Assessment of the efficacy of commercial porcine reproductive and respiratory syndrome virus (PRRSV) vaccines based on measurement of serologic response, frequency of gamma-IFN-producing cells and virological parameters of protection upon challenge

Veterinary Microbiology

Volumn 123, Issue 1-3, 2007, Pages 69-85

  Zuckermann, Federico A ^a   Garcia, Esther Alvarez ^b   Luque, Ivan Diaz ^c   Christopher Hennings, Jane ^d   Doster, Alan ^e   Brito, Monica ^e   Osorio, Fernando ^e  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d SOUTH DAKOTA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Gamma interferon producing cells; IL 10; Neutralizing antibodies; Protective immunity; PRRSV; Vaccines

Indexed keywords

GAMMA INTERFERON; INACTIVATED VACCINE; LIVE VACCINE; NEUTRALIZING ANTIBODY; PROGRESSIS; PYRSVAC 183; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIVIRUS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; MEASUREMENT; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SECRETORY CELL; SEROLOGY; SWINE; VIREMIA; VIROLOGY; VIRUS INFECTION; VIRUS LOAD; VIRUS STRAIN;

ANIMALS; ANTIBODIES, VIRAL; CHEMISTRY, PHARMACEUTICAL; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SEROLOGIC TESTS; SPECIFIC PATHOGEN-FREE ORGANISMS; SWINE; VIRAL VACCINES;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE;

EID: 34250187408     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2007.02.009     Document Type: Article

References (54)

1. Alexopoulos C., Kritas S.K., Kyriakis C.S., Tzika E., and Kyriakis S.C. Sow performance in an endemically porcine reproductive and respiratory syndrome (PRRS)-infected farm after sow vaccination with an attenuated PRRS vaccine. Vet. Microbiol. 111 (2005) 151-157
2. Alno, J., Dethinne, M., Guillaume, J., Hamon, P., Laval, A., Long, T., Renoult, C., Roche, R., 2000. Field efficacy of a new killed vaccine against PRRS for breeder pigs. In: Proceedings of the 16th International Pig Veterinary Soc Congress, Melbourne, Australia, 640.
3. Audonnet, J., Bublot, M., Perez, J., Baudu, P., 2001. United States patent Application 20030003112.
4. Charerntantanakul W., Platt R., Johnson W., Roof M., Vaughn E., and Roth J.A. Immune responses and protection by vaccine and various vaccine adjuvant candidates to virulent porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 109 (2006) 99-115
5. Christopher-Hennings J., Dammen M., Nelson E., Rowland R.R., and Oberst R. Comparison of RNA extraction methods for the detection of porcine reproductive and respiratory syndrome virus from boar semen. J. Virological Methods 136 (2006) 248-253
6. Diaz I., Darwich L., Pappaterra G., Pujols J., and Mateu E. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 86 (2005) 1943-1951
7. Diaz I., Darwich L., Pappaterra G., Pujols J., and Mateu E. Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Virology 351 (2006) 249-259
8. Gorcyca D., Schlesinger K., Chladek D., Morrison R., Wensvoort G., Dee S., and Polson D. A summary of Experimental and Field Studies Evaluating the Safety and Efficacy of RespPRRS/Repro for the Control of PRRS-Induced Reproductive Disease (1995), NOBL Laboratories, Sioux Center, IA
9. Halbur P.G., Paul P.S., Frey M.L., Landgraf J., Eernisse K., Meng X.J., Lum M.A., Andrews J.J., and Rathje J.A. Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Vet. Pathol. 32 (1995) 648-660
10. Hesse, R., Couture, L., Lau, M., BS, D., Ellsworth, S., 1996a, Efficacy of Prime Pac PRRS in controlling PRRS reproductive disease: homologous challenge, 1996.
11. Hesse, R., Couture, L., Lau, M., Wunder, K., Wasmoen, T., 1996b. Efficacy of Prime Pac PRRS in controlling PRRS reproductive disease: heterologous challenge. In: Proceedings 27th Annual Meeting. American Association of Swine Practitioners, Nashvill, TN, USA, pp. 107-110.
12. Joisel, F., Pontoppidan, L., Callen, A., Sokolicek, D., 2003. Improving herd performance through effective PRRS control. Merial Animal Health Newsletter, November 2003.
13. Labarque G., Reeth K.V., Nauwynck H., Drexler C., Van Gucht S., and Pensaert M. Impact of genetic diversity of European-type porcine reproductive and respiratory syndrome virus strains on vaccine efficacy. Vaccine 22 (2004) 4183-4190
14. Labarque G., Van Gucht S., Nauwynck H., Van Reeth K., and Pensaert M. Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines. Vet. Res. 34 (2003) 249-260
15. Labarque G., Van Gucht S., Van Reeth K., Nauwynck H., and Pensaert M. Respiratory tract protection upon challenge of pigs vaccinated with attenuated porcine reproductive and respiratory syndrome virus vaccines. Vet. Microbiol. 95 (2003) 187-197
16. Lager K.M., Mengeling W.L., and Brockmeier S.L. Duration of homologous porcine reproductive and respiratory syndrome virus immunity in pregnant swine. Vet. Microbiol. 58 (1997) 127-133
17. Lager K.M., Mengeling W.L., and Brockmeier S.L. Homologous challenge of porcine reproductive and respiratory syndrome virus immunity in pregnant swine. Vet. Microbiol. 58 (1997) 113-125
18. Lager K.M., Mengeling W.L., and Brockmeier S.L. Evaluation of protective immunity in gilts inoculated with the NADC-8 isolate of porcine reproductive and respiratory syndrome virus (PRRSV) and challenge-exposed with an antigenically distinct PRRSV isolate. Am. J. Vet. Res. 60 (1999) 1022-1027
19. Liu X.S., Xu Y., Hardy L., Khammanivong V., Zhao W., Fernando G.J., Leggatt G.R., and Frazer I.H. IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host. J. Immunol. 171 (2003) 4765-4772
20. Lopez O.J., Oliveira M., Alvarez Garcia E., Kwon B., Doster A., and Osorio F. Protection Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection through Passive Transfer of PRRSV-Neutralizing Antibodies is Dose-dependent. Clin. Vaccine Immunol. 14 (2007) 269-275
21. Lopez O.J., and Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 102 (2004) 155-163
22. Lowe J.E., Husmann R., Firkins L.D., Zuckermann F.A., and Goldberg T.L. Correlation of cell-mediated immunity against porcine reproductive and respiratory syndrome virus with protection against reproductive failure in sows during outbreaks of porcine reproductive and respiratory syndrome in commercial herds. J. Am. Vet. Med. Assoc. 226 (2005) 1707-1711
23. Lowe J.F., Zuckermann F.A., Firkins L.D., Schnitzlein W.M., and Goldberg T.L. Immunologic responses and reproductive outcomes following exposure to wild-type or attenuated porcine reproductive and respiratory syndrome virus in swine under field conditions. J. Am. Vet. Med. Assoc. 228 (2006) 1082-1088
24. Markine-Goriaynoff D., Hulhoven X., Cambiaso C.L., Monteyne P., Briet T., Gonzalez M.D., Coulie P., and Coutelier J.P. Natural killer cell activation after infection with lactate dehydrogenase-elevating virus. J. Gen. Virol. 83 (2002) 2709-2716
25. Marshall N.A., Vickers M.A., and Barker R.N. Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 1. J. Immunol. 170 (2003) 6183-6189
26. Mateu de Antonio E., Husmann R.J., Hansen R., Lunney J.K., Strom D., Martin S., and Zuckermann F.A. Quantitative detection of porcine interferon-gamma in response to mitogen, superantigen and recall viral antigen. Vet. Immunol. Immunopathol. 61 (1998) 265-277
27. Mavromatis I., Kritas S.K., Alexopoulos C., Tsinas A., and Kyriakis S.C. Field evaluation of a live vaccine against porcine reproductive and respiratory syndrome in fattening pigs. Zentralbl. Veterinarmed. B 46 (1999) 603-612
28. Meier W., Galeota J., Husmann R.J., Osorio F., and Zuckermann F.A. Characteristics of the cell-mediated immune response to porcine reproductive and respiratory syndrome virus. In: Morilla A., Yoon K.-J., and Zimmerman J.J. (Eds). Trends in Emerging Viral Infections of Swine (2002), Iowa State Press 355-358
29. Meier W.A., Galeota J., Osorio F.A., Husmann R.J., Schnitzlein W.M., and Zuckermann F.A. Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Virology 309 (2003) 18-31
30. Meier W.A., Husmann R.J., Schnitzlein W.M., Osorio F.A., Lunney J.K., and Zuckermann F.A. Cytokines and synthetic double-stranded RNA augment the T helper 1 immune response of swine to porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 102 (2004) 299-314
31. Meng X.J. Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Vet. Microbiol. 74 (2000) 309-329
32. Mengeling W.L., Lager K.M., and Vorwald A.C. Safety and efficacy of vaccination of pregnant gilts against porcine reproductive and respiratory syndrome. Am. J. Vet. Res. 60 (1999) 796-801
33. Meulenberg J.J., Hulst M.M., de Meijer E.J., Moonen P.L., den Besten A., de Kluyver E.P., Wensvoort G., and Moormann R.J. Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV. Virology 192 (1993) 62-72
34. Neumann E.J., Kliebenstein J.B., Johnson C.D., Mabry J.W., Bush E.J., Seitzinger A.H., Green A.L., and Zimmerman J.J. Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J. Am. Vet. Med. Assoc. 227 (2005) 385-392
35. Nilubol D., Platt K.B., Halbur P.G., Torremorell M., and Harris D.L. The effect of a killed porcine reproductive and respiratory syndrome virus (PRRSV) vaccine treatment on virus shedding in previously PRRSV infected pigs. Vet. Microbiol. 102 (2004) 11-18
36. Osorio F.A., Galeota J.A., Nelson E., Brodersen B., Doster A., Wills R., Zuckermann F., and Laegreid W.W. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology 302 (2002) 9-20
37. Osorio F.A., Zuckermann F., Wills R., Meier W., Christian S., Galeota J., and Doster A. PRRSV: comparison of commercial vaccines in their ability to induce protection against current PRRSV strains of high virulence. Allen D. Leman Swine Conf. 25 (1998) 176-182
38. Philips R., and Dee S. Evaluation of mass vaccination and unidirectional flow for the elimination of PRRS virus from grow/finish populations. Proceedings of the 33rd Annual Meeting American Association of Swine Veterinarians. March 2-5, 2002, Kansas City, MO, USA (2002) 165-166
39. Piras F., Bollard S., Laval F., Joisel F., Reynaud G., Charreyre C., Andreoni C., and Juillard V. Porcine reproductive and respiratory syndrome (PRRS) virus-specific interferon-gamma(+) T-cell responses after PRRS virus infection or vaccination with an inactivated PRRS vaccine. Viral Immunol. 18 (2005) 381-389
40. Pirzadeh B., and Dea S. Immune response in pigs vaccinated with plasmid DNA encoding ORF5 of porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 79 Part 5 (1998) 989-999
41. Plana-Duran J., Bastons M., Urniza A., Vayreda M., Vila X., and Mane H. Efficacy of an inactivated vaccine for prevention of reproductive failure induced by porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 55 (1997) 361-370
42. Reynaud, G., Brun, A., Charreyre, C., 2000. Zootechnical efficacy of vaccination of gilts and sows with an inactivated PRRS vaccine in a contaminated environment. In: Proceedings 16th International Pig Veterinary Soc Congress, Melbourne, Australia, p. 635.
43. Royaee A.R., Husmann R.J., Dawson H.D., Calzada-Nova G., Schnitzlein W.M., Zuckermann F.A., and Lunney J.K. Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination. Vet. Immunol. Immunopathol. 102 (2004) 199-216
44. Scortti M., Prieto C., Simarro I., and Castro J.M. Reproductive performance of gilts following vaccination and subsequent heterologous challenge with European strains of porcine reproductive and respiratory syndrome virus. Theriogenology 66 (2006) 1884-1893
45. Stadejek T., Stankevicius A., Storgaard T., Oleksiewicz M.B., Belak S., Drew T.W., and Pejsak Z. Identification of radically different variants of porcine reproductive and respiratory syndrome virus in Eastern Europe: towards a common ancestor for European and American viruses. J. Gen. Virol. 83 (2002) 1861-1873
46. Su H.C., Nguyen K.B., Salazar-Mather T.P., Ruzek M.C., Dalod M.Y., and Biron C.A. NK cell functions restrain T cell responses during viral infections. Eur. J. Immunol. 31 (2001) 3048-3055
47. Torremorell M., Henry S., and Christianson W.T. Eradication using herd closure. In: Zimmerman J., and Yoon K.-J. (Eds). 2003 PRRS Compendium (2003), National Pork Board, Des Moines, IA 157-162
48. van Woensel P.A., Liefkens K., and Demaret S. Effect on viraemia of an American and a European serotype PRRSV vaccine after challenge with European wild-type strains of the virus. Vet. Rec. 142 (1998) 510-512
49. Wasilk A., Callahan J.D., Christopher-Hennings J., Gay T.A., Fang Y., Dammen M., Reos M.E., Torremorell M., Polson D., Mellencamp M., Nelson E., and Nelson W.M. Detection of U.S., Lelystad, and European-like porcine reproductive and respiratory syndrome viruses and relative quantitation in boar semen and serum samples by real-time PCR. J. Clin. Microbiol. 42 (2004) 4453-4461
50. Wesley R.D., Lager K.M., and Kehrli Jr. M.E. Infection with Porcine reproductive and respiratory syndrome virus stimulates an early gamma interferon response in the serum of pigs. Can. J. Vet. Res. 70 (2006) 176-182
51. Wetzell T. Field experiences using modified live PRRS vaccine in a mass vaccination protocol for the control of PRRS in breeding herds. Proceedings Annual Meeting American Association of Swine Veterinarians. March 6-9, 2004, Des Moines, IA, USA (2004) 259-260
52. Wu W.H., Fang Y., Farwell R., Steffen-Bien M., Rowland R.R., Christopher-Hennings J., and Nelson E.A. A 10-kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b. Virology 287 (2001) 183-191
53. Zuckermann F.A., Husmann R.J., Schwartz R., Brandt J., Mateu de Antonio E., and Martin S. Interleukin-12 enhances the virus-specific interferon gamma response of pigs to an inactivated pseudorabies virus vaccine. Vet. Immunol. Immunopathol. 63 (1998) 57-67
54. Zuckermann F.A., Martin S., Husmann R.J., and Brandt J. Use of interleukin 12 to enhance the cellular immune response of swine to an inactivated herpesvirus vaccine. Adv. Vet. Med. 41 (1999) 447-461