Enhanced active liposomal loading of a poorly soluble ionizable drug using supersaturated drug solutions

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 330-339

  Modi, Sweta ^a   Xiang, Tian Xiang ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

Author keywords

AR 67; Camptothecins; Cyclodextrins; Liposome; Nanotechnology; Supersaturation

Indexed keywords

ACTIVE LOADING; ANTI-CANCER AGENTS; ANTI-TUMORS; ANTICANCER DRUG; AQUEOUS SOLUBILITY; AR-67; CALCIUM ACETATE; CAMPTOTHECIN (CPT); CAMPTOTHECINS; CANCER THERAPY; CHEMICAL EQUILIBRIUMS; DRUG CARRIER; DRUG CONCENTRATION; DRUG DELIVERY SYSTEM; DRUG LOADING; DRUG SOLUTIONS; EXTERNAL DRIVING; EXTERNAL LOADING; GENERAL APPLICATIONS; HIGH CONCENTRATION; INTERNAL PH; IONIZABLE DRUGS; LOW CONCENTRATIONS; MEMBRANE BINDING; METAL CATION; NANO PARTICULATES; RELEASE KINETICS; RING OPENING; SOLID TUMORS; SUPERSATURATED SOLUTIONS; TRANSPORT KINETIC; UPTAKE RATE;

ACETIC ACID; BODY FLUIDS; CYCLODEXTRINS; DIALYSIS MEMBRANES; DRUG DELIVERY; DRUG PRODUCTS; LIPID BILAYERS; LIPOSOMES; LOADS (FORCES); MATHEMATICAL MODELS; NANOTECHNOLOGY; OPTIMIZATION; PATIENT TREATMENT; SUPERSATURATION;

LOADING;

7 TERT BUTYLDIMETHYLSILYL 10 HYDROXYCAMPTOTHECIN; ACETIC ACID; AR 67; CALCIUM ACETATE; CAMPTOTHECIN DERIVATIVE; CYCLODEXTRIN DERIVATIVE; LIPOSOME; SODIUM; SULFOBUTYLETHER BETA CYCLODEXTRIN; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; DIALYSIS MEMBRANE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG TRANSPORT; DRUG UPTAKE; IONIZATION; LIPID BILAYER; MATHEMATICAL MODEL; MEMBRANE BINDING; PH; PRIORITY JOURNAL;

CAMPTOTHECIN; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MODELS, THEORETICAL; ORGANOSILICON COMPOUNDS; PERMEABILITY; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; SOLUBILITY; SOLUTIONS;

EID: 84865323016     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.001     Document Type: Article

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