Phytochemical characterization of Veronica officinalis L., V. teucrium L. and V. orchidea crantz from Romania and their antioxidant and antimicrobial properties

International Journal of Molecular Sciences

Volumn 16, Issue 9, 2015, Pages 21109-21127

  Mocan, Andrei ^a   Vodnar, Dan Cristian ^b   Vlase, Laurian ^a   Crișan, Ovidiu ^a   Gheldiu, Ana Maria ^a   Crișan, Gianina ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE   (Romania)

Author keywords

Antimicrobials; Antioxidants; Phytosterols; V. orchidea crantz; V. teucrium L; Veronica officinalis L.

Indexed keywords

ACACETIN; APIGENIN; BRASSICASTEROL; CAFFEIC ACID; CAMPESTEROL; CHLOROGENIC ACID; ERGOSTEROL; EUPATILIN; EUPATORIN; FERULIC ACID; FLAVONE DERIVATIVE; FLAVONOID; GENTISIC ACID; HISPIDULIN; LUTEOLIN; PARA COUMARIC ACID; PHENOL; PHYTOSTEROL; PLANT EXTRACT; QUERCITRIN; SITOSTEROL; STIGMASTEROL; UNCLASSIFIED DRUG; VERONICA OFFICINALIS EXTRACT; VERONICA ORCHIDEA CRANTZ EXTRACT; VERONICA TEUCRIUM EXTRACT; ANTIINFECTIVE AGENT; ANTIOXIDANT; PHENOL DERIVATIVE; PLANT MEDICINAL PRODUCT;

ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; BACILLUS CEREUS; BROTH DILUTION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ELECTROSPRAY MASS SPECTROMETRY; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LISTERIA IVANOVII; LISTERIA MONOCYTOGENES; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHYTOCHEMISTRY; PSEUDOMONAS AERUGINOSA; ROMANIA; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; TROLOX EQUIVALENT ANTIOXIDANT CAPACITY; VERONICA OFFICINALIS; VERONICA ORCHIDEA CRANTZ; VERONICA TEUCRIUM; CHEMISTRY; CLASSIFICATION; DRUG EFFECTS; ISOLATION AND PURIFICATION; LISTERIA; TRADITIONAL MEDICINE; VERONICA;

ANTI-INFECTIVE AGENTS; ANTIOXIDANTS; LISTERIA; MEDICINE, TRADITIONAL; PHENOLS; PHYTOCHEMICALS; PHYTOSTEROLS; STAPHYLOCOCCUS AUREUS; VERONICA;

EID: 84940970310     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160921109     Document Type: Article

References (41)

1. Wolfender, J.L.; Eugster, P.J.; Bohni, N.; Cuendet, M. Advanced methods for natural products discovery in the field of nutraceuticals. Chimia 2011, 65, 400-406.
2. Pratt, D.E. Phenolic Compounds in Food and Their Effects on Health II; American Chemical Society: Washington, DC, USA, 1992; pp. 352-391.
3. Pop, A.; Berce, C.; Bolfă, P.; Nagy, A.; Cătoi, C.; Dumitrescu, I.B.; Silaghi-Dumitrescu, L.; Loghin, F. Evaluation of the possible endocrine disruptive effect of butylated hydroxitoluene and propyl gallate in immature female rats. Farmacia 2013, 61, 202-211.
4. Dai, J.; Mumper, R.J. Plant phenolics: Extraction, analysis and their antioxidant and anticancer properties. Molecules 2010, 15, 7313-7352.
5. Opara, E.I.; Chohan, M. Culinary herbs and spices: Their bioactive properties, the contribution of polyphenols and the challenges in deducing their true health benefits. Int. J. Mol. Sci. 2014, 15, 19183-19202.
6. Xia, E.-Q.; Deng, G.-F.; Guo, Y.-J.; Li, H.-B. Biological activities of polyphenols from grapes. Int. J. Mol. Sci. 2010, 11, 622-646.
7. Kar, A. Pharmacognosy and Pharmacobiotechnology; New Age International Private Limited: New Dehli, India, 2007; pp. 156-163.
8. Calpe-Berdiel, L.; Escolà-Gil, J.C.; Blanco-Vaca, F. New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 2008, 203, 18-31.
9. Jones, P.J.H.; AbuMweis, S.S. Phytosterols as functional food ingredients: Linkages to cardiovascular disease and cancer. Curr. Opin. Clin. Nutr. Metab. Care 2009, 12, 147-151.
10. Bouic, P.J. Sterols and sterolins: New drugs for the immune system? Drug Discov. Today 2002, 15, 775-778.
11. Albach, D.C.; Jensen, S.R.; Ozgokce, F.; Grayer, R.J. Veronica: Chemical characters for the support of phylogenetic relationships based on nuclear ribosomal and plastid DNA sequence data. Biochem. Syst. Ecol. 2005, 33, 1087-1106.
12. Beara, I.; Živković, J.; Lesjak, M.; Ristić, J.; Šavikin, K.; Maksimović, Z.; Janković, T. Phenolic profile and anti-inflammatory activity of three Veronica species. Ind. Crops Prod. 2015, 63, 276-280.
13. Scarlat, M.; Şandor, V.; Tămaş, M.; Cuparencu, B. Experimental anti-ulcer activity of Veronica officinalis L. extracts. J. Ethnopharmacol. 1985, 13, 157-163.
14. Crişan, G.; Krausz, T.; Şandor, V.; Tămaş, M.; Toader, S. Cercetări asupra efectului hipocolestreolemiant al unor specii de Veronica. Clujul Med. 2003, 76(4), 937-940 (in Romanian).
15. Crişan, G.; Tămaş, M.; Miclăuş, V.; Krausz, T.; Şandor, V.A comparative study of some Veronica species. Rev. Med. Chir. Med. Nat. Iasi 2007, 111, 280-284.
16. Jensen, S.R.; Albach, D.C.; Ohno, T.; Grayer, R.J. Veronica: Iridoids and cornoside as chemosystematic markers. Biochem. Syst. Ecol. 2005, 33, 1031-1047.
17. Crişan, G.; Vlase, L.; Balica, G.; Muntean, D.; Ştefănescu, C.; Păltinean, R.; Tămaş, M; Leucuţa, S. LC/MS analysis of aucubin and catalpol of some Veronica species. Farmacia 2010, 58, 237-242.
18. Gusev, N.F.; Nemereshina, O.N.; Petrova, G.V.; Sychev, M.V. Evaluation of biologically active substances and antibacterial activity of herbal drugs from Veronica L. Russ. J. Biopharm. 2012, 4, 17-22.
19. Kiss, B.; Popa, D.-S.; Crişan, G.; Bojiţă, M.; Loghin, F. The evaluation of antioxidant potential of Veronica officinalis and Rosmarinus officinalis extracts by monitoring malonildialdehide and glutathione levels in rats. Farmacia 2009, 57, 432-441.
20. Kwak, J.H.; Kim, H.J.; Lee, K.H.; Kang, S.C.; Zee, O.P. Antioxidative Iridoid glycosides and phenolic compounds from Veronica peregrine. Arch. Pharm. Res. 2009, 32, 207-213.
21. Harput, U.S.; Saracoglu, I.; Inoue, M.; Ogihara, Y. Anti-inflammatory and cytotoxic activities of five Veronica species. Biol. Pharm. Bull. 2002, 25, 483-486.
22. Saracoglu, I.; Oztunca, F.H.; Nagatsu, A.; Harput, U.S. Iridoid content and biological activities of Veronica cuneifolia subsp. cuneifolia and V. cymbalaria. Pharm. Biol. 2011, 49, 1150-1157.
23. Mocan, A.; Vlase, L.; Vodnar, D.C.; Bischin, C.; Hanganu, D.; Gheldiu, A.-M.; Oprean, R.; Silaghi-Dumitrescu, R.; Crişan, G. Polyphenolic content, antioxidant and antimicrobial activities of Lycium barbarum L. and Lycium chinense Mill. leaves. Molecules 2014, 19, 10056-10073.
24. Mocan, A.; Crişan, G.; Vlase, L.; Crişan, O.; Vodnar, D.C.; Raita, O.; Gheldiu, A.-M.; Toiu, A.; Oprean, R.; Tilea, I. Comparative studies on polyphenolic composition, antioxidant and antimicrobial activities of Schisandra chinensis leaves and fruits. Molecules 2014, 19, 15162-15179.
25. Dezsi, Ş.; Bădărău, A.S.; Bischin, C.; Vodnar, D.C.; Silaghi-Dumitrescu, R.; Gheldiu, A.-M.; Mocan, A.; Vlase, L. Antimicrobial and antioxidant activities and phenolic profile of Eucalyptus globulus Labill. and Corymbia ficifolia (F. Muell.) K.D. Hill & L.A.S. Johnson leaves. Molecules 2015, 20, 4720-4734.
26. Toma, C.-C.; Olah, N.-K.; Vlase, L.; Mogoşan, C.; Mocan, A. Comparative studies on polyphenolic composition, antioxidant and diuretic effects of Nigella sativa L. (black cumin) and Nigella damascena L. (lady-in-a-mist) seeds. Molecules 2015, 20, 9560-9574.
27. Barreira, J.C.M.; Dias, M.I.; Živković, J.; Stojković, D.; Soković, M.; Santos-Buelga, C.; Ferreira, I.C.F.R. Phenolic profiling of Veronica spp. grown in mountain, urban and sandysoil environments. Food Chem. 2014, 163, 275-283.
28. Živković, J.; Barreira, J.C.M.; Stojković, D.; Ćebović, T.; Santos-Buelga, C.; Maksimović, Z.; Ferreira, I.C.F.R. Phenolic profile, antibacterial, antimutagenic and antitumour evaluation of Veronica urticifolia Jacq. J. Funct. Foods 2014, 9, 192-201.
29. Walle, T. Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? Semin. Cancer Biol. 2007, 17, 354-362.
30. Kavvadias, D.; Sand, P.; Youdim, K.A.; Qaiser, M.Z.; Rice-Evans, C.; Baur, R.; Sigel, E.; Rausch, W.-D.; Riederer, P.; Schreier, P. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br. J. Pharmacol. 2004, 142, 811-820.
31. Exarchou, V.; Kanetis, L.; Charalambous, Z.; Apers, S.; Pieters, L.; Gekas, V.; Goulas, V. HPLC-SPE-NMR characterization of major metabolites in Salvia fruticosa Mill. Extract with antifungal potential: Relevance of carnosic acid, carnosol, and hispidulin. J. Agric. Food. Chem. 2015, 63, 457-463.
32. Vlase, L.; Parvu, M.; Parvu, E.A.; Toiu, A. Chemical constituents of three Allium species from romania. Molecules 2013, 18, 114-127.
33. Živković, J.; Ćebović, T.; Maksimović, Z. In vivo and in vitro antioxidant effects of three Veronica species. Cent. Eur. J. Biol. 2012, 7, 559-568.
34. Harput, U.Ş.; Genç, Y.; Khan, N.; Saracoglu, I. Radical scavenging effects of different Veronica species. Rec. Nat. Prod. 2011, 5, 100-107.
35. Simirgiotis, M.J.; Benites, J.; Areche, C.; Sepúlveda, B. Antioxidant capacities and analysis of phenolic compounds in three endemic Nolana species by HPLC-PDA-ESI-MS. Molecules 2015, 20, 11490-11507.
36. Simirgiotis, M.J. Antioxidant capacity and HPLC-DAD-MS profiling of Chilean peumo (Cryptocarya alba) fruits and comparison with German peumo (Crataegus monogyna) from southern Chile. Molecules 2013, 18, 2061-2080.
37. Sharma, R.K. Phytosterols: Wide-spectrum antibacterial agents. Bioorg. Chem. 1993, 21, 49-60.
38. Mahmood, T.; Bibi, Y.; Ishaq, H.; Mahmood, I.; Wahab, A.; Sherwani, S. Complexation and Antimicrobial activities of β sitosterol with trace metals. (Cu(II), Co(II), and Fe(III)). Eur. Acad. Res. 2013, 1, 677-685.
39. Stojković, D.; Živković, J.; Soković, M.; Glamočlija, J.; Ferreira, I.C.F.R.; Janković, T.; Maksimović, Z. Antibacterial activity of Veronica montana L. extract and of protocatechuic acid incorporated in a food system. Food Chem. Toxicol. 2013, 55, 209-213.
40. Dulf, F.V.; Vodnar, D.C.; Dulf, E.-H.; Toşa, M.I. Total phenolic contents, antioxidant activities, and lipid fractions from berry pomaces obtained by solid-state fermentation of two Sambucus species with Aspergillus niger. J. Agric. Food. Chem. 2015, 63, 3489-3500.
41. Tămaş, M.; Toiu, A.; Oniga, I.; Deliu, C.; Oltean, B.; Coldea, G. Quantitative determination of total polyphenols and flavonoids from indigenous species of Epilobium of wild origin and in vitro regenerates plantlets. Contrib. Bot. 2009, XLIV, 119-123.