Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles

Journal of Histochemistry and Cytochemistry

Volumn 56, Issue 1, 2008, Pages 3-6

  Linkous, David H ^a   Flinn, Jane M ^a   Koh, Jae Y ^b   Lanzirotti, Antonio ^c,d   Bertsch, Paul M ^e   Jones, Blair F ^f   Giblin, Leonard J ^g   Frederickson, Christopher J ^g  

^a GEORGE MASON UNIVERSITY   (United States)

^b University of Ulsan College of Medicine   (South Korea)

^c UNIVERSITY OF CHICAGO   (United States)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

^f U S GEOLOGICAL SURVEY   (United States)

^g NeuroBioTex Inc   (United States)

Author keywords

Fluorescence; Glutamate; Hilus; Knockout; Mossy fibers; X ray; Zinc release; ZNT3

Indexed keywords

PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; ZINC; ZNT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN LEVEL; CONTROLLED STUDY; GENE; HIPPOCAMPUS; HISTOCHEMISTRY; MALE; MICROANALYSIS; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SLC30A3 GENE; SYNAPSE VESICLE; X RAY FLUORESCENCE;

ANIMALS; BRAIN; CARRIER PROTEINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOSSY FIBERS, HIPPOCAMPAL; SPECTROMETRY, X-RAY EMISSION; SYNAPTIC VESICLES; ZINC;

MUS;

EID: 37249070874     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.6A7035.2007     Document Type: Article

References (18)

1. Agatsuma S, Lee M, Zhu H, Chen K, Shih JC, Seif I, Hiroi N (2006) Momoamine oxydase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli. Hum Mol Genet 15:2721-2731
2. Cole TB, Martyanova A, Palmiter RD (2001) Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse. Brain Res 891:253-265
3. Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD (1999) Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Proc Natl Acad Sci USA 96:1716-1721
4. Collingwood JF, Mikhaylova A, Davidson M, Batich C, Streit WJ, Terry J, Dobson J (2005) In situ characterization and mapping of iron compounds in Alzheimer's disease tissue. J Alzheimers Dis 7:267-272
5. Flinn JM, Hunter D, Linkous DH, Lanzirotti A, Smith LN, Brightwell J, Jones BF (2005) Enhanced zinc consumption causes memory deficits and increased brain levels of zinc. Physiol Behav 83:793-803
6. Frederickson CJ, Klitenick MA, Manton WI, Kirkpatrick JB (1983) Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat. Brain Res 273:335-339
7. Frederickson RE, Frederickson CJ, Danscher G (1990) In situ binding of bouton zinc reversibly disrupts performance on a spatial memory task. Behav Brain Res 38:25-33
8. Friedlich AL, Lee JY, Van GT, Cherny RA, Volitakis I, Cole TB, Palmiter RD, et al. (2004) Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. J Neurosci 24:3453-3459
9. Klitenick MA, Frederickson CJ, Manton WI (1983) Acid-vapor decomposition for determination of zinc in brain tissue by isotope dilution mass spectrometry. Anal Chem 55:921-923
10. Lassalle JM, Bataille T, Halley H (2000) Reversible inactivation of the hippocampal mossy fiber synapses in mice impairs spatial learning, but neither consolidation nor memory retrieval, in the Morris navigation task. Neurobiol Learn Mem 73:243-257
11. Li Y, Hough CJ, Frederickson CJ, Sarvey JM (2001) Induction of mossy fiber -> Ca3 long-term potentiation requires translocation of synaptically released Zn2+ . J Neurosci 21:8015-8025
12. Li YV, Hough CJ, Sarvey JM (2003) Do we need zinc to think? Sci STKE 182:pe19
13. Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, et al. (2006) Metal exposure and Alzheimer's pathogenesis. J Struct Biol 155:45-51
14. Miller LM, Wang Q, Telivala TP, Smith RJ, Lanzirotti A, Miklossy J (2006) Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. J Struct Biol 155:30-37
15. Molnar P, Nadler JV (2001) Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. Brain Res 910:205-207
16. Palmiter RD, Cole TB, Quaife CJ, Findley SO (1996) ZNT3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci USA 93:14934-14939
17. Ste Marie L, Luquet S, Cole TB, Palmiter RD (2005) Modulation of neuropeptide Y expression in adult mice does not affect feeding. Proc Natl Acad Sci USA 102:18632-18637
18. Wenzel HJ, Cole TB, Born DE, Schwartzkroin PA, Palmiter RD (1997) Ultrastructural localization of zinc transporter-3 (ZNT3) to synaptic vesicle membranes within mossy-fiber boutons in the hippocampus of mouse and monkey. Proc Natl Acad Sci USA 94:12676-12681