Chimeric porcine reproductive and respiratory syndrome virus containing shuffled multiple envelope genes confers cross-protection in pigs

Virology

Volumn 485, Issue , 2015, Pages 402-413

  Tian, Debin ^a   Ni, Yan Yan ^a   Zhou, Lei ^a   Opriessnig, Tanja ^b   Cao, Dianjun ^a   Piñeyro, Pablo ^a,c   Yugo, Danielle M ^a   Overend, Christopher ^a   Cao, Qian ^a   Lynn Heffron, C ^a   Halbur, Patrick G ^c   Pearce, Douglas S ^d   Calvert, Jay G ^d   Meng, Xiang Jin ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c IOWA STATE UNIVERSITY   (United States)

^d ZOETIS   (United States)

Author keywords

Cross protection; DNA shuffling; Envelope genes; Heterologous strains; Porcine reproductive and respiratory syndrome virus (PRRSV); Vaccines

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CONTROLLED STUDY; CROSS PROTECTION; DNA SHUFFLING; ENVELOPE GENE; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; ORF3 GENE; ORF4 GENE; ORF5 GENE; ORF6 GENE; PIG; PILOT STUDY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIROGENESIS; VIRUS NEUTRALIZATION; VIRUS STRAIN; VIRUS VIABILITY; ANIMAL; CELL LINE; GENE ORDER; GENETIC REASSORTMENT; GENETIC RECOMBINATION; GENETICS; IMMUNIZATION; IMMUNOLOGY; PATHOLOGY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; SERODIAGNOSIS; VIROLOGY; VIRUS GENOME; VIRUS REPLICATION;

NEUTRALIZING ANTIBODY; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; CROSS PROTECTION; GENE ORDER; GENOME, VIRAL; IMMUNIZATION; NEUTRALIZATION TESTS; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; REASSORTANT VIRUSES; RECOMBINATION, GENETIC; SWINE; VIRAL ENVELOPE PROTEINS; VIRUS REPLICATION;

EID: 84940757228     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2015.08.021     Document Type: Article

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