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Volumn 47, Issue 9, 2015, Pages 2023-2034

Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC-MS and GC-MS/MS

Author keywords

GC MS; GC MS MS; Guanidino compounds; Plasma; Protocols; Quantification; Saliva; Stable isotope; Urine

Indexed keywords

AMINO ACID; ARGININE; HOMOARGININE; ORNITHINE;

EID: 84940460091     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-1984-3     Document Type: Article
Times cited : (20)

References (35)
  • 1
    • 79960564903 scopus 로고    scopus 로고
    • Stable isotope dilution assay for liquid chromatography-tandem mass spectrometric determination of l-homoarginine in human plasma
    • 1:CAS:528:DC%2BC3MXptleltbg%3D
    • Atzler D, Mieth M, Maas R, Böger RH, Schwedhelm E (2011) Stable isotope dilution assay for liquid chromatography-tandem mass spectrometric determination of l-homoarginine in human plasma. J Chromatogr B 879:2294-2298
    • (2011) J Chromatogr B , vol.879 , pp. 2294-2298
    • Atzler, D.1    Mieth, M.2    Maas, R.3    Böger, R.H.4    Schwedhelm, E.5
  • 2
    • 55749095687 scopus 로고    scopus 로고
    • The l-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: Biological and analytical ramifications
    • 1:CAS:528:DC%2BD1cXhsVSjs7bM 18948222
    • Becker T, Mevius I, de Vries DK, Schaapherder AF, zu Vilsendorf AM, Klempnauer J, Frölich JC, Tsikas D (2009) The l-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications. Nitric Oxide 20:61-67
    • (2009) Nitric Oxide , vol.20 , pp. 61-67
    • Becker, T.1    Mevius, I.2    De Vries, D.K.3    Schaapherder, A.F.4    Zu Vilsendorf, A.M.5    Klempnauer, J.6    Frölich, J.C.7    Tsikas, D.8
  • 3
    • 36148933356 scopus 로고    scopus 로고
    • Sensitivity enhancement of a GC-MS/MS method for asymmetric dimethylarginine (ADMA) by plasma ultrafiltrate reduction
    • 1:CAS:528:DC%2BD2sXhtlGjtbzL 17950239
    • Beckmann B, Gutzki FM, Tsikas D (2008) Sensitivity enhancement of a GC-MS/MS method for asymmetric dimethylarginine (ADMA) by plasma ultrafiltrate reduction. Anal Biochem 372:264-266
    • (2008) Anal Biochem , vol.372 , pp. 264-266
    • Beckmann, B.1    Gutzki, F.M.2    Tsikas, D.3
  • 5
    • 84867579062 scopus 로고    scopus 로고
    • Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine
    • 1:CAS:528:DC%2BC38XhtlCjt7bF 23010440
    • Davids M, Ndika JD, Salomons GS, Blom HJ, Teerlink T (2012a) Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. FEBS Lett 586:3653-3657
    • (2012) FEBS Lett , vol.586 , pp. 3653-3657
    • Davids, M.1    Ndika, J.D.2    Salomons, G.S.3    Blom, H.J.4    Teerlink, T.5
  • 6
    • 84862762069 scopus 로고    scopus 로고
    • Simultaneous determination of asymmetric and symmetric dimethylarginine, l-monomethylarginine, l-arginine, and l-homoarginine in biological samples using stable isotope dilution liquid chromatography tandem mass spectrometry
    • 1:CAS:528:DC%2BC38XpsV2ntL4%3D
    • Davids M, Swieringa E, Palm F, Smith DE, Smulders YM, Scheffer PG, Blom HJ, Teerlink T (2012b) Simultaneous determination of asymmetric and symmetric dimethylarginine, l-monomethylarginine, l-arginine, and l-homoarginine in biological samples using stable isotope dilution liquid chromatography tandem mass spectrometry. J Chromatogr B 900:38-47
    • (2012) J Chromatogr B , vol.900 , pp. 38-47
    • Davids, M.1    Swieringa, E.2    Palm, F.3    Smith, D.E.4    Smulders, Y.M.5    Scheffer, P.G.6    Blom, H.J.7    Teerlink, T.8
  • 8
    • 34248220464 scopus 로고    scopus 로고
    • An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: Methodological considerations
    • 1:CAS:528:DC%2BD2sXlt1aktbg%3D
    • Horowitz JD, Heresztyn T (2007) An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: methodological considerations. J Chromatogr B 851:42-50
    • (2007) J Chromatogr B , vol.851 , pp. 42-50
    • Horowitz, J.D.1    Heresztyn, T.2
  • 9
    • 84908208988 scopus 로고    scopus 로고
    • Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: Is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?
    • 25175517
    • Kayacelebi AA, Pham VV, Willers J, Hahn A, Stichtenoth DO, Jordan J, Tsikas D (2014a) Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA? Int J Cardiol 176:1129-1131
    • (2014) Int J Cardiol , vol.176 , pp. 1129-1131
    • Kayacelebi, A.A.1    Pham, V.V.2    Willers, J.3    Hahn, A.4    Stichtenoth, D.O.5    Jordan, J.6    Tsikas, D.7
  • 10
    • 84906315693 scopus 로고    scopus 로고
    • GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples
    • 1:CAS:528:DC%2BC2cXpvVeju7Y%3D 24923265
    • Kayacelebi AA, Beckmann B, Gutzki FM, Jordan J, Tsikas D (2014b) GC-MS and GC-MS/MS measurement of the cardiovascular risk factor homoarginine in biological samples. Amino Acids 46:2205-2217
    • (2014) Amino Acids , vol.46 , pp. 2205-2217
    • Kayacelebi, A.A.1    Beckmann, B.2    Gutzki, F.M.3    Jordan, J.4    Tsikas, D.5
  • 11
    • 84870821096 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks' gestation and preeclampsia: A case-control study
    • 1:CAS:528:DC%2BC38XhvVSmt7%2FL 22158463
    • Khalil AA, Tsikas D, Akolekar R, Jordan J, Nicolaides KH (2013) Asymmetric dimethylarginine, arginine and homoarginine at 11-13 weeks' gestation and preeclampsia: a case-control study. J Hum Hypertens 27:38-43
    • (2013) J Hum Hypertens , vol.27 , pp. 38-43
    • Khalil, A.A.1    Tsikas, D.2    Akolekar, R.3    Jordan, J.4    Nicolaides, K.H.5
  • 12
    • 0033566683 scopus 로고    scopus 로고
    • Biological significance of endogenous methylarginines that inhibit nitric oxide synthases
    • 1:CAS:528:DyaK1MXlslCks78%3D 10690326
    • Leiper J, Vallance P (1999) Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res 43:542-548
    • (1999) Cardiovasc Res , vol.43 , pp. 542-548
    • Leiper, J.1    Vallance, P.2
  • 13
    • 84903514514 scopus 로고    scopus 로고
    • Mass spectrometric quantification of l-arginine and its pathway related substances in biofluids: The road to maturity
    • 1:CAS:528:DC%2BC3sXhslCltrjN
    • Martens-Lobenhoffer J, Bode-Böher SM (2014) Mass spectrometric quantification of l-arginine and its pathway related substances in biofluids: the road to maturity. J Chromatogr B 964:89-102
    • (2014) J Chromatogr B , vol.964 , pp. 89-102
    • Martens-Lobenhoffer, J.1    Bode-Böher, S.M.2
  • 15
    • 0032555182 scopus 로고    scopus 로고
    • Substrate specificity of NO synthases: Detailed comparison of l-arginine, homo-l-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-l-arginine
    • 1:CAS:528:DyaK1cXktFKqtLg%3D 9671515
    • Moali C, Boucher JL, Sari MA, Stuehr DJ, Mansuy D (1998) Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-l-arginine. Biochemistry 37:10453-10460
    • (1998) Biochemistry , vol.37 , pp. 10453-10460
    • Moali, C.1    Boucher, J.L.2    Sari, M.A.3    Stuehr, D.J.4    Mansuy, D.5
  • 16
    • 0034682557 scopus 로고    scopus 로고
    • Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants
    • 1:CAS:528:DC%2BD3cXjvFKqsb8%3D 10889028
    • Moali C, Brollo M, Custot J, Sari MA, Boucher JL, Stuehr DJ, Mansuy D (2000) Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants. Biochemistry 39:8208-8218
    • (2000) Biochemistry , vol.39 , pp. 8208-8218
    • Moali, C.1    Brollo, M.2    Custot, J.3    Sari, M.A.4    Boucher, J.L.5    Stuehr, D.J.6    Mansuy, D.7
  • 17
    • 0027752805 scopus 로고
    • The l-arginine-nitric oxide pathway
    • 1:CAS:528:DyaK2cXhsF2ntrw%3D 7504210
    • Moncada S, Higgs A (1993) The l-arginine-nitric oxide pathway. N Engl J Med 329:2002-2012
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 18
    • 79954637472 scopus 로고    scopus 로고
    • Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography
    • 1:CAS:528:DC%2BC3MXjvVOjsLo%3D 21311067
    • Pilz S, Tomaschitz A, Meinitzer A, Drechsler C, Ritz E, Krane V, Wanner C, Bohm BO, März W (2011) Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography. Stroke 42:1132-1134
    • (2011) Stroke , vol.42 , pp. 1132-1134
    • Pilz, S.1    Tomaschitz, A.2    Meinitzer, A.3    Drechsler, C.4    Ritz, E.5    Krane, V.6    Wanner, C.7    Bohm, B.O.8    März, W.9
  • 19
    • 0343811639 scopus 로고
    • Homocitrulline and homoarginine synthesis from lysine
    • Ryan WL, Wells IC (1964) Homocitrulline and homoarginine synthesis from lysine. Science 3622:1122-1127
    • (1964) Science , vol.3622 , pp. 1122-1127
    • Ryan, W.L.1    Wells, I.C.2
  • 20
    • 0014515841 scopus 로고
    • Homoarginine synthesis by rat kidney
    • 1:CAS:528:DyaF1MXktVWgsbg%3D 5787221
    • Ryan WL, Johnson RJ, Dimari S (1969) Homoarginine synthesis by rat kidney. Arch Biochem Biophys 131:521-526
    • (1969) Arch Biochem Biophys , vol.131 , pp. 521-526
    • Ryan, W.L.1    Johnson, R.J.2    Dimari, S.3
  • 21
    • 27744550486 scopus 로고    scopus 로고
    • Quantification of ADMA: Analytical approaches
    • 16444874
    • Schwedhelm E (2005) Quantification of ADMA: analytical approaches. Vasc Med 10(Suppl 1):S89-S95
    • (2005) Vasc Med , vol.10 , pp. S89-S95
    • Schwedhelm, E.1
  • 22
    • 34248190179 scopus 로고    scopus 로고
    • High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma
    • 1:CAS:528:DC%2BD2sXlt1aktLs%3D
    • Schwedhelm E, Maas R, Tan-Andresen J, Schulze F, Riederer U, Boger RH (2007) High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma. J Chromatogr B 851:211-219
    • (2007) J Chromatogr B , vol.851 , pp. 211-219
    • Schwedhelm, E.1    Maas, R.2    Tan-Andresen, J.3    Schulze, F.4    Riederer, U.5    Boger, R.H.6
  • 23
    • 84899623176 scopus 로고    scopus 로고
    • Tobacco smoking decreases plasma concentration of the emerging cardiovascular risk marker, l-homoarginine
    • 1:CAS:528:DC%2BC2cXhtVagsrnF 24583919
    • Sobczak A, Prokopowicz A, Radek M, Szula M, Zaciera M, Kurek J, Goniewicz ML (2014) Tobacco smoking decreases plasma concentration of the emerging cardiovascular risk marker, l-homoarginine. Circ J 78:1254-1258
    • (2014) Circ J , vol.78 , pp. 1254-1258
    • Sobczak, A.1    Prokopowicz, A.2    Radek, M.3    Szula, M.4    Zaciera, M.5    Kurek, J.6    Goniewicz, M.L.7
  • 25
    • 34248189154 scopus 로고    scopus 로고
    • HPLC analysis of ADMA and other methylated l-arginine analogs in biological fluids
    • 1:CAS:528:DC%2BD2sXlt1aktLo%3D
    • Teerlink T (2007) HPLC analysis of ADMA and other methylated l-arginine analogs in biological fluids. J Chromatogr B 851:21-29
    • (2007) J Chromatogr B , vol.851 , pp. 21-29
    • Teerlink, T.1
  • 26
    • 0034282976 scopus 로고    scopus 로고
    • Simultaneous derivatization and quantification of the nitric oxide metabolites nitrite and nitrate in biological fluids by gas chromatography/mass spectrometry
    • 1:CAS:528:DC%2BD3cXkvV2murY%3D 10994966
    • Tsikas D (2000) Simultaneous derivatization and quantification of the nitric oxide metabolites nitrite and nitrate in biological fluids by gas chromatography/mass spectrometry. Anal Chem 72:4064-4072
    • (2000) Anal Chem , vol.72 , pp. 4064-4072
    • Tsikas, D.1
  • 27
    • 4444375898 scopus 로고    scopus 로고
    • Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD2cXmsVOjurY%3D 15199238
    • Tsikas D (2004) Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry. Methods Mol Biol 279:81-103
    • (2004) Methods Mol Biol , vol.279 , pp. 81-103
    • Tsikas, D.1
  • 28
    • 45849096877 scopus 로고    scopus 로고
    • A critical review and discussion of analytical methods in the l-arginine/nitric oxide area of basic and clinical research
    • 1:CAS:528:DC%2BD1cXnvVKjt7k%3D 18510938
    • Tsikas D (2008a) A critical review and discussion of analytical methods in the l-arginine/nitric oxide area of basic and clinical research. Anal Biochem 379:139-163
    • (2008) Anal Biochem , vol.379 , pp. 139-163
    • Tsikas, D.1
  • 29
    • 55749112881 scopus 로고    scopus 로고
    • Determination of asymmetric dimethylarginine in biological fluids: A paradigm for a successful analytical story
    • 1:CAS:528:DC%2BD1cXpsVCqtbs%3D
    • Tsikas D (2008b) Determination of asymmetric dimethylarginine in biological fluids: a paradigm for a successful analytical story. Curr Opin Clin Nutr Metabol Care 11:592-600
    • (2008) Curr Opin Clin Nutr Metabol Care , vol.11 , pp. 592-600
    • Tsikas, D.1
  • 30
    • 67650112830 scopus 로고    scopus 로고
    • De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: Standardization, validation, comparison and proof of evidence for their aptitude as internal standards
    • 1:CAS:528:DC%2BD1MXoslehurY%3D
    • Tsikas D (2009) De novo synthesis of trideuteromethyl esters of amino acids for use in GC-MS and GC-tandem MS exemplified for ADMA in human plasma and urine: standardization, validation, comparison and proof of evidence for their aptitude as internal standards. J Chromatogr B 877:2308-2320
    • (2009) J Chromatogr B , vol.877 , pp. 2308-2320
    • Tsikas, D.1
  • 31
    • 84904994046 scopus 로고    scopus 로고
    • Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system?
    • 24931514
    • Tsikas D, Kayacelebi AA (2014) Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system? Circ J 78:2094-2095
    • (2014) Circ J , vol.78 , pp. 2094-2095
    • Tsikas, D.1    Kayacelebi, A.A.2
  • 32
    • 0242412270 scopus 로고    scopus 로고
    • Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative
    • 1:CAS:528:DC%2BD3sXptVegu7Y%3D
    • Tsikas D, Schubert B, Gutzki FM, Sandmann J, Frölich JC (2003) Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative. J Chromatogr B 798:87-99
    • (2003) J Chromatogr B , vol.798 , pp. 87-99
    • Tsikas, D.1    Schubert, B.2    Gutzki, F.M.3    Sandmann, J.4    Frölich, J.C.5
  • 33
    • 79953723439 scopus 로고    scopus 로고
    • Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine
    • 1:CAS:528:DC%2BC3MXkt1WrtLw%3D 21303648
    • Tsikas D, Beckmann B, Gutzki FM, Jordan J (2011) Simultaneous gas chromatography-tandem mass spectrometry quantification of symmetric and asymmetric dimethylarginine in human urine. Anal Biochem 413:60-62
    • (2011) Anal Biochem , vol.413 , pp. 60-62
    • Tsikas, D.1    Beckmann, B.2    Gutzki, F.M.3    Jordan, J.4


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