메뉴 건너뛰기




Volumn 47, Issue 9, 2015, Pages 1697-1702

Homoarginine, arginine, and relatives: analysis, metabolism, transport, physiology, and pathology

Author keywords

Adolescence; Adulthood; AGAT; Biomarker; Childhood; Disease; Health

Indexed keywords

6 N,N' DIMETHYLARGININE; ARGININE; HOMOARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE;

EID: 84940721445     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-2055-5     Document Type: Article
Times cited : (79)

References (49)
  • 2
    • 33344463613 scopus 로고    scopus 로고
    • Effect of arginine supplementation on NO production in man
    • Bode-Böger SM (2006) Effect of arginine supplementation on NO production in man. Eur J Clin Pharmacol 62:91-99
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 91-99
    • Bode-Böger, S.M.1
  • 4
    • 84884647487 scopus 로고    scopus 로고
    • Homoarginine levels are regulated by arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies
    • 1:CAS:528:DC%2BC3sXhsFartr3O 24004504
    • Choe CU, Atzler D, Wild PS, Carter AM, Boger RH, Ojeda F et al (2013) Homoarginine levels are regulated by arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Circulation 128:1451-1461
    • (2013) Circulation , vol.128 , pp. 1451-1461
    • Choe, C.U.1    Atzler, D.2    Wild, P.S.3    Carter, A.M.4    Boger, R.H.5    Ojeda, F.6
  • 5
    • 84940390231 scopus 로고    scopus 로고
    • Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application
    • Cordts K, Atzler D, Qaderi V, Sydow K, Böger RH, Choe CU, Schwedhelm E (2015) Measurement of homoarginine in human and mouse plasma by LC-MS/MS and ELISA: a comparison and a biological application. Amino Acids. doi: 10.1007/s00726-015-2037-7
    • (2015) Amino Acids
    • Cordts, K.1    Atzler, D.2    Qaderi, V.3    Sydow, K.4    Böger, R.H.5    Choe, C.U.6    Schwedhelm, E.7
  • 6
    • 84867579062 scopus 로고    scopus 로고
    • Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine
    • 1:CAS:528:DC%2BC38XhtlCjt7bF 23010440
    • Davids M, Ndika JD, Salomons GS, Blom HJ, Teerlink T (2012) Promiscuous activity of arginine:glycine amidinotransferase is responsible for the synthesis of the novel cardiovascular risk factor homoarginine. FEBS Lett 586:3653-3657
    • (2012) FEBS Lett , vol.586 , pp. 3653-3657
    • Davids, M.1    Ndika, J.D.2    Salomons, G.S.3    Blom, H.J.4    Teerlink, T.5
  • 7
    • 84940459735 scopus 로고    scopus 로고
    • Symmetric dimethylarginine (SDMA) serum levels in rheumatoid arthritis: correlations with insulin resistance and disease activity scores
    • 25772817
    • Dimitroulas T, Hodson J, Sandoo A, Smith J, Kitas GD (2015) Symmetric dimethylarginine (SDMA) serum levels in rheumatoid arthritis: correlations with insulin resistance and disease activity scores. Amino Acids. doi: 10.1007/s00726-015-1953-x
    • (2015) Amino Acids
    • Dimitroulas, T.1    Hodson, J.2    Sandoo, A.3    Smith, J.4    Kitas, G.D.5
  • 10
    • 84940460935 scopus 로고    scopus 로고
    • A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?
    • 25929585
    • Gambaryan S, Tsikas D (2015) A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite? Amino Acids. doi: 10.1007/s00726-015-1986-1
    • (2015) Amino Acids
    • Gambaryan, S.1    Tsikas, D.2
  • 11
    • 33751198519 scopus 로고    scopus 로고
    • Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    • 1:CAS:528:DC%2BD28Xht1GnsLjP 16798825
    • Gladwin MT, Raat NJ, Shiva S, Dezfulian C, Hogg N, Kim-Shapiro DB, Patel RP (2006) Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. Am J Physiol Heart Circ Physiol 291:H2026-2035
    • (2006) Am J Physiol Heart Circ Physiol , vol.291 , pp. H2026-H2035
    • Gladwin, M.T.1    Raat, N.J.2    Shiva, S.3    Dezfulian, C.4    Hogg, N.5    Kim-Shapiro, D.B.6    Patel, R.P.7
  • 12
    • 84940461901 scopus 로고    scopus 로고
    • Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica
    • 26055922
    • Haghikia A, Kayacelebi AA, Beckmann B, Hanff E, Gold R, Haghikia A, Tsikas D (2015) Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica. Amino Acids. doi: 10.1007/s00726-015-2015-0
    • (2015) Amino Acids
    • Haghikia, A.1    Kayacelebi, A.A.2    Beckmann, B.3    Hanff, E.4    Gold, R.5    Haghikia, A.6    Tsikas, D.7
  • 13
    • 0026060469 scopus 로고
    • On the substrate specificity of nitric oxide synthase
    • 1:CAS:528:DyaK38Xht1ektb4%3D 1721880
    • Hecker M, Walsh DT, Vane JR (1991) On the substrate specificity of nitric oxide synthase. FEBS Lett 294:221-224
    • (1991) FEBS Lett , vol.294 , pp. 221-224
    • Hecker, M.1    Walsh, D.T.2    Vane, J.R.3
  • 15
    • 84940460818 scopus 로고    scopus 로고
    • Analysis of l-homoarginine in biological samples by HPLC involving precolumn derivatization with o-phthalaldehyde and N-acetyl-l-cysteine
    • Hou Y, Jia S, Nawaratna G, Hu S, Dahanayaka S, Bazer FW, Wu G (2015) Analysis of l-homoarginine in biological samples by HPLC involving precolumn derivatization with o-phthalaldehyde and N-acetyl-l-cysteine. Amino Acids. doi: 10.1007/s00726-015-1962-9
    • (2015) Amino Acids
    • Hou, Y.1    Jia, S.2    Nawaratna, G.3    Hu, S.4    Dahanayaka, S.5    Bazer, F.W.6    Wu, G.7
  • 16
    • 84939964847 scopus 로고    scopus 로고
    • Safety of long-term dietary supplementation with L-arginine in pigs
    • 1:CAS:528:DC%2BC2MXitlOrsb0%3D 25655382
    • Hu SD, Li XL, Rezaei R, Meininger CJ, McNeal CJ, Wu G (2015) Safety of long-term dietary supplementation with L-arginine in pigs. Amino Acids 47:925-936
    • (2015) Amino Acids , vol.47 , pp. 925-936
    • Hu, S.D.1    Li, X.L.2    Rezaei, R.3    Meininger, C.J.4    McNeal, C.J.5    Wu, G.6
  • 17
    • 0030978412 scopus 로고    scopus 로고
    • Crystal strukture and mechanism of human l-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
    • 1169963 1:CAS:528:DyaK2sXktlCjsbY%3D 9218780
    • Humm A, Fritsche E, Steinbacher S, Huber R (1997) Crystal strukture and mechanism of human l-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. EMBO J 16:3373-3385
    • (1997) EMBO J , vol.16 , pp. 3373-3385
    • Humm, A.1    Fritsche, E.2    Steinbacher, S.3    Huber, R.4
  • 18
    • 84940460091 scopus 로고    scopus 로고
    • Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC-MS and GC-MS/MS
    • Kayacelebi AA, Knöfel AK, Beckmann B, Hanff E, Warnecke G, Tsikas D (2015a) Measurement of unlabeled and stable isotope-labeled homoarginine, arginine and their metabolites in biological samples by GC-MS and GC-MS/MS. Amino Acids. doi: 10.1007/s00726-015-1984-3
    • (2015) Amino Acids
    • Kayacelebi, A.A.1    Knöfel, A.K.2    Beckmann, B.3    Hanff, E.4    Warnecke, G.5    Tsikas, D.6
  • 20
    • 84940446635 scopus 로고    scopus 로고
    • Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease
    • Kayacelebi AA, Willers J, Pham VV, Hahn A, Schneider JY, Rothmann S, Frölich JC, Tsikas D (2015c) Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease. Amino Acids. doi: 10.1007/s00726-015-1915-3
    • (2015) Amino Acids
    • Kayacelebi, A.A.1    Willers, J.2    Pham, V.V.3    Hahn, A.4    Schneider, J.Y.5    Rothmann, S.6    Frölich, J.C.7    Tsikas, D.8
  • 21
    • 84940460551 scopus 로고    scopus 로고
    • The role of arginine, homoarginine and nitric oxide in pregnancy
    • 26092522
    • Khalil A, Hardman L, O'Brien P (2015) The role of arginine, homoarginine and nitric oxide in pregnancy. Amino Acids. doi: 10.1007/s00726-015-2014-1
    • (2015) Amino Acids
    • Khalil, A.1    Hardman, L.2    O'Brien, P.3
  • 22
    • 34547901364 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) - a modulator of nociception in opiate tolerance and addiction?
    • 2025594 1:CAS:528:DC%2BD2sXpt1Sisb0%3D 17625935
    • Kielstein A, Tsikas D, Galloway GP, Mendelson JE (2007) Asymmetric dimethylarginine (ADMA) - a modulator of nociception in opiate tolerance and addiction? Nitric Oxide 17:55-59
    • (2007) Nitric Oxide , vol.17 , pp. 55-59
    • Kielstein, A.1    Tsikas, D.2    Galloway, G.P.3    Mendelson, J.E.4
  • 23
    • 84940379280 scopus 로고    scopus 로고
    • Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease
    • 25859650
    • Kruszelnicka O, Chyrchel B, Golay A, Surdacki A (2015) Differential associations of circulating asymmetric dimethylarginine and cell adhesion molecules with metformin use in patients with type 2 diabetes mellitus and stable coronary artery disease. Amino Acids. doi: 10.1007/s00726-015-1976-3
    • (2015) Amino Acids
    • Kruszelnicka, O.1    Chyrchel, B.2    Golay, A.3    Surdacki, A.4
  • 24
    • 84940722910 scopus 로고    scopus 로고
    • Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood
    • Langen J, Kayacelebi AA, Beckmann B, Weigt-Usinger K, Carmann C, Hörster I, Lilienthal E, Richter-Unruh A, Tsikas D, Lücke T (2015) Homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in short stature children without and with growth hormone deficiency: hArg and ADMA are involved differently in growth in the childhood. Amino Acids. doi: 10.1007/s00726-015-2028-8
    • (2015) Amino Acids
    • Langen, J.1    Kayacelebi, A.A.2    Beckmann, B.3    Weigt-Usinger, K.4    Carmann, C.5    Hörster, I.6    Lilienthal, E.7    Richter-Unruh, A.8    Tsikas, D.9    Lücke, T.10
  • 25
    • 35648988113 scopus 로고    scopus 로고
    • Developmental changes in the l-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age
    • 17892438
    • Lücke T, Kanzelmeyer N, Kemper MJ, Tsikas D, Das AM (2007) Developmental changes in the l-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age. Clin Chem Lab Med 45:1525-1530
    • (2007) Clin Chem Lab Med , vol.45 , pp. 1525-1530
    • Lücke, T.1    Kanzelmeyer, N.2    Kemper, M.J.3    Tsikas, D.4    Das, A.M.5
  • 26
    • 84940460152 scopus 로고    scopus 로고
    • Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia
    • 25792109
    • Magné J, Huneau JF, Borderie D, Mathé V, Bos C, Mariotti F (2015) Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia. Amino Acids. doi: 10.1007/s00726-015-1959-4
    • (2015) Amino Acids
    • Magné, J.1    Huneau, J.F.2    Borderie, D.3    Mathé, V.4    Bos, C.5    Mariotti, F.6
  • 28
  • 29
    • 0032555182 scopus 로고    scopus 로고
    • Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-l-arginine
    • 1:CAS:528:DyaK1cXktFKqtLg%3D 9671515
    • Moali C, Boucher JL, Sari MA, Stuehr DJ, Mansuy D (1998) Substrate specificity of NO synthases: detailed comparison of l-arginine, homo-l-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-l-arginine. Biochemistry 37:10453-10460
    • (1998) Biochemistry , vol.37 , pp. 10453-10460
    • Moali, C.1    Boucher, J.L.2    Sari, M.A.3    Stuehr, D.J.4    Mansuy, D.5
  • 31
    • 84940462137 scopus 로고    scopus 로고
    • Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease
    • 26123985
    • Papageorgiou N, Androulakis E, Papaioannou S, Antoniades C, Tousoulis D (2015) Homoarginine in the shadow of asymmetric dimethylarginine: from nitric oxide to cardiovascular disease. Amino Acids. doi: 10.1007/s00726-015-2017-y
    • (2015) Amino Acids
    • Papageorgiou, N.1    Androulakis, E.2    Papaioannou, S.3    Antoniades, C.4    Tousoulis, D.5
  • 33
    • 79954637472 scopus 로고    scopus 로고
    • Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography
    • 1:CAS:528:DC%2BC3MXjvVOjsLo%3D 21311067
    • Pilz S, Tomaschitz A, Meinitzer A, Drechsler C, Ritz E, Krane V, Wanner C, Böhm BO, März W (2011b) Low serum homoarginine is a novel risk factor for fatal strokes in patients undergoing coronary angiography. Stroke 42:1132-1134
    • (2011) Stroke , vol.42 , pp. 1132-1134
    • Pilz, S.1    Tomaschitz, A.2    Meinitzer, A.3    Drechsler, C.4    Ritz, E.5    Krane, V.6    Wanner, C.7    Böhm, B.O.8    März, W.9
  • 37
    • 84940461552 scopus 로고    scopus 로고
    • Use of the guanidination reaction for determining reactive lysine, bioavailable lysine and gut endogenous lysine
    • 26036685
    • Rutherfurd SM (2015) Use of the guanidination reaction for determining reactive lysine, bioavailable lysine and gut endogenous lysine. Amino Acids. doi: 10.1007/s00726-015-2007-0
    • (2015) Amino Acids
    • Rutherfurd, S.M.1
  • 38
    • 84940460232 scopus 로고    scopus 로고
    • Differential in vitro effects of homoarginine on oxidative stress in plasma, erythrocytes, kidney and liver of rats in the absence and in the presence α-tocopherol, ascorbic acid or l-NAME
    • 25894889
    • Sasso S, Dalmedico L, Magro DD, Pereira EM, Wyse AT, de Lima DD (2015) Differential in vitro effects of homoarginine on oxidative stress in plasma, erythrocytes, kidney and liver of rats in the absence and in the presence α-tocopherol, ascorbic acid or l-NAME. Amino Acids. doi: 10.1007/s00726-015-1973-6
    • (2015) Amino Acids
    • Sasso, S.1    Dalmedico, L.2    Magro, D.D.3    Pereira, E.M.4    Wyse, A.T.5    De Lima, D.D.6
  • 39
    • 84940724083 scopus 로고    scopus 로고
    • Hyperarginemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature
    • 26123990
    • Schlune A, vom Dahl S, Häussinger D, Ensenauer R, Mayatepek E (2015) Hyperarginemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature. Amino Acids. doi: 10.1007/s00726-015-2032-z
    • (2015) Amino Acids
    • Schlune, A.1    Vom Dahl, S.2    Häussinger, D.3    Ensenauer, R.4    Mayatepek, E.5
  • 40
    • 84940459588 scopus 로고    scopus 로고
    • Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir
    • Schneider JY, Rothmann S, Schröder F, Langen J, Lücke T, Mariotti F, Huneau JF, Frölich JC, Tsikas D (2015) Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir. Amino Acids. doi: 10.1007/s00726-015-2031-0
    • (2015) Amino Acids
    • Schneider, J.Y.1    Rothmann, S.2    Schröder, F.3    Langen, J.4    Lücke, T.5    Mariotti, F.6    Huneau, J.F.7    Frölich, J.C.8    Tsikas, D.9
  • 41
    • 84940461793 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin
    • 25921952
    • Sitar ME, Kayacelebi AA, Beckmann B, Kielstein JT, Tsikas D (2015) Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin. Amino Acids. doi: 10.1007/s00726-015-1991-4
    • (2015) Amino Acids
    • Sitar, M.E.1    Kayacelebi, A.A.2    Beckmann, B.3    Kielstein, J.T.4    Tsikas, D.5
  • 43
    • 35948952794 scopus 로고    scopus 로고
    • Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    • 1:CAS:528:DC%2BD2sXhtlartbzN 17726074
    • Thum T, Fleissner F, Klink I, Tsikas D, Jakob M, Bauersachs J, Stichtenoth DO (2007) Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I. J Clin Endocrinol Metab 92:4172-4179
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4172-4179
    • Thum, T.1    Fleissner, F.2    Klink, I.3    Tsikas, D.4    Jakob, M.5    Bauersachs, J.6    Stichtenoth, D.O.7
  • 45
    • 84904994046 scopus 로고    scopus 로고
    • Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system?
    • 24931514
    • Tsikas D, Kayacelebi AA (2014) Do homoarginine and asymmetric dimethylarginine act antagonistically in the cardiovascular system? Circ J 78:2094-2095
    • (2014) Circ J , vol.78 , pp. 2094-2095
    • Tsikas, D.1    Kayacelebi, A.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.