Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein

Journal of Gene Medicine

Volumn 6, Issue 10, 2004, Pages 1082-1091

  Zhang, Jie ^a   Frolov, Ilya ^b   Russell, Stephen J ^a  

^a MAYO CLINIC   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Alphavirus vectors; Fusogenic membrane glycoproteins; Glioma; Sindbis virus; Syncytia; Virus like particles

Indexed keywords

BETA GALACTOSIDASE; MEMBRANE PROTEIN; VIRUS ENVELOPE PROTEIN; VIRUS RNA; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CELL KILLING; CELL STRAIN BHK; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; GIBBON LEUKEMIA VIRUS; GLIOBLASTOMA; GLIOMA CELL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPLICON; SINDBIS VIRUS; STATISTICAL SIGNIFICANCE; TUMOR CELL LINE; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; VIRUS GENOME; VIRUS INFECTION; VIRUS PARTICLE; VIRUS TITRATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BETA-GALACTOSIDASE; BRAIN NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CRICETINAE; DNA FRAGMENTATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIOMA; HUMANS; IN SITU NICK-END LABELING; LAC OPERON; MEMBRANE GLYCOPROTEINS; MICE; MICE, NUDE; MODELS, GENETIC; NEOPLASM TRANSPLANTATION; PLASMIDS; SINDBIS VIRUS; TIME FACTORS;

ALOCASIA MACRORRHIZOS; ALPHAVIRUS; CRICETINAE; GIBBON APE LEUKEMIA VIRUS; HYLOBATES SP.; MUS MUSCULUS; SINDBIS VIRUS;

EID: 13644257013     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.605     Document Type: Article

References (28)

1. Davis FG, Freels S, Grutsch J, Barlas S, Brem S. Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on surveillance, epidemiology, and end results (SEER) data, 1973-1991. J Neurosurg 1998; 88: 1-10.
2. Mizuno M, Yoshida J, Oyama H, Sugita K. Growth inhibition of glioma cells by liposome-mediated cell transfection with tumor necrosis factor-alpha gene - its enhancement by prior gamma-interferon treatment. Neurol Med Chir (Tokyo) 1992; 32: 873-876.
3. Dong Y, Wen P, Manome Y, et al. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther 1996; 7: 713-720.
4. Moriuchi S, Wolfe D, Tamura M, et al. Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model. Gene Ther 2002; 9: 584-591.
5. Galanis E, Bateman A, Johnson K, et al. Use of viral fusogenic membrane glycoproteins as novel therapeutic transgenes in gliomas. Hum Gene Ther 2001; 12: 811-821.
6. Brade AM, Szmitko P, Ngo D, et al. Heat-directed tumor cell fusion. Hum Gene Ther 2003; 14: 447-461.
7. Strauss JH, Strauss EG. The alphaviruses: gene expression, replication, and evolution. Microbiol Rev 1994; 58: 491-562.
8. Menard S, Tagliabue E, Colnaghi MI. The 67 kDa laminin receptor as a prognostic factor in human cancer. Breast Cancer Res Treat 1998; 52: 137-145.
9. Basolo F, Pollina L, Pacini F, et al. Expression of the Mr 67 000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study. Clin Cancer Res 1996; 2: 1777-1780.
10. Sanjuan X, Fernandez PL, Miquel R, et al. Overexpression of the 67-kD laminin receptor correlates with tumour progression in human colorectal carcinoma. J Pathol 1996; 179 376-380.
11. Levine B, Huang Q, Isaacs JT, et al. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature 1993; 361: 739-742.
12. Jan JT, Chatterjee S, Griffin DE. Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide. J Virol 2000; 74: 6425-6432.
13. Balachandran S, Roberts PC, Kipperman T, et al. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/caspase-8 death signaling pathway. J Virol 2000; 74: 1513-1523.
14. Rolls MM, Webster P, Balba NH, Rose JK. Novel infectious particles generated by expression of the vesicular stomatitis virus glycoprotein from a self-replicating RNA. Cell 1994; 79: 497-506.
15. Lebedeva I, Fujita K, Nihrane A, Silver J. Infectious particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes. J Virol 1997; 71: 7061-7067.
16. Bredenbeek PJ, Frolov I, Rice CM, Schlesinger S. Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs. J Virol 1993; 67: 6439-6446.
17. Fielding AK, Maurice M, Morling FJ, et al. Inverse targeting of retroviral vectors: selective gene transfer in a mixed population of hematopoietic and nonhematopoietic cells. Blood 1998; 91: 1802-1809.
18. Cathomen T, Naim HY, Cattaneo R. Measles viruses with altered envelope protein cytoplasmic tails gain cell fusion competence. J Virol 1998; 72: 1224-1234.
19. Kärber G. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch Exp Pathol Pharmakol 1931; 162: 480-483.
20. Griffin DE, Hardwick JM. Regulators of apoptosis on the road to persistent alphavirus infection. Annu Rev Microbiol 1997; 51 565-592.
21. Pelosi G, Pasini F, Bresaola E, et al. High-affinity monomeric 67-kD laminin receptors and prognosis in pancreatic endocrine tumours. J Pathol 1997; 183: 62-69.
22. van den Brule FA, et al. Expression of the 67 kD laminin receptor in human ovarian carcinomas as defined by a monoclonal antibody, MLuC5. Eur J Cancer 1996; 32A: 1598-1602.
23. Bateman AR, Bullough F, Murphy S, et al. Viral fusogenic membrane glycoproteins kill solid tumor cells by nonapoptotic mechanisms that promote cross presentation of tumor antigens by dendritic cells. Cancer Res 2002; 62: 6566-6578.
24. Fielding AK, Chapel-Fernandes S, Chadwick MP, et al. A hyperfusogenic gibbon ape leukemia envelope glycoprotein: targeting of a cytotoxic gene by ligand display. Hum Gene Ther 2000; 11: 817-826.
25. Higuchi H, Bronk SF, Bateman A, et al. Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death: implications for gene therapy. Cancer Res 2000; 60: 6396-6402.
26. Tseng JC, Levin B, Hurtado A, et al. Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol 2004; 22: 70-77.
27. Wang KS, Kuhn RJ, Strauss EG, et al. High-affinity laminin receptor is a receptor for Sindbis virus in mammalian cells. J Virol 1992; 66: 4992-5001.
28. Wilson CA, Eiden MV. Viral and cellular factors governing hamster cell infection by murine and gibbon ape leukemia viruses. J Virol 1991; 65: 5975-5982.