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Volumn 9, Issue 2, 2015, Pages 94-105

Recent advances in ocular drug delivery, with special emphasis on lipid based nanocarriers

Author keywords

Biodegradation; Eye; Lipid nanocarrier; Ophthalmic delivery; Patents

Indexed keywords

BIOCHEMISTRY; BIOCOMPATIBILITY; BIODEGRADATION; DRUG PRODUCTS; LIPIDS; LIPOSOMES; MEDICAL NANOTECHNOLOGY; PATENTS AND INVENTIONS; TARGETED DRUG DELIVERY;

EID: 84940907263     PISSN: 18722105     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221050902150819151841     Document Type: Article
Times cited : (13)

References (76)
  • 1
    • 84975321252 scopus 로고    scopus 로고
    • Timolol lipophilic ion-pair incorporated submicron emulsion: A potential ocular drug delivery system
    • [1] Suresh PK, Koner P, Das S. Timolol lipophilic ion-pair incorporated submicron emulsion: A potential ocular drug delivery system. Int J Res Pharm Biomed Sci 2011; 2(4): 1686-91.
    • (2011) Int J Res Pharm Biomed Sci , vol.2 , Issue.4 , pp. 1686-1691
    • Suresh, P.K.1    Koner, P.2    Das, S.3
  • 3
    • 84940915013 scopus 로고    scopus 로고
    • Nanosized emulsions as a drug carrier for ocular drug delivery: A review
    • [3] Dewangan D, Suresh PK. Nanosized emulsions as a drug carrier for ocular drug delivery: A review, JITPS 2011; 2(2): 59-75.
    • (2011) JITPS , vol.2 , Issue.2 , pp. 59-75
    • Dewangan, D.1    Suresh, P.K.2
  • 4
    • 0036130360 scopus 로고    scopus 로고
    • Microemulsions as ocular drug delivery systems: Recent developments and future challenges
    • [4] Vandamme TF. Microemulsions as ocular drug delivery systems: Recent developments and future challenges. Prog Retin Eye Res 2002; 21: 15-34.
    • (2002) Prog Retin Eye Res , vol.21 , pp. 15-34
    • Vandamme, T.F.1
  • 5
    • 84911493996 scopus 로고    scopus 로고
    • Nanocarriers for ocular delivery for possible benefits in the treatment of anterior uveitis: Focus on current paradigms and future directions
    • [5] Suresh PK, Sah AK. Nanocarriers for ocular delivery for possible benefits in the treatment of anterior uveitis: Focus on current paradigms and future directions. Exp Opin Drug Deliv 2014; 11(11): 1-22.
    • (2014) Exp Opin Drug Deliv , vol.11 , Issue.11 , pp. 1-22
    • Suresh, P.K.1    Sah, A.K.2
  • 7
    • 79959361327 scopus 로고    scopus 로고
    • Drug delivery to eye: Special reference to nanoparticles
    • [7] Das S, Suresh PK. Drug delivery to eye: Special reference to nanoparticles. Int J Drug Deliv 2010; 2: 12-21.
    • (2010) Int J Drug Deliv , vol.2 , pp. 12-21
    • Das, S.1    Suresh, P.K.2
  • 9
    • 84940917769 scopus 로고    scopus 로고
    • New controlled release technologies broaden opportunities for ophthalmic therapies
    • [9] Haders DJ. New controlled release technologies broaden opportunities for ophthalmic therapies. Drug Del Tech 2008; 8(7): 48-53.
    • (2008) Drug Del Tech , vol.8 , Issue.7 , pp. 48-53
    • Haders, D.J.1
  • 12
    • 33644529511 scopus 로고    scopus 로고
    • Understanding emulsion eye drop technology
    • [12] Hom MM, Simmons PA. Understanding emulsion eye drop technology. Rev Optometry 2003; 140 (3): 124-6.
    • (2003) Rev Optometry , vol.140 , Issue.3 , pp. 124-126
    • Hom, M.M.1    Simmons, P.A.2
  • 14
    • 33344461703 scopus 로고    scopus 로고
    • W/o microemulsion for ocular delivery platform for ocular irritation and precorneal retention
    • [14] Alany RG, Radesb T, Nicollc J, Tuckerb IG, Davies NM. W/o microemulsion for ocular delivery platform for ocular irritation and precorneal retention. J Contr Rel 2006; 111: 145-52.
    • (2006) J Contr Rel , vol.111 , pp. 145-152
    • Alany, R.G.1    Radesb, T.2    Nicollc, J.3    Tuckerb, I.G.4    Davies, N.M.5
  • 15
    • 12944302554 scopus 로고    scopus 로고
    • Systemic FK506 improved tear secretion in dry eye associated with chronic graft versus host disease
    • [15] Aoki S, Mizote H, Minamoto A, M Suzuki, Mishima HK, Tanaka H. Systemic FK506 improved tear secretion in dry eye associated with chronic graft versus host disease. Br J Ophthalmol 2005; 89: 243-4.
    • (2005) Br J Ophthalmol , vol.89 , pp. 243-244
    • Aoki, S.1    Mizote, H.2    Minamoto, A.3    Suzuki, M.4    Mishima, H.K.5    Tanaka, H.6
  • 16
    • 77954416176 scopus 로고    scopus 로고
    • Feasibility of lipid nanoparticles for ocular delivery of antiinflammatory drugs
    • [16] Souto EB, Doktorovovoa S, Mira GE, Egea MA, Garcia ML. Feasibility of lipid nanoparticles for ocular delivery of antiinflammatory drugs. Curr Eye Res 2010; 35(7): 537-52.
    • (2010) Curr Eye Res , vol.35 , Issue.7 , pp. 537-552
    • Souto, E.B.1    Doktorovovoa, S.2    Mira, G.E.3    Egea, M.A.4    Garcia, M.L.5
  • 18
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • [18] Müller RH, Radtke M, Wissing SA. Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 2002a; 242: 121-8.
    • (2002) Int J Pharm , vol.242 , pp. 121-128
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 19
    • 2242472082 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
    • [19] Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002b; 54: S131-55.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. S131-S155
    • Müller, R.H.1    Radtke, M.2    Wissing, S.A.3
  • 20
    • 70450204572 scopus 로고    scopus 로고
    • Biocompatible microemulsions for fabrication of glyceryl monostearate solid lipid nanoparticles (SLN) of tretinoin
    • [20] Shah KA, Joshi MD, Patravale VB. Biocompatible microemulsions for fabrication of glyceryl monostearate solid lipid nanoparticles (SLN) of tretinoin. J Biomed Nanotech 2009; 5: 396-400.
    • (2009) J Biomed Nanotech , vol.5 , pp. 396-400
    • Shah, K.A.1    Joshi, M.D.2    Patravale, V.B.3
  • 21
    • 19744369697 scopus 로고    scopus 로고
    • Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system
    • [21] Caboi F, Lazzari P, Pani L, et al. Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system. Chem Phys Lipids 2005; 135: 147-56.
    • (2005) Chem Phys Lipids , vol.135 , pp. 147-156
    • Caboi, F.1    Lazzari, P.2    Pani, L.3
  • 22
    • 80052103054 scopus 로고    scopus 로고
    • Garciaa. Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye
    • [22] Joana A, Sasha N, Maria A, Egea E. Soutoc ML. Garciaa. Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye. Coll Surf B: Bioint 2011; 88: 150-7.
    • (2011) Coll Surf B: Bioint , vol.88 , pp. 150-157
    • Joana, A.1    Sasha, N.2    Maria, A.3    Egea, E.4    Soutoc, M.L.5
  • 23
    • 78650178421 scopus 로고    scopus 로고
    • Nanostructured lipid carrier (NLC) coated with chitosan oligosaccharides and its potential use in ocular drug delivery system
    • [23] Luo Q, Zhao J, Zhang X, Pan W. Nanostructured lipid carrier (NLC) coated with chitosan oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm 2011; 403: 185-91.
    • (2011) Int J Pharm , vol.403 , pp. 185-191
    • Luo, Q.1    Zhao, J.2    Zhang, X.3    Pan, W.4
  • 24
    • 78349311591 scopus 로고    scopus 로고
    • Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution
    • [24] Shen J, Deng Y, Jin X, Ping Q, Su Z, Li L. Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution. Int J Pharm 2010; 402(1-2): 248-53.
    • (2010) Int J Pharm , vol.402 , Issue.1-2 , pp. 248-253
    • Shen, J.1    Deng, Y.2    Jin, X.3    Ping, Q.4    Su, Z.5    Li, L.6
  • 25
    • 0037093721 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
    • [25] Cavalli R, Gasco MR, Chetoni P, Burgalassi S, Saettone MF. Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin. Int J Pharm 2002; 238(1-2): 241-5.
    • (2002) Int J Pharm , vol.238 , Issue.1-2 , pp. 241-245
    • Cavalli, R.1    Gasco, M.R.2    Chetoni, P.3    Burgalassi, S.4    Saettone, M.F.5
  • 26
    • 41349106751 scopus 로고    scopus 로고
    • Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
    • [26] Attama AA, Reichl S, Müller-Goymann CC. Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct. Int J Pharm 2008; 355(1-2): 307-13.
    • (2008) Int J Pharm , vol.355 , Issue.1-2 , pp. 307-313
    • Attama, A.A.1    Reichl, S.2    Müller-Goymann, C.C.3
  • 27
    • 53949111819 scopus 로고    scopus 로고
    • Cyclosporine A loaded SLNs: Evaluation of cellular uptake and corneal cytotoxicity
    • [27] Gokce EH, Sandri G, Bonferoni MC, et al. Cyclosporine A loaded SLNs: Evaluation of cellular uptake and corneal cytotoxicity. Int J Pharm 2008; 364: 76-86.
    • (2008) Int J Pharm , vol.364 , pp. 76-86
    • Gokce, E.H.1    Sandri, G.2    Bonferoni, M.C.3
  • 29
    • 79251646878 scopus 로고    scopus 로고
    • A potential new therapeutic system for glaucoma: Solid lipid nanoparticles containing methazolamide
    • [29] Li R, Jiang S, Liu D, et al. A potential new therapeutic system for glaucoma: solid lipid nanoparticles containing methazolamide. J Microencapsul 2011; 28: 134-41.
    • (2011) J Microencapsul , vol.28 , pp. 134-141
    • Li, R.1    Jiang, S.2    Liu, D.3
  • 30
    • 33847403965 scopus 로고    scopus 로고
    • Liposome-encapsulated mitomycin C for the reduction of corneal healing rate and ocular toxicity
    • [30] Chetoni P, Burgalassi S, Monti D, Najarro M, Boldrini E. Liposome-encapsulated mitomycin C for the reduction of corneal healing rate and ocular toxicity. J Drug Deliv Sci Technol 2007; 17: 43-8.
    • (2007) J Drug Deliv Sci Technol , vol.17 , pp. 43-48
    • Chetoni, P.1    Burgalassi, S.2    Monti, D.3    Najarro, M.4    Boldrini, E.5
  • 31
    • 78649901051 scopus 로고    scopus 로고
    • Liposomes as an ocular delivery system of fluconazole: In vitro studies
    • [31] Habib FS, Fouad EA, Rhaman MSA, Fathalla D. Liposomes as an ocular delivery system of fluconazole: in vitro studies. Acta Ophthalmol 2010; 88: 901-4.
    • (2010) Acta Ophthalmol , vol.88 , pp. 901-904
    • Habib, F.S.1    Fouad, E.A.2    Rhaman, M.3    Fathalla, D.4
  • 32
    • 34249291291 scopus 로고    scopus 로고
    • Mechanism of adjuvant activity of cationic liposome: Phosphorylation of a MAP kinase, ERK and induction of chemokines
    • [32] Yan W, Chen W, Huang L. Mechanism of adjuvant activity of cationic liposome: Phosphorylation of a MAP kinase, ERK and induction of chemokines. Mol Immunol 2007; 44(15): 3672-81.
    • (2007) Mol Immunol , vol.44 , Issue.15 , pp. 3672-3681
    • Yan, W.1    Chen, W.2    Huang, L.3
  • 33
    • 33745002935 scopus 로고    scopus 로고
    • Cationic liposomes as potential carriers for ocular administration of peptides with antiherpetic activity
    • [33] Cortesi R, Argnani R, Esposito E, et al. Cationic liposomes as potential carriers for ocular administration of peptides with antiherpetic activity. Int J Pharm 2006; 317: 90-100.
    • (2006) Int J Pharm , vol.317 , pp. 90-100
    • Cortesi, R.1    Argnani, R.2    Esposito, E.3
  • 34
    • 0033020812 scopus 로고    scopus 로고
    • Characterization and in vivo ocular absorption of liposome-encapsulated acyclovir
    • [34] Fresta M, Panico AM, Bucolo C, Giannavola C, Puglisi G. Characterization and in vivo ocular absorption of liposome-encapsulated acyclovir. J Pharm Pharmacol 1999; 51: 565-7.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 565-567
    • Fresta, M.1    Panico, A.M.2    Bucolo, C.3    Giannavola, C.4    Puglisi, G.5
  • 35
    • 77955049646 scopus 로고    scopus 로고
    • Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: Improving preocular retention and ocular bioavailability
    • [35] Gan L, Han S, Shen J, et al. Self-assembled liquid crystalline nanoparticles as a novel ophthalmic delivery system for dexamethasone: improving preocular retention and ocular bioavailability. Int J Pharm 2010; 396: 179-87.
    • (2010) Int J Pharm , vol.396 , pp. 179-187
    • Gan, L.1    Han, S.2    Shen, J.3
  • 36
    • 27844529489 scopus 로고    scopus 로고
    • Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide
    • [36] Guinedi AS, Mortada ND, Mansour S, et al. Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide. Int J Pharm 2005; 306: 71-82.
    • (2005) Int J Pharm , vol.306 , pp. 71-82
    • Guinedi, A.S.1    Mortada, N.D.2    Mansour, S.3
  • 37
    • 84896797477 scopus 로고    scopus 로고
    • Ocular drug delivery systems: An overview
    • [37] Patel A, Cholkar K, Agrahari V, et al. Ocular drug delivery systems: an overview. World J Pharmacol 2013; 2(2): 47-64.
    • (2013) World J Pharmacol , vol.2 , Issue.2 , pp. 47-64
    • Patel, A.1    Cholkar, K.2    Agrahari, V.3
  • 38
    • 84862826803 scopus 로고    scopus 로고
    • Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera
    • [38] Chopra P, Hao J, Li SK. Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera. J Cont Rel 2002; 160: 96-104.
    • (2002) J Cont Rel , vol.160 , pp. 96-104
    • Chopra, P.1    Hao, J.2    Li, S.K.3
  • 39
    • 23944453408 scopus 로고    scopus 로고
    • Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate
    • [39] Yamaguchi M, Yasued SI, Isowaki A, et al. Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate. Int J Pharm 2005; 301: 121-8.
    • (2005) Int J Pharm , vol.301 , pp. 121-128
    • Yamaguchi, M.1    Yasued, S.I.2    Isowaki, A.3
  • 40
    • 67650751095 scopus 로고    scopus 로고
    • Mucoadhesive properties of chitosan-coated ophthalmic lipid emulsion containing indomethacin in tear fluid
    • [40] Yamaguchi M, Ueda K, Isowaki A, et al. Mucoadhesive properties of chitosan-coated ophthalmic lipid emulsion containing indomethacin in tear fluid. Biol Pharm Bull 2009; 32: 1266-71.
    • (2009) Biol Pharm Bull , vol.32 , pp. 1266-1271
    • Yamaguchi, M.1    Ueda, K.2    Isowaki, A.3
  • 41
    • 0031018113 scopus 로고    scopus 로고
    • Ex-vivo permeation study of indomethacin from a submicron emulsion through albino rabbit cornea
    • [41] Muchar S, Abdulrazik M, Frucht-Pery J, Benita S. Ex-vivo permeation study of indomethacin from a submicron emulsion through albino rabbit cornea. J Contr Rel 1997; 44: 55-64.
    • (1997) J Contr Rel , vol.44 , pp. 55-64
    • Muchar, S.1    Abdulrazik, M.2    Frucht-Pery, J.3    Benita, S.4
  • 42
    • 0023155034 scopus 로고
    • Partition characteristics and retention of anti-inflamatory steroids in liposomal ophthalmic preparations
    • [42] Taniguchi K, Yamazawa N, Itakura K, Morisaki K and Hayashi S. Partition characteristics and retention of anti-inflamatory steroids in liposomal ophthalmic preparations. Chem Pharm Bull 1987; 35: 1214-22.
    • (1987) Chem Pharm Bull , vol.35 , pp. 1214-1222
    • Taniguchi, K.1    Yamazawa, N.2    Itakura, K.3    Morisaki, K.4    Hayashi, S.5
  • 43
    • 0023945571 scopus 로고
    • Efficacy of a liposome preparation of antiinflammatory steroid as an ocular drug-delivery system
    • [43] Taniguchi K, Itakura K, Yamazawa N, Morisaki K, Hayashi S, Yamada Y. Efficacy of a liposome preparation of antiinflammatory steroid as an ocular drug-delivery system. J Pharmacobiodyn 1988; 11: 39-46.
    • (1988) J Pharmacobiodyn , vol.11 , pp. 39-46
    • Taniguchi, K.1    Itakura, K.2    Yamazawa, N.3    Morisaki, K.4    Hayashi, S.5    Yamada, Y.6
  • 44
    • 80052103054 scopus 로고    scopus 로고
    • Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye
    • [44] Araújo J, Nikolic S, Egea MA, Souto EB, García ML. Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye. Colloids Surf B: Biointerf 2011; 88: 150-7.
    • (2011) Colloids Surf B: Biointerf , vol.88 , pp. 150-157
    • Araújo, J.1    Nikolic, S.2    Egea, M.A.3    Souto, E.B.4    García, M.L.5
  • 45
    • 77953356716 scopus 로고    scopus 로고
    • Optimization and physicochemical characterization of a triamcinolone acetonide loaded NLC for ocular antiangiogenic applications
    • [45] Araújo J, Gonzalez-Mira E, Egea MA, Garcia ML, Souto EB. Optimization and physicochemical characterization of a triamcinolone acetonide loaded NLC for ocular antiangiogenic applications. Int J Pharm, 2010; 393(1-2): 167-75.
    • (2010) Int J Pharm , vol.393 , Issue.1 , pp. 167-175
    • Araújo, J.1    Gonzalez-Mira, E.2    Egea, M.A.3    Garcia, M.L.4    Souto, E.B.5
  • 46
    • 84455205699 scopus 로고    scopus 로고
    • Improved and safe transcorneal delivery of flurbiprofen by NLC and NLC-based hydrogels
    • [46] Gonzalez-Mira E, Nikoli S, Calpena AC, et al. Improved and safe transcorneal delivery of flurbiprofen by NLC and NLC-based hydrogels. J Pharm Sci 2012; 101: 707-25.
    • (2012) J Pharm Sci , vol.101 , pp. 707-725
    • Gonzalez-Mira, E.1    Nikoli, S.2    Calpena, A.C.3
  • 47
    • 77956650644 scopus 로고    scopus 로고
    • Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC
    • [47] Gonzalez-Mira E, Egea MA, Garcia ML, Souto EB. Design and ocular tolerance of flurbiprofen loaded ultrasound-engineered NLC. Colloids Surf B Biointerf 2010; 81(2): 412-21.
    • (2010) Colloids Surf B Biointerf , vol.81 , Issue.2 , pp. 412-421
    • Gonzalez-Mira, E.1    Egea, M.A.2    Garcia, M.L.3    Souto, E.B.4
  • 48
    • 84855864937 scopus 로고    scopus 로고
    • Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery
    • [48] Tian B, Luo Q, Song S, et al. Novel surface-modified nanostructured lipid carriers with partially deacetylated water-soluble chitosan for efficient ocular delivery. J Pharm Sci 2012; 101: 1040-9.
    • (2012) J Pharm Sci , vol.101 , pp. 1040-1049
    • Tian, B.1    Luo, Q.2    Song, S.3
  • 49
    • 67649101315 scopus 로고    scopus 로고
    • Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery
    • [49] Shen J, Wang Y, Ping Q, et al. Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery. J Control Release 2009; 137(3): 217-23.
    • (2009) J Control Release , vol.137 , Issue.3 , pp. 217-223
    • Shen, J.1    Wang, Y.2    Ping, Q.3
  • 50
    • 72449183701 scopus 로고    scopus 로고
    • Cyclosporine A-loaded solid lipid nanoparticles: Ocular tolerance and in vivo drug release in rabbit eyes
    • [50] Gokce EH, Sandri G, Egrilmez S, et al. Cyclosporine A-loaded solid lipid nanoparticles: ocular tolerance and in vivo drug release in rabbit eyes. Curr Eye Res 2009; 34(11): 996-1003.
    • (2009) Curr Eye Res , vol.34 , Issue.11 , pp. 996-1003
    • Gokce, E.H.1    Sandri, G.2    Egrilmez, S.3
  • 51
    • 70350604541 scopus 로고    scopus 로고
    • Sustained release and permeation of timolol from surface-modified solid lipid nanoparticles through bioengineered human cornea
    • [51] Attama AA, Reichl S, Müller-Goymann CC. Sustained release and permeation of timolol from surface-modified solid lipid nanoparticles through bioengineered human cornea. Curr Eye Res 2009; 34: 698-705.
    • (2009) Curr Eye Res , vol.34 , pp. 698-705
    • Attama, A.A.1    Reichl, S.2    Müller-Goymann, C.C.3
  • 52
    • 0031438323 scopus 로고    scopus 로고
    • Preparation and evaluation of acetazolamide liposomes as ocular delivery systems
    • [52] El-Gazayerly ON, Hikal AH, Preparation and evaluation of acetazolamide liposomes as ocular delivery systems. Int J Pharm1997; 158: 121-7.
    • Int J Pharm1997 , vol.158 , pp. 121-127
    • El-Gazayerly, O.N.1    Hikal, A.H.2
  • 53
    • 77955446156 scopus 로고    scopus 로고
    • Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability
    • [53] Han S, Shen J, Gan Y, et al. Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability. Acta Pharmacol Sin 2010; 31: 990-8.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 990-998
    • Han, S.1    Shen, J.2    Gan, Y.3
  • 54
    • 12344267896 scopus 로고    scopus 로고
    • Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system
    • [54] Aggarwal D, Kaur IP. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. Int J Pharm 2005; 290: 155-9.
    • (2005) Int J Pharm , vol.290 , pp. 155-159
    • Aggarwal, D.1    Kaur, I.P.2
  • 55
    • 84861592634 scopus 로고    scopus 로고
    • Novel micelle carriers for cyclosporin A topical ocular delivery: In vivo cornea penetration, ocular distribution and efficacy studies
    • [55] Tommaso CD, Bourges JL, Valamanesh Fatemeh. Novel micelle carriers for cyclosporin A topical ocular delivery: in vivo cornea penetration, ocular distribution and efficacy studies. Eur J Pharm Biopharm 2012; 81: 257-64.
    • (2012) Eur J Pharm Biopharm , vol.81 , pp. 257-264
    • Tommaso, C.D.1    Bourges, J.L.2    Fatemeh, V.3
  • 56
    • 79957513828 scopus 로고    scopus 로고
    • Novel NSAIDs ophthalmic formulation: Flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect
    • [56] Shen J, Gan L, Zhu C, et al. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect. Int J Pharm 2011; 412: 115-22.
    • (2011) Int J Pharm , vol.412 , pp. 115-122
    • Shen, J.1    Gan, L.2    Zhu, C.3
  • 57
    • 51649130848 scopus 로고    scopus 로고
    • A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers
    • [57] Li X, Nie SF, Kong J, Li N, Ju CY, Pan W. A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers. Int J Pharm 2008; 363(1-2): 177-82.
    • (2008) Int J Pharm , vol.363 , Issue.1 , pp. 177-182
    • Li, X.1    Nie, S.F.2    Kong, J.3    Li, N.4    Ju, C.Y.5    Pan, W.6
  • 58
    • 79953234715 scopus 로고    scopus 로고
    • Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo
    • [58] Liu Z, Zhang X, Wu H, Li J, Shu L, Liu R, Li L, Li N. Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo. Drug Dev Ind Pharm 2011; 37(4): 475-81.
    • (2011) Drug Dev Ind Pharm , vol.37 , Issue.4 , pp. 475-481
    • Liu, Z.1    Zhang, X.2    Wu, H.3    Li, J.4    Shu, L.5    Liu, R.6    Li, L.7    Li, N.8


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