메뉴 건너뛰기




Volumn 87, Issue 24, 2013, Pages 13456-13465

Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; ISOPROTEIN; NONSTRUCTURAL PROTEIN 2; PROTEIN ANTIBODY; PROTEINASE; VIRUS PROTEIN;

EID: 84888039348     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02435-13     Document Type: Article
Times cited : (58)

References (56)
  • 5
    • 0034775965 scopus 로고    scopus 로고
    • High frequency RNA recombination in porcine reproductive and respiratory syndrome virus occurs preferentially between parental sequences with high similarity
    • van Vugt JJ, Storgaard T, Oleksiewicz MB, Botner A. 2001. High frequency RNA recombination in porcine reproductive and respiratory syndrome virus occurs preferentially between parental sequences with high similarity. J. Gen. Virol. 82:2615-2620.
    • (2001) J. Gen. Virol. , vol.82 , pp. 2615-2620
    • van Vugt, J.J.1    Storgaard, T.2    Oleksiewicz, M.B.3    Botner, A.4
  • 6
    • 0033063134 scopus 로고    scopus 로고
    • Recombination between North American strains of porcine reproductive and respiratory syndrome virus
    • Yuan S, Nelsen CJ, Murtaugh MP, Schmitt BJ, Faaberg KS. 1999. Recombination between North American strains of porcine reproductive and respiratory syndrome virus. Virus Res. 61:87-98.
    • (1999) Virus Res. , vol.61 , pp. 87-98
    • Yuan, S.1    Nelsen, C.J.2    Murtaugh, M.P.3    Schmitt, B.J.4    Faaberg, K.S.5
  • 7
    • 16344393530 scopus 로고    scopus 로고
    • The origin and evolution of porcine reproductive and respiratory syndrome viruses
    • Hanada K, Suzuki Y, Nakane T, Hirose O, Gojobori T. 2005. The origin and evolution of porcine reproductive and respiratory syndrome viruses. Mol. Biol. Evol. 22:1024-1031.
    • (2005) Mol. Biol. Evol. , vol.22 , pp. 1024-1031
    • Hanada, K.1    Suzuki, Y.2    Nakane, T.3    Hirose, O.4    Gojobori, T.5
  • 11
    • 45849089115 scopus 로고    scopus 로고
    • Genetic polymorphism of the nsp2 gene in North American type-porcine reproductive and respiratory syndrome virus
    • Yoshii M, Okinaga T, Miyazaki A, Kato K, Ikeda H, Tsunemitsu H. 2008. Genetic polymorphism of the nsp2 gene in North American type-porcine reproductive and respiratory syndrome virus. Arch. Virol. 153:1323-1334.
    • (2008) Arch. Virol. , vol.153 , pp. 1323-1334
    • Yoshii, M.1    Okinaga, T.2    Miyazaki, A.3    Kato, K.4    Ikeda, H.5    Tsunemitsu, H.6
  • 12
    • 33750417154 scopus 로고    scopus 로고
    • Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus
    • Han J, Wang Y, Faaberg KS. 2006. Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Virus Res. 122:175-182.
    • (2006) Virus Res. , vol.122 , pp. 175-182
    • Han, J.1    Wang, Y.2    Faaberg, K.S.3
  • 13
    • 29744455503 scopus 로고    scopus 로고
    • The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity
    • Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. 2005. The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J. Virol. 79:15189-15198.
    • (2005) J. Virol. , vol.79 , pp. 15189-15198
    • Barretto, N.1    Jukneliene, D.2    Ratia, K.3    Chen, Z.4    Mesecar, A.D.5    Baker, S.C.6
  • 15
    • 77954461006 scopus 로고    scopus 로고
    • The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions
    • Sun Z, Chen Z, Lawson SR, Fang Y. 2010. The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions. J. Virol. 84:7832-7846.
    • (2010) J. Virol. , vol.84 , pp. 7832-7846
    • Sun, Z.1    Chen, Z.2    Lawson, S.R.3    Fang, Y.4
  • 17
    • 77949499693 scopus 로고    scopus 로고
    • Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response
    • Chen Z, Zhou X, Lunney JK, Lawson S, Sun Z, Brown E, Christopher-Hennings J, Knudsen D, Nelson E, Fang Y. 2010. Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response. J. Gen. Virol. 91:1047-1057.
    • (2010) J. Gen. Virol. , vol.91 , pp. 1047-1057
    • Chen, Z.1    Zhou, X.2    Lunney, J.K.3    Lawson, S.4    Sun, Z.5    Brown, E.6    Christopher-Hennings, J.7    Knudsen, D.8    Nelson, E.9    Fang, Y.10
  • 18
    • 69449091717 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus Nsp2 cysteine protease domain possesses both trans-and cis-cleavage activities
    • 8 July. doi:10.1128/JVI.00834-09.
    • Han J, Rutherford MS, Faaberg KS. 8 July 2009. Porcine reproductive and respiratory syndrome virus Nsp2 cysteine protease domain possesses both trans-and cis-cleavage activities. J. Virol. doi:10.1128/JVI.00834-09.
    • (2009) J. Virol.
    • Han, J.1    Rutherford, M.S.2    Faaberg, K.S.3
  • 19
    • 0029044301 scopus 로고
    • The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases
    • Snijder EJ, Wassenaar AL, Spaan WJ, Gorbalenya AE. 1995. The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases. J. Biol. Chem. 270:16671-16676.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16671-16676
    • Snijder, E.J.1    Wassenaar, A.L.2    Spaan, W.J.3    Gorbalenya, A.E.4
  • 20
    • 84860235854 scopus 로고    scopus 로고
    • Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus
    • Sun Y, Han M, Kim C, Calvert JG, Yoo D. 2012. Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus. Viruses 4:424-446.
    • (2012) Viruses , vol.4 , pp. 424-446
    • Sun, Y.1    Han, M.2    Kim, C.3    Calvert, J.G.4    Yoo, D.5
  • 21
    • 0035104619 scopus 로고    scopus 로고
    • Epitope mapping porcine reproductive and respiratory syndrome virus by phage display:the nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes
    • Oleksiewicz MB, Botner A, Toft P, Normann P, Storgaard T. 2001. Epitope mapping porcine reproductive and respiratory syndrome virus by phage display:the nsp2 fragment of the replicase polyprotein contains a cluster of B-cell epitopes. J. Virol. 75:3277-3290.
    • (2001) J. Virol. , vol.75 , pp. 3277-3290
    • Oleksiewicz, M.B.1    Botner, A.2    Toft, P.3    Normann, P.4    Storgaard, T.5
  • 22
    • 58149263132 scopus 로고    scopus 로고
    • Virus-specific host miRNAs:antiviral defenses or promoters of persistent infection?
    • Mahajan VS, Drake A, Chen J. 2009. Virus-specific host miRNAs:antiviral defenses or promoters of persistent infection? Trends Immunol. 30:1-7.
    • (2009) Trends Immunol. , vol.30 , pp. 1-7
    • Mahajan, V.S.1    Drake, A.2    Chen, J.3
  • 23
    • 0035008260 scopus 로고    scopus 로고
    • Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex
    • Snijder EJ, van Tol H, Roos N, Pedersen KW. 2001. Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex. J. Gen. Virol. 82:985-994.
    • (2001) J. Gen. Virol. , vol.82 , pp. 985-994
    • Snijder, E.J.1    van Tol, H.2    Roos, N.3    Pedersen, K.W.4
  • 24
    • 0034072633 scopus 로고    scopus 로고
    • Virus-encoded proteinases and proteolytic processing in the Nidovirales
    • Ziebuhr J, Snijder EJ, Gorbalenya AE. 2000. Virus-encoded proteinases and proteolytic processing in the Nidovirales. J. Gen. Virol. 81:853-879.
    • (2000) J. Gen. Virol. , vol.81 , pp. 853-879
    • Ziebuhr, J.1    Snijder, E.J.2    Gorbalenya, A.E.3
  • 25
    • 0030856299 scopus 로고    scopus 로고
    • Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein:evidence that NSP2 acts as a cofactor for the NSP4 serine protease
    • Wassenaar AL, Spaan WJ, Gorbalenya AE, Snijder EJ. 1997. Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein:evidence that NSP2 acts as a cofactor for the NSP4 serine protease. J. Virol. 71:9313-9322.
    • (1997) J. Virol. , vol.71 , pp. 9313-9322
    • Wassenaar, A.L.1    Spaan, W.J.2    Gorbalenya, A.E.3    Snijder, E.J.4
  • 26
    • 77649188698 scopus 로고    scopus 로고
    • The arterivirus replicase
    • Perlman S, Gallagher T, Snijder EJ (ed), ASM Press, Washington, DC.
    • van Hemert MJ, Snijder EJ. 2008. The arterivirus replicase, p 83-101. In Perlman S, Gallagher T, Snijder EJ (ed), The nidoviruses. ASM Press, Washington, DC.
    • (2008) The nidoviruses , pp. 83-101
    • van Hemert, M.J.1    Snijder, E.J.2
  • 27
    • 66849101997 scopus 로고    scopus 로고
    • Antibody response to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural proteins and implications for diagnostic detection and differentiation of PRRSV types I and II
    • Brown E, Lawson S, Welbon C, Gnanandarajah J, Li J, Murtaugh MP, Nelson EA, Molina RM, Zimmerman JJ, Rowland RR, Fang Y. 2009. Antibody response to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural proteins and implications for diagnostic detection and differentiation of PRRSV types I and II. Clin. Vaccine Immunol. 16:628-635.
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 628-635
    • Brown, E.1    Lawson, S.2    Welbon, C.3    Gnanandarajah, J.4    Li, J.5    Murtaugh, M.P.6    Nelson, E.A.7    Molina, R.M.8    Zimmerman, J.J.9    Rowland, R.R.10    Fang, Y.11
  • 28
    • 0034118786 scopus 로고    scopus 로고
    • Competitive ELISA for detection of antibodies to porcine reproductive and respiratory syndrome virus using recombinant E. coli-expressed nucleocapsid protein as antigen
    • Dea S, Wilson L, Therrien D, Cornaglia E. 2000. Competitive ELISA for detection of antibodies to porcine reproductive and respiratory syndrome virus using recombinant E. coli-expressed nucleocapsid protein as antigen. J. Virol. Methods 87:109-122.
    • (2000) J. Virol. Methods , vol.87 , pp. 109-122
    • Dea, S.1    Wilson, L.2    Therrien, D.3    Cornaglia, E.4
  • 29
    • 33748684385 scopus 로고    scopus 로고
    • Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus
    • de Lima M, Pattnaik AK, Flores EF, Osorio FA. 2006. Serologic marker candidates identified among B-cell linear epitopes of Nsp2 and structural proteins of a North American strain of porcine reproductive and respiratory syndrome virus. Virology 353:410-421.
    • (2006) Virology , vol.353 , pp. 410-421
    • de Lima, M.1    Pattnaik, A.K.2    Flores, E.F.3    Osorio, F.A.4
  • 30
    • 1442348815 scopus 로고    scopus 로고
    • Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States
    • Fang Y, Kim DY, Ropp S, Steen P, Christopher-Hennings J, Nelson EA, Rowland RR. 2004. Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States. Virus Res. 100:229-235.
    • (2004) Virus Res. , vol.100 , pp. 229-235
    • Fang, Y.1    Kim, D.Y.2    Ropp, S.3    Steen, P.4    Christopher-Hennings, J.5    Nelson, E.A.6    Rowland, R.R.7
  • 32
    • 84856860892 scopus 로고    scopus 로고
    • Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles
    • Nogales A, Marquez-Jurado S, Galan C, Enjuanes L, Almazan F. 2012. Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles. J. Virol. 86:1261-1266.
    • (2012) J. Virol. , vol.86 , pp. 1261-1266
    • Nogales, A.1    Marquez-Jurado, S.2    Galan, C.3    Enjuanes, L.4    Almazan, F.5
  • 37
    • 35348840283 scopus 로고    scopus 로고
    • Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture
    • Han J, Liu G, Wang Y, Faaberg KS. 2007. Identification of nonessential regions of the nsp2 replicase protein of porcine reproductive and respiratory syndrome virus strain VR-2332 for replication in cell culture. J. Virol. 81:9878-9890.
    • (2007) J. Virol. , vol.81 , pp. 9878-9890
    • Han, J.1    Liu, G.2    Wang, Y.3    Faaberg, K.S.4
  • 38
    • 77956864495 scopus 로고    scopus 로고
    • Proteolytic products of the porcine reproductive and respiratory syndrome virus nsp2 replicase protein
    • Han J, Rutherford MS, Faaberg KS. 2010. Proteolytic products of the porcine reproductive and respiratory syndrome virus nsp2 replicase protein. J. Virol. 84:10102-10112.
    • (2010) J. Virol. , vol.84 , pp. 10102-10112
    • Han, J.1    Rutherford, M.S.2    Faaberg, K.S.3
  • 39
    • 0031985681 scopus 로고    scopus 로고
    • Infectious transcripts from cloned genome-length cDNA of porcine reproductive and respiratory syndrome virus
    • Meulenberg JJ, Bos-de Ruijter JN, van de Graaf R, Wensvoort G, Moormann RJ. 1998. Infectious transcripts from cloned genome-length cDNA of porcine reproductive and respiratory syndrome virus. J. Virol. 72:380-387.
    • (1998) J. Virol. , vol.72 , pp. 380-387
    • Meulenberg, J.J.1    Bos-de Ruijter, J.N.2    van de Graaf, R.3    Wensvoort, G.4    Moormann, R.J.5
  • 40
    • 8444241086 scopus 로고    scopus 로고
    • Characterization of heteroclite subgenomic RNAs associated with PRRSV infection
    • Yuan S, Murtaugh MP, Schumann FA, Mickelson D, Faaberg KS. 2004. Characterization of heteroclite subgenomic RNAs associated with PRRSV infection. Virus Res. 105:75-87.
    • (2004) Virus Res. , vol.105 , pp. 75-87
    • Yuan, S.1    Murtaugh, M.P.2    Schumann, F.A.3    Mickelson, D.4    Faaberg, K.S.5
  • 41
    • 24644466505 scopus 로고    scopus 로고
    • Probability of porcine reproductive and respiratory syndrome (PRRS) virus infection as a function of exposure route and dose
    • Hermann JR, Munoz-Zanzi CA, Roof MB, Burkhart K, Zimmerman JJ. 2005. Probability of porcine reproductive and respiratory syndrome (PRRS) virus infection as a function of exposure route and dose. Vet. Microbiol. 110:7-16.
    • (2005) Vet. Microbiol. , vol.110 , pp. 7-16
    • Hermann, J.R.1    Munoz-Zanzi, C.A.2    Roof, M.B.3    Burkhart, K.4    Zimmerman, J.J.5
  • 42
    • 34250971354 scopus 로고
    • Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche
    • Kärber G. 1931. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol. 162:480-483.
    • (1931) Naunyn Schmiedebergs Arch. Exp. Pathol. Pharmakol. , vol.162 , pp. 480-483
    • Kärber, G.1
  • 43
    • 63449125728 scopus 로고    scopus 로고
    • Cryo-electron tomography of porcine reproductive and respiratory syndrome virus:organization of the nucleocapsid
    • Spilman MS, Welbon C, Nelson E, Dokland T. 2009. Cryo-electron tomography of porcine reproductive and respiratory syndrome virus:organization of the nucleocapsid. J. Gen. Virol. 90:527-535.
    • (2009) J. Gen. Virol. , vol.90 , pp. 527-535
    • Spilman, M.S.1    Welbon, C.2    Nelson, E.3    Dokland, T.4
  • 45
    • 84863255662 scopus 로고    scopus 로고
    • Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells
    • Li Y, Tas A, Snijder EJ, Fang Y. 2012. Identification of porcine reproductive and respiratory syndrome virus ORF1a-encoded non-structural proteins in virus-infected cells. J. Gen. Virol. 93:829-839.
    • (2012) J. Gen. Virol. , vol.93 , pp. 829-839
    • Li, Y.1    Tas, A.2    Snijder, E.J.3    Fang, Y.4
  • 46
    • 0031879009 scopus 로고    scopus 로고
    • ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex
    • van der Meer Y, van Tol H, Locker JK, Snijder EJ. 1998. ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex. J. Virol. 72:6689-6698.
    • (1998) J. Virol. , vol.72 , pp. 6689-6698
    • van der Meer, Y.1    van Tol, H.2    Locker, J.K.3    Snijder, E.J.4
  • 47
    • 33750912753 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection
    • doi:10.1186/1743-422X-3-90
    • Cafruny WA, Duman RG, Wong GH, Said S, Ward-Demo P, Rowland RR, Nelson EA. 2006. Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection. Virol. J. 3:90. doi:10.1186/1743-422X-3-90.
    • (2006) Virol. J. , vol.3 , pp. 90
    • Cafruny, W.A.1    Duman, R.G.2    Wong, G.H.3    Said, S.4    Ward-Demo, P.5    Rowland, R.R.6    Nelson, E.A.7
  • 48
    • 78649322018 scopus 로고    scopus 로고
    • The PRRSV replicase:exploring the multifunctionality of an intriguing set of nonstructural proteins
    • Fang Y, Snijder EJ. 2010. The PRRSV replicase:exploring the multifunctionality of an intriguing set of nonstructural proteins. Virus Res. 154:61-76.
    • (2010) Virus Res. , vol.154 , pp. 61-76
    • Fang, Y.1    Snijder, E.J.2
  • 49
    • 0028833654 scopus 로고
    • Molecular analysis of the ORFs 3 to 7 of porcine reproductive and respiratory syndrome virus, Quebec reference strain
    • Mardassi H, Mounir S, Dea S. 1995. Molecular analysis of the ORFs 3 to 7 of porcine reproductive and respiratory syndrome virus, Quebec reference strain. Arch. Virol. 140:1405-1418.
    • (1995) Arch. Virol. , vol.140 , pp. 1405-1418
    • Mardassi, H.1    Mounir, S.2    Dea, S.3
  • 50
    • 79551500825 scopus 로고    scopus 로고
    • Characterization of equine humoral antibody response to the nonstructural proteins of equine arteritis virus
    • Go YY, Snijder EJ, Timoney PJ, Balasuriya UB. 2011. Characterization of equine humoral antibody response to the nonstructural proteins of equine arteritis virus. Clin. Vaccine Immunol. 18:268-279.
    • (2011) Clin. Vaccine Immunol. , vol.18 , pp. 268-279
    • Go, Y.Y.1    Snijder, E.J.2    Timoney, P.J.3    Balasuriya, U.B.4
  • 51
    • 34247464685 scopus 로고    scopus 로고
    • Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus:analysis of isolates collected between 1999 and 2004
    • Fang Y, Schneider P, Zhang WP, Faaberg KS, Nelson EA, Rowland RR. 2007. Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus:analysis of isolates collected between 1999 and 2004. Arch. Virol. 152:1009-1017.
    • (2007) Arch. Virol. , vol.152 , pp. 1009-1017
    • Fang, Y.1    Schneider, P.2    Zhang, W.P.3    Faaberg, K.S.4    Nelson, E.A.5    Rowland, R.R.6
  • 53
    • 78649324929 scopus 로고    scopus 로고
    • In vivo growth of porcine reproductive and respiratory syndrome virus engineered nsp2 deletion mutants
    • Faaberg KS, Kehrli ME, Jr, Lager KM, Guo B, Han J. 2010. In vivo growth of porcine reproductive and respiratory syndrome virus engineered nsp2 deletion mutants. Virus Res. 154:77-85.
    • (2010) Virus Res. , vol.154 , pp. 77-85
    • Faaberg, K.S.1    Kehrli Jr., M.E.2    Lager, K.M.3    Guo, B.4    Han, J.5
  • 54
    • 34248207613 scopus 로고    scopus 로고
    • Monoclonal antibody and porcine antisera recognized B-cell epitopes of Nsp2 protein of a Chinese strain of porcine reproductive and respiratory syndrome virus
    • Yan Y, Guo X, Ge X, Chen Y, Cha Z, Yang H. 2007. Monoclonal antibody and porcine antisera recognized B-cell epitopes of Nsp2 protein of a Chinese strain of porcine reproductive and respiratory syndrome virus. Virus Res. 126:207-215.
    • (2007) Virus Res. , vol.126 , pp. 207-215
    • Yan, Y.1    Guo, X.2    Ge, X.3    Chen, Y.4    Cha, Z.5    Yang, H.6
  • 55
    • 0027968068 scopus 로고
    • CLUSTAL W:improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ. 1994. CLUSTAL W:improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.