Liposomes as an ocular delivery system of fluconazole: In-vitro studies

Acta Ophthalmologica

Volumn 88, Issue 8, 2010, Pages 901-904

  Habib, Fawzia S ^a   Fouad, Ehub A ^a   Abdel Rhaman, Mohamed S ^b   Fathalla, Dina ^a  

^a Assiut University   (Egypt)

^b Assiut University Faculty of Medicine   (Egypt)

Author keywords

Candida keratitis; fluconazole liposomal formulation; fluconazole solution

Indexed keywords

EYE DROPS; FLUCONAZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DOSE REDUCTION; HEALING; HYPOPYON; IN VITRO STUDY; INOCULATION; KERATITIS; LIPOSOMAL DELIVERY; NONHUMAN; PRIORITY JOURNAL; RABBIT; ULCER;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; CORNEAL STROMA; CORNEAL ULCER; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; EYE INFECTIONS, FUNGAL; FLUCONAZOLE; LIPOSOMES; RABBITS; TREATMENT OUTCOME;

EID: 78649901051     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2009.01584.x     Document Type: Article

References (22)

1. Abbasoglu OE, Hosal BM, Sener B, Erdemoglu N, &, Gursel E, (2001): Penetration of topical fluconazole into human aqueous humor. Exp Eye Res 72: 147-151.
2. Al-Hussaini AK, Daef EAE, El-Shanawany AA, &, Abd El-Rahman MS, (1994): Etiology of Microbial Keratitis. Bull Ophthalmol Soc Egypt 87: 647-652.
3. Ambrosini A, Bossi G, Dante S, Dubinib G, Leone L, Bossi M, &, Zolese G, (1998): Lipid-drug interaction: thermodynamic and structural effects of antimicotic fluconazole on DPPC liposomes. Chem Phys Lipids 95: 37-47.
4. Behrens-Baumann W, Klinge B, &, RÅchel R, (1990): Topical fluconazole for experimental candida keratits in rabbits. Br J Ophthalmol 74: 40-42.
5. Bochot A, Fattal E, Grossiord JL, Puisieux F, &, Couvreur P, (1998): Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel. Int J Pharm 162: 119.
6. 125 I- labeled iodoxuridine liposomes. Acta Ophthalmol (Copenh) 64: 298-301.
7. El-Gazayerly ON, &, Hikal AH, (1997): Preparation and evaluation of acetazolamide liposomes as an ocular delivery system. Int J Pharm 158: 121-127.
8. Fre'zard F, (1999): Liposomes: from biophysics to the design of peptide vaccines. Braz J Med Biol Res 32: 181-189.
9. Goldblum D, Frueh BE, Sarra G, Katsoulis K, &, Zimmerli S, (2005): Topical caspofungin for treatment of keratitis caused by Candida albicans in a rabbit model. Antimicrob Agents Chemotherapy 49: 1359-1363.
10. Kaur IP, Garg A, Singla AK, &, Aggarwal D, (2004): Vesicular systems in ocular delivery: an overview. Int J Pharm 269: 1-14.
11. Klotz SA, Penn CC, Negvesky GJ, &, Butrus SI, (2000): Fungal and parasitic infections of the eye. Clin Microbiol Rev 13: 662-685.
12. Lee VHL, (1993): Precorneal, corneal and postcorneal factors. In:, Mitra AK, (ed.). Ophthalmic drug delivery systems. New York: Marcel Dekker, 59-82.
13. Lin H-C, Hsiao C-H, Ma DH, Yeh L-K, Tan H-Y, Lin M-Y, &, Huang SC-M, (2009): Medical treatment for combined Fusarium and Acanthamoeba keratitis. Acta Ophthalmol 87: 199-203.
14. Narendran N, Balasubramaniam B, Johnson E, Dick A, &, Mayer E, (2008): Five-year retrospective review of guideline-based management of fungal endophthalmitis. Acta Ophthalmol 86: 525-532.
15. A'Day DM, (1990): Orally administered antifungal therapy for experimental keratomycosis. Trans Am Ophthalmol Soc 88: 685.
16. Oh YK, Nix DE, &, Straubinger RM, (1995): Formulation and efficacy of liposome-encapsulated antibiotics for therapy of intracellular Mycobacterium avium infection. Antimicrob Agents Chemother 9: 2104-2111.
17. Price MF, LaRocco MT, &, Gentry LO, (1994): Fluconazole susceptibilities of Candida species and distribution of species recovered from blood cultures over a 5-year period. Antimicrob Agents Chemother 38: 1422-1424.
18. Schreiber W, Olbriscb A, Vorwerk CK, König W, &, Bebrens-Baumann W, (2003): Combined topical fluconazole and corticosteroid treatment for experimental candida albicans keratomycosis. Invest Ophthalmol Vis Sci 44: 2634-2643.
19. Stevens DA, (1988): The new generation of antifungal drugs. Eur J Clin Microbiol 7: 732-735.
20. Suzoka F, &, Papahadjopoulos D, (1978): Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci USA 75: 4194-4198.
21. Yee RW, Cheng CJ, Meenakshi S, Ludden TM, Wallace JE, &, Rinaldi MG, (1997): Ocular penetration and pharmacokinetics of topical fluconazole. Cornea 16: 64-71.
22. Yilmaz S, &, Maden A, (2005): Sever fungal keratitis treated with subconjunctival fluconazole. Am J Ophthalmol 140: 454-458.