메뉴 건너뛰기




Volumn 47, Issue 9, 2015, Pages 1875-1883

Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood

Author keywords

ADMA; Arginine; Children; Growth hormone; Homoarginine; IGF 1; Short stature

Indexed keywords

EDETIC ACID; GROWTH HORMONE; HOMOARGININE; N(G),N(G) DIMETHYLARGININE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; THYROTROPIN; ARGININE; HUMAN GROWTH HORMONE; N,N-DIMETHYLARGININE;

EID: 84940722910     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-2028-8     Document Type: Article
Times cited : (16)

References (57)
  • 2
    • 0031984163 scopus 로고    scopus 로고
    • Body mass index in growth hormone deficient children before and during growth hormone treatment
    • 1:CAS:528:DyaK1cXhsVSgtw%3D%3D 9438784
    • Baars J, Van den Broeck J, le Cessie S (1998) Body mass index in growth hormone deficient children before and during growth hormone treatment. Horm Res 49:39-45
    • (1998) Horm Res , vol.49 , pp. 39-45
    • Baars, J.1    Van Den Broeck, J.2    Le Cessie, S.3
  • 5
    • 0031017867 scopus 로고    scopus 로고
    • Increased cerebrovascular mortality in patients with hypopituitarism
    • 1:STN:280:DyaK2s3ht1OnsQ%3D%3D
    • Bulow B, Hagmar L, Mikoczy Z, Nordström CH, Erfurth EM (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrin 46:75-81
    • (1997) Clin Endocrin , vol.46 , pp. 75-81
    • Bulow, B.1    Hagmar, L.2    Mikoczy, Z.3    Nordström, C.H.4    Erfurth, E.M.5
  • 9
    • 4644312361 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency
    • 1:CAS:528:DC%2BD2cXpsVSitb4%3D
    • Colao A, Di Somma C, Filippella M, Rota F, Piconello R, Orio F, Vitale G, Lombardi G (2004) Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf) 61(3):360-366
    • (2004) Clin Endocrinol (Oxf) , vol.61 , Issue.3 , pp. 360-366
    • Colao, A.1    Di Somma, C.2    Filippella, M.3    Rota, F.4    Piconello, R.5    Orio, F.6    Vitale, G.7    Lombardi, G.8
  • 10
    • 33744955981 scopus 로고    scopus 로고
    • The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis
    • 1:CAS:528:DC%2BD28XlvVCgsLY%3D 16537686
    • Colao A, Di Somma C, Spiezia S, Rota F, Pivonello R, Savastano S, Lombardi G (2006) The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis. J Clin Endocrinol Metab 91(6):2191-2200
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.6 , pp. 2191-2200
    • Colao, A.1    Di Somma, C.2    Spiezia, S.3    Rota, F.4    Pivonello, R.5    Savastano, S.6    Lombardi, G.7
  • 11
    • 33344473316 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of angiogenesis
    • 1:CAS:528:DC%2BD28XhslCjs7s%3D
    • Cooke JP (2006) Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of angiogenesis. Eur J Clin Pharmacol 62:115-121
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 115-121
    • Cooke, J.P.1
  • 12
    • 0031054463 scopus 로고    scopus 로고
    • Nitric oxide synthase: role in the genesis of vascular disease
    • 1:CAS:528:DyaK2sXhtFOkurY%3D 9046979
    • Cooke JP, Dzau VJ (1997) Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48:489-509
    • (1997) Annu Rev Med , vol.48 , pp. 489-509
    • Cooke, J.P.1    Dzau, V.J.2
  • 13
    • 84867579062 scopus 로고    scopus 로고
    • Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine
    • 1:CAS:528:DC%2BC38XhtlCjt7bF 23010440
    • Davids M, Ndika JD, Salomons GS, Blom HJ, Teerlink T (2012) Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. FEBS Lett 586:3653-3657
    • (2012) FEBS Lett , vol.586 , pp. 3653-3657
    • Davids, M.1    Ndika, J.D.2    Salomons, G.S.3    Blom, H.J.4    Teerlink, T.5
  • 14
    • 0035808024 scopus 로고    scopus 로고
    • Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine Study
    • 1:STN:280:DC%2BD3MnoslSnsA%3D%3D 11733400
    • Davis PH, Dawson JD, Riley WA, Lauer RM (2001) Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine Study. Circulation 104:2815-2819
    • (2001) Circulation , vol.104 , pp. 2815-2819
    • Davis, P.H.1    Dawson, J.D.2    Riley, W.A.3    Lauer, R.M.4
  • 15
    • 67649909241 scopus 로고    scopus 로고
    • Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study
    • 2747309 19520251
    • Dawson JD, Sonka M, Blecha MB, Lin W, Davis PH (2009) Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study. J Am Coll Cardiol 53(24):2273-2279
    • (2009) J Am Coll Cardiol , vol.53 , Issue.24 , pp. 2273-2279
    • Dawson, J.D.1    Sonka, M.2    Blecha, M.B.3    Lin, W.4    Davis, P.H.5
  • 16
    • 84907978299 scopus 로고    scopus 로고
    • Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth hormone deficiency: effect of 12-month growth hormone replacement therapy
    • De Marco S, Marcovecchio ML, Caniglia D, De Leonibus C, Chiarelli F, Mohn A (2014) Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth hormone deficiency: effect of 12-month growth hormone replacement therapy. Growth Horm IGF Res 5:216-220
    • (2014) Growth Horm IGF Res , vol.5 , pp. 216-220
    • De Marco, S.1    Marcovecchio, M.L.2    Caniglia, D.3    De Leonibus, C.4    Chiarelli, F.5    Mohn, A.6
  • 18
    • 84906971102 scopus 로고    scopus 로고
    • Lipid patterns in treated growth hormone deficient children vs. short stature controls
    • 1:CAS:528:DC%2BC2cXhslWiurbN 24859507
    • Foster C, Burton A, Scholl J, Scott ML, Gunter V, McCormick K (2014) Lipid patterns in treated growth hormone deficient children vs. short stature controls. J Pediatr Endocrinol Metab 27:909-914
    • (2014) J Pediatr Endocrinol Metab , vol.27 , pp. 909-914
    • Foster, C.1    Burton, A.2    Scholl, J.3    Scott, M.L.4    Gunter, V.5    McCormick, K.6
  • 19
    • 0030813303 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition and hypertension in children and adolescents
    • 1:STN:280:DyaK2svisVaqsA%3D%3D 9280214
    • Goonasekera CDA, Rees DD, Woolard P, Frend A, Shah V, Dillon MJ (1997) Nitric oxide synthase inhibition and hypertension in children and adolescents. J Hypertens 15:901-909
    • (1997) J Hypertens , vol.15 , pp. 901-909
    • Goonasekera, C.D.A.1    Rees, D.D.2    Woolard, P.3    Frend, A.4    Shah, V.5    Dillon, M.J.6
  • 20
    • 0026060469 scopus 로고
    • On the substrate specificity of nitric oxide synthase
    • 1:CAS:528:DyaK38Xht1ektb4%3D 1721880
    • Hecker M, Walsh DT, Vane JR (1991) On the substrate specificity of nitric oxide synthase. FEBS Lett 294:221-224
    • (1991) FEBS Lett , vol.294 , pp. 221-224
    • Hecker, M.1    Walsh, D.T.2    Vane, J.R.3
  • 21
    • 66349132215 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and the effect of folat substitution in children with familial hypercholesterolemia and diabetes mellitus type I
    • 1:CAS:528:DC%2BD1MXlslOisLc%3D 18380539
    • Jehlicka P, Stozicky F, Mayer OJR, Varvarovska J, Racek J, Trefil L, Siala K (2009) Asymmetric dimethylarginine and the effect of folat substitution in children with familial hypercholesterolemia and diabetes mellitus type I. Physiol Res 58:179-184
    • (2009) Physiol Res , vol.58 , pp. 179-184
    • Jehlicka, P.1    Stozicky, F.2    Mayer, O.J.R.3    Varvarovska, J.4    Racek, J.5    Trefil, L.6    Siala, K.7
  • 23
    • 84908208988 scopus 로고    scopus 로고
    • Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?
    • 25175517
    • Kayacelebi AA, Pham VV, Willers J, Hahn A, Stichtenoth DO, Jordan J, Tsikas D (2014a) Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA? Int J Cardiol 176(3):1129-1131
    • (2014) Int J Cardiol , vol.176 , Issue.3 , pp. 1129-1131
    • Kayacelebi, A.A.1    Pham, V.V.2    Willers, J.3    Hahn, A.4    Stichtenoth, D.O.5    Jordan, J.6    Tsikas, D.7
  • 24
    • 84906315693 scopus 로고    scopus 로고
    • GC-MS and GC- MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples
    • 1:CAS:528:DC%2BC2cXpvVeju7Y%3D 24923265
    • Kayacelebi AA, Beckmann B, Gutzki FM, Jordan J, Tsikas D (2014b) GC-MS and GC- MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples. Amino Acids 46:2205-2217
    • (2014) Amino Acids , vol.46 , pp. 2205-2217
    • Kayacelebi, A.A.1    Beckmann, B.2    Gutzki, F.M.3    Jordan, J.4    Tsikas, D.5
  • 25
    • 84940460091 scopus 로고    scopus 로고
    • Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC-MS and GC-MS/MS
    • Kayacelebi AA, Knöfel AK, Beckmann B, Hanff E, Warnecke G, Tsikas D (2015a) Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC-MS and GC-MS/MS. Amino Acids. doi: 10.1007/s00726-015-1984-3
    • (2015) Amino Acids
    • Kayacelebi, A.A.1    Knöfel, A.K.2    Beckmann, B.3    Hanff, E.4    Warnecke, G.5    Tsikas, D.6
  • 26
    • 84940459167 scopus 로고    scopus 로고
    • Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans
    • Kayacelebi AA, Langen J, Weigt-Usinger K, Chobanyan-Jürgens K et al (2015b) Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans. Amino Acids. doi: 10.1007/s00726-015-2012-3
    • (2015) Amino Acids
    • Kayacelebi, A.A.1    Langen, J.2    Weigt-Usinger, K.3    Chobanyan-Jürgens, K.4
  • 27
    • 84898488798 scopus 로고    scopus 로고
    • Effect of one-year growth hormone therapy on body composition and cardio-metabolic risk in Indian children with growth hormone deficiency
    • 24066645
    • Khadilkar V, Ekbote V, Kajale N, Khadilkar A, Chiplonkar S, Kinare A (2014) Effect of one-year growth hormone therapy on body composition and cardio-metabolic risk in Indian children with growth hormone deficiency. Endocr Res 39(2):73-78
    • (2014) Endocr Res , vol.39 , Issue.2 , pp. 73-78
    • Khadilkar, V.1    Ekbote, V.2    Kajale, N.3    Khadilkar, A.4    Chiplonkar, S.5    Kinare, A.6
  • 28
    • 84870821096 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks' gestation and preeclampsia: a case-control study
    • 1:CAS:528:DC%2BC38XhvVSmt7%2FL 22158463
    • Khalil AA, Tsikas D, Akolekar R, Jordan J, Nicolaides KH (2013) Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks' gestation and preeclampsia: a case-control study. J Hum Hypertens 27:38-43
    • (2013) J Hum Hypertens , vol.27 , pp. 38-43
    • Khalil, A.A.1    Tsikas, D.2    Akolekar, R.3    Jordan, J.4    Nicolaides, K.H.5
  • 29
    • 34547901364 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) - a modulator of nociception in opiate tolerance and addiction?
    • 2025594 1:CAS:528:DC%2BD2sXpt1Sisb0%3D 17625935
    • Kielstein A, Tsikas D, Galloway GP, Mendelson JE (2007) Asymmetric dimethylarginine (ADMA) - a modulator of nociception in opiate tolerance and addiction? Nitric Oxide 17:55-59
    • (2007) Nitric Oxide , vol.17 , pp. 55-59
    • Kielstein, A.1    Tsikas, D.2    Galloway, G.P.3    Mendelson, J.E.4
  • 30
    • 0027935871 scopus 로고
    • Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin
    • 1:CAS:528:DyaK2cXmsVOisrc%3D
    • Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, Rosén T, Lindstedt G, Lundberg PA, Bengtsson BA (1994) Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol (Oxf) 41:351-357
    • (1994) Clin Endocrinol (Oxf) , vol.41 , pp. 351-357
    • Landin-Wilhelmsen, K.1    Wilhelmsen, L.2    Lappas, G.3    Rosén, T.4    Lindstedt, G.5    Lundberg, P.A.6    Bengtsson, B.A.7
  • 31
    • 38849160036 scopus 로고    scopus 로고
    • Effects of normalization of plasma testosterone evels in hypogonadal men on plasma levels and urinary excretion of asymmetric dimethylarginine (ADMA)
    • 1:CAS:528:DC%2BD1cXjt1Gjt70%3D 18176911
    • Leifke E, Kinzel M, Tsikas D, Gooren L, Frölich JC, Brabant G (2008) Effects of normalization of plasma testosterone evels in hypogonadal men on plasma levels and urinary excretion of asymmetric dimethylarginine (ADMA). Horm Metab Res 40:56-59
    • (2008) Horm Metab Res , vol.40 , pp. 56-59
    • Leifke, E.1    Kinzel, M.2    Tsikas, D.3    Gooren, L.4    Frölich, J.C.5    Brabant, G.6
  • 32
    • 33344456589 scopus 로고    scopus 로고
    • The synthesis and metabolism of asymmetric dimethylarginine (ADMA)
    • Leiper M, Vallance P (2006) The synthesis and metabolism of asymmetric dimethylarginine (ADMA). Eur J Clin Pharmacol 62:33-38
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 33-38
    • Leiper, M.1    Vallance, P.2
  • 33
    • 42049086543 scopus 로고    scopus 로고
    • Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I
    • 2291494 1:CAS:528:DC%2BD1cXks1ags74%3D 18182451
    • Li G, Del Rincon JP, Jahn LA, Wu Y, Gaylinn B, Thorner MO, Liu Z (2008) Growth hormone exerts acute vascular effects independent of systemic or muscle insulin-like growth factor I. J Clin Endocrinol Metab 93:1379-1385
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1379-1385
    • Li, G.1    Del Rincon, J.P.2    Jahn, L.A.3    Wu, Y.4    Gaylinn, B.5    Thorner, M.O.6    Liu, Z.7
  • 35
    • 35648966680 scopus 로고    scopus 로고
    • Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia
    • 17142130
    • Lücke T, Tsikas D, Kanzelmeyer N, Vaske B, Das AM (2006) Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia. Metabolism 55:1599-1603
    • (2006) Metabolism , vol.55 , pp. 1599-1603
    • Lücke, T.1    Tsikas, D.2    Kanzelmeyer, N.3    Vaske, B.4    Das, A.M.5
  • 36
    • 35648988113 scopus 로고    scopus 로고
    • Developmental changes in the l-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age
    • 17892438
    • Lücke T, Kanzelmeyer N, Kemper MJ, Tsikas D, Das AM (2007) Developmental changes in the l-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age. Clin Chem Lab Med 45:1525-1530
    • (2007) Clin Chem Lab Med , vol.45 , pp. 1525-1530
    • Lücke, T.1    Kanzelmeyer, N.2    Kemper, M.J.3    Tsikas, D.4    Das, A.M.5
  • 37
    • 44449115611 scopus 로고    scopus 로고
    • Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal semental glomerulosclerosis (FSGS)
    • 18175783
    • Lücke T, Kanzelmeyer N, Chobanyan K, Tsikas D, Franke D, Kemper MJ, Ehrich JHH, Das AM (2008) Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal semental glomerulosclerosis (FSGS). Nephrol Dial Transplant 23:734-740
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 734-740
    • Lücke, T.1    Kanzelmeyer, N.2    Chobanyan, K.3    Tsikas, D.4    Franke, D.5    Kemper, M.J.6    Ehrich, J.H.H.7    Das, A.M.8
  • 39
    • 0032555182 scopus 로고    scopus 로고
    • Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N omega- hydroxy derivatives, and N omega-hydroxynor-l-arginine
    • 1:CAS:528:DyaK1cXktFKqtLg%3D 9671515
    • Moali C, Boucher JL, Sari MA, Stuehr DJ, Mansuy D (1998) Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N omega- hydroxy derivatives, and N omega-hydroxynor-l-arginine. Biochemistry 37:10453-10460
    • (1998) Biochemistry , vol.37 , pp. 10453-10460
    • Moali, C.1    Boucher, J.L.2    Sari, M.A.3    Stuehr, D.J.4    Mansuy, D.5
  • 41
    • 79954637472 scopus 로고    scopus 로고
    • Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography
    • 1:CAS:528:DC%2BC3MXjvVOjsLo%3D 21311067
    • Pilz S, Tomaschitz A, Meinitzer A, Drechsler C, Ritz E, Krane V, Wanner C, Böhm BO, März W (2011a) Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography. Stroke 42:1132-1134
    • (2011) Stroke , vol.42 , pp. 1132-1134
    • Pilz, S.1    Tomaschitz, A.2    Meinitzer, A.3    Drechsler, C.4    Ritz, E.5    Krane, V.6    Wanner, C.7    Böhm, B.O.8    März, W.9
  • 46
    • 0025333249 scopus 로고
    • Premature mortality due to cardiovascular disease in hypopituitarism
    • 1:STN:280:DyaK3czjtFGltg%3D%3D 1973979
    • Rosen T, Bengtsson BA (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336(8710):285-288
    • (1990) Lancet , vol.336 , Issue.8710 , pp. 285-288
    • Rosen, T.1    Bengtsson, B.A.2
  • 47
    • 0024358177 scopus 로고
    • Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH- deficient children
    • 1:STN:280:DyaK3c%2Fmt1CgsQ%3D%3D 2685009
    • Rosenbaum M, Gernter JM, Leiber RL (1989) Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH- deficient children. J Clin Endocrinol Metab 69:1274-1281
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 1274-1281
    • Rosenbaum, M.1    Gernter, J.M.2    Leiber, R.L.3
  • 49
    • 55649091391 scopus 로고    scopus 로고
    • Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency
    • 1:CAS:528:DC%2BD1cXhtlyktr%2FF 19013291
    • Setola E, Monti LD, Lanzi R, Lucotti P, Losa M, Gatti E, Galluccio E, Oldani M, Fermo I, Giovannelli M, Bosi E, Piatti PM (2008) Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency. Metabolism 57:1685-1690
    • (2008) Metabolism , vol.57 , pp. 1685-1690
    • Setola, E.1    Monti, L.D.2    Lanzi, R.3    Lucotti, P.4    Losa, M.5    Gatti, E.6    Galluccio, E.7    Oldani, M.8    Fermo, I.9    Giovannelli, M.10    Bosi, E.11    Piatti, P.M.12
  • 50
    • 35948952794 scopus 로고    scopus 로고
    • Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    • 1:CAS:528:DC%2BD2sXhtlartbzN 17726074
    • Thum T, Fleissner F, Klink I, Tsikas D, Jakob M, Bauersachs J, Stichtenoth DO (2007) Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I. J Clin Endocrinol Metab 92:4172-4179
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4172-4179
    • Thum, T.1    Fleissner, F.2    Klink, I.3    Tsikas, D.4    Jakob, M.5    Bauersachs, J.6    Stichtenoth, D.O.7
  • 52
    • 67650112830 scopus 로고    scopus 로고
    • De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards
    • 1:CAS:528:DC%2BD1MXoslehurY%3D 19168404
    • Tsikas D (2009) De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards. J Chromatogr B Analyt Technol Biomed Life Sci 877(23):2308-2320
    • (2009) J Chromatogr B Analyt Technol Biomed Life Sci , vol.877 , Issue.23 , pp. 2308-2320
    • Tsikas, D.1
  • 53
    • 84904994046 scopus 로고    scopus 로고
    • Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system?
    • 24931514
    • Tsikas D, Kayacelebi AA (2014) Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system? Circ J 78(8):2094-2095
    • (2014) Circ J , vol.78 , Issue.8 , pp. 2094-2095
    • Tsikas, D.1    Kayacelebi, A.A.2
  • 54
    • 0242412270 scopus 로고    scopus 로고
    • Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectometry as methyl ester tri(N- pentrafluoropropionyl) derivate
    • 1:CAS:528:DC%2BD3sXptVegu7Y%3D 14630363
    • Tsikas D, Schubert B, Grutzki FM, Sandmann J, Frölich JC (2003) Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectometry as methyl ester tri(N- pentrafluoropropionyl) derivate. J Chromatogr B Analyt Technol Biomed Life Sci 798:87-99
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.798 , pp. 87-99
    • Tsikas, D.1    Schubert, B.2    Grutzki, F.M.3    Sandmann, J.4    Frölich, J.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.