Paediatric uses of atypical antipsychotics

Expert Opinion on Pharmacotherapy

Volumn 1, Issue 5, 2000, Pages 935-945

  Findling, Robert L ^a   McNamara, Nora K ^a   Gracious, Barbara L ^a  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Adolescents; Antipsychotic drugs; Aripiprazole; Children; Clozapine; Olanzapine; Quetiapine; Risperidone; Sertindole; Ziprasidone

Indexed keywords

NEUROLEPTIC AGENT;

CHILD; CLINICAL TRIAL; HUMAN; PSYCHOSIS; REVIEW;

ANTIPSYCHOTIC AGENTS; CHILD; CLINICAL TRIALS; HUMANS; PSYCHOTIC DISORDERS;

EID: 0034232554     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.1.5.935     Document Type: Article

References (84)

1. KAPLAN SL, SIMMS RM, BUSNER J: Prescribing practices of outpatient child psychiatrists. J. Am. Acad. Child Aciolesc. Psychiatry (1994) 33:35-44.
2. KAPLAN SL, BUSNER J: Child psychopharmacoepidemiology: Inpatient prescribing practices. Psychopharmacol. Bull. (1996) 32:462. (Abstract).
3. FINDLING RL, SCHULZ SC, REED MD, BLUMER JL: The antipsychotics: a pediatric perspective. Ped. Clin. North America (1998) 45:1205-1232.
4. A comprehensive review of the use of typical and atypical antipsychotics in young people.
5. KEEPERS GA, CLAPPISON VJ, CASEY DE: Initial anticholinergic prophylaxis for ncuroleptic-induced extrapyramidal syndromes. Arch. Gen. Psychiatry (1983) 40:1113-1117.
6. BIRMAHER B, BAKER R, KAPUR S, QUINTANA H, GANGULI R: Clozapine for the treatment of adolescents with schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry (1992) 31:160-164.
7. BLANZ B, SCHMIDT MH: Clozapine for schizophrenia [letter]. J. Am. Acad. Child Adolesc. Psychiatry (1993) 32:223-224.
8. BOXER GH, DAVIDSON J: More on clozapine [letter]. J.
9. Am. Acad. Child Adolesc. Psychiatry (1992) 31:993-99-4.
10. CAINE ED, POLINSKY RJ, KARTZINEL R, EBERT MH: The trial use of clozapine for abnormal involuntary movement disorders. Am. J. Psychiatry (1979) 136:317-320.
11. FRAZIER JA, GORDON CT, MCKENNA K, LENANE MC, JIH D, RAPOPORT JL: An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry (1994) 33:658-663.
12. An open prospective trial of clozapine in adolescents with schizophrenia, suggesting therapeutic effectiveness.
13. FUCHS DC: Clozapine treatment of bipolar disorder in a young adolescent. J. Am. Acad. Child Adolesc. Psychiatry (1994) 33:1299-1302.
14. GONZALEZ A, MICHANIE C: Clozapine for refractory psychosis [letter].J. Am. Acad. Child Adolesc. Psychiatry (1992)31:1169-1170.
15. JACOBSEN LK, WALKER MC, EDWARDS JE, CHAPPELL PB, WOOLSTON JL: Clozapine in the treatment of a young adolescent with schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry (1994) 33:645-650.
16. KOWATCH RA, SUPPES T, GILFILLAN SK, FUENTES RM, BRANNEMANN BD, EMSLIE GJ: Clozapine treatment of children and adolescents with bipolar disorder and schizophrenia: a clinical case series. J. Child Adolesc. Psycbopbarmacol. (1995) 5:241-253.
17. KUMRA S, FRAZIER JA, JACOBSEN LK et al.: Childhoodonset schizophrenia: a double-blind clozapine halopcridol comparison. Arch. Gen. Psychiatry (1996) 53:1090-1097.
18. Te largest randomised clinical trial of clozapine in young people. Clozapine was found to be superior to lialoperidol in symptom reduction.
19. LEVKOVITCH Y, KRONENBERG J, KAYSER N et a!.: Clozapine for tardive dyskincsla in adolescents. Brain Dev. (1995) 17:213-215.16.
20. MACEWAN TH, MORTON MJS: Use of clozapine in a child with treatment-resistant schizophrenia. Br. J. Psychiatry (1996) 168: 376-378.
21. MANDOKI M: Clozapine for adolescents with psychosis: literature and two case reports. J. Child Adolesc. Psychophannacol. (1993) 3:213-221.
22. MANDOKI MW: Anti-aggressive effects of clozapinc in children and adolescents. Btol. Psychiatry (1994) 35:744-745. (Abstract).
23. MOZES T, TOREN P, CHERNAUZAN N et al.: Clozapine treatment in very early onset schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry (1994) 33:65-70.
24. REMSCHMIDT H, SCHULZ E, MARTIN M: An open trial of clozapine in thirty-six adolescents with schizophrenia. J. Child. Adolesc. Psychophannacol. (1994) 4:31-41. One of the largest clinical reports of clozapine in teenagers.
25. SIEFEN G, REMSCHMIDT H: Behandlungsergebnisse mit Clozapin bei schizophrenen Jugendlichen. Z. KinderJugendpsychtat. (1986) 14:245-257.
26. TOWBIN KE, DYKENS EM, PUGLIESE RG: Clozapine for early developmental delays with childhood-onset schizophrenia: protocol and 15-month outcome. J. Am. Acad. Child Adolesc. Psycbiatry (l994) 33:651-657.
27. TURETZ M, MOZES T, TOREN P et al.: An open trial of clozapine in iicuroleptic-resistant childhood-onset schizophrenia. Br.J. Psychiatry (1997) 170:507-510. An open, prospective study of clozapine in children with schizophrenia in which therapeutic benefit was observed.
28. ZUDDAS A, LEDDA MG, FRATTA A et al.: Clinical effects of clozapine on autistic disorder. Am. J. Psychiatry (1996) 153:738.
29. SZIGETHY E, BRENT S, FINDLING RL: Quetiapine for refractory schizophrenia. J. Am. Acad. Child Adolesc. Psychiatry (1998) 37:1127-1128.
30. AMAN MG, FINDLING RL, DERIVAN A: Risperidonc versus placebo for severe conduct disorder in children with mental retardation. Scientific Proceedings of the Annual Meeting of the American Academy of Child and Adolescent Psychiatry and the Canadian Academy of Child Psychiatry. Chicago, USA (1999) NR-205.
31. thAnnual Meeting of the American College of Nettropsychophannacology. Las Croabas, Puerto Rico (1998) 253.
32. FINDLING RL, MCNAMARA NK, BRANICKY LA, SCHLUCHTER MD, LEMON E, BLUMER JL: A double-blind pilot study of rispcridone in conduct disorder. J. Am. Acad. Child Adolesc. Psychiatry (2000) 39:509-516.
33. The first published double-blind study of risperidone in youths. Results suggest efficacy for children with conduct disorder.
34. ARMENTEROS JL, WHITAKER AH, WELIKSON M et al.: Risperidone in adolescents with schizophrenia: An open pilot study. J. Am. Acad. Child Adolesc. Psychiatry. (1997) 36:694-700.
35. A prospective open study in which antipsychotic effectiveness was described.
36. BRUUN RD, BUDMAN CL: Rispcridone as a treatment for Tourette's syndrome. / Clin. Psychiatry (1996) 57:29-31.
37. COZZA SJ, EDISON DL: Rispcridone in adolescents [letter]./ Am. Acad. Child Adolesc. Psychiatry (1994) 33: 1211.
38. DICKER R, SOUS S: Risperidone treatment of a psychotic adolescent [letter]. Am. J. Psychiatry (1996) 153:441-442.
39. FINDLING RL, MAXWELL K, WIZNITZER M: An open clinical trial of rispcridone monotherapy in young children with autistic disorder. Psychopbarmacol. Bull. (1997) 33:155-159.
40. FISMAN S, STEELE M: Use of risperidone in pervasive developmental disorders : A case series./ Child'Adolesc. Psycbopharmacol. (1996) 6:177-190.
41. FITZGERALD KD, STEWART CM, TAWILE V, ROSENBERG DR: Risperidone augmentation of scrotonin reuptake inhibitor treatment of pediatric obsessive compulsive disorder. J Child Adolesc. Fsychopharmacol. (1999) 9:115-123.
42. FRAS I, MAJOR LF: Clinical experience with risperidone [letter]. / Am. Acad. Child Adolesc. Psychiatry (1995) 34:833.
43. FRAZIER JA, MEYER MC, BIEDEMAN J et al: Risperidone treatment for juvenile bipolar disorders: a retrospective chart review. J. Am. Acad. Child Adolesc. Psychiatry (1999) 38:960-965.
44. GRCEVICH SJ, FINDLING RL, ROWANE WA et al: Risperidone in the treatment of children and adolescents with schizophrenia: A retrospective study. J. Child Adolesc. Psycbopharmacol. (1996) 6:251-257.
45. HARDAN A, JOHNSON K, JOHNSON C, HRECZNYJ B: Case study: Rispcridone treatment of children and adolescents with developmental disorders. / Am. Acad. Child Adolesc. Psychiatry (1996) 35:1551-1556.
46. HORRIGAN JP, BARNHILL LJ: Rispcridone and explosive aggressive autism. J. Aut.Deu. Disord.(1997) 27:313-323.
47. KEWLEY GD: Rispcridone in comorbid ADHD and ODD/CD [letter]. J. Am. Acad Child Adolesc Psychiatry (1999) 38:1327-1328.
48. KLEINSASSER BJ, MISRA LK, BHATARA VS, SANCHEZ J: Rispcridone in the treatment of chorciform movements and aggressiveness in a child with 'PANDAS'. S. Dakota J. Med. (1999) 52:345-347.
49. LOMBROSO PJ, SCAHILL L, KING RA et ai: Risperidone treatment of children and adolescents with chronic tic disorders: A preliminary report. J. Am. Acad. Child Adolesc. Psychiatry (1995) 34:1147-1152.
50. MANDOKI M\V: Risperidone treatment of children and adolescents: Increased risk of extrapyramidal side effects?/ Child. Adolesc. Psycbopharmacol.(.1995) 5:49-67
51. MCDOUGLECJ, HOLMES JP, BRONSON MR et al.: Risperidone treatment of children and adolescents with pervasive developmental disorders: A prospective, open-label study./ Am. Acad. Child Adolesc. Psychiatry (1997) 36: 685-693.
52. A relatively large study in which effectiveness was described in a heterogeneous cohort of youths with pervasive developmental disorders.
53. NICOLSON R, AWAD G, SLOMAN L: An open trial of risperidone in young autistic children. J. Am. Acad. Child Adolesc. Psychiatry (1998) 37:372-376.
54. PERRY R, PATAKI C, MUNOZ-SILVA DM, ARMENTEROS J, SILVA RR: Risperidone in children and adolescents with pervasive developmental disorder: pilot trial and follow-up. / Child Adolesc. Psychopharmacol. (1997) 7:167-179.
55. QUINTANA H, KESHAVAN M: Risperidone in children and adolescents with schizophrenia./ Am. Acad. Child Adolesc. Psychiatry (1995) 34:1292-1296.
56. SCHREIER HA: Risperidone for young children with mood disorders and aggressive behavior. J. Child Adolesc. Psycbophannacol. (1998) 8:49-59
57. SIMEON JG, CARREY NJ, WIGGINS D, MILIN RP, HOSENBOCUS SN: Risptridone effects in treatmentresistant adolescents: preliminary case reports. J. Child Adolesc. Psychopharmacol. (1995) 5:69-79.
58. SIPAHIMALANI A, MASAND PS: Use of risperidone in delirium: case reports. Ann. Clin. Psychiatry (1997) 9:105-107.
59. SOURANDER A: Risperidone for treatment of childhood schizophrenia. Am. J. Psychiatry (1997) 154:1476.
60. SZIGETHY E, WIZNITZER M, BRANICKY LA, MAXWELL K, FINDLING RL: Rispcridonc-induced hcpatotoxicity in children and adolescents? A chart review study. J. Child Adolesc. Psycbophannacol. (1999) 9:93-98.
61. BHADRINATH BR: Olanzapine in Tourette syndrome. Br.J. Psychiatry (1998) 172:366.
62. CHANG KD, KETTER TA: Mood stabilizer augmentation with olanzapinc in acutely manic children. J Child Adolesc. Psycbophannacol. (2000) 10:45-49.
63. FRAZIER JA, BIEDERMAN J.JACOBS TG et ah. Olanzapine in the treatment of bipolar-disorder hi juveniles. Schiz. Res. (2000) 41:194.
64. HEIMANN S\V: High-dose olanzapinc in an adolescent [letter]. J Am. Acad. Child Adolesc. Psychiatry (1999) 38:496-498.
65. HORRIGAN JP, BARNHILL LJ, COURVOISIE HE: Olanzapinc inPDD. J Am. Acad. ChildAdolesc. Psychiatry (1997) 36:1166-1167.
66. KARAM-HAGE M, GHAZIUDDIN N: Olanzapine in Tourettc's disorder. J. Am. Acad. Child Adolesc.Psychiatry (2000) 39:139.
67. KEMNER C, VAN ENGELAND H, TUYNMAN-QUA H: An open-label study of olanzapine in children with FDD.
68. ScbizRes. (2000) 41:194.
69. KRISHNAMOORTHY J, KING BH: Open-label olanzapine treatment in five preadolescent children. J. Child Adolesc. Psychopbarmacol. (1998) 8:107-113.
70. KUMRA S, JACOBSEN LK, LENANE M et ah. Childhoodonset schizophrenia: an open-label study of olanzapine in adolescents. J Am. Acad. Child Adolesc. Psychiatry (1998) 37:377-385.
71. A prospective study in which more modest benefit than what was noted with clozapine in this population is reported.
72. MALEK-AHMADI P, SIMONDS JF: Olanzapine for autistic disorder with hyperactivity. J. Am. Acad. Child Adolesc. Psychiatry (1998) 37:902-903.
73. MANDOKI M: Olanzapine in the treatment of early onset schizophrenia in children and adolescents. Biol. Psychiatry (1997) 41:22S.
74. POTENZA MN, HOLMES JP, KANES SJ, MCDOUGLE CJ: Olanzapine treatment of children, adolescents and adults with pervasive developmental disorders: an open-label pilot study. J. Clin. Psychophannacol. (1999) 19:37-44.
75. SCHULZ SC, FINDLING RL, BRANICKY LA, YOUNG CM, FRIEDMAN L: Olanzapine in adolescents with psychotic disorder. Schiz. Res. (1999) 36:297.
76. SEMERCI ZB: Olanzapine in Tourette's Disorder. J Am. Acad. Child Adolesc. Psychiatry (2000) 39:140.
77. SOUTULLO CA, SORTER MT, FOSTER KD, MCELORY SL, KECK PE: Olanzapinc in the treatment of adolescent acute mania: a report of seven cases. J. Affect. Disord. (1999) 53:279-283.
78. HEALY E, SUBOTSKY F, PIPE R: Quetiapine in adolescent psychosis. J. Am. Acad. Child Adolesc. Psychiatry (1999) 38:1329.
79. MARTIN A, KOENIG K, SCAHILL L, BREGMAN J: Open-label quetiapine in the treatment of children and adolescents with autistic disorder. J Child Adolesc. Psychopharniacol. (1999) 9:99-107.
80. A prospective open trial in which most youths did not respond favourably to quetiapine treatment
81. MCCONVILLE B, ARVANITIS L, THYRUM P, SMITH K: Pharmacokinetics, tolerability and clinical effectiveness of quetiapine in adolescents with selected psychotic disorders. Eur. Neuropsycbopbarmacol. (1999) 9 (Suppl. 5);S267.
82. SCHALLER JL, BEHAR D: Quetiapine for refractory mania in a child. J Am. Acad. Child Adolesc. Psychiatry (1999) 38:498-499.
83. SALLEE FR, KURLAN R, GOETZ CG et al: Ziprasidone treatment of children and adolescents with Tourette's syndrome: a pilot study. J. Am. Acad. Child Adolesc. Psychiatry (2000) 39:292-299.
84. A relatively large placebo-controlled study of ziprasidone in youths with movement disorders. Ziprasidone was noted to be superior to placebo.