Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage

FEBS Journal

Volumn 282, Issue 17, 2015, Pages 3438-3451

  Teranishi, Yasuhiro ^a,b   Inoue, Mitsuhiro ^a,b   Yamamoto, Natsuko Goto ^a,b   Kihara, Takahiro ^a,b   Wiehager, Birgitta ^a   Ishikawa, Taizo ^b   Winblad, Bengt ^a   Schedin Weiss, Sophia ^a   Frykman, Susanne ^a   Tjernberg, Lars O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Alzheimer's disease; amyloid peptide; Notch; proton myo inositol cotransporter; secretase

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CARRIER PROTEIN; GAMMA SECRETASE; GROWTH FACTOR RECEPTOR; NEUROTROPHIN 3; NOTCH RECEPTOR; PROTON MYO INOSITOL COTRANSPORTER; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; AMYLOID BETA PROTEIN[1-40]; ATP8A1 PROTEIN, MOUSE; CARBAMIC ACID DERIVATIVE; DIPEPTIDE; ENZYME INHIBITOR; GLUCOSE TRANSPORTER; INOSITOL; L 685458; PEPTIDE FRAGMENT; PHOSPHOLIPID TRANSFER PROTEIN; PROTEIN BINDING; PROTON; SECRETASE; SLC2A13 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PURIFICATION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS REGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN CHEMISTRY; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HIPPOCAMPUS; METABOLISM; MICROSOME; MOLECULAR GENETICS; NERVE CELL; PRIMARY CELL CULTURE; PROTEIN DEGRADATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATASES; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN CHEMISTRY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAMATES; DIPEPTIDES; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HIPPOCAMPUS; HUMANS; INOSITOL; MICE; MICROSOMES; MOLECULAR SEQUENCE ANNOTATION; NEURONS; PEPTIDE FRAGMENTS; PHOSPHOLIPID TRANSFER PROTEINS; PRIMARY CELL CULTURE; PROTEIN BINDING; PROTEIN STABILITY; PROTEOLYSIS; PROTONS; RECEPTORS, NOTCH; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84940721622     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13353     Document Type: Article

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