-
1
-
-
84862884156
-
Mitochondrial quality control: An integrated network of pathways
-
Fischer F, Hamann A, Osiewacz HD: Mitochondrial quality control: An integrated network of pathways. Trends Biochem Sci 2012; 37: 284-292.
-
(2012)
Trends Biochem Sci
, vol.37
, pp. 284-292
-
-
Fischer, F.1
Hamann, A.2
Osiewacz, H.D.3
-
2
-
-
77953357982
-
Impaired quality control of mitochondria: Aging from a new perspective
-
Weber TA, Reichert AS: Impaired quality control of mitochondria: Aging from a new perspective. Exp Gerontol 2010; 45: 503-511.
-
(2010)
Exp Gerontol
, vol.45
, pp. 503-511
-
-
Weber, T.A.1
Reichert, A.S.2
-
3
-
-
1242320514
-
Genes, mitochondria and aging in filamentous fungi
-
Osiewacz HD: Genes, mitochondria and aging in filamentous fungi. Ageing Res Rev 2002; 28: 1-18.
-
(2002)
Ageing Res Rev
, vol.28
, pp. 1-18
-
-
Osiewacz, H.D.1
-
4
-
-
0030826910
-
Genetic regulation of aging
-
Osiewacz HD: Genetic regulation of aging. J Mol Med 1997; 75: 715-727.
-
(1997)
J Mol Med
, vol.75
, pp. 715-727
-
-
Osiewacz, H.D.1
-
5
-
-
0027082452
-
The role of mitochondrial DNA rearrangements in aging and human diseases
-
Osiewacz HD, Hermanns J: The role of mitochondrial DNA rearrangements in aging and human diseases. Aging (Milano) 1992; 4: 273- 286.
-
(1992)
Aging (Milano)
, vol.4
, pp. 273-286
-
-
Osiewacz, H.D.1
Hermanns, J.2
-
6
-
-
77953507107
-
Mitochondrial DNA mutations in disease and aging
-
Wallace DC: Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen 2010; 51: 440-450.
-
(2010)
Environ Mol Mutagen
, vol.51
, pp. 440-450
-
-
Wallace, D.C.1
-
7
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly Y, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG: Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429: 417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
Bohlooly, Y.7
Gidlof, S.8
Oldfors, A.9
Wibom, R.10
Tornell, J.11
Jacobs, H.T.12
Larsson, N.G.13
-
8
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C, Prolla TA: Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005; 309: 481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
9
-
-
34047116291
-
Mitochondrial point mutations do not limit the natural lifespan of mice
-
Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA: Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 2007; 39: 540-543.
-
(2007)
Nat Genet
, vol.39
, pp. 540-543
-
-
Vermulst, M.1
Bielas, J.H.2
Kujoth, G.C.3
Ladiges, W.C.4
Rabinovitch, P.S.5
Prolla, T.A.6
Loeb, L.A.7
-
10
-
-
0015319592
-
The biologic clock the mitochondria?
-
Harman D: The biologic clock: The mitochondria? J Am Geriatr Soc 1972; 20: 145-147.
-
(1972)
J Am Geriatr Soc
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
11
-
-
73749085674
-
When a theory of aging ages badly
-
Lapointe J, Hekimi S: When a theory of aging ages badly. Cell Mol Life Sci 2010; 67: 1-8.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 1-8
-
-
Lapointe, J.1
Hekimi, S.2
-
12
-
-
67650091290
-
Increasing organismal healthspan by enhancing mitochondrial protein quality control
-
Luce K, Osiewacz HD: Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat Cell Biol 2009; 11: 852-858.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 852-858
-
-
Luce, K.1
Osiewacz, H.D.2
-
13
-
-
77953230237
-
Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening
-
Zintel S, Schwitalla D, Luce K, Hamann A, Osiewacz HD: Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening. Exp Gerontol 2010; 45: 525-532.
-
(2010)
Exp Gerontol
, vol.45
, pp. 525-532
-
-
Zintel, S.1
Schwitalla, D.2
Luce, K.3
Hamann, A.4
Osiewacz, H.D.5
-
14
-
-
57749095081
-
Against the oxidative damage theory of aging: Superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
-
Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, Matscheski A, Vanfleteren JR, Gems D: Against the oxidative damage theory of aging: Superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev 2008; 22: 3236-3241.
-
(2008)
Genes Dev
, vol.22
, pp. 3236-3241
-
-
Doonan, R.1
McElwee, J.J.2
Matthijssens, F.3
Walker, G.A.4
Houthoofd, K.5
Back, P.6
Matscheski, A.7
Vanfleteren, J.R.8
Gems, D.9
-
15
-
-
84861231389
-
A systems biological analysis links ROS metabolism to mitochondrial protein quality control
-
Kowald A, Hamann A, Zintel S, Ullrich S, Klipp E, Osiewacz HD: A systems biological analysis links ROS metabolism to mitochondrial protein quality control. Mech Ageing Dev 2012; 133: 331-337.
-
(2012)
Mech Ageing Dev
, vol.133
, pp. 331-337
-
-
Kowald, A.1
Hamann, A.2
Zintel, S.3
Ullrich, S.4
Klipp, E.5
Osiewacz, H.D.6
-
16
-
-
70349464469
-
Oxidative inactivation of mitochondrial aconitase results in iron and H 2 O 2 -mediated neurotoxicity in rat primary mesencephalic cultures
-
Cantu D, Schaack J, Patel M: Oxidative inactivation of mitochondrial aconitase results in iron and H 2 O 2 -mediated neurotoxicity in rat primary mesencephalic cultures. PLoS One 2009; 4:e7095.
-
(2009)
PLoS One
, vol.4
-
-
Cantu, D.1
Schaack, J.2
Patel, M.3
-
17
-
-
0029064257
-
Superoxide radical and iron modulate aconitase activity in mammalian cells
-
Gardner PR, Raineri I, Epstein LB, White CW: Superoxide radical and iron modulate aconitase activity in mammalian cells. J Biol Chem 1995; 270: 13399-13405.
-
(1995)
J Biol Chem
, vol.270
, pp. 13399-13405
-
-
Gardner, P.R.1
Raineri, I.2
Epstein, L.B.3
White, C.W.4
-
18
-
-
38549101188
-
Quality control of mitochondria: Protection against neurodegeneration and ageing
-
Tatsuta T, Langer T: Quality control of mitochondria: Protection against neurodegeneration and ageing. EMBO J 2008; 27: 306-314.
-
(2008)
EMBO J
, vol.27
, pp. 306-314
-
-
Tatsuta, T.1
Langer, T.2
-
19
-
-
48949119155
-
Mitochondrial protein quality control: Implications in ageing
-
Friguet B, Bulteau AL, Petropoulos I: Mitochondrial protein quality control: Implications in ageing. Biotechnol J 2008; 3: 757-764.
-
(2008)
Biotechnol J
, vol.3
, pp. 757-764
-
-
Friguet, B.1
Bulteau, A.L.2
Petropoulos, I.3
-
20
-
-
84861715696
-
Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain
-
Adam C, Picard M, Dequard-Chablat M, Sellem CH, Denmat SH, Contamine V: Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain. PLoS One 2012; 7:e38138.
-
(2012)
PLoS One
, vol.7
-
-
Adam, C.1
Picard, M.2
Dequard-Chablat, M.3
Sellem, C.H.4
Denmat, S.H.5
Contamine, V.6
-
21
-
-
84055190025
-
Unmasking a temperature-dependent effect of the P anserina i -AAA protease on aging and development
-
Weil A, Luce K, Drose S, Wittig I, Brandt U, Osiewacz HD: Unmasking a temperature-dependent effect of the P. anserina i -AAA protease on aging and development. Cell Cycle 2011; 10: 4280-4290.
-
(2011)
Cell Cycle
, vol.10
, pp. 4280-4290
-
-
Weil, A.1
Luce, K.2
Drose, S.3
Wittig, I.4
Brandt, U.5
Osiewacz, H.D.6
-
22
-
-
84879151902
-
Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain
-
Fischer F, Weil A, Hamann A, Osiewacz HD: Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain. Nat Commun 2013; 4: 1397.
-
(2013)
Nat Commun
, vol.4
, pp. 1397
-
-
Fischer, F.1
Weil, A.2
Hamann, A.3
Osiewacz, H.D.4
-
23
-
-
80053352130
-
Mitochondrial quality control by the ubiquitin-proteasome system
-
Taylor EB, Rutter J: Mitochondrial quality control by the ubiquitin-proteasome system. Biochem Soc Trans 2011; 39: 1509-1513.
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1509-1513
-
-
Taylor, E.B.1
Rutter, J.2
-
24
-
-
34247528121
-
A proteomics approach to identify the ubiquitinated proteins in mouse heart
-
Jeon HB, Choi ES, Yoon JH, Hwang JH, Chang JW, Lee EK, Choi HW, Park ZY, Yoo YJ: A proteomics approach to identify the ubiquitinated proteins in mouse heart. Biochem Biophys Res Commun 2007; 357: 731- 736.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 731-736
-
-
Jeon, H.B.1
Choi, E.S.2
Yoon, J.H.3
Hwang, J.H.4
Chang, J.W.5
Lee, E.K.6
Choi, H.W.7
Park, Z.Y.8
Yoo, Y.J.9
-
25
-
-
33845876643
-
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
-
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz HD: Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol 2007; 9: 99-105.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 99-105
-
-
Scheckhuber, C.Q.1
Erjavec, N.2
Tinazli, A.3
Hamann, A.4
Nystrom, T.5
Osiewacz, H.D.6
-
26
-
-
79960339919
-
The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate C elegans longevity
-
Yang CC, Chen D, Lee SS, Walter L: The dynamin- related protein DRP-1 and the insulin signaling pathway cooperate to modulate C. elegans longevity. Aging Cell 2011; 10: 724- 728.
-
(2011)
Aging Cell
, vol.10
, pp. 724-728
-
-
Yang, C.C.1
Chen, D.2
Lee, S.S.3
Walter, L.4
-
27
-
-
68249087424
-
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
-
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K: Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol 2009; 11: 958- 966.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 958-966
-
-
Ishihara, N.1
Nomura, M.2
Jofuku, A.3
Kato, H.4
Suzuki, S.O.5
Masuda, K.6
Otera, H.7
Nakanishi, Y.8
Nonaka, I.9
Goto, Y.10
Taguchi, N.11
Morinaga, H.12
Maeda, M.13
Takayanagi, R.14
Yokota, S.15
Mihara, K.16
-
28
-
-
84865544952
-
Mitochondrial fission, fusion, and stress
-
Youle RJ, van der Bliek AM: Mitochondrial fission, fusion, and stress. Science 2012; 337: 1062-1065.
-
(2012)
Science
, vol.337
, pp. 1062-1065
-
-
Youle, R.J.1
Van Der Bliek, A.M.2
-
29
-
-
79959519163
-
The essential role of evasion from cell death in cancer
-
Kelly GL, Strasser A: The essential role of evasion from cell death in cancer. Adv Cancer Res 2011; 111: 39-96.
-
(2011)
Adv Cancer Res
, vol.111
, pp. 39-96
-
-
Kelly, G.L.1
Strasser, A.2
-
30
-
-
44649195647
-
Apoptosis pathways in fungal growth, development and ageing
-
Hamann A, Brust D, Osiewacz HD: Apoptosis pathways in fungal growth, development and ageing. Trends Microbiol 2008; 16: 276- 283.
-
(2008)
Trends Microbiol
, vol.16
, pp. 276-283
-
-
Hamann, A.1
Brust, D.2
Osiewacz, H.D.3
-
31
-
-
78349264668
-
Cyclophilin D links programmed cell death and organismal aging in Podospora anserina
-
Brust D, Daum B, Breunig C, Hamann A, Kuhlbrandt W, Osiewacz HD: Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. Aging Cell 2010; 9: 761-775.
-
(2010)
Aging Cell
, vol.9
, pp. 761-775
-
-
Brust, D.1
Daum, B.2
Breunig, C.3
Hamann, A.4
Kuhlbrandt, W.5
Osiewacz, H.D.6
-
32
-
-
34547946356
-
Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes
-
Groebe K, Krause F, Kunstmann B, Unterluggauer H, Reifschneider NH, Scheckhuber CQ, Sastri C, Stegmann W, Wozny W, Schwall GP, Poznanovic S, Dencher NA, Jansen-Durr P, Osiewacz HD, Schrattenholz A: Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes. Exp Gerontol 2007; 42: 887-898.
-
(2007)
Exp Gerontol
, vol.42
, pp. 887-898
-
-
Groebe, K.1
Krause, F.2
Kunstmann, B.3
Unterluggauer, H.4
Reifschneider, N.H.5
Scheckhuber, C.Q.6
Sastri, C.7
Stegmann, W.8
Wozny, W.9
Schwall, G.P.10
Poznanovic, S.11
Dencher, N.A.12
Jansen-Durr, P.13
Osiewacz, H.D.14
Schrattenholz, A.15
-
33
-
-
76749136290
-
Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy
-
Marzetti E, Hwang JCY, Lees HA, Wohlgemuth SE, Dupont-Versteegden EE, Carter CS, Bernabei R, Leeuwenburgh C: Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta 2009; 1800: 235-244.
-
(2009)
Biochim Biophys Acta
, vol.1800
, pp. 235-244
-
-
Marzetti, E.1
Hwang, J.C.Y.2
Lees, H.A.3
Wohlgemuth, S.E.4
Dupont-Versteegden, E.E.5
Carter, C.S.6
Bernabei, R.7
Leeuwenburgh, C.8
-
34
-
-
77955380974
-
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice
-
Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-Otin M, Tanokura M, Prolla TA, Leeuwenburgh C: Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One 2010; 5:e11468.
-
(2010)
PLoS One
, vol.5
-
-
Hiona, A.1
Sanz, A.2
Kujoth, G.C.3
Pamplona, R.4
Seo, A.Y.5
Hofer, T.6
Someya, S.7
Miyakawa, T.8
Nakayama, C.9
Samhan-Arias, A.K.10
Servais, S.11
Barger, J.L.12
Portero-Otin, M.13
Tanokura, M.14
Prolla, T.A.15
Leeuwenburgh, C.16
-
35
-
-
79952266729
-
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
-
Albany, N.Y.
-
Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA: Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany, N.Y.) 2010; 2: 914-923.
-
(2010)
Aging
, vol.2
, pp. 914-923
-
-
Hafner, A.V.1
Dai, J.2
Gomes, A.P.3
Xiao, C.Y.4
Palmeira, C.M.5
Rosenzweig, A.6
Sinclair, D.A.7
-
36
-
-
84865547276
-
Mitochondrial dynamics and apoptosis-the ER connection
-
Hoppins S, Nunnari J: Mitochondrial dynamics and apoptosis-the ER connection. Science 2012; 337: 1052-1054.
-
(2012)
Science
, vol.337
, pp. 1052-1054
-
-
Hoppins, S.1
Nunnari, J.2
-
37
-
-
80054765894
-
A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans
-
Lu Y, Rolland SG, Conradt B: A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans. Proc Natl Acad Sci USA 2011; 108:E813-E822.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
-
-
Lu, Y.1
Rolland, S.G.2
Conradt, B.3
|