Contrasting pathogenesis of atopic dermatitis and psoriasis - Part I: Clinical and pathologic concepts

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 5, 2011, Pages 1110-1118

  Guttman Yassky, Emma ^a,b   Nograles, Kristine E ^a   Krueger, James G ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Atopic dermatitis; pathogenesis; psoriasis; therapy

Indexed keywords

ALEFACEPT; BCG VACCINE; CALCINEURIN INHIBITOR; CYCLOSPORIN A; EFALIZUMAB; FILAGGRIN; GENTAMICIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; INVOLUCRIN; MEASLES VACCINE; OMALIZUMAB; PERTUSSIS VACCINE; PIMECROLIMUS; RECOMBINANT GAMMA INTERFERON; TACROLIMUS;

ANTIGEN BINDING; ASTHMA; ATOPIC DERMATITIS; CELL DIFFERENTIATION; CELL INFILTRATION; CELL MEMBRANE DEPOLARIZATION; CELLULAR IMMUNITY; CLINICAL FEATURE; CYTOKINE PRODUCTION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL SANITATION; EPIDERMIS; GENE DELETION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HUMAN; HYGIENE THEORY; IMMUNOPATHOGENESIS; INFECTION SENSITIVITY; KERATINOCYTE; LOSS OF FUNCTION MUTATION; MEMBRANE DAMAGE; NONHUMAN; ONSET AGE; PREVALENCE; PRIORITY JOURNAL; PSORIASIS; REVIEW; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; THEORY; VACCINATION;

EID: 79955608104     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.01.053     Document Type: Article

References (115)

1. E. Guttman-Yassky, K.E. Nograles, and J.G. Krueger Contrasting pathogenesis of atopic dermatitis and psoriasis, part II: Immune cell subsets and therapeutic concepts J Allergy Clin Immunol 2011 In press
2. K.E. Nograles, B. Davidovici, and J.G. Krueger New insights in the immunologic basis of psoriasis Semin Cutan Med Surg 29 2010 3 9
3. E. Guttman-Yassky, and J.G. Krueger Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research Br J Dermatol 157 2007 1103 1115 (Pubitemid 350115667)
4. F.O. Nestle, D.H. Kaplan, and J. Barker Psoriasis N Engl J Med 361 2009 496 509
5. E. Guttman-Yassky, M.A. Lowes, J. Fuentes-Duculan, J. Whynot, I. Novitskaya, and I. Cardinale Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis J Allergy Clin Immunol 119 2007 1210 1217 (Pubitemid 46654193)
6. G.J. de Jongh, P.L. Zeeuwen, M. Kucharekova, R. Pfundt, P.G. van der Valk, and W. Blokx High expression levels of keratinocyte antimicrobial proteins in psoriasis compared with atopic dermatitis J Invest Dermatol 125 2005 1163 1173
7. T. Bieber, and N. Novak Pathogenesis of atopic dermatitis: new developments Curr Allergy Asthma Rep 9 2009 291 294
8. L.S. Fonacier, S.C. Dreskin, and D.Y. Leung Allergic skin diseases J Allergy Clin Immunol 125 suppl 2010 S138 S149
9. Y. Tokura Extrinsic and intrinsic types of atopic dermatitis J Dermatol Sci 58 2010 1 7
10. J.A. Odhiambo, H.C. Williams, T.O. Clayton, C.F. Robertson, and M.I. Asher Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three J Allergy Clin Immunol 124 2009 1251 1258 e23
11. T. Bieber Atopic dermatitis Ann Dermatol 22 2010 125 137
12. J.D. Bos, E.E. Brenninkmeijer, M.E. Schram, M.A. Middelkamp-Hup, P.I. Spuls, and J.H. Smitt Atopic eczema or atopiform dermatitis Exp Dermatol 19 2010 325 331
13. S. Romagnani The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology 112 2004 352 363 (Pubitemid 38859512)
14. H. Garn, and H. Renz Epidemiological and immunological evidence for the hygiene hypothesis Immunobiology 212 2007 441 452 (Pubitemid 46825255)
15. S. Sehra, F.M. Tuana, M. Holbreich, N. Mousdicas, R.S. Tepper, and C.H. Chang Scratching the surface: towards understanding the pathogenesis of atopic dermatitis Crit Rev Immunol 28 2008 15 43 (Pubitemid 351264073)
16. T.T. Chang, and S.R. Stevens Atopic dermatitis: the role of recombinant interferon-gamma therapy Am J Clin Dermatol 3 2002 175 183 (Pubitemid 34533777)
17. E. Christophers Genotyping psoriasis J Invest Dermatol 120 2003 xvii
18. R.A. Snyder Psoriatic arthritis: a dermatologist's perspective Am J Clin Dermatol 11 suppl 1 2010 19 22
19. E. Guttman-Yassky, M. Suarez-Farinas, A. Chiricozzi, K.E. Nograles, A. Shemer, and J. Fuentes-Duculan Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis J Allergy Clin Immunol 124 2009 1235 1244 e58
20. T. Bieber Atopic dermatitis N Engl J Med 358 2008 1483 1494
21. M. Zaiac The role of biological agents in the treatment of nail psoriasis Am J Clin Dermatol 11 suppl 1 2010 27 30
22. M.A. Lowes, A.M. Bowcock, and J.G. Krueger Pathogenesis and therapy of psoriasis Nature 445 2007 866 873
23. M. Boguniewicz, and D.Y. Leung Recent insights into atopic dermatitis and implications for management of infectious complications J Allergy Clin Immunol 125 2010 4 15
24. E. Tschachler Psoriasis: the epidermal component Clin Dermatol 25 2007 589 595 (Pubitemid 350087609)
25. I. Nomura, B. Gao, M. Boguniewicz, M.A. Darst, J.B. Travers, and D.Y. Leung Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis J Allergy Clin Immunol 112 2003 1195 1202 (Pubitemid 37550015)
26. P.M. Elias, and M. Schmuth Abnormal skin barrier in the etiopathogenesis of atopic dermatitis Curr Opin Allergy Clin Immunol 9 2009 437 446
27. J.M. Jensen, R. Folster-Holst, A. Baranowsky, M. Schunck, S. Winoto-Morbach, and C. Neumann Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis J Invest Dermatol 122 2004 1423 1431 (Pubitemid 38757224)
28. P.M. Elias, Y. Hatano, and M.L. Williams Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms J Allergy Clin Immunol 121 2008 1337 1343
29. E. Proksch, J.M. Brandner, and J.M. Jensen The skin: an indispensable barrier Exp Dermatol 17 2008 1063 1072
30. C.R. Harding The stratum corneum: structure and function in health and disease Dermatol Ther 17 suppl 1 2004 6 15
31. D. Wilsmann-Theis, T. Hagemann, J. Jordan, T. Bieber, and N. Novak Facing psoriasis and atopic dermatitis: are there more similarities or more differences? Eur J Dermatol 18 2008 172 180 (Pubitemid 351554807)
32. R. Heidenreich, M. Rocken, and K. Ghoreschi Angiogenesis drives psoriasis pathogenesis Int J Exp Pathol 90 2009 232 248
33. Y. Zhang, H. Matsuo, and E. Morita Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis Arch Dermatol Res 297 2006 425 429 (Pubitemid 43288220)
34. P.M. Elias, J. Arbiser, B.E. Brown, H. Rossiter, M.Q. Man, and F. Cerimele Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis Am J Pathol 173 2008 689 699
35. K.E. Nograles, R.D. Brasington, and A.M. Bowcock New insights into the pathogenesis and genetics of psoriatic arthritis Nat Clin Pract Rheumatol 5 2009 83 91
36. E. Guttman-Yassky, M.A. Lowes, J. Fuentes-Duculan, L.C. Zaba, I. Cardinale, and K.E. Nograles Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis J Immunol 181 2008 7420 7427
37. A. De Benedetto, R. Agnihothri, L.Y. McGirt, L.G. Bankova, and L.A. Beck Atopic dermatitis: a disease caused by innate immune defects? J Invest Dermatol 129 2009 14 30
38. I. Mittermann, K.J. Aichberger, R. Bunder, N. Mothes, H. Renz, and R. Valenta Autoimmunity and atopic dermatitis Curr Opin Allergy Clin Immunol 4 2004 367 371 (Pubitemid 39274077)
39. P. Schmid-Grendelmeier, S. Fluckiger, R. Disch, A. Trautmann, B. Wuthrich, and K. Blaser IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis J Allergy Clin Immunol 115 2005 1068 1075 (Pubitemid 40616225)
40. S. Altrichter, E. Kriehuber, J. Moser, R. Valenta, T. Kopp, and G. Stingl Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis J Invest Dermatol 128 2008 2232 2239
41. S. Zeller, C. Rhyner, N. Meyer, P. Schmid-Grendelmeier, C.A. Akdis, and R. Crameri Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema J Allergy Clin Immunol 124 2009 278 285 e1-7
42. D. Wilsman-Theis, T. Hagemann, J. Jordan, T. Bieber, and N. Novak Facing psoriasis and atopic dermatitis: are there more similarities or more differences? Eur J Dermatol 18 2008 172 180 (Pubitemid 351554807)
43. E.D. Roberson, and A.M. Bowcock Psoriasis genetics: breaking the barrier Trends Genet 26 2010 415 423
44. J.W. Holloway, S.H. Arshad, and S.T. Holgate Using genetics to predict the natural history of asthma? J Allergy Clin Immunol 126 2010 200 211
45. F.D. Finkelman, J.A. Boyce, D. Vercelli, and M.E. Rothenberg Key advances in mechanisms of asthma, allergy, and immunology in 2009 J Allergy Clin Immunol 125 2010 312 318
46. K.C. Barnes Genomewide association studies in allergy and the influence of ethnicity Curr Opin Allergy Clin Immunol 10 2010 427 433
47. S.F. Thomsen, C.S. Ulrik, K.O. Kyvik, J.B. Hjelmborg, L.R. Skadhauge, and I. Steffensen Importance of genetic factors in the etiology of atopic dermatitis: a twin study Allergy Asthma Proc 28 2007 535 539
48. Y.H. Chien, W.L. Hwu, and B.L. Chiang The genetics of atopic dermatitis Clin Rev Allergy Immunol 33 2007 178 190
49. J.T. Elder, A.T. Bruce, J.E. Gudjonsson, A. Johnston, P.E. Stuart, and T. Tejasvi Molecular dissection of psoriasis: integrating genetics and biology J Invest Dermatol 130 2010 1213 1226
50. J.T. Elder Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis Genes Immun 10 2009 201 209
51. C. Mauro, E. Crescenzi, R. De Mattia, F. Pacifico, S. Mellone, and S. Salzano Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis J Biol Chem 281 2006 2631 2638 (Pubitemid 43845724)
52. C. de Guzman Strong, S. Conlan, C.B. Deming, J. Cheng, K.E. Sears, and J.A. Segre A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis Hum Mol Genet 19 2010 1453 1460
53. K.C. Barnes An update on the genetics of atopic dermatitis: scratching the surface in 2009 J Allergy Clin Immunol 125 2010 16 31 e1-11
54. R. de Cid, E. Riveira-Munoz, P.L. Zeeuwen, J. Robarge, W. Liao, and E.N. Dannhauser Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis Nat Genet 41 2009 211 215
55. X.J. Zhang, W. Huang, S. Yang, L.D. Sun, F.Y. Zhang, and Q.X. Zhu Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21 Nat Genet 41 2009 205 210
56. D.Y. Leung Our evolving understanding of the functional role of filaggrin in atopic dermatitis J Allergy Clin Immunol 124 2009 494 495
57. G.M. O'Regan, A. Sandilands, W.H. McLean, and A.D. Irvine Filaggrin in atopic dermatitis J Allergy Clin Immunol 124 2009 R2 R6
58. M.K. Oyoshi, R. He, L. Kumar, J. Yoon, and R.S. Geha Cellular and molecular mechanisms in atopic dermatitis Adv Immunol 102 2009 135 226
59. C.N. Palmer, A.D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, and S.P. Lee Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis Nat Genet 38 2006 441 446
60. Y. Zhao, A. Terron-Kwiatkowski, H. Liao, S.P. Lee, M.H. Allen, and P.R. Hull Filaggrin null alleles are not associated with psoriasis J Invest Dermatol 127 2007 1878 1882 (Pubitemid 47075371)
61. M. Akiyama FLG mutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics Br J Dermatol 162 2010 472 477
62. R.A. van den Oord, and A. Sheikh Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis BMJ 339 2009 b2433
63. N. Novak, S. Koch, J.P. Allam, and T. Bieber Dendritic cells: bridging innate and adaptive immunity in atopic dermatitis J Allergy Clin Immunol 125 2010 50 59
64. P.Y. Ong, and D.Y. Leung Immune dysregulation in atopic dermatitis Curr Allergy Asthma Rep 6 2006 384 389 (Pubitemid 44340170)
65. K.E. Nograles, L.C. Zaba, A. Shemer, J. Fuentes-Duculan, I. Cardinale, and T. Kikuchi IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells J Allergy Clin Immunol 123 2009 1244 1252
66. Q. Hamid, M. Boguniewicz, and D.Y. Leung Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis J Clin Invest 94 1994 870 876 (Pubitemid 24251022)
67. E. Proksch, R. Folster-Holst, M. Brautigam, M. Sepehrmanesh, S. Pfeiffer, and J.M. Jensen Role of the epidermal barrier in atopic dermatitis J Dtsch Dermatol Ges 7 2009 899 910
68. I. Jakasa, M.M. Verberk, M. Esposito, J.D. Bos, and S. Kezic Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients J Invest Dermatol 127 2007 129 134 (Pubitemid 46005670)
69. D.Y. Leung, and T. Bieber Atopic dermatitis Lancet 361 2003 151 160 (Pubitemid 36092023)
70. K.C. Madison Barrier function of the skin: "la raison d'etre" of the epidermis J Invest Dermatol 121 2003 231 241 (Pubitemid 36969895)
71. J.M. Jensen, and E. Proksch The skin's barrier G Ital Dermatol Venereol 144 2009 689 700
72. Z. Nemes, and P.M. Steinert Bricks and mortar of the epidermal barrier Exp Mol Med 31 1999 5 19 (Pubitemid 29164098)
73. A. Di Nardo, P. Wertz, A. Giannetti, and S. Seidenari Ceramide and cholesterol composition of the skin of patients with atopic dermatitis Acta Derm Venereol 78 1998 27 30 (Pubitemid 28103674)
74. M.J. Cork, S.G. Danby, Y. Vasilopoulos, J. Hadgraft, M.E. Lane, and M. Moustafa Epidermal barrier dysfunction in atopic dermatitis J Invest Dermatol 129 2009 1892 1908
75. S. Weidinger, T. Illig, H. Baurecht, A.D. Irvine, E. Rodriguez, and A. Diaz-Lacava Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations J Allergy Clin Immunol 118 2006 214 219 (Pubitemid 43949588)
76. T.C. Scharschmidt, M.Q. Man, Y. Hatano, D. Crumrine, R. Gunathilake, and J.P. Sundberg Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens J Allergy Clin Immunol 124 2009 496 506 e1-6
77. B.J. Nickoloff, and Y. Naidu Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin J Am Acad Dermatol 30 1994 535 546 (Pubitemid 24121751)
78. E. Proksch, W.M. Holleran, G.K. Menon, P.M. Elias, and K.R. Feingold Barrier function regulates epidermal lipid and DNA synthesis Br J Dermatol 128 1993 473 482 (Pubitemid 23155942)
79. R. He, M.K. Oyoshi, H. Jin, and R.S. Geha Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge Proc Natl Acad Sci U S A 104 2007 15817 15822 (Pubitemid 350035382)
80. J. Henderson, K. Northstone, S.P. Lee, H. Liao, Y. Zhao, and M. Pembrey The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study J Allergy Clin Immunol 121 2008 872 877 e9
81. S.J. Brown, and A.D. Irvine Atopic eczema and the filaggrin story Semin Cutan Med Surg 27 2008 128 137 (Pubitemid 351938748)
82. T. Jung, and G. Stingl Atopic dermatitis: therapeutic concepts evolving from new pathophysiologic insights J Allergy Clin Immunol 122 2008 1074 1081
83. E. Maggi The TH1/TH2 paradigm in allergy Immunotechnology 3 1998 233 244 (Pubitemid 28098326)
84. H.C. Oettgen, and R.S. Geha IgE in asthma and atopy: cellular and molecular connections J Clin Invest 104 1999 829 835 (Pubitemid 29536329)
85. P. Parronchi, F. Brugnolo, S. Sampognaro, and E. Maggi Genetic and environmental factors contributing to the onset of allergic disorders Int Arch Allergy Immunol 121 2000 2 9 (Pubitemid 30079539)
86. C. Incorvaia, F. Frati, N. Verna, S. D'Alo, A. Motolese, and S. Pucci Allergy and the skin Clin Exp Immunol 153 suppl 1 2008 27 29 (Pubitemid 352020380)
87. W.H. Reeves Autoimmune mechanisms in psoriasis Semin Dermatol 10 1991 217 224
88. P.F. Cheung, C.K. Wong, A.W. Ho, S. Hu, D.P. Chen, and C.W. Lam Activation of human eosinophils and epidermal keratinocytes by Th2 cytokine IL-31: implication for the immunopathogenesis of atopic dermatitis Int Immunol 22 2010 453 467
89. H. Konishi, H. Tsutsui, T. Murakami, S. Yumikura-Futatsugi, K. Yamanaka, and M. Tanaka IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions Proc Natl Acad Sci U S A 99 2002 11340 11345 (Pubitemid 34920927)
90. C.S. Munro, E.M. Higgins, J.M. Marks, B.M. Daly, P.S. Friedmann, and S. Shuster Cyclosporin A in atopic dermatitis: therapeutic response is dissociated from effects on allergic reactions Br J Dermatol 124 1991 43 48
91. D.J. Hijnen, E. Knol, C. Bruijnzeel-Koomen, and M. de Bruin-Weller Cyclosporin A treatment is associated with increased serum immunoglobulin E levels in a subgroup of atopic dermatitis patients Dermatitis 18 2007 163 165 (Pubitemid 47583222)
92. I.G. Jang, J.K. Yang, H.J. Lee, J.Y. Yi, H.O. Kim, and C.W. Kim Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma J Am Acad Dermatol 42 2000 1033 1040
93. R.A. Krathen, and S. Hsu Failure of omalizumab for treatment of severe adult atopic dermatitis J Am Acad Dermatol 53 2005 338 340 (Pubitemid 40979597)
94. B. Hayek, P. Heil, M. Laimer, D. Maurer, T. Hultsch, and G. Stingl Omalizumab treatment downregulation of IgE/FcERI on dendritic cells in patients with atopic dermatitis XXIII EAACI Congress 2004 European Academy of Allergy and Clinical Immunology Amsterdam 744
95. G.J. Rodrigo, H. Neffen, and J.A. Castro-Rodriguez Efficacy and safety of subcutaneous omalizumab versus placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review Chest 139 2011 28 35
96. B. Belloni, M. Ziai, A. Lim, B. Lemercier, M. Sbornik, and S. Weidinger Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels J Allergy Clin Immunol 120 2007 1223 1225 (Pubitemid 350047479)
97. S.Y. Park, M.R. Choi, J.I. Na, S.W. Youn, K.C. Park, and C.H. Huh Recalcitrant atopic dermatitis treated with omalizumab Ann Dermatol 22 2010 349 352
98. T. Werfel The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis J Invest Dermatol 129 2009 1878 1891
99. D. Simon, E. Vassina, S. Yousefi, E. Kozlowski, L.R. Braathen, and H.U. Simon Reduced dermal infiltration of cytokine-expressing inflammatory cells in atopic dermatitis after short-term topical tacrolimus treatment J Allergy Clin Immunol 114 2004 887 895 (Pubitemid 39330261)
100. D. Simon, E. Vassina, S. Yousefi, L.R. Braathen, and H.U. Simon Inflammatory cell numbers and cytokine expression in atopic dermatitis after topical pimecrolimus treatment Allergy 60 2005 944 951 (Pubitemid 40813818)
101. W. Hoetzenecker, R. Ecker, T. Kopp, A. Stuetz, G. Stingl, and A. Elbe-Burger Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis J Allergy Clin Immunol 115 2005 1276 1283 (Pubitemid 40824602)
102. E.G. Harper, E.L. Simpson, R.H. Takiguchi, M.D. Boyd, S.E. Kurtz, and A.C. Bakke Efalizumab therapy for atopic dermatitis causes marked increases in circulating effector memory CD4+ T cells that express cutaneous lymphocyte antigen J Invest Dermatol 128 2008 1173 1181 (Pubitemid 351543209)
103. A. Wollenberg, and E. Klein Current aspects of innate and adaptive immunity in atopic dermatitis Clin Rev Allergy Immunol 33 2007 35 44 (Pubitemid 351514142)
104. A. Blauvelt, S.T. Hwang, and M.C. Udey 11. Allergic and immunologic diseases of the skin J Allergy Clin Immunol 111 suppl 2003 S560 S570
105. H. Okada, C. Kuhn, H. Feillet, and J.F. Bach The "hygiene hypothesis" for autoimmune and allergic diseases: an update Clin Exp Immunol 160 2010 1 9
106. J.W. Upham, and P.G. Holt Environment and development of atopy Curr Opin Allergy Clin Immunol 5 2005 167 172 (Pubitemid 40434467)
107. A.P. Grammatikos The genetic and environmental basis of atopic diseases Ann Med 40 2008 482 495
108. O. Palomares, G. Yaman, A.K. Azkur, T. Akkoc, M. Akdis, and C.A. Akdis Role of Treg in immune regulation of allergic diseases Eur J Immunol 40 2010 1232 1240
109. D.J. Ahern, and D.S. Robinson Regulatory T cells as a target for induction of immune tolerance in allergy Curr Opin Allergy Clin Immunol 5 2005 531 536 (Pubitemid 41679989)
110. H. Renz, N. Blumer, S. Virna, S. Sel, and H. Garn The immunological basis of the hygiene hypothesis Chem Immunol Allergy 91 2006 30 48 (Pubitemid 43097194)
111. H. Sugiyama, R. Gyulai, E. Toichi, E. Garaczi, S. Shimada, and S.R. Stevens Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation J Immunol 174 2005 164 173 (Pubitemid 40007402)
112. A.H. van den Biggelaar, S.L. Prescott, M. Roponen, M.A. Nadal-Sims, C.J. Devitt, and S. Phuanukoonnon Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations J Allergy Clin Immunol 124 2009 544 550 e1-2
113. M. Rottem, and Y. Shoenfeld Vaccination and allergy Curr Opin Otolaryngol Head Neck Surg 12 2004 223 231 (Pubitemid 38679963)
114. P.G. Holt, J. Rowe, R. Loh, and P.D. Sly Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood Vaccine 21 2003 3432 3435 (Pubitemid 36792098)
115. G. Pershagen Can immunization affect the development of allergy? Pediatr Allergy Immunol 11 suppl 13 2000 26 28