Mechanistic model and analysis of doxorubicin release from liposomal formulations

Journal of Controlled Release

Volumn 217, Issue , 2015, Pages 82-91

  Fugit, Kyle D ^a   Xiang, Tian Xiang ^a   Choi, Du H ^b   Kangarlou, Sogol ^a   Csuhai, Eva ^c   Bummer, Paul M ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

^b Inje University   (South Korea)

^c TRANSYLVANIA UNIVERSITY   (United States)

Author keywords

Cancer chemotherapy; DOXIL; Dynamic dialysis; Liposomes; Mechanistic modeling; Release kinetics

Indexed keywords

AMMONIA; ASSOCIATION REACTIONS; CHEMOTHERAPY; DIALYSIS; FORECASTING; KINETICS; LIPOSOMES; STATISTICS; SUSPENSIONS (FLUIDS);

BOX-BEHNKEN EXPERIMENTAL DESIGN; CANCER CHEMOTHERAPY; DEVELOPMENT AND APPLICATIONS; DOXIL; MECHANISTIC MODELING; QUANTITATIVE CHARACTERIZATION; RELEASE KINETICS; SUSPENSION CONCENTRATIONS;

DIALYSIS MEMBRANES;

AMMONIA; DOXORUBICIN; ANTINEOPLASTIC ANTIBIOTIC; ARTIFICIAL MEMBRANE; MACROGOL DERIVATIVE;

ARTICLE; CANCER CHEMOTHERAPY; COMPUTER; CONTROLLED STUDY; DIALYSIS MEMBRANE; DILUTION; DISSOLUTION; DRUG APPROVAL; DRUG FORMULATION; DRUG TRANSPORT; FOOD AND DRUG ADMINISTRATION; IONIZATION; LIPOSOMAL DELIVERY; PH; PRECIPITATION; PRIORITY JOURNAL; SUSPENSION; ANALOGS AND DERIVATIVES; ARTIFICIAL MEMBRANE; CHEMICAL MODEL; CHEMISTRY; DRUG RELEASE; RENAL REPLACEMENT THERAPY;

AMMONIA; ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; DRUG LIBERATION; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; RENAL DIALYSIS;

EID: 84940827921     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.08.024     Document Type: Article

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