Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

Brain

Volumn 137, Issue 1, 2014, Pages 137-152

  Grabrucker, Stefanie ^a   Jannetti, Linda ^a   Eckert, Matti ^a   Gaub, Simone ^a   Chhabra, Resham ^a   Pfaender, Stefanie ^a   Mangus, Katharina ^a   Reddy, Parameshwar Pasham ^b   Rankovic, Vladan ^b   Schmeisser, Michael J ^a   Kreutz, Michael R ^b   Ehret, Günter ^a   Boeckers, Tobias M ^a   Grabrucker, Andreas M ^a  

^a UNIVERSITY OF ULM   (Germany)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

Author keywords

ASD; PSD; Shank3; synapse

Indexed keywords

PROSAP SHANK PROTEIN; PROSAP1 SHANK2 PROTEIN; PROSAP2 SHANK3 PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; ZINC;

ADULT; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; FEMALE; GENETIC DISORDER; HAPLOINSUFFICIENCY; HUMAN; HYPERACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MOUSE MODEL; MUSCLE HYPOTONIA; NEUROBIOLOGY; NONHUMAN; OVERRESPONSIVITY; PHELAN MCDERMID SYNDROME; PHENOTYPE; POSTSYNAPTIC DENSITY; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; RISK FACTOR; SEIZURE; SOCIAL BEHAVIOR; VOCALIZATION; YOUNG ADULT; ZINC DEFICIENCY;

ASD; PSD; SHANK3; SYNAPSE; ZN2+;

ANIMALS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CELLS, CULTURED; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHROMOSOME DELETION; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 22; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; ORGAN CULTURE TECHNIQUES; PREGNANCY; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SAPOSINS; SPECTROMETRY, FLUORESCENCE; SYNAPSES; TRANSFECTION; VOCALIZATION, ANIMAL; ZINC;

EID: 84892702866     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt303     Document Type: Article

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