Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity

Journal of Immunology

Volumn 184, Issue 10, 2010, Pages 5595-5603

  Nakajima, Saeko ^a   Honda, Tetsuya ^a   Sakata, Daiji ^a   Egawa, Gyohei ^a   Tanizaki, Hideaki ^a   Otsuka, Atsushi ^a   Moniaga, Catharina Sagita ^a   Watanabe, Takeshi ^a   Miyachi, Yoshiki ^a   Narumiya, Shuh ^a   Kabashima, Kenji ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; PROSTACYCLIN; PROSTACYCLIN SYNTHASE; PROSTANOID RECEPTOR; PROSTAGLANDIN E RECEPTOR; PROSTANOID RECEPTOR EP1; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; INTERFERON PRODUCTION; LYMPH NODE CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; ADOPTIVE TRANSFER; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SKIN ALLERGY; UPREGULATION;

ADOPTIVE TRANSFER; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DERMATITIS, ALLERGIC CONTACT; DISEASE MODELS, ANIMAL; EPOPROSTENOL; FEMALE; HYPERSENSITIVITY, DELAYED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN KINASE INHIBITORS; RECEPTORS, PROSTAGLANDIN E; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; UP-REGULATION;

EID: 77954750018     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903260     Document Type: Article

References (42)

1. Liew, F. Y. 2002. T(H)1 and T(H)2 cells: a historical perspective. Nat. Rev. Immunol. 2: 55-60.
2. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17: 138-146.
3. Weaver, C. T., R. D. Hatton, P. R. Mangan, and L. E. Harrington. 2007. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852.
4. Badou, A., M. Savignac, M. Moreau, C. Leclerc, G. Foucras, G. Cassar, P. Paulet, D. Lagrange, P. Druet, J. C. Guéry, and L. Pelletier. 2001. Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN-gamma production. Eur. J. Immunol. 31: 2487-2496.
5. Constant, S. L., and K. Bottomly. 1997. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15: 297-322.
6. Szabo, S. J., B. M. Sullivan, S. L. Peng, and L. H. Glimcher. 2003. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21: 713-758.
7. Kabashima, K., and Y. Miyachi. 2004. Prostanoids in the cutaneous immune response. J. Dermatol. Sci. 34: 177-184.
8. Matsuoka, T., and S. Narumiya. 2008. The roles of prostanoids in infection and sickness behaviors. J. Infect. Chemother. 14: 270-278.
9. Narumiya, S., Y. Sugimoto, and F. Ushikubi. 1999. Prostanoid receptors: structures, properties, and functions. Physiol. Rev. 79: 1193-1226.
10. Goodwin, J. S., and J. Ceuppens. 1983. Regulation of the immune response by prostaglandins. J. Clin. Immunol. 3: 295-315.
11. Hasler, F., H. G. Bluestein, N. J. Zvaifler, and L. B. Epstein. 1983. Analysis of the defects responsible for the impaired regulation of EBV-induced B cell proliferation by rheumatoid arthritis lymphocytes. II. Role of monocytes and the increased sensitivity of rheumatoid arthritis lymphocytes to prostaglandin E. J. Immunol. 131: 768-772.
12. Betz, M., and B. S. Fox. 1991. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146: 108-113.
13. Nataraj, C., D. W. Thomas, S. L. Tilley, M. T. Nguyen, R. Mannon, B. H. Koller, and T. M. Coffman. 2001. Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. J. Clin. Invest. 108: 1229-1235.
14. Kabashima, K., T. Saji, T. Murata, M. Nagamachi, T. Matsuoka, E. Segi, K. Tsuboi, Y. Sugimoto, T. Kobayashi, Y. Miyachi, et al. 2002. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J. Clin. Invest. 109: 883-893.
15. Nagamachi, M., D. Sakata, K. Kabashima, T. Furuyashiki, T. Murata, E. Segi-Nishida, K. Soontrapa, T. Matsuoka, Y. Miyachi, and S. Narumiya. 2007. Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. J. Exp. Med. 204: 2865-2874.
16. Yao, C., D. Sakata, Y. Esaki, Y. Li, T. Matsuoka, K. Kuroiwa, Y. Sugimoto, and S. Narumiya. 2009. Prostaglandin E(2)-EP4 signaling promotes immune inflammation through T(H)1 cell differentiation and T(H)17 cell expansion. Nat Med. 15: 633-640.
17. Lee, I. Y., Y. D. Bae, D. I. Jeoung, D. Kang, C. H. Park, S. H. Kim, and J. Choe. 2007. Prostacyclin production is not controlled by prostacyclin synthase but by cyclooxygenase-2 in a human follicular dendritic cell line, HK. Mol. Immunol. 44: 3168-3172.
18. Sugimoto, M., I. Arai, N. Futaki, Y. Hashimoto, T. Sakurai, Y. Honma, and S. Nakaike. 2006. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice. Exp. Dermatol. 15: 875-882.
19. Jaffar, Z., K. S. Wan, and K. Roberts. 2002. A key role for prostaglandin I2 in limiting lung mucosal Th2, but not Th1, responses to inhaled allergen. J. Immunol. 169: 5997-6004. (Pubitemid 35291707)
20. Shephard, E. G., L. Malan, C. M. Macfarlane, W. Mouton, and J. R. Joubert. 1985. Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. Br. J. Clin. Pharmacol. 19: 459-470.
21. Schulman, E. S., N. F. Adkinson, Jr., and H. H. Newball. 1982. Cyclooxygenase metabolites in human lung anaphylaxis: airway vs. parenchyma. J. Appl. Physiol. 53: 589-595.
22. Namba, T., H. Oida, Y. Sugimoto, A. Kakizuka, M. Negishi, A. Ichikawa, and S. Narumiya. 1994. cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J. Biol. Chem. 269: 9986-9992.
23. Zhou, W., T. S. Blackwell, K. Goleniewska, J. F. O'Neal, G. A. Fitzgerald, M. Lucitt, R. M. Breyer, and R. S. Peebles, Jr. 2007. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. J. Leukoc. Biol. 81: 809-817.
24. Idzko, M.,H.Hammad,M. vanNimwegen,M.Kool, N.Vos, H. C. Hoogsteden, and B. N. Lambrecht. 2007. Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J. Clin. Invest. 117: 464-472.
25. Jaffar, Z., M. E. Ferrini, M. C. Buford, G. A. Fitzgerald, and K. Roberts. 2007. Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma. J. Immunol. 179: 6193-6203.
26. Bianco, S., M. Robuschi, R. Ceserani, and C. Gandolfi. 1980. Effects of prostacyclin on aspecifically and specifically induced bronchoconstriction in asthmatic patients. Eur. J. Respir. Dis. Suppl. 106: 81-87.
27. Hardy, C. C., P. Bradding, C. Robinson, and S. T. Holgate. 1988. Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma. J. Appl. Physiol. 64: 1567-1574.
28. Hashimoto, K., B. S. Graham, M. W. Geraci, G. A. FitzGerald, K. Egan, W. Zhou, K. Goleniewska, J. F. O'Neal, J. D. Morrow, R. K. Durbin, et al. 2004. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. J. Virol. 78: 10303-10309.
29. Wang, B., C. Feliciani, I. Freed, Q. Cai, and D. N. Sauder. 2001. Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies. J. Leukoc. Biol. 70: 185-191.
30. Mori, T., K. Kabashima, R. Yoshiki, K. Sugita, N. Shiraishi, A. Onoue, E. Kuroda, M. Kobayashi, U. Yamashita, and Y. Tokura. 2008. Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. J. Invest. Dermatol. 128: 1719-1727.
31. Murata, T., F. Ushikubi, T. Matsuoka, M. Hirata, A. Yamasaki, Y. Sugimoto, A. Ichikawa, Y. Aze, T. Tanaka, N. Yoshida, et al. 1997. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388: 678-682.
32. Jessup, H. K., A. W. Brewer, M. Omori, E. A. Rickel, A. L. Budelsky, B. R. Yoon, S. F. Ziegler, and M. R. Comeau. 2008. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J. Immunol. 181: 4311-4319.
33. Kabashima, K., K. Sugita, N. Shiraishi, H. Tamamura, N. Fujii, and Y. Tokura. 2007. CXCR4 engagement promotes dendritic cell survival and maturation. Biochem. Biophys. Res. Commun. 361: 1012-1016.
34. Kamata, T., M. Yamashita, M. Kimura, K. Murata, M. Inami, C. Shimizu, K. Sugaya, C. R. Wang, M. Taniguchi, and T. Nakayama. 2003. src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation. J. Clin. Invest. 111: 109-119.
35. Kabashima, K., T. Murata, H. Tanaka, T. Matsuoka, D. Sakata, N. Yoshida, K. Katagiri, T. Kinashi, T. Tanaka, M. Miyasaka, et al. 2003. Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat. Immunol. 4: 694-701.
36. Kabashima, K., D. Sakata, M. Nagamachi, Y. Miyachi, K. Inaba, and S. Narumiya. 2003. Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat. Med. 9: 744-749.
37. Grabbe, S., and T. Schwarz. 1998. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol. Today 19: 37-44. (Pubitemid 28078607)
38. Murray, A. J. 2008. Pharmacological PKA inhibition: all may not be what it seems. Sci. Signal. 1: re4.
39. Honda, T., E. Segi-Nishida, Y. Miyachi, and S. Narumiya. 2006. Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. J. Exp. Med. 203: 325-335.
40. Dustin, M. L. 2008. T-cell activation through immunological synapses and kinapses. Immunol. Rev. 221: 77-89.
41. Szczeklik, A., R. J. Gryglewski, G. Czerniawska-Mysik, and E. Nizankowska. 1986. Aspirin sensitive asthma and arachidonic acid transformation. N. Engl. Reg. Allergy Proc. 7: 21-25.
42. Takahashi, Y., S. Tokuoka, T. Masuda, Y. Hirano,M. Nagao, H. Tanaka, N. Inagaki, S. Narumiya, and H. Nagai. 2002. Augmentation of allergic inflammation in prostanoid IP receptor deficient mice. Br. J. Pharmacol. 137: 315-322.