Determination of intraliposomal pH and its effect on membrane partitioning and passive loading of a hydrophobic camptothecin, DB-67

International Journal of Pharmaceutics

Volumn 352, Issue 1-2, 2008, Pages 17-28

  Joguparthi, Vijay ^a   Feng, Shaoxin ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

Author keywords

Camptothecins; Drug encapsulation; Fluorescence; Intraliposomal pH; Lipid bilayers; Liposomes; Membrane binding; Nanoparticles; Tumor drug delivery

Indexed keywords

ANTINEOPLASTIC AGENT; BUFFER; CAMPTOTHECIN DERIVATIVE; DB 67; LIPOSOME; PHENOL DERIVATIVE; SILATECAN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG BINDING; DRUG STRUCTURE; EQUILIBRIUM DIALYSIS; FLUORESCENCE SPECTROSCOPY; HYDROPHOBICITY; IONIZATION; MEMBRANE BINDING; PARTICLE SIZE; PARTITION CHROMATOGRAPHY; PH MEASUREMENT; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; LIPID BILAYERS; LIPOSOMES; MODELS, CHEMICAL; ORGANOSILICON COMPOUNDS; PERMEABILITY; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; WATER;

EID: 39549104080     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.10.003     Document Type: Article

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