메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

18β-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination

Author keywords

[No Author keywords available]

Indexed keywords

18ALPHA-GLYCYRRHETINIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; CHEMOKINE; GLYCYRRHETINIC ACID;

EID: 84940886858     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13713     Document Type: Article
Times cited : (45)

References (41)
  • 1
    • 0036953725 scopus 로고    scopus 로고
    • Microglia in diseases of the central nervous system
    • Nelson, P. T., Soma, L. A. & Lavi, E. Microglia in diseases of the central nervous system. Ann Med 34, 491-500 (2002).
    • (2002) Ann Med , vol.34 , pp. 491-500
    • Nelson, P.T.1    Soma, L.A.2    Lavi, E.3
  • 2
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-8 (2005).
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 3
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • Gonzalez-Scarano, F. & Baltuch, G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 22, 219-40 (1999).
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 4
    • 84879294268 scopus 로고    scopus 로고
    • Peripheral elevation of TNF-Alpha leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis
    • Yang, G., Parkhurst, C. N., Hayes, S. & Gan, W. B. Peripheral elevation of TNF-Alpha leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 110, 10306-11 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 10306-10311
    • Yang, G.1    Parkhurst, C.N.2    Hayes, S.3    Gan, W.B.4
  • 5
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner, F. L. et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med 11, 146-52 (2005).
    • (2005) Nat Med , vol.11 , pp. 146-152
    • Heppner, F.L.1
  • 6
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the cns
    • Kreutzberg, G. W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19, 312-8 (1996).
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 7
    • 0033559346 scopus 로고    scopus 로고
    • Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
    • Sorensen, T. L. et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest 103, 807-15 (1999).
    • (1999) J Clin Invest , vol.103 , pp. 807-815
    • Sorensen, T.L.1
  • 8
    • 33645527193 scopus 로고    scopus 로고
    • Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis
    • Butovsky, O. et al. Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J Clin Invest 116, 905-15 (2006).
    • (2006) J Clin Invest , vol.116 , pp. 905-915
    • Butovsky, O.1
  • 9
    • 84861835782 scopus 로고    scopus 로고
    • Microglial inhibitory factor (mif/tkp) mitigates secondary damage following spinal cord injury
    • Emmetsberger, J. & Tsirka, S. E. Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury. Neurobiol Dis 47, 295-309 (2012).
    • (2012) Neurobiol Dis , vol.47 , pp. 295-309
    • Emmetsberger, J.1    Tsirka, S.E.2
  • 10
    • 77957062260 scopus 로고    scopus 로고
    • Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: Therapeutic implications in a model of multiple sclerosis
    • Linker, R. A. et al. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 133, 2248-63 (2010).
    • (2010) Brain , vol.133 , pp. 2248-2263
    • Linker, R.A.1
  • 11
    • 77952571744 scopus 로고    scopus 로고
    • Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis
    • Xiao, Y. et al. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia 58, 932-42 (2010).
    • (2010) Glia , vol.58 , pp. 932-942
    • Xiao, Y.1
  • 12
    • 74049090876 scopus 로고    scopus 로고
    • 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha
    • Xiao, Y. et al. 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. J Biol Chem 285, 1128-37 (2010).
    • (2010) J Biol Chem , vol.285 , pp. 1128-1137
    • Xiao, Y.1
  • 13
    • 59849086862 scopus 로고    scopus 로고
    • Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in pc12 cells via modulation of the pi3k/akt pathway
    • Kao, T. C., Shyu, M. H. & Yen, G. C. Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway. J Agric Food Chem 57, 754-61 (2009).
    • (2009) J Agric Food Chem , vol.57 , pp. 754-761
    • Kao, T.C.1    Shyu, M.H.2    Yen, G.C.3
  • 14
    • 79956116032 scopus 로고    scopus 로고
    • Rorgammat drives production of the cytokine gm-csf in helper t cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri, L. et al. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12, 560-7 (2011).
    • (2011) Nat Immunol , vol.12 , pp. 560-567
    • Codarri, L.1
  • 15
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of t(h)17 cells is dependent on il-1-And il-23-induced production of the cytokine gm-csf
    • El-Behi, M. et al. The encephalitogenicity of T(H)17 cells is dependent on IL-1-And IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12, 568-75 (2011).
    • (2011) Nat Immunol , vol.12 , pp. 568-575
    • El-Behi, M.1
  • 16
    • 68849112732 scopus 로고    scopus 로고
    • Activation of pparbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release
    • Piqueras, L. et al. Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release. J Leukoc Biol 86, 115-22 (2009).
    • (2009) J Leukoc Biol , vol.86 , pp. 115-122
    • Piqueras, L.1
  • 17
    • 0035260881 scopus 로고    scopus 로고
    • Chemokines and disease
    • Gerard, C. & Rollins, B. J. Chemokines and disease. Nat Immunol 2, 108-15 (2001).
    • (2001) Nat Immunol , vol.2 , pp. 108-115
    • Gerard, C.1    Rollins, B.J.2
  • 18
    • 3142729054 scopus 로고    scopus 로고
    • Chemokines and glial cells: A complex network in the central nervous system
    • Ambrosini, E. & Aloisi, F. Chemokines and glial cells: a complex network in the central nervous system. Neurochem Res 29, 1017-38 (2004).
    • (2004) Neurochem Res , vol.29 , pp. 1017-1038
    • Ambrosini, E.1    Aloisi, F.2
  • 19
    • 0036847841 scopus 로고    scopus 로고
    • Microglia as liaisons between the immune and central nervous systems: Functional implications for multiple sclerosis
    • Carson, M. J. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 40, 218-31 (2002).
    • (2002) Glia , vol.40 , pp. 218-231
    • Carson, M.J.1
  • 20
    • 25444484079 scopus 로고    scopus 로고
    • Microglial cell activation and proliferation precedes the onset of cns autoimmunity
    • Ponomarev, E. D., Shriver, L. P., Maresz, K. & Dittel, B. N. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J Neurosci Res 81, 374-89 (2005).
    • (2005) J Neurosci Res , vol.81 , pp. 374-389
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Dittel, B.N.4
  • 21
    • 33644993675 scopus 로고    scopus 로고
    • Activation of glia and microglial p38 mapk in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    • Piao, Z. G. et al. Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain 121, 219-31 (2006).
    • (2006) Pain , vol.121 , pp. 219-231
    • Piao, Z.G.1
  • 22
    • 34447331410 scopus 로고    scopus 로고
    • Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of jun n-terminal kinase and p38 mitogen-Activated protein kinase in activated rat microglia
    • Zhou, Y., Ling, E. A. & Dheen, S. T. Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-Activated protein kinase in activated rat microglia. J Neurochem 102, 667-78 (2007).
    • (2007) J Neurochem , vol.102 , pp. 667-678
    • Zhou, Y.1    Ling, E.A.2    Dheen, S.T.3
  • 23
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the cns: From biology to therapy
    • Franklin, R. J. & Ffrench-Constant, C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 9, 839-55 (2008).
    • (2008) Nat Rev Neurosci , vol.9 , pp. 839-855
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 25
    • 77954473191 scopus 로고    scopus 로고
    • Myelin repair is accelerated by inactivating cxcr2 on nonhematopoietic cells
    • Liu, L. et al. Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells. J Neurosci 30, 9074-83 (2010).
    • (2010) J Neurosci , vol.30 , pp. 9074-9083
    • Liu, L.1
  • 26
    • 0036310558 scopus 로고    scopus 로고
    • Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination
    • Jurevics, H. et al. Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination. J Neurochem 82, 126-36 (2002).
    • (2002) J Neurochem , vol.82 , pp. 126-136
    • Jurevics, H.1
  • 27
    • 34948888764 scopus 로고    scopus 로고
    • Lingo-1 antagonist promotes spinal cord remyelination and axonal integrity in mog-induced experimental autoimmune encephalomyelitis
    • Mi, S. et al. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med 13, 1228-33 (2007).
    • (2007) Nat Med , vol.13 , pp. 1228-1233
    • Mi, S.1
  • 28
    • 73149124029 scopus 로고    scopus 로고
    • Notch1 signaling plays a role in regulating precursor differentiation during cns remyelination
    • Zhang, Y. et al. Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci USA 106, 19162-7 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19162-19167
    • Zhang, Y.1
  • 29
    • 24344453717 scopus 로고    scopus 로고
    • Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate schwann cells lead to functional recovery of the demyelinated mouse spinal cord
    • Girard, C. et al. Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate Schwann cells lead to functional recovery of the demyelinated mouse spinal cord. J Neurosci 25, 7924-33 (2005).
    • (2005) J Neurosci , vol.25 , pp. 7924-7933
    • Girard, C.1
  • 30
    • 77952562399 scopus 로고    scopus 로고
    • Bdnf+/? Mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain
    • Vondran, M. W., Clinton-Luke, P., Honeywell, J. Z. & Dreyfus, C. F. BDNF+/? mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain. Glia 58, 848-56 (2010).
    • (2010) Glia , vol.58 , pp. 848-856
    • Vondran, M.W.1    Clinton-Luke, P.2    Honeywell, J.Z.3    Dreyfus, C.F.4
  • 31
    • 0034652416 scopus 로고    scopus 로고
    • Brain-immune connection: Immuno-regulatory properties of cns-resident cells
    • Becher, B., Prat, A. & Antel, J. P. Brain-immune connection: immuno-regulatory properties of CNS-resident cells. Glia 29, 293-304 (2000).
    • (2000) Glia , vol.29 , pp. 293-304
    • Becher, B.1    Prat, A.2    Antel, J.P.3
  • 32
    • 0041319041 scopus 로고    scopus 로고
    • Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the cns
    • Babcock, A. A., Kuziel, W. A., Rivest, S. & Owens, T. Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci 23, 7922-30 (2003).
    • (2003) J Neurosci , vol.23 , pp. 7922-7930
    • Babcock, A.A.1    Kuziel, W.A.2    Rivest, S.3    Owens, T.4
  • 33
    • 0029757386 scopus 로고    scopus 로고
    • Gap-junction disassembly and connexin 43 dephosphorylation induced by 18 beta-glycyrrhetinic acid
    • Guan, X., Wilson, S., Schlender, K. K. & Ruch, R. J. Gap-junction disassembly and connexin 43 dephosphorylation induced by 18 beta-glycyrrhetinic acid. Mol Carcinog 16, 157-64 (1996).
    • (1996) Mol Carcinog , vol.16 , pp. 157-164
    • Guan, X.1    Wilson, S.2    Schlender, K.K.3    Ruch, R.J.4
  • 34
    • 0032167724 scopus 로고    scopus 로고
    • Blockade by 18beta-glycyrrhetinic acid of intercellular electrical coupling in Guinea-pig arterioles
    • Yamamoto, Y., Fukuta, H., Nakahira, Y. & Suzuki, H. Blockade by 18beta-glycyrrhetinic acid of intercellular electrical coupling in guinea-pig arterioles. J Physiol 511 (Pt 2), 501-8 (1998).
    • (1998) J Physiol , vol.511 , pp. 501-508
    • Yamamoto, Y.1    Fukuta, H.2    Nakahira, Y.3    Suzuki, H.4
  • 35
    • 84931282029 scopus 로고    scopus 로고
    • Antileishmanial effect of 18beta-glycyrrhetinic acid is mediated by toll-like receptor-dependent canonical and noncanonical p38 activation
    • Gupta, P., Das, P. K. & Ukil, A. Antileishmanial Effect of 18beta-Glycyrrhetinic Acid Is Mediated by Toll-Like Receptor-Dependent Canonical and Noncanonical p38 Activation. Antimicrob Agents Chemother 59, 2531-9 (2015).
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 2531-2539
    • Gupta, P.1    Das, P.K.2    Ukil, A.3
  • 36
    • 0036730869 scopus 로고    scopus 로고
    • Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: Inhibition of cytochrome p450 2e1 expression
    • Jeong, H. G. et al. Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. Pharmacol Res 46, 221-7 (2002).
    • (2002) Pharmacol Res , vol.46 , pp. 221-227
    • Jeong, H.G.1
  • 37
    • 84866064720 scopus 로고    scopus 로고
    • The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system
    • Eugenin, E. A. et al. The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. J Neuroimmune Pharmacol 7, 499-518 (2012).
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 499-518
    • Eugenin, E.A.1
  • 38
    • 24744435759 scopus 로고    scopus 로고
    • Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis
    • Aharoni, R., Arnon, R. & Eilam, R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J Neurosci 25, 8217-28 (2005).
    • (2005) J Neurosci , vol.25 , pp. 8217-8228
    • Aharoni, R.1    Arnon, R.2    Eilam, R.3
  • 40
    • 32244442040 scopus 로고    scopus 로고
    • Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes
    • Du, Y., Fischer, T. Z., Clinton-Luke, P., Lercher, L. D. & Dreyfus, C. F. Distinct effects of p75 in mediating actions of neurotrophins on basal forebrain oligodendrocytes. Mol Cell Neurosci 31, 366-75 (2006).
    • (2006) Mol Cell Neurosci , vol.31 , pp. 366-375
    • Du, Y.1    Fischer, T.Z.2    Clinton-Luke, P.3    Lercher, L.D.4    Dreyfus, C.F.5
  • 41
    • 34248650931 scopus 로고    scopus 로고
    • Passive induction of experimental allergic encephalomyelitis
    • Stromnes, I. M. & Goverman, J. M. Passive induction of experimental allergic encephalomyelitis. Nat Protoc 1, 1952-60 (2006).
    • (2006) Nat Protoc , vol.1 , pp. 1952-1960
    • Stromnes, I.M.1    Goverman, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.