketogenic diet on vitamin and mineral levels. J Hum Nutr Diet 25:16–26
    • (2012) J Hum Nutr Diet , vol.25 , pp. 16-26
    • Christodoulides, S.S.1    Neal, E.G.2    Fitzsimmons, G.3
  • 22
    • 84880430181 scopus 로고    scopus 로고
    • Changes in serum levels of selenium, zinc and copper in patients on a ketogenic diet using Ketonformula
    • PID: 23951940
    • Hayashi A, Kumada T, Nozaki F et al (2013) Changes in serum levels of selenium, zinc and copper in patients on a ketogenic diet using Ketonformula. No To Hattatsu 45:288–293
    • (2013) No To Hattatsu , vol.45 , pp. 288-293
    • Hayashi, A.1    Kumada, T.2    Nozaki, F.3
  • 23
    • 84903374561 scopus 로고    scopus 로고
    • Effects of low-carbohydrate, high-fat diets on apparent digestibility of minerals and trace elements in rats
    • COI: 1:CAS:528:DC%2BC2cXhtFSru7zO, PID: 24985005
    • Frommelt L, Bielohuby M, Stoehr BJ et al (2014) Effects of low-carbohydrate, high-fat diets on apparent digestibility of minerals and trace elements in rats. Nutrition 30:869–875
    • (2014) Nutrition , vol.30 , pp. 869-875
    • Frommelt, L.1    Bielohuby, M.2    Stoehr, B.J.3
  • 24
    • 80053385072 scopus 로고    scopus 로고
    • Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain
    • COI: 1:CAS:528:DC%2BC3MXht1Grsb7J, PID: 21911210
    • Lee JY, Kim JS, Byun HR et al (2011) Dependence of the histofluorescently reactive zinc pool on zinc transporter-3 in the normal brain. Brain Res 1418:12–22
    • (2011) Brain Res , vol.1418 , pp. 12-22
    • Lee, J.Y.1    Kim, J.S.2    Byun, H.R.3
  • 25
    • 0344394903 scopus 로고    scopus 로고
    • Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury
    • COI: 1:CAS:528:DC%2BD3sXptVektrk%3D, PID: 14637104
    • Lee JY, Kim JH, Palmiter RD et al (2003) Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury. Exp Neurol 184:337–347
    • (2003) Exp Neurol , vol.184 , pp. 337-347
    • Lee, J.Y.1    Kim, J.H.2    Palmiter, R.D.3
  • 26
    • 37249070874 scopus 로고    scopus 로고
    • Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles
    • COI: 1:CAS:528:DC%2BD2sXhsVOrurfK, PID: 17712179
    • Linkous DH, Flinn JM, Koh JY et al (2008) Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles. J Histochem Cytochem 56:3–6
    • (2008) J Histochem Cytochem , vol.56 , pp. 3-6
    • Linkous, D.H.1    Flinn, J.M.2    Koh, J.Y.3
  • 27
    • 84861215573 scopus 로고    scopus 로고
    • ZnT3: a zinc transporter active in several organs
    • COI: 1:CAS:528:DC%2BC38Xht1amurk%3D, PID: 21866305
    • Smidt K, Rungby J (2012) ZnT3: a zinc transporter active in several organs. Biometals 25:1–8
    • (2012) Biometals , vol.25 , pp. 1-8
    • Smidt, K.1    Rungby, J.2
  • 28
    • 1542335712 scopus 로고    scopus 로고
    • Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain
    • COI: 1:CAS:528:DC%2BD2cXhs1Ontrg%3D, PID: 14681234
    • Lee JY, Kim JH, Hong SH et al (2004) Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain. J Biol Chem 279:8602–8607
    • (2004) J Biol Chem , vol.279 , pp. 8602-8607
    • Lee, J.Y.1    Kim, J.H.2    Hong, S.H.3
  • 29
    • 84906962312 scopus 로고    scopus 로고
    • Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc
    • COI: 1:STN:280:DC%2BC2M7jvVKqug%3D%3D, PID: 25246287
    • Baltaci AK, Mogulkoc R, Ayyildiz M et al (2014) Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism: the role of zinc. Bratisl Lek Listy 115:498–501
    • (2014) Bratisl Lek Listy , vol.115 , pp. 498-501
    • Baltaci, A.K.1    Mogulkoc, R.2    Ayyildiz, M.3
  • 30
    • 0141629349 scopus 로고    scopus 로고
    • Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissues of rats performing swimming exercise
    • COI: 1:CAS:528:DC%2BD3sXntFyltb0%3D, PID: 12958407
    • Ozturk A, Baltaci AK, Mogulkoc R et al (2003) Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissues of rats performing swimming exercise. Biol Trace Elem Res 94:157–166
    • (2003) Biol Trace Elem Res , vol.94 , pp. 157-166
    • Ozturk, A.1    Baltaci, A.K.2    Mogulkoc, R.3
  • 31
    • 0028928331 scopus 로고
    • Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues
    • COI: 1:CAS:528:DyaK2MXks1Gis7w%3D, PID: 7757885
    • Shaheen AA, el-Fattah AA (1995) Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues. Int J Biochem Cell Biol 27:89–95
    • (1995) Int J Biochem Cell Biol , vol.27 , pp. 89-95
    • Shaheen, A.A.1    el-Fattah, A.A.2
  • 32
    • 0006372708 scopus 로고    scopus 로고
    • Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals
    • COI: 1:CAS:528:DyaK1MXmslGjsw%3D%3D, PID: 10051227
    • Kim YH, Kim EY, Gwag BJ et al (1999) Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience 89:175–182
    • (1999) Neuroscience , vol.89 , pp. 175-182
    • Kim, Y.H.1    Kim, E.Y.2    Gwag, B.J.3
  • 33
    • 0034573392 scopus 로고    scopus 로고
    • Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes
    • COI: 1:STN:280:DC%2BD3M7gs1Kqtw%3D%3D, PID: 11090611
    • Noh KM, Koh JY (2000) Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J Neurosci 20:RC111
    • (2000) J Neurosci , vol.20 , pp. RC111
    • Noh, K.M.1    Koh, J.Y.2
  • 34
    • 0032588001 scopus 로고    scopus 로고
    • Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
    • COI: 1:STN:280:DyaK1M7ktFGjug%3D%3D, PID: 9987035
    • Kim EY, Koh JY, Kim YH et al (1999) Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur J Neurosci 11:327–334
    • (1999) Eur J Neurosci , vol.11 , pp. 327-334
    • Kim, E.Y.1    Koh, J.Y.2    Kim, Y.H.3
  • 35
    • 84874943262 scopus 로고    scopus 로고
    • Trace element, antioxidant activity, and lipid peroxidation levels in brain cortex of gerbils after cerebral ischemic injury
    • COI: 1:CAS:528:DC%2BC3sXjs1yiu7Y%3D, PID: 23334863
    • Fang KM, Cheng FC, Huang YL et al (2013) Trace element, antioxidant activity, and lipid peroxidation levels in brain cortex of gerbils after cerebral ischemic injury. Biol Trace Elem Res 152:66–74
    • (2013) Biol Trace Elem Res , vol.152 , pp. 66-74
    • Fang, K.M.1    Cheng, F.C.2    Huang, Y.L.3
  • 36
    • 84901347296 scopus 로고    scopus 로고
    • Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology
    • PID: 24860500
    • Wong BX, Hung YH, Bush AI et al (2014) Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology. Front Aging Neurosci 6:91
    • (2014) Front Aging Neurosci , vol.6 , pp. 91
    • Wong, B.X.1    Hung, Y.H.2    Bush, A.I.3
  • 37
    • 84904582549 scopus 로고    scopus 로고
    • Interactions of metals and apolipoprotein E in Alzheimer’s disease
    • PID: 24971061
    • Xu H, Finkelstein DI, Adlard PA (2014) Interactions of metals and apolipoprotein E in Alzheimer’s disease. Front Aging Neurosci 6:121
    • (2014) Front Aging Neurosci , vol.6 , pp. 121
    • Xu, H.1    Finkelstein, D.I.2    Adlard, P.A.3
  • 38
    • 84891373794 scopus 로고    scopus 로고
    • Markers of cholesterol transport are associated with amyloid deposition in the brain
    • COI: 1:CAS:528:DC%2BC3sXhsleitL%2FO, PID: 24199960
    • Hughes TM, Lopez OL, Evans RW et al (2014) Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiol Aging 35:802–807
    • (2014) Neurobiol Aging , vol.35 , pp. 802-807
    • Hughes, T.M.1    Lopez, O.L.2    Evans, R.W.3
  • 39
    • 77952888035 scopus 로고    scopus 로고
    • Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXltFOmsb8%3D, PID: 20307625
    • Nuutinen T, Suuronen T, Kauppinen A et al (2010) Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer’s disease. Neurosci Lett 475:64–68
    • (2010) Neurosci Lett , vol.475 , pp. 64-68
    • Nuutinen, T.1    Suuronen, T.2    Kauppinen, A.3
  • 40
    • 79956276295 scopus 로고    scopus 로고
    • Increased expression of acyl-coenzyme A: cholesterol acyltransferase-1 and elevated cholesteryl esters in the hippocampus after excitotoxic injury
    • COI: 1:CAS:528:DC%2BC3MXmsVWktL4%3D, PID: 21514367
    • Kim JH, Ee SM, Jittiwat J et al (2011) Increased expression of acyl-coenzyme A: cholesterol acyltransferase-1 and elevated cholesteryl esters in the hippocampus after excitotoxic injury. Neuroscience 185:125–134
    • (2011) Neuroscience , vol.185 , pp. 125-134
    • Kim, J.H.1    Ee, S.M.2    Jittiwat, J.3
  • 41
    • 84856226228 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration
    • COI: 1:CAS:528:DC%2BC38XhsVeku7Y%3D, PID: 22079154
    • Zhang XM, Mao XJ, Zhang HL et al (2012) Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration. Exp Neurol 233:323–332
    • (2012) Exp Neurol , vol.233 , pp. 323-332
    • Zhang, X.M.1    Mao, X.J.2    Zhang, H.L.3
  • 42
    • 17044412511 scopus 로고    scopus 로고
    • Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice
    • COI: 1:CAS:528:DC%2BD2MXivFyqsLc%3D, PID: 15823260
    • Noh HS, Kim DW, Kang SS et al (2005) Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice. Brain Res 1042:114–118
    • (2005) Brain Res , vol.1042 , pp. 114-118
    • Noh, H.S.1    Kim, D.W.2    Kang, S.S.3
  • 43
    • 84879699812 scopus 로고    scopus 로고
    • How does the ketogenic diet work? Four potential mechanisms
    • PID: 23670253
    • Danial NN, Hartman AL, Stafstrom CE et al (2013) How does the ketogenic diet work? Four potential mechanisms. J Child Neurol 28:1027–1033
    • (2013) J Child Neurol , vol.28 , pp. 1027-1033
    • Danial, N.N.1    Hartman, A.L.2    Stafstrom, C.E.3
  • 44
    • 55349119933 scopus 로고    scopus 로고
    • Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet
    • PID: 19049599
    • Bough K (2008) Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet. Epilepsia 49:91–93
    • (2008) Epilepsia , vol.49 , pp. 91-93
    • Bough, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.