Asymmetric dimethylarginine (ADMA): An endogenous inhibitor of angiogenesis

European Journal of Clinical Pharmacology

Volumn 62, Issue 1, 2006, Pages 115-121

  Cooke, John P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dimethylarginine dimethylaminohydrolase; Hypercholesterolemia; Nitric oxide synthase

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIOXIDANT; ARGININE; DIMETHYLARGININASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TETRAHYDROBIOPTERIN; VASCULOTROPIN; FIBROBLAST GROWTH FACTOR;

ANGIOGENESIS; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR RISK; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERHOMOCYSTEINEMIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SYNTHESIS; ATHEROGENESIS; BONE MARROW CELL; CARDIOVASCULAR DISEASE; CELL INTERACTION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; COMPETITIVE INHIBITION; DISEASE ASSOCIATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENETIC ASSOCIATION; PLEIOTROPY; PROTEIN EXPRESSION; STEM CELL MOBILIZATION;

EID: 33344473316     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-005-0005-y     Document Type: Conference Paper

References (62)

1. Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407:249-257
2. Hood JD, Meininger CJ, Ziche M, Granger HJ (1998) VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells. Am J Physiol 274(3 Pt2):H1054-H1058
3. van der Zee R, Murohara T, Luo Z, Zollmann F, Passeri J, Lekutat C, Isner JM (1997) Vascular endothelial growth factor/ vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95:1030-1037
4. Inoue N, Venema RC, Sayegh HS, Ohara Y, Murphy TJ, Harrison DG (1995) Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor-beta 1. Arterioscler Thromb Vasc Biol 15:1255-1261
5. Wu HM, Yuan Y, McCarthy M, Granger HJ (1996) Acidic and basic FGFs dilate arterioles of skeletal muscle through a NO-dependent mechanism. Am J Physiol 271(3 Pt2):H1087-H1093
6. Tiefenbacher CP, Chilian WM (1997) Basic fibroblast growth factor and heparin influence coronary arteriolar tone by causing endothelium dependent dilation. Cardiovasc Res 34:411-417
7. Babaei S, Teichert-Kuliszewska K, Monge JC, Mohamed F, Bendeck MP, Stewart DJ (1998) Role of nitric oxide in the angiogenic response in vitro to basic fibroblast growth factor. Circ Res 82:1007-1015
8. Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC (1997) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 100:3131-3139
9. Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, Garcia-Cardena G, Madri JA, Sessa WC (1997) Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. Am J Pathol 150:1835-1844
10. Ziche M, Morbidelli L, Masini E, Amerini S, Granger HJ, Maggi CA, Geppetti P, Ledda F (1994) Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 94:2036-2044
11. Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99:2625-2634
12. Dimmeler S, Hermann C, Galle J, Zeiher AM (1999) Up-regulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis- suppressive effects of shear stress on endothelial cells. Arterioscler Thromb Vasc Biol 19:656-664
13. Rossig L, Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Mulsch A, Dimmeler S (1999) Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem 274:6823-6826
14. Morbidelli L, Chang CH, Douglas JG, Granger HJ, Ledda F, Ziche M (1996) Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 270(1 Pt 2):H411-H415
15. Ziche M, Parenti A, Ledda F, Dell'Era P, Granger HJ, Maggi CA, Presta M (1997) Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF. Circ Res 80:845-852
16. Murohara T, Witzenbichler B, Spyridopoulos I, Asahara T, Ding B, Sullivan A, Losordo DW, Isner JM (1999) Role of endothelial nitric oxide synthase in endothelial cell migration. Arterioscler Thromb Vasc Biol 19:1156-1161
17. Noiri E, Lee E, Testa J, Quigley J, Colflesh D, Keese CR, Giaever I, Goligorsky MS (1998) Podokinesis in endothelial cell migration: role of nitric oxide. Am J Physiol 274(1 Pt 1): C236-C244
18. Ho H-KV, Jang JJ, Kaji S, Spektor G, Fong A, Yang P, Hu RS, Schatzman R, Quertermous T, Cooke JP (2004) Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. Circulation 109:1314-1319
19. Hudlicka O (1998) Is physiological angiogenesis in skeletal muscle regulated by changes in microcirculation? Microcirculation 5:7-23
20. Dulak J, Jozkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, Wojtowicz A, Szuba A, Cooke JP (2000) Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20:659-666
21. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM, Dimmeler S (2003) Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 9:1370-1376
22. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T (2003) Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348:593-600
23. Cooke JP, Dzau VJ (1997) Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48:489-509
24. Chen CH, Cartwright J Jr, Li Z, Lou S, Nguyen NH, Gotto AM Jr, Henry PD (1997) Inhibitory effects of hypercholesterolemia and ox-LDL on angiogenesis-like endothelial growth in rabbit aortic explants. Essential role of fibroblast growth factor. Arterioscler Thromb Vasc Biol 17:1303-1312
25. Chen CH, Henry PD (1997) Atherosclerosis as a microvascular disease: impaired angiogenesis mediated by suppressed basic fibroblast growth factor expression. Proc Assoc Am Physicians 109:351-361
26. Simon BC, Cunningham LD, Cohen RA (1990) Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery. J Clin Invest 86:75-79
27. Van Belle E, Rivard A, Chen D, Silver M, Bunting S, Ferrara N, Symes JF, Bauters C, Isner JM (1997) Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation 96:2667-2674
28. Murohara T, Asahara T, Silver M, Bauters C, Masuda H, Kalka C, Kearney M, Chen D, Symes JF, Fishman MC, Huang PL, Isner JM (1998) Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest 10:2567-2578
29. Ohara Y, Petersen TE, Harrison DG (1993) Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91:2546-2551
30. Rubanyi GM, Vanhoutte PM (1986) Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol 250(5 Pt 2):H822-H827
31. Beckman JS, Koppenol WH (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol 271:C1424-C1437
32. Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM (1992) Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem 267:24173-24176
33. Stroes E, Kastelein J, Cosentino F, Erkelens W, Wever R, Koomans H, Luscher T, Rabelink T (1997) Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 99:41-46
34. Xia Y, Tsai AL, Berka V, Zweier JL (1998) Superoxide generation from endothelial nitric-oxide synthase: a Ca2+/cal-modulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem 273:25804-25808
35. Kirkwood AP Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB (1995) Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res 77:510-518
36. Vasquez-Vivar J, Kalyanaraman B, Martasek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr (1998) Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. Proc Natl Acad Sci U S A 95:9220-9225
37. Huang A, Vita JA, Venema RC, Keaney J (2000) Ascorbic acid enhances endothelial nitric oxide synthase activity by increasing intracellular tetrahydrobiopterin. J Biol Chem 275:17399-17406
38. Oemar BS, Tschudi MR, Godoy N, Brovkovich V, Malinski T, Luscher TF (1998) Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis. Circulation 97:2494-2498
39. Liao JK, Shin WS, Lee WY, Clark SL (1995) Oxidized low-density lipoprotein decreases the expression of endothelial nitric oxide synthase. J Biol Chem 270:319-324
40. Lee J, Ryu H, Ferrante RJ, Morris SM, Ratan RR (2003) Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A 100:4843-4848
41. Vallance P, Leone A, Calver A, Collier J, Moncada S (1992) Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 20(Suppl 12):S60-S62
42. Bode-Böger SM, Böger RH, Kienke S, Junker W, Frölich JC (1996) Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Commun 219:598-603
43. Böger RH, Bode-Böger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP (1998) Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia. Circulation 98: 1842-1847
44. Fajardo LF, Kowalski J, Kwan HH, Prionas SD, Allison AC (1988) Methods in laboratory investigation: the disc angiogen esis system. Lab Invest 58:718-724
45. Kowalski J, Kwan HH, Prionas SD, Allison AC, Fajardo LF (1992) Characterization and applications of the disc angiogenesis system. Exp Mol Pathol 56:1-19
46. Jang J, Ho H-K, Kwan HH, Adimoolam S, Fajardo LF, Cooke JP (2000) Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Circulation 102:1414-1419
47. Chan JR, Böger RH, Bode-Böger SM, Tangphao O, Tsao P, Blaschke TF, Cooke JP (2000) Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Arterioscler Thromb Vasc Biol 20:1040-1046
48. Lundman P, Eriksson MJ, Stuhlinger M, Cooke JP, Hamsten H, Tornvall P (2001) Mild to moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine. J Am Coll Cardiol 38:111-116
49. Abbasi F, Asagmi T, Cooke JP, Lamendola C, McLaughlin T, Reaven GM, Stuehlinger M, Tsao PS (2001) Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Am J Cardiol 88:1201-1203
50. Stuhlinger MC, Abbasi F, Chu JW, Lamendola C, McLaughlin TL, Cooke JP, Reaven GM, Tsao PS (2002) Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA 287:1420-1426
51. Asagami T, Abbasi F, Stuehlinger M, Lamendola C, McLaughlin T, Cooke JP, Reaven GM, Tsao PS (2002) Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes. Metabolism 51:843-846
52. Stuhlinger MC, Oka RK, Graf EE, Schmolzer I, Upson BM, Kapoor O, Szuba A, Malinow MR, Wascher TC, Pachinger O, Cooke JP (2003) Endothelial dysfunction induced by hyperhomocysteinemia: role of ADMA. Circulation 108:933-938
53. Weis M, Kledal TN, Lin KY, Panchal SN, Gao SZ, Valantine HA, Mocarski ES, Cooke JP (2004) Cytomegalovirus infection impairs the NOS pathway. Role of ADMA in transplant arteriosclerosis. Circulation 109:500-505
54. MacAllister RJ, Fickling SA, Whitley GSJ, Vallance P (1994) Metabolism of methylarginines by human vasculature: implications for the regulation of nitric oxide synthesis. Br J Pharmacol 112:43-48
55. MacAllister RJ, Parry H, Kimoto M, Ogawa T, Russell RJ, Hodson H, Whitley GS, Vallance P (1996) Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol 119:1533-1540
56. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP (1999) A novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99:3092-3095
57. Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, Tsuji H, Reaven GM, Cooke JP (2002) Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 106:987-992
58. Stuhlinger MC, Tsao PS, Her J-H, Kimoto M, Balint RF, Cooke JP (2001) Homocysteine impairs the NO synthase pathway - role of asymmetric dimethylarginine. Circulation 104:2569-2575
59. Leiper J, Murray-Rust J, McDonald N, Vallance P (2002) S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A 99:13527-13532
60. Dayoub H, Achan V, Adimoolam S, Jacobi J, Stuehlinger M, Wang B, Tsao PS, Kimoto M, Vallance P, Patterson AJ, Cooke JP (2003) DDAH regulates NO synthesis: genetic and physiological evidence. Circulation 108:1043-1048
61. Kostourou V, Robinson SP, Whitley GS, Griffiths JR (2003) Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging. Cancer Res 63:4960-4966
62. Jacobi J, Sydow K, von Degenfeld G, Zhang Y, Dayoub H, Wang B, Patterson AJ, Kimoto M, Blau HM, Cooke JP (2005) Overexpression of dimethylarginine dimethylaminohydrolase (DDAH) reduces tissue ADMA levels and enhances angiogenesis. Circulation 111:1431-1438