Overexpression of apolipoprotein E4 increases kainic-acid-induced hippocampal neurodegeneration

Experimental Neurology

Volumn 233, Issue 1, 2012, Pages 323-332

  Zhang, Xing Mei ^a   Mao, Xi Jing ^a   Zhang, Hong Liang ^a   Zheng, Xiang Yu ^a   Pham, Therese ^a   Adem, Abdu ^b   Winblad, Bengt ^a   Mix, Eilhard ^c   Zhu, Jie ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Apolipoprotein E; Hippocampus; Isoform; Kainic acid; Neurodegeneration; Neuroinflammation

Indexed keywords

APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CD86 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; ISOPROTEIN; KAINIC ACID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL ACTIVATION; CELL FUNCTION; CELL LOSS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; ENCEPHALITIS; HIPPOCAMPUS; IMMUNE RESPONSE; MALE; MICROGLIA; MOUSE; MYOCLONUS SEIZURE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REARING; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD11B; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ASTROCYTES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID AGONISTS; EXPLORATORY BEHAVIOR; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; KAINIC ACID; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; SEIZURES; STATISTICS, NONPARAMETRIC;

EID: 84856226228     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.10.024     Document Type: Article

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