Regulating the surface poly(ethylene glycol) density of polymeric nanoparticles and evaluating its role in drug delivery in vivo

Biomaterials

Volumn 69, Issue , 2015, Pages 1-11

  Du, Xiao Jiao ^a   Wang, Ji Long ^a   Liu, Wei Wei ^a   Yang, Jin Xian ^b   Sun, Chun Yang ^a   Sun, Rong ^b   Li, Hong Jun ^a   Shen, Song ^a   Luo, Ying Li ^a   Ye, Xiao Dong ^b   Zhu, Yan Hua ^a   Yang, Xian Zhu ^a   Wang, Jun ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Biological behaviors; Cancer therapy; Drug delivery; PEGylation; Polymeric nanoparticles; Self assembly

Indexed keywords

ALIPHATIC COMPOUNDS; CONTROLLED DRUG DELIVERY; DRUG DELIVERY; DRUG PRODUCTS; ETHYLENE GLYCOL; MAMMALS; MOLAR RATIO; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYOLS; TARGETED DRUG DELIVERY; TUMORS;

ANTI-TUMOR EFFICACY; BIOLOGICAL BEHAVIOR; CANCER THERAPY; CONTROLLABLE SIZE; CRITICAL TECHNIQUE; PEGYLATION; POLY (EPSILONCAPROLACTONE); POLYMERIC NANOPARTICLES;

SELF ASSEMBLY;

AXIN; AXIN 2; BETA CATENIN; BIOLOGICAL MARKER; CATHEPSIN K; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; OSTEOCLAST ASSOCIATED RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEIN TRAP; TITANIUM; UNCLASSIFIED DRUG; WNT PROTEIN; ANTINEOPLASTIC AGENT; DOCETAXEL; DRUG CARRIER; LACTONE; MACROGOL DERIVATIVE; NANOPARTICLE; POLY(ETHYLENE GLYCOL)-BLOCK-POLY(EPSILON-CAPROLACTONE); POLYCAPROLACTONE; POLYESTER; TAXOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; BONE PROSTHESIS; BONE REMODELING; CALVARIA; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; IMMUNOHISTOCHEMISTRY; IMPLANTATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROSTHESIS LOOSENING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WEAR DEBRIS INDUCED PERI IMPLANT OSTEOLYSIS; ANIMAL; BAGG ALBINO MOUSE; BREAST; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; NUDE MOUSE; PATHOLOGY; RAW 264.7 CELL LINE; SURFACE PROPERTY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG CARRIERS; FEMALE; HUMANS; LACTONES; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS; RAW 264.7 CELLS; SURFACE PROPERTIES; TAXOIDS;

EID: 84940768051     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.07.048     Document Type: Article

References (52)

1. Hubbell J.A., Chilkoti A. Nanomaterials for drug delivery. Science 2012, 337:303-305.
2. Veronese F.M., Pasut G. PEGylation, successful approach to drug delivery. Drug Discov. Today 2005, 10:1451-1458.
3. Dai Q., Walkey C., Chan W.C.W. Polyethylene glycol backfilling mitigates the negative impact of the protein corona on nanoparticle cell targeting. Angew. Chem. Int. Ed. 2014, 53:5093-5096.
4. Knop K., Hoogenboom R., Fischer D., Schubert U.S. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew. Chem. Int. Ed. 2010, 49:6288-6308.
5. Gabizon A., Catane R., Uziely B., Kaufman B., Safra T., Cohen R., et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 1994, 54:987-992.
6. Lim W.T., Tan E.H., Toh C.K., Hee S.W., Leong S.S., Ang P.C., et al. Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol-PM) in patients with solid tumors. Ann. Oncol. 2010, 21:382-388.
7. O'Brien M.E.R., Wigler N., Inbar M., Rosso R., Grischke E., Santoro A., et al. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX (TM)/Doxil (R)) versus conventional doxorubicin for first-line treatment of metastatic breast cancer. Ann. Oncol. 2004, 15:440-449.
8. Jokerst J.V., Lobovkina T., Zare R.N., Gambhir S.S. Nanoparticle PEGylation for imaging and therapy. Nanomedicine Lond. U. K. 2011, 6:715-728.
9. Han X.P., Li Z.B., Sun J., Luo C., Li L., Liu Y.H., et al. Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation. J. Control. Release 2015, 197:29-40.
10. Essa S., Rabanel J.M., Hildgen P. Characterization of rhodamine loaded PEG-g-PLA nanoparticles (NPs): effect of poly(ethylene glycol) grafting density. Int. J. Pharm. 2011, 411:178-187.
11. Mosqueira V.C., Legrand P., Morgat J.L., Vert M., Mysiakine E., Gref R., et al. Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density. Pharm. Res. 2001, 18:1411-1419.
12. Xia X.H., Yang M.X., Wang Y.C., Zheng Y.Q., Li Q.G., Chen J.Y., et al. Quantifying the coverage density of poly(ethylene glycol) chains on the surface of gold nanostructures. ACS Nano 2012, 6:512-522.
13. Akiyama Y., Mori T., Katayama Y., Niidome T. The effects of PEG grafting level and injection dose on gold nanorod biodistribution in the tumor-bearing mice. J. Control. Release 2009, 139:81-84.
14. Liu H.Y., Liu T.L., Wang H., Li L.L., Tan L.F., Fu C.H., et al. Impact of PEGylation on the biological effects and light heat conversion efficiency of gold nanoshells on silica nanorattles. Biomaterials 2013, 34:6967-6975.
15. Sacchetti C., Motamedchaboki K., Magrini A., Palmieri G., Mattei M., Bernardini S., et al. Surface polyethylene glycol conformation influences the protein corona of polyethylene glycol-modified single-walled carbon nanotubes: potential implications on biological performance. ACS Nano 2013, 7:1974-1989.
16. 4 nanoparticles for reduced non-specific uptake by macrophage cells. Adv. Mater 2007, 19:3163-3166.
17. Perry J.L., Reuter K.G., Kai M.P., Herlihy K.P., Jones S.W., Luft J.C., et al. PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. Nano Lett. 2012, 12:5304-5310.
18. Walkey C.D., Olsen J.B., Guo H.B., Emili A., Chan W.C.W. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J. Am. Chem. Soc. 2012, 134:2139-2147.
19. Gref R., Lück M., Quellec P., Marchand M., Dellacherie E., Harnisch S., et al. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. B 2000, 18:301-313.
20. Qhattal H.S.S., Hye T., Alali A., Liu X.L. Hyaluronan polymer length, grafting density, and surface poly(ethylene glycol) coating influence in vivo circulation and tumor targeting of hyaluronan-grafted liposomes. ACS Nano 2014, 8:5423-5440.
21. Shiraishi K., Sanada Y., Mochizuki S., Kawano K., Maitani Y., Sakurai K., et al. Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors. J. Control. Release 2015, 203:77-84.
22. Li S.D., Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 2008, 5:496-504.
23. Albanese A., Tang P.S., Chan W.C.W. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu. Rev. Biomed. Eng. 2012, 14:1-16.
24. Alexis F., Pridgen E., Molnar L.K., Farokhzad O.C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 2008, 5:505-515.
25. 198Au-doped nanostructures with different shapes for in vivo analyses of their biodistribution, tumor uptake, and intratumoral distribution. ACS Nano 2014, 8:4385-4394.
26. Sykes E.A., Chen J., Zheng G., Chan W.C.W. Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency. ACS Nano 2014, 8:5696-5706.
27. Choi H.S., Liu W.H., Misra P., Tanaka E., Zimmer J.P., Ipe B.I., et al. Renal clearance of quantum dots. Nat. Biotechnol. 2007, 25:1165-1170.
28. Dellian M., Yuan F., Trubetskoy V.S., Torchilin V.P., Jain R.K. Vascular permeability in a human tumour xenograft: molecular charge dependence. Br. J. Cancer 2000, 82:1513-1518.
29. Ernsting M.J., Murakami M., Roy A., Li S.D. Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. J. Control. Release 2013, 172:782-794.
30. Fang C., Shi B., Pei Y.Y., Hong M.H., Wu J., Chen H.Z. In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size. Eur. J. Pharm. Sci. 2006, 27:27-36.
31. Perrault S.D., Walkey C., Jennings T., Fischer H.C., Chan W.C.W. Mediating tumor targeting efficiency of nanoparticles through design. Nano Lett. 2009, 9:1909-1915.
32. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of Sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol. 2011, 6:815-823.
33. Sun T.M., Du J.Z., Yan L.F., Mao H.Q., Wang J. Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials 2008, 29:4348-4355.
34. Wang Y.C., Shen S.Y., Wu Q.P., Chen D.P., Wang J., Steinhoff G., et al. Block copolymerization of ε-caprolactone and 2-methoxyethyl ethylene phosphate initiated by aluminum isopropoxide: synthesis, characterization, and kinetics. Macromolecules 2006, 39:8992-8998.
35. Glotzer S.C. Some assembly required. Science 2004, 306:419-420.
36. Cui H.G., Chen Z.Y., Zhong S., Wooley K.L., Pochan D.J. Block copolymer assembly via kinetic control. Science 2007, 317:647-650.
37. Gaucher G., Dufresne M.H., Sant V.P., Kang N., Maysinger D., Leroux J.C. Block copolymer micelles: preparation, characterization and application in drug delivery. J. Control. Release 2005, 109:169-188.
38. Shuai X.T., Ai H., Nasongkla N., Kim S., Gao J.M. Micellar carriers based on block copolymers of poly(ε-caprolactone) and poly(ethylene glycol) for doxorubicin delivery. J. Control. Release 2004, 98:415-426.
39. Yang Q., Jones S.W., Parker C.L., Zamboni W.C., Bear J.E., Lai S.K. Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation. Mol. Pharm. 2014, 11:1250-1258.
40. Damodaran V.B., Fee C.J., Ruckh T., Popat K.C. Conformational studies of covalently grafted poly(ethylene glycol) on modified solid matrices using X-ray photoelectron spectroscopy. Langmuir 2010, 26:7299-7306.
41. Nance E.A., Woodworth G.F., Sailor K.A., Shih T.Y., Xu Q.G., Swaminathan G., et al. A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci. Transl. Med. 2012, 4:149ra119.
42. Liu Y., Hu Y.X., Huang L. Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles. Biomaterials 2014, 35:3027-3034.
43. Baish J.W., Stylianopoulos T., Lanning R.M., Kamoun W.S., Fukumura D., Munn L.L., et al. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:1799-1803.
44. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer-chemotherapy - mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986, 46:6387-6392.
45. Misra R., Acharya S., Sahoo S.K. Cancer nanotechnology: application of nanotechnology in cancer therapy. Drug Discov. Today 2010, 15:842-850.
46. Li Y., Liu R.Y., Yang J., Shi Y.J., Ma G.H., Zhang Z.Z., et al. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials 2015, 41:1-14.
47. Mishra S., Webster P., Davis M.E. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur. J. Cell Biol. 2004, 83:97-111.
48. Yang X.Z., Du X.J., Liu Y., Zhu Y.H., Liu Y.Z., Li Y.P., et al. Rational design of polyion complex nanoparticles to overcome cisplatin resistance in cancer therapy. Adv. Mater 2014, 26:931-936.
49. Zhao J., Feng S.S. Effects of PEG tethering chain length of vitamin E TPGS with a Herceptin-functionalized nanoparticle formulation for targeted delivery of anticancer drugs. Biomaterials 2014, 35:3340-3347.
50. Hu Y., Xie J.W., Tong Y.W., Wang C.H. Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells. J. Control. Release 2007, 118:7-17.
51. Miteva M., Kirkbride K.C., Kilchrist K.V., Werfel T.A., Li H.M., Nelson C.E., et al. Tuning PEGylation of mixed micelles to overcome intracellular and systemic siRNA delivery barriers. Biomaterials 2015, 38:97-107.
52. Hak S., Helgesen E., Hektoen H.H., Huuse E.M., Jarzyna P.A., Mulder W.J.M., et al. The effect of nanoparticle polyethylene glycol surface density on ligand-directed tumor targeting studied in vivo by dual modality imaging. ACS Nano 2012, 6:5648-5658.