Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 3, 2015, Pages 769-780

  Wiegman, Coen H ^a   Michaeloudes, Charalambos ^a   Haji, Gulammehdi ^a   Narang, Priyanka ^a   Clarke, Colin J ^a   Russell, Kirsty E ^a   Bao, Wuping ^a   Pavlidis, Stelios ^b   Barnes, Peter J ^a   Kanerva, Justin ^b   Bittner, Anton ^b   Rao, Navin ^b   Murphy, Michael P ^c   Kirkham, Paul A ^a   Chung, Kian Fan ^a   Adcock, Ian M ^a   Brightling, Christopher E ^d   Davies, Donna E ^d   Finch, Donna K ^d   Fisher, Andrew J ^d   Gaw, Alasdair ^d   Knox, Alan J ^d   Mayer, Ruth J ^d   Polkey, Michael ^d   Salmon, Michael ^d   Singh, David ^d   more..

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d MRC Mitochondrial Biology Unit ^*

Author keywords

airway hyperresponsiveness; airway smooth muscle; antioxidant; chronic obstructive pulmonary disease; inflammation; mitochondria; MitoQ; oxidative stress; Ozone; proliferation

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; HYDROGEN PEROXIDE; INTERLEUKIN 8; MITOQ; OZONE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TIRON; TRANSFORMING GROWTH FACTOR BETA; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; 10-(6'-UBIQUINONYL)DECYLTRIPHENYLPHOSPHONIUM BROMIDE; MULTIENZYME COMPLEX; ORGANOPHOSPHORUS COMPOUND; UBIQUINONE;

AGED; AIRWAY REMODELING; AIRWAY SMOOTH MUSCLE CELL; ALLERGIC PNEUMONITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPATHOLOGY; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; HUMAN; HUMAN CELL; LUNG CAPACITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY; SMOKING; ADULT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BRONCHIAL HYPERREACTIVITY; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PNEUMONIA; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE CELL;

ADULT; AGED; AIRWAY REMODELING; ANIMALS; ANTIOXIDANTS; BRONCHIAL HYPERREACTIVITY; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MIDDLE AGED; MITOCHONDRIA; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; OZONE; PNEUMONIA; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; SMOKING; UBIQUINONE;

EID: 84940838385     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.046     Document Type: Article

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