Combined dyslipidemia in childhood

Journal of Clinical Lipidology

Volumn 9, Issue 5, 2015, Pages S41-S56

  Kavey, Rae Ellen W ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Adolescent; Atherogenic dyslipidemia; Child; Combined dyslipidemia; Dyslipidemia; Mixed dyslipidemia; Obesity

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; ATHEROSCLEROSIS; BEVERAGE; CALORIC INTAKE; CARBOHYDRATE INTAKE; CHILD; COMBINED DYSLIPIDEMIA; DYSLIPIDEMIA; FEMALE; HUMAN; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIPID BLOOD LEVEL; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; WEIGHT GAIN; WEIGHT REDUCTION; BLOOD; COMPLICATION; DYSLIPIDEMIAS; PATHOLOGY; PREVALENCE;

ATHEROSCLEROSIS; CHILD; DYSLIPIDEMIAS; HUMANS; OBESITY; PREVALENCE;

EID: 84940960421     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2015.06.008     Document Type: Review

References (194)

1. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction: National Heart, Lung and Blood Institute Pediatrics 128 Suppl 5 2011 S213 S256
2. J. Otvos Measurement of triglyceride-rich lipoproteins by nuclear magnetic resonance spectroscopy Clin Cardiol 22 1999 II21 II27
3. L. Kuller, A. Arnold, R. Tracy, and et al. Nuclear magnetic resonance spectroscopy of lipoproteins and risk of coronary heart disease in the Cardiovascular Health Study Arterioscler Thromb Vasc Biol 22 2002 1175 1180
4. G.J. Blake, J.D. Otvos, N. Rifai, and P.M. Ridker Low-density lipoprotein particle concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women Circulation 106 2002 1930 1937
5. R.M. Krauss Dense low density lipoproteins and coronary artery disease Am J Cardiol 75 6 1995 53B 57B
6. R.S. Rosenson, J.D. Otvos, and D.S. Freedman Relations of lipoprotein subclass levels and low density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC-1) trial Am J Cardiol 90 2 2002 89 94
7. K. El Harchaoui, W.A. van der Steeg, E.S. Stroes, and et al. Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population study J Am Coll Cardiol 49 5 2007 547 553
8. R.H. Mackey, L.H. Kuller, K. Sutton-Tyrrell, and et al. Lipoprotein subclasses and coronary artery calcium in postmenopausal women from the Healthy Women study Am J Cardiol 90 8A 2002 71i 76i
9. J.D. Otvos, D. Collins, D.S. Freedman, and et al. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial Circulation 113 12 2006 1556 1563
10. W.C. Cromwell, J.D. Otvos, M.J. Keyes, and et al. LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study - Implications for LDL management J Clin Lipidol 1 6 2007 583 592
11. M. Arca, A. Montali, S. Valiente, and et al. Usefulness of atherogenic dyslipidemia for predicting cardiovascular risk in patients with angiographically defined coronary artery disease Am J Cardiol 100 10 2007 1511 1516
12. H.F. Hoff, J.L. Titus, R.J. Bajardo, R.L. Jackson, and et al. Lipoproteins in atherosclerotic lesions. Localization by immunofluorescence of apo-low density lipoproteins in human atherosclerotic arteries from normal and hyperlipoproteinemics Arch Pathol 99 5 1975 253 258
13. F. Nigon, P. Lesnik, M. Rouis, and et al. Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor J Lipid Res 32 1991 1741 1753
14. K. Berneis, D.M. Shames, P.J. Blanche, and et al. Plasma clearance of human low-density lipoprotein in human apolipoprotein B transgenic mice is related to particle diameter Metabolism 53 4 2004 483 487
15. M. La Belle, and R.M. Krauss Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns J Lipid Res 31 9 1990 1577 1588
16. K. Olin-Lewis, R.M. Krauss, M. La Belle, and et al. ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan J Lipid Res 43 11 2002 1969 1977
17. M.J. Shin, and R.M. Krauss Apolipoprotein CIII bound to apoB-containing lipoproteins is associated with small, dense LDL independent of plasma triglyceride levels in healthy men Atherosclerosis 211 1 2010 337 341
18. J. De Graaf, H.L. Hak-Lemmers, M.P. Hectors, and et al. Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects Arterioscler Thromb 11 1991 298 306
19. D.S. Freedman, B.A. Bowman, J.D. Otvos, and et al. Levels and correlates of LDL and VLDL particle sizes among children: the Bogalusa Heart study Atherosclerosis 152 2 2000 441 449
20. Centers for Disease Control and Prevention. Prevalence of abnormal lipid levels among youths - United States, 1999-2006. MMWR Morb Mortal Wkly Rep;59:29-33.
21. C.L. Ogden, M.D. Carroll, B.K. Kit, and K.M. Flegal Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010 JAMA 307 2012 483 490
22. P. Deshmukh-Taskar, T.A. Nicklas, M. Morales, S.J. Yang, I. Zakeri, and G.S. Berenson Tracking of overweight status from childhood to young adulthood: the Bogalusa Heart Study Eur J Clin Nutr 60 2006 48 57
23. D.S. Freedman, Z. Mei, S.R. Srinivasan, G.S. Berenson, and W.H. Dietz Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study J Pediatr 150 2007 12 17.e2
24. D.S. Freedman, W.H. Dietz, S.R. Srinivasan, and G.S. Berenson The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study Pediatrics 103 1999 1175 1182
25. P.W. Franks, R.L. Hanson, W.C. Knowler, M.L. Sievers, P.H. Bennett, and H.C. Looker Childhood obesity, other cardiovascular risk factors, and premature death N Engl J Med 362 2010 485 493
26. E.S. Ford, A.H. Mokdad, and U.A. Ajani Trends in risk factors for cardiovascular disease among children and adolescents in the United States Pediatrics 114 2004 1534 1544
27. R.L. Findling, N.K. McNamara, and B.L. Gracious Pediatric uses of atypical antipsychotics Expert Opin Pharmacother 1 5 2000 935 945
28. C.U. Correll, P. Manu, V. Olshanskiy, and et al. Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents JAMA 302 16 2009 1765 1773
29. S.R. Srinivasan, M.G. Frontini, J. Xu, and G.S. Berenson Utility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemia and other cardiovascular risks: the Bogalusa Heart Study Pediatrics 118 1 2006 201 206
30. D.L. Rainwater, C.A. McMahan, G.T. Malcom, and et al. Lipid and apolipoprotein predictors of atherosclerosis in youth: apolipoprotein concentrations do not materially improve prediction of arterial lesions in PDAY subjects. The PDAY Research Group Arterioscler Thromb Vasc Biol 19 3 1999 753 761
31. M.G. Frontini, S.R. Srinivasan, J.H. Xu, R. Tang, M.G. Bond, and G. Berenson Utility of non-high-density lipoprotein cholesterol versus other lipoprotein measures in detecting subclinical atherosclerosis in young adults (The Bogalusa Heart Study) Am J Cardiol 100 1 2007 64 68
32. C. Li, E.S. Ford, P.E. McBride, and et al. Non-high density lipoprotein cholesterol concentration is associated with the metabolic syndrome among US youth aged 12-19 years J Pediatr 158 2011 201 207
33. J.S. Rana, S.M. Boekholdt, J.J. Kastelein, and P.K. Shah The role of non-HDL cholesterol in risk stratification for coronary artery disease Curr Atheroscler Rep 14 2 2012 130 134
34. S.M. Boekholdt, B.J. Arsenault, S. Mora, and et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis JAMA 307 12 2012 1302 1309
35. J.M. Gaziano, J. Michael, C.H. Hennekens, and et al. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction Circulation 96 1997 2520 2525
36. P.L. da Luz, D. Favorato, J.R. Faria-Neto, and et al. High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease Clinics (Sao Paulo) 63 4 2008 427 432
37. T.S. Hannon, F. Bacha, S.J. Lee, and et al. Use of markers of dyslipidemia to identify overweight youth with insulin resistance Pediatr Diabetes 7 2006 260 266
38. P. DiBonito, N. Moio, C. Scilla, and et al. Usefulness of the high triglyceride-to-HDL cholesterol ratio to identify cardiometabolic risk factors and preclinical signs of organ damage in outpatient children Diabetes Care 35 1 2012 158 162
39. L. Pacifico, E. Bonci, G. Andreoli, and et al. Association of serum triglyceride-to-HDL cholesterol ratio with carotid intima media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents Nutr Metab Cardiovasc Dis 24 7 2014 737 743
40. C. Giannini, N. Santoro, S. Caprio, and et al. The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds Diabetes Care 34 2011 1869 1874
41. R. Hoffman Increased fasting triglyceride levels are associated with hepatic insulin resistance in Caucasian but not African-American adolescents Diabetes Care 29 6 2006 1402 1404
42. A.E. Sumner Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults J Pediatr 155 3 2009 S7.e7 S7.e11
43. E. D'Adamo, V. Northrup, R. Weiss, and et al. Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion Am J Clin Nutr 92 2010 500 508
44. S.F. Burns, S.J. Lee, and S.A. Arslanian Surrogate lipid markers for small dense low-density lipoprotein particles in overweight youth J Pediatr 161 6 2012 991 996
45. M.D. Marcus, T. Baranowski, L.L. DeBar, and et al. Severe obesity and selected risk factors in a sixth grade multiracial cohort: the HEALTHY study J Adolesc Health 47 2010 604 607
46. M. Mietus-Snyder, K.L. Drews, J.D. Otvos, and et al. Low-density lipoprotein cholesterol versus particle number in middle school children J Pediatr 163 2013 355 362
47. M. Miller Managing mixed dyslipidemia in special populations Prev Cardiol 13 2 2010 78 83
48. L. Wu, and K.G. Parhofer Diabetic dyslipidemia Metabolism 63 12 2014 1469 1479
49. J.L. Goldstein, H.G. Schrott, W.R. Hazzard, and et al. Hyperlipidemia in coronary artery disease. II. Genetic analysis of of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia J Clin Invest 52 1973 1544 1568
50. A. Gaddi, A.F. Cicero, F.O. Odoo, A.A. Poli, and R. Paoletti Practical guidelines for familial combined hyperlipidemia diagnosis: an up-date Vasc Health Risk Manag 3 2007 877 886
51. A.F. Cicero, G. Derosa, P. Maffioli, A. Reggi, E. Grandi, and C. Borghi Influence of metabolic syndrome superposition on familial combined hyperlipoproteinemia cardiovascular complication rate Arch Med Sci 9 2013 238 242
52. M.C.G.J. Brouwers, M.M.J. van Greevenbroek, C.D.A. Stehouwer, and et al. The genetics of familial combined hyperlipidemia Nat Rev Endocrinol 8 2012 352 362
53. P. Pauciullo, M. Gentile, G. Marotta, and et al. Small dense low-density lipoprotein in familial combined hyperlipidemia: independent of metabolic syndrome and related to history of cardiovascular events Atherosclerosis 203 2009 320 324
54. A.F. Ayyobi, S.H. McGladdery, M.J. McNeely, and et al. Small, dense LDL and elevated apoliporotein B are common characteristics for the three major lipid phenotypes of familial combined hyperlipidemia Arterioscler Thromb Vasc Biol 23 2003 1289 1294
55. A.D. Sniderman, J. Ribalta, and M. Castro Cabezas How should FCHL be defined and how should we think about its metabolic basis Nutr Metab Cardiovasc Dis 11 2001 259 273
56. A.D. Sniderman, M.C. Cabezas, J. Ribalta, and et al. A proposal to redefine familial combined hyperlipidemia - Third workshop on FCHL held in Barcelona from 3 to 5 May, 2001, during the scientific sessions of the European Society for Clinical Investigation Eur J Clin Invest 32 2002 71 73
57. G.F. Lewis, C. Xiao, and R.A. Hegele Hypertriglyceridemia in the genomic era: a new paradigm Endocr Rev 36 1 2015 131 147
58. I. Tabas, K.J. Williams, and J. Boren Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications Circulation 116 2007 1832 1844
59. H.N. Ginsberg, Y.L. Zhang, and A. Hernandez-Ono Regulation of plasma triglycerides in insulin resistance and diabetes Arch Med Res 36 2005 232 240
60. P.R. Blackett, K.S. Blevins, E. Quintana, and et al. ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth Metabolism 54 2005 180 187
61. H.C. McGill Jr., C.A. McMahan, A.W. Zieske, and et al. Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group Arterioscler Thromb Vasc Biol 20 2000 1998 2004
62. W.P. Newman 3rd, D.S. Freedman, A.W. Voors, and et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study N Engl J Med 314 1986 138 144
63. G.S. Berenson, S.R. Srinivasan, W. Bao, W.P. Newman 3rd, R.E. Tracy, and W.A. Wattigney Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study N Engl J Med 338 1998 1650 1656
64. R. Wunsch, G. de Sousa, and T. Reinehr Intima-media thickness in obesity: relation to hypertension and dyslipidaemia Arch Dis Child 90 2005 1097
65. J. Fang, J.P. Zhang, C.X. Luo, X.M. Yu, and L.Q. Lv Carotid intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance Int J Med Sci 7 2010 278 283
66. J.G. Ayer, J.A. Harmer, S. Nakhla, and et al. HDL-cholesterol, blood pressure, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children Arterioscler Thromb Vasc Biol 29 2009 943 949
67. M. Juonala, J.S. Viikari, T. Ronnemaa, and et al. Associations of dyslipidemias from childhood to adulthood with carotid intima-media thickness, elasticity, and brachial flow-mediated dilatation in adulthood: the Cardiovascular Risk in Young FinFinns Study Arterioscler Thromb Vasc Biol 28 2008 1012 1017
68. E.M. Urbina, T.R. Kimball, C.E. McCoy, P.R. Khoury, S.R. Daniels, and L.M. Dolan Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function Circulation 119 2009 2913 2919
69. E.M. Urbina, T.R. Kimball, P.R. Khoury, S.R. Daniels, and L.M. Dolan Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitus J Hypertens 28 2010 1692 1698
70. E.M. Urbina, P.R. Khoury, C. McCoy, S.R. Daniels, T.R. Kimball, and L.M. Dolan Cardiac and vascular consequences of pre-hypertension in youth J Clin Hypertens (Greenwich) 13 2011 332 342
71. E.M. Urbina, P.R. Khoury, C.E. McCoy, L.M. Dolan, S.R. Daniels, and T.R. Kimball Triglyceride to HDL-C ratio and increased arterial stiffness in children, adolescents, and young adults Pediatrics 131 2013 e1082 e1090
72. C.G. Magnussen, A. Venn, R. Thomson, and et al. The association of pediatric low- and high-density lipoprotein cholesterol dyslipidemia classifications and change in dyslipidemia status with carotid intima-media thickness in adulthood: evidence from the cardiovascular risk in Young Finns study, the Bogalusa Heart study, and the CDAH (Childhood Determinants of Adult Health) study J Am Coll Cardiol 53 2009 860 869
73. T. Koivistoinen, N. Hutri-Kahonen, M. Juonala, and et al. Apolipoprotein B is related to arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study Atherosclerosis 214 2011 220 224
74. J.A. Morrison, C.J. Glueck, P.S. Horn, S. Yeramaneni, and P. Wang Pediatric triglycerides predict cardiovascular disease events in the fourth to fifth decade of life Metabolism 58 9 2009 1277 1284
75. J.A. Morrison, C.J. Glueck, and P. Wang Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabetes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton-lipid research clinics follow-up study Metabolism 61 2012 531 541
76. M.D. Jensen Role of body fat distribution and the metabolic consequences of obesity J Clin Endocrinol Metab 93 2008 S57 S63
77. J.A. de Lemos, and I.J. Neeland Separating the VAT from the FAT. New insights into the cardiometabolic risks of obesity JACC Cardiovasc Imaging 7 12 2014 1236 1238
78. N. Cossrow, and B. Falkner Race/ethnic issues in obesity and obesity-related consequences J Clin Endocrinol Metab 89 6 2004 2590 2594
79. J.C.N. Chan, V. Malik, W. Jia, and et al. Diabetes in Asia: epidemiology, risk factors and pathophysiology JAMA 301 20 2009 2129 2140
80. A.S. Greenberg, and M.S. Obin Obesity and the role of adipose tissue in inflammation and metabolism Am J Clin Nutr 83 Suppl 2006 S461 S465
81. R.N. Bergsman, S.P. Kim, K.J. Catalano, and et al. Why visceral fat is bad: mechanisms of the metabolic syndrome Obesity 14 Suppl 2006 S16 S19
82. S.J. Robins, A. Lyass, J.P. Zachariah, J.M. Massaro, and R.S. Vasan Insulin resistance and the relationship of dyslipidemia to coronary heart disease: the Framingham Heart Study Arterioscler Thromb Vasc Biol 31 2011 1208 1214
83. S. Arslanian, and C. Suprasongsin Insulin sensitivity, lipids and body composition in childhood: is syndrome X present? J Clin Endocrinol Metab 81 1996 1058 1062
84. S.R. Srinivasan, L. Myers, and G.S. Berenson Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study Diabetes 51 1 2002 Jan 204 209
85. I. Zavaroni, E. Dall'Aglio, O. Alpi, and et al. Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride Atherosclerosis 55 1985 259 266
86. C.N. Lapur, T.J. Yost, and R.H. Eckel Insulin responsiveness of adipose tissue lipoprotein lipase is delayed but preserved in obesity J Clin Endocrinol Metab 59 1984 1176 1182
87. J. Steinberger, C. Moorehead, V. Katch, and et al. Relationship between insulin resistance and abnormal lipid profile in obese adolescents J Pediatr 126 5 pt 1 1995 690 695
88. E.M. Urbina, Z. Gao, P.R. Khoury, and et al. Insulin resistance and arterial stiffness in healthy adolescents and young adults Diabetologia 55 3 2012 625 631
89. V. Giorgio, F. Prono, F. Graziano, and V. Nobili Pediatric non-alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets BMC Pediatr 13 2013 40 50
90. S. Berardis, and E. Sokal Pediatric non-alcoholic fatty liver disease: an increasing public health problem Eur J Pediatr 173 2014 131 139
91. J.P. Molleston, J.B. Schwimmer, K.P. Yates, and et al. Histological abnormalities in children with non-alcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels J Pediatr 164 4 2014 707 713
92. J.P. Mann, R. Goonetilleke, and P. McKiernan Paediatric non-alcoholic fatty liver disease: a practical overview for non-specialists Arch Dis Child 100 2015 673 677
93. P. Vajro, S. Lenta, P. Socha, and et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee J Pediatr Gastroenterol Nutr 54 5 2012 700 713
94. V. Nobili, M. Marcellini, R. Devito, and et al. NAFLD in children: a prospective clinical pathological study and effect of lifestyle advice Hepatology 44 2006 458 465
95. N. Alkhouri, C. Carter-Kent, M. Elias, and A.E. Feldstein Atherogenic dyslipidemia and cardiovascular risk in children with nonalcoholic fatty liver disease Clin Lipidol 6 3 2011 305 314
96. G. Targher, L. Bertolini, R. Padovani, and et al. Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease Diabetes Care 29 6 2006 1325 1330
97. N.N. Than, and P.N. Newsome A concise review of non-alcoholic fatty liver disease Atherosclerosis 239 1 2015 192 202
98. L. Pacifico, C. Chiesa, C. Anania, and et al. Nonalcoholic fatty liver disease and the heart in children and adolescents World J Gatroenterol 20 27 2014 9055 9071
99. G.M. Reaven Banting lecture 1988. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607
100. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (ATP III): final report Circulation 106 2002 3143 3421
101. G. Marchesisn, M. Brizi, G. Bianchi, and et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome Diabetes 50 8 2001 1844 1850
102. H. Beltran-Sanchez, M.O. Harhay, M.M. Harhay, and et al. Prevalence and trends of metabolic syndrome in the adult U.S. population, 199-2010 J Am Coll Cardiol 62 2013 697 703
103. E.S. Ford, W.H. Giles, and W.H. Dietz Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey JAMA 287 3 2002 356 359
104. J. Steinberger, S.R. Daniels, R.H. Eckel, and et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American heart Association Circulation 119 2009 628 647
105. S.D. De Ferranti, K. Gauvreau, D.S. Ludwig, and et al. Prevalence of the metabolic syndrome in American adolescents: findings from the third national health and nutrition survey Circulation 110 2004 2494 2497
106. J.A. Morrison, L.A. Friedman, and C. Gray-McGuire Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: the Princeton Lipid Research Clinics Follow-up Study Pediatrics 120 2007 340 345
107. J. Steinberger, and S.R. Daniels Obesity, insulin resistance, diabetes and cardiovascular risk in children. A scientific statement from the American Heart Association Circulation 107 2003 1448 1453
108. C. Levy-Marchal, S. Arslanian, W. Cutfield, and et al. Insulin resistance in children: consensus, perspective, and future directions J Clin Endocrinol Metab 95 12 2010 5189 5198
109. Type 2 diabetes in children and adolescents. American Diabetes Association Diabetes Care 23 3 2000 381 389
110. K.A. Irizarry, V. Brito, and M. Freemark Screening for metabolic and reproductive complications in obese children and adolescents Pediatr Ann 43 9 2014 e210 e217
111. H.S. Lee, H.S. Park, and Js Hwang HbA1c and glucose intolerance in obese children and adolescents Diabet Med 29 7 2012 e102 e105
112. L.H. Epstein, L.H. Kuller, R.R. Wing, A. Valoski, and J. McCurley The effect of weight control on lipid changes in obese children Am J Dis Child 143 4 1989 454 457
113. D. Nemet, S. Barkan, Y. Epstein, O. Friedland, G. Kowen, and A. Eliakim Short- and long-term beneficial effects of a combined dietary-behavioral-physical activity intervention for the treatment of childhood obesity Pediatrics 115 4 2005 e443 e449
114. M.D. Becque, V.L. Katch, A.P. Rocchini, C.R. Marks, and C. Moorehead Coronary risk incidence of obese adolescents: reduction by exercise plus diet intervention Pediatrics 81 5 1988 605 612
115. M.A. Ferguson, B. Gutin, N.A. Le, and et al. Effects of exercise training and its cessation on components of the insulin resistance syndrome in obese children Int J Obes Relat Metab Disord 23 8 1999 889 895
116. H.S. Kang, B. Gutin, P. Barbeau, and et al. Physical training improves insulin resistance syndrome markers in obese adolescents Med Sci Sports Exerc 34 12 2002 1920 1927
117. K.J. Stewart Exercise training and the cardiovascular consequences of type 2 diabetes and hypertension: plausible mechanisms for improving cardiovascular health JAMA 288 2002 1622 1631
118. A.S. Kelly, R.J. Wetzsteon, D.R. Kaiser, J. Steinberger, A.J. Bank, and D.R. Dengel Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise J Pediatr 145 2004 731 736
119. C.L. Davis, N.K. Pollock, J.L. Waller, and et al. Exercise dose and diabetes risk in overweight and obese children. A randomized controlled trial JAMA 308 11 2012 1103 1112
120. B. Pieke, A. von Eckardstein, E. Gulbahce, and et al. Treatment of hypertriglyceridemia by two diets rich in unsaturated fatty acids or in carbohydrates: effects on lipoprotein subclasses, lipolytic enzymes, lipid transfer proteins, insulin and leptin Int J Obes Relat Metab Disord 24 2000 1286 1296
121. T. Ohta, R. Nakamura, Y. Ikeda, S. Hattori, and I. Matsuda Follow up study on children with dyslipidaemia detected by mass screening at 18 months of age: effect of 12 months dietary treatment Eur J Pediatr 152 11 1993 939 943
122. Y. Pan, and C.A. Pratt Metabolic syndrome and its association with diet and physical activity in US adolescents J Am Diet Assoc 108 2 2008 276 286
123. M.A. Pereira, J. Swain, A.B. Goldfine, N. Rifai, and D.S. Ludwig Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss JAMA 292 20 2004 2482 2490
124. C.B. Ebbeling, M.M. Leidig, K.B. Sinclair, L.G. Seger-Shippee, H.A. Feldman, and D.S. Ludwig Effects of an ad libitum low-glycemic load diet on cardiovascular disease risk factors in obese young adults Am J Clin Nutr 81 5 2005 976 982
125. C.B. Ebbeling, M.M. Leidig, H.A. Feldman, M.M. Lovesky, and D.S. Ludwig Effects of a low glycemic-load vs low fat diet in obese young adults JAMA 297 2007 2092 2102
126. C.B. Ebbeling, M.M. Leidig, K.B. Sinclair, J.P. Hangen, and D.S. Ludwig A reduced glycemic load diet in the treatment of adolescent obesity Arch Pediatr Adolesc Med 157 2003 773 779
127. S.B. Sondike, N. Copperman, and M.S. Jacobson Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factors in overweight adolescents J Pediatr 142 3 2003 253 258
128. S. Kirk, B. Brehm, B.E. Saelens, and et al. Role of carbohydrate modification in weight management among obese children: a randomized clinical trial J Pediatr 161 2012 320 327
129. R.E. Pratt, R.E. Kavey, and D. Quinzi Combined dyslipidemia in obese children: response to a focused lifestyle approach J Clin Lipidol 8 2 2014 181 186
130. J.S. Wooten, K.D. Biggerstaff, and V. Ben-Ezra Responses of LDL and HDL particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise J Appl Physiol 107 2009 794 800
131. P.W. Siri-Tarino, P.T. Williams, H.S. Fernstrom, R.S. Rawlings, and R.M. Krauss Reversal of small, dense LDL subclass phenotype by normalization of adiposity Obesity (Silver Spring) 17 2009 1768 1775
132. T.T. Laitinen, K. Pahkala, C.G. Magnussen, and et al. Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the Cardiovascular Risk in Young Finns Study Circulation 125 2012 1971 1978
133. H. Aatola, T. Koivistoinen, N. Hutri-Kahonen, and et al. Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study Circulation 122 2010 2521 2528
134. N. Nordstrand, E. Gjevestad, J.K. Hertel, and et al. Arterial stiffness, lifestyle intervention and a low-calorie diet in morbidly obese patients-a nonrandomized clinical trial Obesity (Silver Spring) 21 2013 690 697
135. A.L. Dengo, E.A. Dennis, J.S. Orr, and et al. Arterial destiffening with weight loss in overweight and obese middle-aged and older adults Hypertension 55 2010 855 861
136. R. Wunsch, G. de Sousa, A.M. Toschke, and T. Reinehr Intima-media thickness in obese children before and after weight loss Pediatrics 118 2006 2334 2340
137. H. Niinikoski, H. lagstrom, E. Jokinen, and et al. Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP study Circulation 116 2007 1032 1040
138. Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol. The Dietary Intervention Study in Children (DISC). The Writing Group for the DISC Collaborative Research Group JAMA 273 18 1995 1429 1435
139. E. Obarzanek, S.Y. Kimm, B.A. Barton, et al. DISC Collaborative Research Group Long-term safety and efficacy of a cholesterol-lowering diet in children with elevated low-density lipoprotein cholesterol: seven-year results of the Dietary Intervention Study in Children (DISC) Pediatrics 107 2 2001 256 264
140. L. Van Horn, E. Obarzanek, L.A. Friedman, N. Gernhofer, and B. Barton Children's adaptations to a fat-reduced diet: the Dietary Intervention Study in Children (DISC) Pediatrics 115 6 2005 1723 1733
141. Physical Activity Guidelines for Americans 2008 Office of Disease Prevention and Health Promotion Rochester, NY Available at: http://www.health.gov/PAGuidelines/ Accessed February 12, 2015
142. U. Ekelund, J. Luan, L.B. Sherar, D.W. Esliger, P. Griew, and A. Cooper Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents JAMA 307 2012 704 712
143. M.T. Mello, A. de Piano, J. Carnier, and et al. Long-term effects of aerobic plus resistance training on the metabolic syndrome and adiponectinemia in obese adolescents J Clin Hypertens 13 2011 343 350
144. R. Monzavi, D. Dreimane, M.E. Geffner, and et al. Improvement in risk factors for metabolic syndrome and insulin resistance in overweight youth who are treated with lifestyle intervention Pediatrics 117 6 2006 1111 1118
145. A. Szamosi, A. Czinner, T. Szamosi, and et al. Effect of diet and physical exercise treatment on insulin resistance syndrome of schoolchildren J Am Coll Nutr 27 1 2008 177 183
146. D.A. Caranti, M.T. de Mello, W.L. Prado, and et al. Short- and long-term beneficial effects of a multidisciplinary therapy for the control of metabolic syndrome in obese adolescents Metabolism 56 9 2007 1293 1300
147. A.K. Chen, C.K. Roberts, and R.J. Barnard Effect of a short-term diet and exercise intervention on metabolic syndrome in overweight children Metabolism 55 7 2006 871 878
148. Z. Kasprzak, and L. Pilaczyńska-Szcześniak Effect of diet and physical activity on physiological and biochemical parameters of obese adolescents Acta Sci Pol Technol Aliment 9 1 2010 95 104
149. P.T. Katzmarzyk, A.S. Leon, J.H. Wilmore, and et al. Targeting the metabolic syndrome with exercise: evidence from the HERITAGE family study Med Sci Sports Exerc 35 10 2003 1703 1709
150. R. Monzavi, D. Dreimane, M.E. Geffner, and et al. Improvement in risk factors for metabolic syndrome and insulin resistance in overweight youth who are treated with lifestyle intervention Pediatrics 117 6 2006 1111 1118
151. C. Pedrosa, B.M. Oliveira, I. Albuquerque, and et al. Metabolic syndrome, adipokines and ghrelin in overweight and obese schoolchildren: results of a 1-year lifestyle intervention programme Eur J Pediatr 170 4 2011 483 492
152. D.A. Caranti, M.T. de Mello, W.L. Prado, and et al. Short- and long-term beneficial effects of a multidisciplinary therapy for the control of metabolic syndrome in obese adolescents Metabolism 56 9 2007 1293 1300
153. M.D. Tsiros, N. Sinn, and L. Brennan Cognitive behavioral therapy improves diet and body composition in overweight and obese adolescents Am J Clin Nutr 87 2008 1134 1140
154. J.A. Bianchini, D.F. da Silva, C.C. Nardo, and et al. Multidisciplinary therapy reduces risk factors for metabolic syndrome in obese adolescents Eur J Pediatr 172 2 2013 215 221
155. L. Pontrelli, W. Parris, K. Adeli, and R.C. Cheung Atorvastatin treatment beneficially alters the lipoprotein profile and increases low-density lipoprotein particle diameter in patients with combined dyslipidemia and impaired fasting glucose/type 2 diabetes Metabolism 51 2002 334 342
156. I.F. Gazi, V. Tsimihodimos, A.D. Tselepis, M. Elisaf, and D.P. Mikhailidis Clinical importance and therapeutic modulation of small dense low-density lipoprotein particles Expert Opin Biol Ther 7 2007 53 72
157. W.L. Isley, J.M. Miles, B.W. Patterson, and W.S. Harris The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus J Lipid Res 47 2006 193 200
158. M.J. Chapman Pitavastatin: novel effects on lipid parameters Atheroscler Suppl 12 2011 277 284
159. S.J. Nicholls, G. Brandrup-Wognsen, M. Palmer, and P.J. Barter Meta-analysis of comparative efficacy of increasing dose of atorvastatin versus rosuvastatin versus simvastatin on lowering levels of atherogenic lipids (from VOYAGER) Am J Cardiol 105 2010 69 76
160. C.J. Packard, T. Demant, J.P. Stewart, and et al. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions J Lipid Res 41 2000 305 318
161. J.R. Crouse 3rd, J.S. Raichlen, W.A. Riley, and et al. Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial JAMA 297 2007 1344 1353
162. J.L. Fleg, M. Mete, B.V. Howard, and et al. Effect of statins alone versus statins plus ezetimibe on carotid atherosclerosis in type 2 diabetes: the SANDS (Stop Atherosclerosis in Native Diabetics Study) trial J Am Coll Cardiol 52 2008 2198 2205
163. M. Hongo, S. Kumazaki, A. Izawa, and et al. Low-dose rosuvastatin improves arterial stiffness in high-risk Japanese patients with dyslipidemia in a primary prevention group Circ J 75 2011 2660 2667
164. H. Yokoyama, M. Kawasaki, Y. Ito, S. Minatoguchi, and H. Fujiwara Effects of fluvastatin on the carotid arterial media as assessed by integrated backscatter ultrasound compared with pulse-wave velocity J Am Coll Cardiol 46 2005 2031 2037
165. Cholesterol Treatment Trialists' Collaboration Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials Lancet 385 2015 1397 1405
166. A. van der Graaf, J. Rodenburg, M.N. Vissers, and et al. Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia J Pediatr 152 2008 873 878
167. T. Nozue, I. Michishita, Y. Ito, and T. Hirano Effects of statin on small dense low-density lipoprotein cholesterol and remnant-like particle cholesterol in heterozygous familial hypercholesterolemia J Atheroscler Thromb 15 2008 146 153
168. H.E. Bays Adiposopathy: is "sick fat" a cardiovascular disease? J Am Coll Cardiol 57 2011 2461 2473
169. H.J. Avis, M.N. Vissers, E.A. Stein, and et al. A systematic review and meta-analysis of statin therapy in children with familial hypercholesterolemia Arterioscler Thromb Vasc Biol 27 2007 1803 1810
170. S. de Jongh, M.R. Lilien, J. op't Roodt, E.S. Stroes, H.D. Bakker, and J.J. Kastelein Early statin therapy restores endothelial function in children with familial hypercholesterolemia J Am Coll Cardiol 40 2002 2117 2121
171. A. Wiegman, B.A. Hutten, E. de Groot, and et al. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial JAMA 292 2004 331 337
172. R.B. Goldberg, and A.K. Sabharal Fish oil in the treatment of dyslipidemia Current Opin Endocrinol Diabetes Obes 15 2008 167 174
173. R. DeCaterina n-3 fatty acids in cardiovascular disease N Engl J Med 364 2011 2439 2450
174. Risk Prevention Study Collaborative Group M.C. Roncaglioni, M. Tombesi, F. Avanzini, and et al. n-3 fatty acids in patients with multiple cardiovascular risk factors N Engl J Med 368 2013 1800 1808
175. D. Mozzafarian, and J.H. Wu Omega 3-fatty acids and cardiovascular disease: effects on risk factors, molecular pathways and clinical events J Am Coll Cardiol 58 2011 2047 2067
176. S.S. Gidding, C. Prospero, J. Hossain, and et al. A double-blind randomized trial of fish oil to lower triglycerides and improve cardiometabolic risk in adolescents J Pediatr 165 2014 497 503
177. S.D. de Ferranti, C.E. Milliren, E.R. Denhoff, and et al. Using high dose omega-3 fatty acid supplements to lower triglyceride levels in 10- to 19-year-olds Clin Pediatr (Phila) 53 5 2014 428 438
178. R. Franssen, M. Vergeer, E.S. Stroes, and et al. Combination statin-fibrate therapy: safety aspects Diabetes Obes Metab 11 2 2009 89 94
179. S. Fazio Management of mixed dyslipidemia in patients with or at risk for cardiovascular disease: a role for combination fibrate therapy Clin Ther 30 2 2008 294 306
180. M.H. Davidson, A. Armani, J.M. McKenney, and et al. Safety considerations with fibrate therapy Am J Cardiol 99 6A 2007 3C 18C
181. T.A. Jacobson, P.H. Jones, and E.M. Roth Combination therapy with rosuvastatin and fenofibric acid for mixed dyslipidemia: overview of efficacy and safety Clin Lipidol 5 2010 1 23
182. M. Guerin, E. Bruckert, P.J. Dolphin, and et al. Fenofibrate reduces plasma cholesterol ester transfer from HDL to VLDL and normalizes the atherogenic dense LDL profile in combined hyperlipidemia Arterioscler Thromb Vasc Biol 16 1996 763 772
183. S. Abourbih, K.B. Filion, L. Joseph, and et al. Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review Am J Med 122 2009 962 980
184. E. Bruckert, J. Labreuche, D. Deplanque, and et al. Fibrates effect on cardiovascular risk is greater in patients with high triglyceride levels or atherogenic dyslipidemia profile: a systematic review and meta-analysis J Cardiovasc Pharmacol 57 2 2011 267 272
185. M. Lee, J.L. Saver, A. Towfighi, and et al. Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis Atherosclerosis 217 2 2011 492 498
186. K.A.H. Wheeler, R.J. West, J.K. Lloyd, and J. Barley Double blind trial of bezafibrate in familial hypercholesterolaemia Arch Dis Child 60 1 1985 34 37
187. J. Steinmetz, C. Morin, E. Panek, G. Siest, and P. Drouin Biological variations in hyperlipidemic children and adolescents treated with fenofibrate Clin Chim Acta 112 1981 43 53
188. M. Becker, D. Staab, and K. Von Bergmann Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate Pediatrics 89 1992 138 142
189. C.M. Smalley, and S.J. Goldberg A pilot study in the efficacy and safety of gemfibrozil in a pediatric population J Clin Lipidol 2 2008 106 111
190. E. Bruckert, J. Labreuche, and P. Amarenco Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis Atherosclerosis 210 2 2010 353 361
191. The AIM-HIGH Investigators Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy N Engl J Med 365 2011 2255 2267 [Erratum, N Engl J Med. 2012;367:189.]
192. The HPS2-THRIVE Collaborative Group Effects of extended-release niacin with laropiprant in high-risk patients N Engl J Med 371 2014 203 212
193. R.B. Colletti, E.J. Neufeld, N.K. Roff, T.L. McAuliffe, A.L. Baker, and J.W. Newburger Niacin treatment of hypercholesterolemia in children Pediatrics 92 1993 78 82
194. D. Pastori, L. Polimeni, F. Baratta, and et al. The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease Dig Liver Dis 47 2015 4 11