Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors

Journal of Controlled Release

Volumn 203, Issue , 2015, Pages 77-84

  Shiraishi, Kouichi ^a   Sanada, Yusuke ^b   Mochizuki, Shinichi ^b   Kawano, Kumi ^c   Maitani, Yoshie ^b   Sakurai, Kazuo ^b   Yokoyama, Masayuki ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF KITAKYUSHU   (Japan)

^c HOSHI UNIVERSITY   (Japan)

Author keywords

Macrophage uptake; Outermost shell surface PEG density; Polymeric micelle; Small angle X ray scattering; Structural characteristics

Indexed keywords

LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; POLYMERS; SURFACE SCATTERING; X RAY SCATTERING;

AGGREGATION NUMBERS; AREA UNDER THE CURVES; FIELD FLOW FRACTIONATION; MULTI-ANGLE LIGHT SCATTERINGS; POLYMERIC MICELLE; SHELL SURFACE; STABILITY RESULTS; STRUCTURAL CHARACTERISTICS;

MICELLES;

POLY(ETHYLENE GLYCOL) BLOCK POLY(PARTIALLY BENZYL ESTERIFIED ASPARTIC ACID)MICELLE; POLYMER; UNCLASSIFIED DRUG; ASPARAGINASE; ASPARAGINASE MACROGOL; ASPARTIC ACID; DRUG CARRIER; MACROGOL DERIVATIVE; MICELLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; DENSITY; FIELD FLOW FRACTIONATION; FIELD FLOW FRACTIONATION WITH MULTI ANGLE LIGHT SCATTERING; IN VIVO STUDY; LIGHT SCATTERING; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; ESTERIFICATION; METABOLISM; MICELLE; SMALL ANGLE SCATTERING; X RAY DIFFRACTION;

ANIMALS; ASPARAGINASE; ASPARTIC ACID; CELLS, CULTURED; DRUG CARRIERS; ESTERIFICATION; MACROPHAGES; MICE, INBRED C57BL; MICELLES; POLYETHYLENE GLYCOLS; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

EID: 84923286758     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.02.017     Document Type: Article

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