Novel vehicle based on cubosomes for ophthalmic delivery of flurbiprofen with low irritancy and high bioavailability

Acta Pharmacologica Sinica

Volumn 31, Issue 8, 2010, Pages 990-998

  Han, Shun ^a   Shen, Jin Qiu ^b   Gan, Yong ^a   Geng, Hai Ming ^c   Zhang, Xin Xin ^a   Zhu, Chun Liu ^a   Gan, Li ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c Wuhan Wuyao Science Technology Co Ltd   (China)

Author keywords

corneal permeability; cubosomes; flurbiprofen; ocular drug delivery systems; ocular irritation

Indexed keywords

CUBOSOME; DRUG VEHICLE; EYE DROPS; FLURBIPROFEN; GLYCEROL; GLYCEROL OLEATE; POLOXAMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; CORNEA PERMEABILITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; EYE IRRITATION; HISTOLOGY; IN VITRO STUDY; INCUBATION TEMPERATURE; MICRODIALYSIS; NONHUMAN; PARTICLE SIZE; RABBIT; RADIATION SCATTERING; SCORING SYSTEM; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CORNEA; DRUG DELIVERY SYSTEMS; FLURBIPROFEN; MALE; MICRODIALYSIS; MICROSCOPY, ELECTRON, TRANSMISSION; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; PERMEABILITY; RABBITS;

EID: 77955446156     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.98     Document Type: Article

References (32)

1. Waterbury L, Kunysz EA, Bewerman R. Effect of steroidal and non steroidal anti-infammatory agents on corneal wound healing. J Ocul Pharmacol 1987; 3: 43-54.
2. Schalnus R. Topical nonsteroidal anti-inflammatory therapy in ophthalmology. Ophthalmologica 2003; 217: 89-98.
3. Joseph TM. A critical look at ocular allergy drugs. Am Fam Physician 1996; 53: 2637-2642
4. Stroobants A, Fabre K, Maudgal PC. Effect of non-steroidal anti-infammatory drugs (NSAID) on the rabbit corneal epithelium studied by scanning electron microscopy. Bull Soc Belge Ophtalmol 2000; 276: 73-81.
5. Arajo J, Vega E, Lopes C, Egea MA, Garcia ML, Souto EB. Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres. Colloid Surfaces B 2009; 72: 48-56.
6. Label information of Ocufen. Label approved on 08/25/2003. Available from: http://www.accessdata.fda.gov/drugsatfda-docs/ label/2003/19404scp020- ocufen-lbl.pdf
7. Ahuja M, Dhake AS, Sharma SK, Majumdar DK. Topical ocular delivery of NSAIDs. AAPS J 2008; 10: 229-241
8. Li N, Zhuang CY, Wang M, Sun XY, Nie SF, Pan WS. Liposome coated with low molecular weight chitosan and its potential use in ocular drug delivery. Int J Pharm 2009; 379: 131-138
9. Gan L, Gan Y, Zhu CL, Zhang XX, Zhu JB. Novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A: in vitro and in vivo results. Int J Pharm 2009; 365: 143-149
10. Ibrahim HK, El-Leithy IS, Makky AA. Mucoadhesive nanoparticles as carrier systems for prolonged ocular delivery of gatifloxacin/ prednisolone bitherapy. Mol Pharm 2010; 7: 576-585
11. Nakano M, Sugita A, Matsuoka H, Handa T. Small-angle X-ray scatter ing and 13C-NMR investigation on the internal structure of cubosomes. Langmuir 2001; 17: 3917-3922
12. Malmsten M. Soft drug delivery systems. Soft Matter 2006; 2: 760-769
13. Zhao XY, Zhang J, Zheng LQ, Li DH. Studies of cubosomes as a sustained drug delivery system. J Disp Sci Tech 2004; 25: 795-799
14. Larsson K. Aqueous dispersion of cubic lipid water phases. Curr Opin Colloid Interface Sci 2000; 5: 64-69
15. Garg G, Saraf S, Saraf S. Cubosomes: an overview. Biol Pharm Bull 2007; 30: 350-353
16. Johnsson M, Barauskas J, Norlin A, Tiberg F. Physicochemical and drug delivery aspects of lipid-based liquid crystalline nanoparticles: A case study of intravenously administered propofol. J Nanosci Nano-technol 2006; 6: 3017-3024
17. Chung H, Kim J, Um JY, Kwon IC, Jeong SY. Self-assembled nanocubicle as a carrier for peroral insulin delivery. Diabetologia 2002; 45: 448-451
18. Esposito E, Cortesi R, Drechsler M, Paccamiccio L, Mariani P, Contado C, et al. Cubosome dispersions as delivery systems for percutaneous administration of indomethacin. Pharm Res 2005; 22: 2163-2173
19. Larsson K. Cubic lipid-water phases: Structures and biomembrane aspects. J Phys Chem 1989; 93: 7304-7314
20. Gupta PK, Hung CT, Perrier DG. Quantitation of the release of doxorubicin from colloidal dosage forms using dynamic dialysis. J Pharm Sci 1987; 76: 141-145
21. Rozier A, Manuel C, Groove J, Plazonet B. Gelrite: a novel ion activated, in situ gelling polymer for ophthalmic vehicles. Effect on bioavailability of timolol. Int J Pharm 1989; 57: 163-168
22. O'Brien WJ, Edelhauser HF. The corneal penetration of trifluoro-thymidine, adenine -arabinoside, and idoxuidine: a comparative study. Invest Ophthalmol Vis Sci 1977; 16: 1093-1103
23. Baydoun L, Furrer P, Gurny R, Muller-Goymann CC. New surface-active polymers for ophthalmic formulations: evaluation of ocular tolerance. Eur J Pharm Biopharm 2004; 58: 169-175
24. Tak RV, Pal D, Gao H, Dey S, Mitra AK. Transport of acyclovir ester prodrugs through rabbit cornea and SIRC-rabbit corneal epithelial cell line. J Pharm Sci 2001; 90: 1505-1515
25. Neto C, Aloisi G, Baglioni P, Larsson K. Imaging soft-matter with the atomic force microscopy: cubosomes and hexosomes. J Phys Chem B 1999; 103: 3896-3899
26. Spicer PT. Progress in liquid crystalline dispersions: cubosomes. Curr Opin Colloid Interf Sci 2005; 10: 274-279
27. Boyd BJ. Characterisation of drug release from cubosomes using the pressure ultrafltration method. Int J Pharm 2003; 260: 239-247
28. Saettone MF, Chetoni P, Cerbai R, Mazzanti G, Braghiroli L. Evaluation of ocular permeation enhancers: In vitro effects on corneal transport of four [beta]-blockers and in vitro/in vivo toxic activity. Int J Pharm 1996; 142: 103-113
29. Rittenhouse KD, Peiffer RL, Pollack GM. Evaluation of microdialysis sampling of aqueous humor for in vivo models of ocular absorption and disposition. J Pharmaceut Biomed 1998; 16: 951-959
30. Katragadda S, Gunda S, Hariharan S, Mitra AK. Ocular pharma-cokinetics of acyclovir amino acid ester prodrugs in the anterior chamber: Evaluation of their utility in treating ocular HSV infections. Int J Pharm 2008; 359: 15-24.
31. Levy MY, Schutze W, Fuhrer C, Benita S. Characterization of diazepam submicron emulsion interface: role of oleic acid. J Microencapsul 1994; 11: 79-92.
32. Lopes LB, Speretta FFF, Bentley MVLB. Enhancement of skin penetration of vitamin K using monoolein-based liquid crystalline systems. Eur J Pharmaceut Sci 2007; 32: 209-215