A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients

Human Gene Therapy

Volumn 8, Issue 5, 1997, Pages 597-613

  Alvarez, Ronald D ^a   Curiel, David T ^b  

^a Dept of Obstetrics and Gynecology   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ADENOVIRUS; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL PROTOCOL; CLINICAL TRIAL; EXPRESSION VECTOR; FEMALE; GENE THERAPY; GRANULOCYTOPENIA; HERPES SIMPLEX VIRUS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; NEUTROPENIA; OVARY CANCER; PATIENT SELECTION; PHASE 1 CLINICAL TRIAL; THROMBOCYTOPENIA; VIRUS GENE; VIRUS RECOMBINANT;

EID: 0030908735     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.5-597     Document Type: Article

References (24)

1. Boring, C., Squires, T., Tong, T. and Montgomery, S. Cancer statistics, 1994. CA - A Cancer Journal for Clinicians 44, 7-26 (1994).
2. Bloss, J.D., Liao, S.-Y., Buller, R.E., Manetta, A., Berman, M.L., McMeekin, S., Bloss, L.P. and DiSaia, P.J. Extraovarian peritoneal serous papillary adenocarcinoma: A case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol 50, 347-351 (1993).
3. Stanbridge, E. Identifying tumor suppressor genes in human colorectal cancer. Science 247, 12-13 (1990).
4. Friedmann, T. Gene therapy of cancer through restoration of tumor-suppressor functions. Cancer 70, 1810-1817 (1992).
5. Karp, J.E. and Broder, S. New directions in molecular medicine. Cancer Research 54, 653-665 (1994).
6. Sikora, K. Gene therapy for cancer. Tibtech 11, 197-201 (1993).
7. Tiberghien, P. Use of Suicide Genes in Gene Therapy. Journal Leukocyte Biology 56, 203-209 (1994).
8. Wigler, M., Silverstein, S., Lee, L., Pellier, A., Cheng, Y. and Axel, R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11, 223-232 (1977).
9. Elion, G.B., Furman, P.A., Fyfe, J.A., DeMiranda, P., Beauchamp, L. and Schaeffer, H.J. Selectivity of action of an antiherpertic agent, 9-(2-hydroxyethoxymethyl) guanine. PNAS 74, 5716-5720 (1977).
10. Furman, P.A., McGujirt, P.V., Keller, P.M., Fyfe, J.A. and Elion, G.B. Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with herpes virus genetic information. Virology 102, 420-430 (1980).
11. Abe, A., Takeo, T., Emi, N., Tanimoto, M., Ueda, R., Yee, J.-K., Friedmann, T. and Saito, H. Transduction of a drug-sensitive toxic gene into human leukemia cell lines with a novel retroviral vector. PSEMB 203, 354 (1993).
12. Culver, K.W., Ram, Z., Walbridge, S., Ishii, H., Oldfield, E.H. and Blaese, R.M. In vivo gene transfer with retroviral vector-producing cells for the treatment of experimental brain tumors. Science 256, 1550-1552 (1992).
13. Barba, D., Hardin, J., Sadelain, M. and Gage, F.H. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. PNAS 91, 4348-4352 (1993).
14. Ram, Z., Culver, K.W., Walbridge, S., Blaese, R.M. and Oldfield, E.H. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer 53, 83-88 (1993).
15. Freeman, S., Whartenby, K.A., Koeplin, D.S. et al. Tumor regression when a fraction of the tumor cells contain the HSV-TK gene. J Cell Biochem 16, 47 (1992).
16. Link, C.J. and Moorman, D. A phase I trial of in vivo gene therapy with the herpes simplex thymidine kinase/ganciclovir system for the treatment of refractory or recurrent ovarian cancer. Human Gene Therapy 7, 1161-1179 (1996).
17. Smythe, R.W., Hwang, H.C., Amin, K.M., Eck, S.L., Davidson, B.L., Wilson, J.M., Kaiser, L.R. and Abelda, S.M. Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: An effective in vitro sensitization system. Cancer Research 54, 2055-2059 (1994).
18. Smythe, W.R., Kaiser, L.R., Hwang, H.C., Amin, K.M., Pilewski, J.M., Eck, S.J., Wilson, J.M. and Abelda, S.M. Successful adenovirus-mediated gene transfer in an in vivo model of human malignant mesothelioma. Ann Thorac Surg 57, 1395-1401 (1994).
19. Brody, S.L., Jaffe, H.A., Han, S.K., Wersto, R.P. and Crystal, R.G. Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors. Human Gene Therapy 5, 437-447 (1994).
20. Kozarsky, K.F. and Wilson, J.M. Gene therapy: adenovirus vectors [Review]. Curr Opin Genetics and Development 3, 499-503 (1993).
21. Becker, T.C., Noel, R.J., Coats, W.S., Gomez-Foix, A.M., Alam, T., Gerard, R.D. and Newgard, C.B. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods in Cell Biol 43, 161-189 (1994).
22. Deshane, J., Siegal, G.P., Alvarez, R.D., Wang, M., Feng, M., Cabrera, G., Kay, M. and Curiel, D.T. A strategy to accomplish gene therapy for ovarian carcinoma based upon targeted tumor cell killing via an intracellular antibody directed against the erbB-2 oncoprotein. In press (1995).
23. Braly, P., Doroshow, J. and Hoff, S. Technical aspects of intraperitoneal chemotherapy in abdominal carcinomatosis. Gynecol Oncol 25, 319-333 (1986).
24. Jenkins, J., Sugarbaker, P.H., Gianla, F.J. and Myers, C.E. Technical considerations in the use of intraperitoneal chemotherapy administered by Tenckhoff catheter. Surg Gynecol Obstet 154, 858-864 (1982).