-
1
-
-
0037673945
-
Osteoclast differentiation and activation
-
Boyle, W. J., Simonet, W. S. & Lacey, D. L. Osteoclast differentiation and activation. Nature 423, 337-342 (2003).
-
(2003)
Nature
, vol.423
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
2
-
-
0033398996
-
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors
-
Arai, F. et al. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors. J Exp Med. 190, 1741-1754 (1999).
-
(1999)
J Exp Med
, vol.190
, pp. 1741-1754
-
-
Arai, F.1
-
3
-
-
0032540319
-
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
-
Lacey, D. L. et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165-176 (1998).
-
(1998)
Cell
, vol.93
, pp. 165-176
-
-
Lacey, D.L.1
-
4
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
Kong, Y. Y. et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315-323 (1999).
-
(1999)
Nature
, vol.397
, pp. 315-323
-
-
Kong, Y.Y.1
-
5
-
-
30644469500
-
RANKL-RANK signaling in osteoclastogenesis and bone disease
-
Wada, T., Nakashima, T., Hiroshi, N. & Penninger, J. M. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 12, 17-25 (2006).
-
(2006)
Trends Mol Med
, vol.12
, pp. 17-25
-
-
Wada, T.1
Nakashima, T.2
Hiroshi, N.3
Penninger, J.M.4
-
6
-
-
56549098575
-
RANK/RANKL: Regulators of immune responses and bone physiology
-
Leibbrandt, A. & Penninger, J. M. RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143, 123-150 (2008).
-
(2008)
Ann N y Acad Sci
, vol.1143
, pp. 123-150
-
-
Leibbrandt, A.1
Penninger, J.M.2
-
7
-
-
15444381042
-
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis
-
Gohda, J. et al. RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J. 24, 790-799 (2005).
-
(2005)
EMBO J
, vol.24
, pp. 790-799
-
-
Gohda, J.1
-
8
-
-
70349100754
-
Ca2+ -NFATc1 signaling is an essential axis of osteoclast differentiation
-
Negishi-Koga, T. & Takayanagi, H. Ca2+ -NFATc1 signaling is an essential axis of osteoclast differentiation. Immunol Rev. 231, 241-256 (2009).
-
(2009)
Immunol Rev
, vol.231
, pp. 241-256
-
-
Negishi-Koga, T.1
Takayanagi, H.2
-
9
-
-
33947583822
-
Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems
-
Takayanagi, H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 7, 292-304 (2007).
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 292-304
-
-
Takayanagi, H.1
-
10
-
-
0043267732
-
Genetic regulation of osteoclast development and function
-
Teitelbaum, S. L. & Ross, F. P. Genetic regulation of osteoclast development and function. Nat Rev Genet. 4, 638-649 (2003).
-
(2003)
Nat Rev Genet
, vol.4
, pp. 638-649
-
-
Teitelbaum, S.L.1
Ross, F.P.2
-
12
-
-
84863116031
-
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J
-
Zhao, B., Grimes, S. N., Li, S., Hu, X. & Ivashkiv, L. B. TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med. 209, 319-334 (2012).
-
(2012)
J Exp Med
, vol.209
, pp. 319-334
-
-
Zhao, B.1
Grimes, S.N.2
Li, S.3
Hu, X.4
Ivashkiv, L.B.5
-
13
-
-
84855854953
-
Osteoporosis and inflammation
-
Mundy, G. R. Osteoporosis and inflammation. Nutr Rev. 65, S147-151 (2007).
-
(2007)
Nutr Rev
, vol.65
, pp. S147-151
-
-
Mundy, G.R.1
-
14
-
-
21044455484
-
Osteoblasts and osteoclasts in bone remodeling and inflammation
-
Tanaka, Y., Nakayamada, S. & Okada, Y. Osteoblasts and osteoclasts in bone remodeling and inflammation. Curr Drug Targets Inflamm Allergy 4, 325-328 (2005).
-
(2005)
Curr Drug Targets Inflamm Allergy
, vol.4
, pp. 325-328
-
-
Tanaka, Y.1
Nakayamada, S.2
Okada, Y.3
-
15
-
-
31944443249
-
Osteoporosis: A still increasing prevalence
-
Reginster, J. Y. & Burlet, N. Osteoporosis: a still increasing prevalence. Bone 38, S4-9 (2006).
-
(2006)
Bone
, vol.38
, pp. S4-9
-
-
Reginster, J.Y.1
Burlet, N.2
-
16
-
-
70249116821
-
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan
-
Abu-Taha, M. et al. Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. J Immunol 183, 1393-1402 (2009).
-
(2009)
J Immunol
, vol.183
, pp. 1393-1402
-
-
Abu-Taha, M.1
-
17
-
-
79959509852
-
Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment
-
Saeed, H. et al. Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment. J Bone Miner Res. 26, 1494-1505 (2011).
-
(2011)
J Bone Miner Res
, vol.26
, pp. 1494-1505
-
-
Saeed, H.1
-
18
-
-
9344269652
-
CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts
-
Yu, X., Huang, Y., Collin-Osdoby, P. & Osdoby, P. CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts. J Bone Miner Res. 19, 2065-2077 (2004).
-
(2004)
J Bone Miner Res
, vol.19
, pp. 2065-2077
-
-
Yu, X.1
Huang, Y.2
Collin-Osdoby, P.3
Osdoby, P.4
-
19
-
-
33947129740
-
Antiviral gene expression in rheumatoid arthritis: Role of IKKepsilon and interferon regulatory factor 3
-
Sweeney, S. E., Mo, L. & Firestein, G. S. Antiviral gene expression in rheumatoid arthritis: role of IKKepsilon and interferon regulatory factor 3. Arthritis Rheum. 56, 743-752 (2007).
-
(2007)
Arthritis Rheum
, vol.56
, pp. 743-752
-
-
Sweeney, S.E.1
Mo, L.2
Firestein, G.S.3
-
20
-
-
58849149469
-
Synergistic benefit in inflammatory arthritis by targeting i kappaB kinase epsilon and interferon beta
-
Corr, M., Boyle, D. L., Ronacher, L., Flores, N. & Firestein, G. S. Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta. Ann Rheum Dis. 68, 257-263 (2009).
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 257-263
-
-
Corr, M.1
Boyle, D.L.2
Ronacher, L.3
Flores, N.4
Firestein, G.S.5
-
21
-
-
58849134282
-
Interferon beta for rheumatoid arthritis: New clothes for an old kid on the block
-
Vervoordeldonk, M. J., Aalbers, C. J. & Tak, P. P. Interferon beta for rheumatoid arthritis: new clothes for an old kid on the block. Ann Rheum Dis. 68, 157-158 (2009).
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 157-158
-
-
Vervoordeldonk, M.J.1
Aalbers, C.J.2
Tak, P.P.3
-
22
-
-
63849232702
-
Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis
-
Dieguez-Gonzalez, R. et al. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. Ann Rheum Dis. 68, 579-583 (2009).
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 579-583
-
-
Dieguez-Gonzalez, R.1
-
23
-
-
84858689774
-
Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis
-
Hammaker, D., Boyle, D. L. & Firestein, G. S. Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis. Rheumatology 51, 610-618 (2012).
-
(2012)
Rheumatology
, vol.51
, pp. 610-618
-
-
Hammaker, D.1
Boyle, D.L.2
Firestein, G.S.3
-
24
-
-
84890928018
-
TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation
-
Sun, Q. et al. TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. J Bone Miner Res. 29, 90-102 (2014).
-
(2014)
J Bone Miner Res
, vol.29
, pp. 90-102
-
-
Sun, Q.1
-
25
-
-
25644441851
-
Amlexanox for the treatment of recurrent aphthous ulcers
-
Bell, J. Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 25, 555-566 (2005).
-
(2005)
Clin Drug Investig
, vol.25
, pp. 555-566
-
-
Bell, J.1
-
26
-
-
0023140399
-
Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase
-
Makino, H., Saijo, T., Ashida, Y., Kuriki, H. & Maki, Y. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. Int Arch Allergy Appl Immunol. 82, 66-71 (1987).
-
(1987)
Int Arch Allergy Appl Immunol
, vol.82
, pp. 66-71
-
-
Makino, H.1
Saijo, T.2
Ashida, Y.3
Kuriki, H.4
Maki, Y.5
-
27
-
-
84875179301
-
An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice
-
Reilly, S. M. et al. An inhibitor of the protein kinases TBK1 and IKK-varepsilon improves obesity-related metabolic dysfunctions in mice. Nat Med. 19, 313-321 (2013).
-
(2013)
Nat Med
, vol.19
, pp. 313-321
-
-
Reilly, S.M.1
-
28
-
-
33846031926
-
The molecular understanding of osteoclast differentiation
-
Asagiri, M. & Takayanagi, H. The molecular understanding of osteoclast differentiation. Bone 40, 251-264 (2007).
-
(2007)
Bone
, vol.40
, pp. 251-264
-
-
Asagiri, M.1
Takayanagi, H.2
-
29
-
-
33845984343
-
Molecular regulation of osteoclast activity
-
Bruzzaniti, A. & Baron, R. Molecular regulation of osteoclast activity. Rev Endocr Metab Disord. 7, 123-139 (2006).
-
(2006)
Rev Endocr Metab Disord
, vol.7
, pp. 123-139
-
-
Bruzzaniti, A.1
Baron, R.2
-
30
-
-
38449099230
-
Control of osteoclast activity and bone loss by IKK subunits: New targets for therapy
-
Ruocco, M. G. & Karin, M. Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Adv Exp Med Biol. 602, 125-134 (2007).
-
(2007)
Adv Exp Med Biol
, vol.602
, pp. 125-134
-
-
Ruocco, M.G.1
Karin, M.2
-
31
-
-
19344374949
-
I{kappa} B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
-
Ruocco, M. G. et al. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 201, 1677-1687 (2005).
-
(2005)
J Exp Med
, vol.201
, pp. 1677-1687
-
-
Ruocco, M.G.1
-
32
-
-
18744366041
-
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
-
Takayanagi, H. et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev cell 3, 889-901 (2002).
-
(2002)
Dev Cell
, vol.3
, pp. 889-901
-
-
Takayanagi, H.1
-
33
-
-
0028173214
-
C-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
-
Grigoriadis, A. E. et al. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266, 443-448 (1994).
-
(1994)
Science
, vol.266
, pp. 443-448
-
-
Grigoriadis, A.E.1
-
34
-
-
2942731511
-
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
-
Matsuo, K. et al. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem. 279, 26475-26480 (2004).
-
(2004)
J Biol Chem
, vol.279
, pp. 26475-26480
-
-
Matsuo, K.1
-
35
-
-
67349238305
-
Inhibition of osteoblastic bone formation by nuclear factor-kappaB
-
Chang, J. et al. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med. 15, 682-689 (2009).
-
(2009)
Nat Med
, vol.15
, pp. 682-689
-
-
Chang, J.1
-
36
-
-
77957272074
-
Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice
-
Alles, N. et al. Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice. Endocrinology 151, 4626-4634 (2010).
-
(2010)
Endocrinology
, vol.151
, pp. 4626-4634
-
-
Alles, N.1
-
37
-
-
84884505578
-
Mitogen-activated protein kinase pathways in osteoblasts
-
Greenblatt, M. B., Shim, J. H. & Glimcher, L. H. Mitogen-activated protein kinase pathways in osteoblasts. Annu Rev Cell Dev Biol. 29, 63-79 (2013).
-
(2013)
Annu Rev Cell Dev Biol
, vol.29
, pp. 63-79
-
-
Greenblatt, M.B.1
Shim, J.H.2
Glimcher, L.H.3
-
38
-
-
41949136377
-
Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss
-
Sun, L. et al. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A. 105, 4289-4294 (2008).
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 4289-4294
-
-
Sun, L.1
-
39
-
-
84856387483
-
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2
-
Delhase, M. et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 109, E177-186 (2012).
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E177-186
-
-
Delhase, M.1
-
40
-
-
84937421430
-
Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss
-
Guan, H., Zhao, L., Cao, H., Chen, A. & Xiao, J. Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss. FASEB J. 29, 1092-101 (2015).
-
(2015)
FASEB J
, vol.29
, pp. 1092-1101
-
-
Guan, H.1
Zhao, L.2
Cao, H.3
Chen, A.4
Xiao, J.5
-
41
-
-
11144354330
-
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
-
Koga, T. et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428, 758-763 (2004).
-
(2004)
Nature
, vol.428
, pp. 758-763
-
-
Koga, T.1
-
42
-
-
38449118017
-
Generation of osteoclasts in vitro, and assay of osteoclast activity
-
Takahashi, N., Udagawa, N., Kobayashi, Y. & Suda, T. Generation of osteoclasts in vitro, and assay of osteoclast activity. Methods Mol Med. 135, 285-301 (2007).
-
(2007)
Methods Mol Med
, vol.135
, pp. 285-301
-
-
Takahashi, N.1
Udagawa, N.2
Kobayashi, Y.3
Suda, T.4
-
43
-
-
79951821134
-
Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKLmediated NF-κ B and MAPK signaling pathways
-
Li, C. et al. Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKLmediated NF-κ B and MAPK signaling pathways. J Bone Miner Res. 26, 644-656 (2011).
-
(2011)
J Bone Miner Res
, vol.26
, pp. 644-656
-
-
Li, C.1
-
44
-
-
84868141449
-
Generation of mesenchymal stem cell lines from murine bone marrow
-
Sreejit, P., Dilip, K. B. & Verma, R. S. Generation of mesenchymal stem cell lines from murine bone marrow. Cell Tissue Res. 350, 55-68 (2012).
-
(2012)
Cell Tissue Res
, vol.350
, pp. 55-68
-
-
Sreejit, P.1
Dilip, K.B.2
Verma, R.S.3
-
45
-
-
4544245138
-
Isolation of BM mesenchymal stem cells by plastic adhesion or negative selection: Phenotype, proliferation kinetics and differentiation potential
-
Tondreau, T. et al. Isolation of BM mesenchymal stem cells by plastic adhesion or negative selection: phenotype, proliferation kinetics and differentiation potential. Cytotherapy 6, 372-379 (2004).
-
(2004)
Cytotherapy
, vol.6
, pp. 372-379
-
-
Tondreau, T.1
-
46
-
-
33644796337
-
Mesenchymal stem cells: Isolation, in vitro expansion and characterization
-
Beyer Nardi, N. & da Silva Meirelles, L. Mesenchymal stem cells: isolation, in vitro expansion and characterization. Handb Exp Pharmacol. 174, 249-282 (2006).
-
(2006)
Handb Exp Pharmacol
, vol.174
, pp. 249-282
-
-
Beyer Nardi, N.1
Da Silva, M.L.2
-
47
-
-
68949157440
-
Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling
-
Koide, M. et al. Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling. J Bone Miner Res. 24, 1469-1480 (2009).
-
(2009)
J Bone Miner Res
, vol.24
, pp. 1469-1480
-
-
Koide, M.1
-
48
-
-
20144373896
-
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1
-
Takatsuna, H. et al. Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1. J Bone Miner Res. 20, 653-662 (2005).
-
(2005)
J Bone Miner Res
, vol.20
, pp. 653-662
-
-
Takatsuna, H.1
-
49
-
-
77954756294
-
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
-
Bouxsein, M. L. et al. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 25, 1468-1486 (2010).
-
(2010)
J Bone Miner Res
, vol.25
, pp. 1468-1486
-
-
Bouxsein, M.L.1
-
50
-
-
33646248066
-
Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss
-
Lee, S. K. et al. Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res. 21, 695-702 (2006).
-
(2006)
J Bone Miner Res
, vol.21
, pp. 695-702
-
-
Lee, S.K.1
-
51
-
-
0034007273
-
Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
-
Montero, A. et al. Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest. 105, 1085-1093 (2000).
-
(2000)
J Clin Invest
, vol.105
, pp. 1085-1093
-
-
Montero, A.1
-
52
-
-
84875054244
-
Decitabine represses translocated MYC oncogene in Burkitt lymphoma
-
Guan, H. et al. Decitabine represses translocated MYC oncogene in Burkitt lymphoma. J Pathol. 229, 775-783 (2013).
-
(2013)
J Pathol
, vol.229
, pp. 775-783
-
-
Guan, H.1
-
53
-
-
77956579875
-
KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma
-
Guan, H. et al. KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma. Blood 116, 1469-1478 (2010).
-
(2010)
Blood
, vol.116
, pp. 1469-1478
-
-
Guan, H.1
|