Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Li, Feng ^a,b   Wiegman, Cornelis ^a   Seiffert, Joanna M ^a   Zhu, Jie ^a   Clarke, Colin ^a   Chang, Yan ^c   Bhavsar, Pank ^a   Adcock, Ian ^a   Zhang, Junfeng ^c   Zhou, Xin ^b   Chung, Kian Fan ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; EMPHYSEMA; EXPECTORANTS; GENE EXPRESSION; LUNG; MALONDIALDEHYDE; MICE; OZONE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS;

EID: 84894078252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080782     Document Type: Article

References (29)

1. Chung KF, Adcock IM (2008) Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir J 31: 1334-1356. doi:10.1183/09031936.00018908. PubMed: 18515558.
2. Decramer M, Janssens W, Miravitlles M (2012) Chronic obstructive pulmonary disease. Lancet 379: 1341-1351. S0140- doi:10.1016/S0140-6736(11) 60968-9. PubMed: 22314182. 6736(11)60968-9. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1016/S0140-6736(11)60968-9
3. Ciencewicki J, Trivedi S, Kleeberger SR (2008) Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol 122: 456-468. S0091- doi:10.1016/j.jaci.2008.08.004. PubMed: 18774381. 6749(08)01485-1. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1016/j.jaci.2008.08.004
4. Chung KF, Marwick JA (2010) Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci 1203: 85-91. doi:10.1111/j.1749-6632.2010.05600.x. PubMed: 20716288.
5. Triantaphyllopoulos K, Hussain F, Pinart M, Zhang M, Li F et al. (2011) A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. Am J Physiol Lung Cell Mol Physiol 300: L691-L700. doi:10.1152/ajplung.00252.2010. PubMed: 21355040. ajplung.00252.2010. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1152/ajplung.00252.2010
6. Tuder RM, Yoshida T, Arap W, Pasqualini R, Petrache I (2006) State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc 3: 503-510. doi:10.1513/pats. 200603-054MS. PubMed: 16921129. 3/6/503. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1513/pats.200603-054MS
7. Churg A, Cosio M, Wright JL (2008) Mechanisms of cigarette smokeinduced COPD: insights from animal models. Am J Physiol Lung Cell Mol Physiol, 294: 294: L612-L631 PubMed: 18223159. 00390.2007. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1152/ajplung.00390.2007
8. Rahman I, Macnee W (2012) Antioxidant pharmacological therapies for COPD. Curr Opin Pharmacol, 12: S1471-S4892. PubMed: 22349417. 12)00016-1. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1016/j.coph.2012.01.015
9. Millea PJ (2009) N-acetylcysteine: multiple clinical applications. Am Fam Physician 80: 265-269. PubMed: 19621836.
10. Rubio ML, Martin-Mosquero MC, Ortega M, Peces-Barba G, González-Mangado N (2004) Oral N-acetylcysteine attenuates elastase-induced pulmonary emphysema in rats. Chest 125: 1500-1506. doi:10.1378/chest.125.4.1500. PubMed: 15078764. (Pubitemid 38501368)
11. March TH, Wilder JA, Esparza DC, Cossey PY, Blair LF et al. (2006) Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice. Toxicol Sci 92: 545-559. doi:10.1093/toxsci/kfl016. PubMed: 16699168. kfl016. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1093/toxsci/kfl016
12. Katre A, Ballinger C, Akhter H, Fanucchi M, Kim DK et al. (2011) Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice. Inhal Toxicol 23: 486-494. doi:10.3109/08958378.2011. 584919. PubMed: 21689010.
13. Braber S, Henricks PA, Nijkamp FP, Kraneveld AD, Folkerts G; Braber S, Henricks PA, Nijkamp FP, Kraneveld AD, Folkerts G (2010) Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. Respir Res 11: 99: 1465-9921-11-99. PubMed: 20649997. PII]; 10.1186/1465-9921-11-99 [doi]. PubMed: 20649997.
14. Chakrabarti S, Patel KD (2005) Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res 31: 599-621. doi:10.1080/ 019021490944232. PubMed: 16019990. L147KJ228LL24236. PII;Retrieved onpublished at whilst December year 1111 from. doi: 10.1080/019021490944232
15. Lin JL, Thomas PS (2010) Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease. COPD 7: 291-306. doi:10.3109/15412555.2010.496818. PubMed: 20673039.
16. Scichilone N, Battaglia S, La SA, Bellia V (2006) Clinical implications of airway hyperresponsiveness in COPD. Int J Chron Obstruct Pulmon Dis 1: 49-60 PubMed: 18046902
17. van den Berge M, Vonk JM, Gosman M, Lapperre TS, Snoeck-Stroband JB et al. (2012) Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD. Eur Respir J, 40: 1098-105. PubMed: 22523354.
18. Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P et al. (2007) Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol 103: 1189-1195. doi:10.1152/japplphysiol.00172. 2007. PubMed: 17626835. 00172.2007. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1152/japplphysiol.00172.2007
19. Williams AS, Nath P, Leung SY, Khorasani N, McKenzie AN et al. (2008) Modulation of ozone-induced airway hyperresponsiveness and inflammation by interleukin-13. Eur Respir J 32: 571-578. doi:10.1183/09031936.00121607. PubMed: 18417511. 09031936.00121607. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1183/09031936.00121607
20. Li F, Zhang M, Hussain F, Triantaphyllopoulos K, Clark AR et al. (2011) Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids. Eur Respir J 37: 933-942. doi:10.1183/09031936.00021110. PubMed: 20693246. 09031936.00021110. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1183/09031936.00021110
21. Held HD, Uhlig S (2000) Mechanisms of endotoxin-induced airway and pulmonary vascular hyperreactivity in mice. Am J Respir Crit Care Med 162: 1547-1552. doi:10.1164/ajrccm.162.4.9912079. PubMed: 11029375.
22. Schütze N, Lehmann I, Bönisch U, Simon JC, Polte T (2010) Exposure to mycotoxins increases the allergic immune response in a murine asthma model. Am J Respir Crit Care Med 181: 1188-1199. doi:10.1164/rccm.200909- 1350OC. PubMed: 20194814. 200909-1350OC. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1164/rccm.200909-1350OC
23. Tighe RM, Li Z, Potts EN, Frush S, Liu N et al. (2011) Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J Immunol 187: 4800-4808. doi:10.4049/jimmunol.1101312. PubMed: 21930959. jimmunol.1101312. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.4049/jimmunol.1101312
24. Potts-Kant EN, Li Z, Tighe RM, Lindsey JY, Frush BW et al. (2012) NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidantinduced emphysema in mice. Free Radic Biol Med 52: 705-715. S0891-doi:10.1016/j.freeradbiomed.2011. 11.027. PubMed: 22198263. 5849(11)01214-7. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1016/j.freeradbiomed.2011.11.027
25. Heili FS, Del Puerto-Nevado L, Pérez-Rial S, Martin-Mosquero C, Ortega et al. (2008) Improving the cadmium-induced centriacinar emphysema model in rats by concomitant anti-oxidant treatment. Clin Exp Pharmacol Physiol 35: 1337-1342. doi:10.1111/j.1440-1681.2008.05026.x. PubMed: 18759863. CEP5026. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1111/j.1440-1681.2008.05026.x
26. Cai S, Chen P, Zhang C, Chen JB, Wu J (2009) Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats. Respirology 14: 354-359. doi:10.1111/j.1440-1843. 2009.01511.x. PubMed: 19341424. RES1511. PII;Retrieved onpublished at whilst December year 1111 from. doi: 10.1111/j.1440-1843.2009.01511.x
27. Kohansal R, Martinez-Camblor P, Agustí A, Buist AS, Mannino DM et al. (2009) The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am J Respir Crit Care Med 180: 3-10. doi:10.1164/rccm.200901-0047OC. PubMed:19342411. 200901-0047OC. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1164/rccm.200901-0047OC
28. Willemse BW, ten Hacken NH, Rutgers B, Lesman-Leegte IG, Timens W et al. (2004) Smoking cessation improves both direct and indirect airway hyperresponsiveness in COPD. Eur Respir J 24: 391-396. doi:10.1183/09031936.04. 00117603. PubMed: 15358697. 24/3/391. PII.
29. Miller M, Cho JY, Pham A, Friedman PJ, Ramsdell J et al. (2011) Persistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 years. Chest 139: 1380-1387. doi:10.1378/chest.10- 0705. PubMed: 20966041. chest.10-0705. PII;Retrieved onpublished at whilst December year 1111 from. doi:10.1378/chest.10-0705