Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II

Amino Acids

Volumn 43, Issue 2, 2012, Pages 805-811

  Chobanyan Jürgens, Kristine ^a   Fuchs, Anne Jule ^b   Tsikas, Dimitrios ^a   Kanzelmeyer, Nele ^a   Das, Anibh M ^a   Illsinger, Sabine ^a   Vaske, Bernhard ^a   Jordan, Jens ^a   Lücke, Thomas ^c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b University of Mayence   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

ADMA; Children; DDAH; DMA; Hypercholesterolemia; Nitric oxide

Indexed keywords

CREATININE; DIMETHYLAMINE; DIMETHYLARGININASE; HYPOCHOLESTEROLEMIC AGENT; N(G),N(G) DIMETHYLARGININE; NITRATE; NITRITE;

AGE; ARTICLE; BLOOD LEVEL; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HYPERLIPOPROTEINEMIA TYPE 2; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD; URINARY EXCRETION; URINE LEVEL;

ADOLESCENT; AMIDOHYDROLASES; ARGININE; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE; STATISTICS, NONPARAMETRIC;

EID: 84864778692     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1136-3     Document Type: Article

References (31)

1. Becker T, Mevius I, de Vries DK, Schaaherder AFM, Meyer zu Vilsendorf A, Klempnauer J, Frölich JC, Tsikas D (2009) The Larginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications. Nitric Oxide 20:61-67
2. Böger RH, Bode-Böger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP (1998) Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 98:1842-1847
3. Böger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Böger SM (2000) LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. Circ Res 87:99-105
4. Brooks ER, Langman CB, Wang S, Price HE, Hodges AL, Darling L, Yang AZ, Smith FA (2009) Methylated arginine derivatives in children and adolescents with chronic kidney disease. Pediatr Nephrol 24:129-134
5. Eid HM, Eritsland J, Larsen J, Arnesen H, Seljeflot I (2003) Increased levels of asymmetric dimethylarginine in populations at risk for atherosclerotic disease. Effects of pravastatin. Atherosclerosis 166:279-284
6. Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO 3rd, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR Jr, Feelisch M, Lundberg JO (2005) The emerging biology of the nitrite anion. Nat Chem Biol 1:308-314
7. Goonasekera CDA, Rees DD, Woolard P, Frend A, Shah V, Dillon MJ (1997) Nitric oxide synthase inhibitors and hypertension in children and adolescents. J Hypertens 15:901-909
8. Horowitz JD, Heresztyn T (2007) An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies. J Chromatogr B 851:42-50
9. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP (1999) Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 99:3092-3095
10. Jehlicka P, Stozicky F, Mayer OJR, Varvarovska J, Racek J, Trefil L, Siala K (2009) Asymmetric dimethylarginine an the effect of folat substitution in children with familial hypercholesterolemia and diabetes mellitus type 1. Physiol Res 58:179-184
11. Kanzelmeyer N, Tsikas D, Chobanyan-Jürgens K, Beckmann B, Vaske B, Illsinger S, Das AM, Lücke T (2011) Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria. Amino Acids. doi:10.1007/s00726-011- 0892
12. Leiper JM, Vallance P (2006) The synthesis and metabolism of asymmetric dimethylarginine (ADMA). Eur J Clin Pharmacol 62:33-38
13. Lu TM, Ding YA, Leu HB, Yin WH, Sheu WH, Chu KM (2004) Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol 94:157-161
14. Lücke T, Tsikas D, Kanzelmeyer N, Vaske B, Das AM (2006) Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in citrullinemia. Metabolism 55:1599-1603
15. Lücke T, Kanzelmeyer N, Kemper MJ, Tsikas D, Das AM (2007) Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age. Clin Chem Lab Med 45:1525-1530
16. Lücke T, Kanzelmeyer N, Chobanyan K, Tsikas D, Franke D, Kemper MJ, Ehrich JH, Das AM (2008) Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal segmental glomerulosclerosis (FSGS). Nephrol Dial Transplant 23:734-740
17. Nakamura T, Sato E, Fujiwara N, Kawagoe Y, Ueda Y, Suzuki T, Ueda S, Adachi H, Okuda S, Yamagishi S (2009) Ezetimibe decreases serum levels of asymmetric dimethylarginine (ADMA) and ameliorates renal injury in non-diabetic chronic kidney disease patients in a cholesterol-independent manner. Pharmacol Res 60:525-528
18. Nanayakkara PW, Kiefte-de Jong JC, ter Wee PM, Stehouwer CD, van Ittersum FJ, Olthof MR, Teerlink T, Twisk JW, van Guldener C, Smulders YM (2009) Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD. Am J Kidney Dis 53:41-50
19. Oguz A, Uzunlulu M (2008) Short term fluvastatin treatment lowers serum asymmetric dimethylarginine levels in patients with metabolic syndrome. Int Heart J 49:303-311
20. Palm M, Onozato ML, Luo Z, Wilcox CS (2007) Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 293:3227-3245
21. Surdacki A, Tsikas D, Mayatepek E, Frölich JC (2003) Elevated urinary excretion of nitric oxide metabolites in young infants with Zellweger syndrome. Clin Chim Acta 334:111-115
22. Tan B, Jiang DJ, Huang H, Jia SJ, Jiang JL, Hu CP, Li YJ (2007) Taurine protects against low-density lipoprotein-induced endothelial dysfunction by the DDAH/ADMA pathway. Vascul Pharmacol 46:338-345
23. Tsikas D (2000) Simultaneous derivatization and quantification of the nitric oxide metabolites nitrite and nitrate in biological fluids by gas-chromatography/mass spectrometry. Anal Chem 72:4064-4072
24. Tsikas D (2008a) A critical review and discussion of analytical methods in the L-arginine/nitric oxide (NO) area of basic and clinical research. Anal Biochem 379:139-163
25. Tsikas D (2008b) Determination of asymmetric dimethylarginine (ADMA) in biological fluids: a paradigm for a successful analytical story. Curr Opin Clin Nutr Metab Care 11:592-600
26. Tsikas D, Schubert B, Gutzki FM, Sandmann J, Frölich JC (2003) Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatographytandemmass spectrometry asmethyl ester tri (N-pentafluoropropionyl) derivative. J Chromatogr B 798:87-99
27. Tsikas D, Thum T, Becker T, Pham VV, Chobanyan K, Mitschke A, Beckmann B, Gutzki FM, Bauersachs J, Stichtenoth DO (2007) Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease. J Chromatogr B 851:229-239
28. Tsikas D, Schwarz A, Stichtenoth DO (2010) Simultaneous measurement of [15N]nitrate and [15N]nitrite enrichment and concentration in urine by gas chromatography mass spectrometry as pentafluorobenzyl derivatives. Anal Chem 82:2585-2587
29. Wolf C, Lorenzen JM, Stein S, Tsikas D, Störk S, Weidemann F, Ertl G, Anker S, Bauersachs J, Thum T (2011) Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease. Int J Cardiol. doi:10.1016/j.ijcard.2010.11.003
30. Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37:1-17
31. Wu G, Bazer FW, Davis TA, Kim SW, Li P, Rhoads JM, Satterfield MC, Smith SB, Spencer TE, Yin YL (2009) Arginine metabolism and nutrition in growth, health and disease. Amino Acids 37:153-168