메뉴 건너뛰기




Volumn 47, Issue 9, 2015, Pages 1779-1793

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from l-arginine or nitrite?

Author keywords

cGMP; Mass spectrometry; Nitric oxide; Nitric oxide synthase; Pitfalls; Platelets; sGC

Indexed keywords

ARGININE; CITRULLINE; CYCLIC GMP; INDUCIBLE NITRIC OXIDE SYNTHASE; INORGANIC COMPOUND; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; NITROGEN DERIVATIVE; ORGANIC COMPOUND;

EID: 84940460935     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-015-1986-1     Document Type: Article
Times cited : (49)

References (127)
  • 1
    • 72249108763 scopus 로고    scopus 로고
    • Generation of nitric oxide from nitrite by carbonic anhydrase: A possible link between metabolic activity and vasodilation
    • 1:CAS:528:DC%2BD1MXhsFOltLnN 19820197
    • Aamand R, Dalsgaard T, Jensen FB, Simonsen U, Roepstorff A, Fago A (2009) Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation. Am J Physiol Heart Circ Physiol 297:H2068-H2074
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , pp. H2068-H2074
    • Aamand, R.1    Dalsgaard, T.2    Jensen, F.B.3    Simonsen, U.4    Roepstorff, A.5    Fago, A.6
  • 2
    • 84898668124 scopus 로고    scopus 로고
    • A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes
    • 3958531 24642865
    • Akrawinthawong K, Park JW, Piknova B, Sibmooh N, Fucharoen S, Schechter AN (2014) A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes. PLoS One 9:e92435
    • (2014) PLoS One , vol.9
    • Akrawinthawong, K.1    Park, J.W.2    Piknova, B.3    Sibmooh, N.4    Fucharoen, S.5    Schechter, A.N.6
  • 3
    • 78650938912 scopus 로고    scopus 로고
    • Platelet activation in hypertension associated with hypercholesterolemia: Effects of irbesartan
    • 1:CAS:528:DC%2BC3MXitFCqtrc%3D 20961397
    • Alexandru N, Popov D, Dragan E, Andrei E, Georgescu A (2011) Platelet activation in hypertension associated with hypercholesterolemia: effects of irbesartan. J Thromb Haemost 9:173-184
    • (2011) J Thromb Haemost , vol.9 , pp. 173-184
    • Alexandru, N.1    Popov, D.2    Dragan, E.3    Andrei, E.4    Georgescu, A.5
  • 4
    • 0036854506 scopus 로고    scopus 로고
    • Insulin influences the nitric oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric oxide synthase
    • 1:CAS:528:DC%2BD38XpsVags70%3D 12444902
    • Anfossi G, Massucco P, Mattiello L, Balbo A, Russo I, Doronzo G, Rolle L, Ghigo D, Fontana D, Bosia A, Trovati M (2002a) Insulin influences the nitric oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric oxide synthase. Eur J Endocrinol 147:689-700
    • (2002) Eur J Endocrinol , vol.147 , pp. 689-700
    • Anfossi, G.1    Massucco, P.2    Mattiello, L.3    Balbo, A.4    Russo, I.5    Doronzo, G.6    Rolle, L.7    Ghigo, D.8    Fontana, D.9    Bosia, A.10    Trovati, M.11
  • 5
    • 0036178665 scopus 로고    scopus 로고
    • Adenosine increases human platelet levels of cGMP through nitric oxide: Possible role in its antiaggregating effect
    • 1:CAS:528:DC%2BD38XhsFans7o%3D 11864710
    • Anfossi G, Russo I, Massucco P, Mattiello L, Cavalot F, Balbo A, Trovati M (2002b) Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect. Thromb Res 105:71-78
    • (2002) Thromb Res , vol.105 , pp. 71-78
    • Anfossi, G.1    Russo, I.2    Massucco, P.3    Mattiello, L.4    Cavalot, F.5    Balbo, A.6    Trovati, M.7
  • 6
    • 0036125499 scopus 로고    scopus 로고
    • Catecholamines, via beta-adrenoceptors, increase intracellular concentrations of 3′,5′-cyclic guanosine monophosphate (cGMP) through nitric oxide in human platelets
    • 1:CAS:528:DC%2BD38XislGjs7s%3D 11916090
    • Anfossi G, Russo I, Massucco P, Mattiello L, Trovati M (2002c) Catecholamines, via beta-adrenoceptors, increase intracellular concentrations of 3′,5′-cyclic guanosine monophosphate (cGMP) through nitric oxide in human platelets. Thromb Haemost 87:539-540
    • (2002) Thromb Haemost , vol.87 , pp. 539-540
    • Anfossi, G.1    Russo, I.2    Massucco, P.3    Mattiello, L.4    Trovati, M.5
  • 7
    • 84920280318 scopus 로고    scopus 로고
    • Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo
    • 1:CAS:528:DC%2BC2cXhvFSqtbnF 25163536
    • Apostoli GL, Solomon A, Smallwood MJ, Winyard PG, Emerson M (2014) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo. J Thromb Haemost 12:1880-1889
    • (2014) J Thromb Haemost , vol.12 , pp. 1880-1889
    • Apostoli, G.L.1    Solomon, A.2    Smallwood, M.J.3    Winyard, P.G.4    Emerson, M.5
  • 9
    • 12444347843 scopus 로고    scopus 로고
    • Characterization of a novel type of endogenous activator of soluble guanylyl cyclase
    • 1:CAS:528:DC%2BD2MXksVWnsA%3D%3D 15509556
    • Balashova N, Chang FJ, Lamothe M, Sun Q, Beuve A (2005) Characterization of a novel type of endogenous activator of soluble guanylyl cyclase. J Biol Chem 280:2186-2196
    • (2005) J Biol Chem , vol.280 , pp. 2186-2196
    • Balashova, N.1    Chang, F.J.2    Lamothe, M.3    Sun, Q.4    Beuve, A.5
  • 10
    • 84859045120 scopus 로고    scopus 로고
    • Radiochemical high-performance liquid chromatography detection of arginine metabolism in human endothelial cells
    • 1:CAS:528:DC%2BC38Xls1ehu7Y%3D 22381370
    • Barilli A, Visigalli R, Rotoli BM, Bussolati O, Gazzola GC, Parolari A, Dall'Asta V (2012) Radiochemical high-performance liquid chromatography detection of arginine metabolism in human endothelial cells. Anal Biochem 424:156-161
    • (2012) Anal Biochem , vol.424 , pp. 156-161
    • Barilli, A.1    Visigalli, R.2    Rotoli, B.M.3    Bussolati, O.4    Gazzola, G.C.5    Parolari, A.6    Dall'Asta, V.7
  • 11
    • 70449160875 scopus 로고
    • Presence of carbonic anhydrase in human platelets
    • 1:CAS:528:DyaG2sXnt1Kqtw%3D%3D 13428160
    • Belloni F, Turpini R (1957) Presence of carbonic anhydrase in human platelets. Haematologica 42:217-225
    • (1957) Haematologica , vol.42 , pp. 217-225
    • Belloni, F.1    Turpini, R.2
  • 13
    • 42649094850 scopus 로고    scopus 로고
    • Use of functional highly purified human platelets for the identification of new proteins of the IPP signaling pathway
    • 1:CAS:528:DC%2BD1cXlvVCms70%3D 17931695
    • Birschmann I, Mietner S, Dittrich M, Pfrang J, Dandekar T, Walter U (2008) Use of functional highly purified human platelets for the identification of new proteins of the IPP signaling pathway. Thromb Res 122:59-68
    • (2008) Thromb Res , vol.122 , pp. 59-68
    • Birschmann, I.1    Mietner, S.2    Dittrich, M.3    Pfrang, J.4    Dandekar, T.5    Walter, U.6
  • 15
    • 84856591759 scopus 로고    scopus 로고
    • Doubts concerning functional endothelial nitric oxide synthase in human erythrocytes
    • 22308286
    • Böhmer A, Beckmann B, Sandmann J, Tsikas D (2012) Doubts concerning functional endothelial nitric oxide synthase in human erythrocytes. Blood 119:1322-1323
    • (2012) Blood , vol.119 , pp. 1322-1323
    • Böhmer, A.1    Beckmann, B.2    Sandmann, J.3    Tsikas, D.4
  • 16
    • 84867234834 scopus 로고    scopus 로고
    • Potential pitfalls with the use of acetoxy (CH(3)COO) drugs in studies on nitric oxide synthase in platelets
    • 23000842
    • Böhmer A, Niemann J, Schwedhelm KS, Meyer HH, Gambaryan S, Tsikas D (2013) Potential pitfalls with the use of acetoxy (CH(3)COO) drugs in studies on nitric oxide synthase in platelets. Nitric Oxide 28:14-16
    • (2013) Nitric Oxide , vol.28 , pp. 14-16
    • Böhmer, A.1    Niemann, J.2    Schwedhelm, K.S.3    Meyer, H.H.4    Gambaryan, S.5    Tsikas, D.6
  • 17
    • 84904296542 scopus 로고    scopus 로고
    • 15N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: Development, validation, and applications to assess NOS uncoupling and human platelets NOS activity
    • 15N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity. J Chromatogr B 965:173-182
    • (2014) J Chromatogr B , vol.965 , pp. 173-182
    • Böhmer, A.1    Gambaryan, S.2    Flentje, M.3    Jordan, J.4    Tsikas, D.5
  • 18
    • 84938600659 scopus 로고    scopus 로고
    • Human blood platelets lack nitric oxide synthase activity
    • 25360996
    • Böhmer A, Gambaryan S, Tsikas D (2014b) Human blood platelets lack nitric oxide synthase activity. Platelets. doi: 10.3109/09537104.2014.974024
    • (2014) Platelets
    • Böhmer, A.1    Gambaryan, S.2    Tsikas, D.3
  • 19
    • 0036479305 scopus 로고    scopus 로고
    • Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at ser1179 by akt-independent mechanisms: Role of protein kinase a
    • 1:CAS:528:DC%2BD38XhtVaktr8%3D 11729190
    • Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H (2002) Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at ser1179 by akt-independent mechanisms: role of protein kinase a. J Biol Chem 277:3388-3396
    • (2002) J Biol Chem , vol.277 , pp. 3388-3396
    • Boo, Y.C.1    Sorescu, G.2    Boyd, N.3    Shiojima, I.4    Walsh, K.5    Du, J.6    Jo, H.7
  • 20
    • 84867754221 scopus 로고    scopus 로고
    • The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
    • 1:CAS:528:DC%2BC38XhsFKku7jI 22869793
    • Burkhart JM, Vaudel M, Gambaryan S, Radau S, Walter U, Martens L, Geiger J, Sickmann A, Zahedi RP (2012) The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood 120:e73-e82
    • (2012) Blood , vol.120 , pp. e73-e82
    • Burkhart, J.M.1    Vaudel, M.2    Gambaryan, S.3    Radau, S.4    Walter, U.5    Martens, L.6    Geiger, J.7    Sickmann, A.8    Zahedi, R.P.9
  • 22
    • 0034681455 scopus 로고    scopus 로고
    • Endothelial nitric-oxide synthase (type iii) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
    • 1:CAS:528:DC%2BD3cXhsVymt70%3D 10671564
    • Butt E, Bernhardt M, Smolenski A, Kotsonis P, Frohlich LG, Sickmann A, Meyer HE, Lohmann SM, Schmidt HH (2000) Endothelial nitric-oxide synthase (type iii) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. J Biol Chem 275:5179-5187
    • (2000) J Biol Chem , vol.275 , pp. 5179-5187
    • Butt, E.1    Bernhardt, M.2    Smolenski, A.3    Kotsonis, P.4    Frohlich, L.G.5    Sickmann, A.6    Meyer, H.E.7    Lohmann, S.M.8    Schmidt, H.H.9
  • 24
    • 2342624541 scopus 로고    scopus 로고
    • Glycoprotein iib/iiia inhibition enhances platelet nitric oxide release
    • 1:CAS:528:DC%2BD2cXktVOjsrs%3D 15140587
    • Chakrabarti S, Clutton P, Varghese S, Cox D, Mascelli MA, Freedman JE (2004) Glycoprotein iib/iiia inhibition enhances platelet nitric oxide release. Thromb Res 113:225-233
    • (2004) Thromb Res , vol.113 , pp. 225-233
    • Chakrabarti, S.1    Clutton, P.2    Varghese, S.3    Cox, D.4    Mascelli, M.A.5    Freedman, J.E.6
  • 25
    • 0030071631 scopus 로고    scopus 로고
    • Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets
    • 1:CAS:528:DyaK28XivVOhsQ%3D%3D 8656650
    • Chen LY, Mehta JL (1996) Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets. J Cardiovasc Pharmacol 27:154-158
    • (1996) J Cardiovasc Pharmacol , vol.27 , pp. 154-158
    • Chen, L.Y.1    Mehta, J.L.2
  • 26
    • 84893411833 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in red blood cells: Key to a new erythrocrine function?
    • 3909820 1:CAS:528:DC%2BC2cXht1Kqt7rI 24494200
    • Cortese-Krott MM, Kelm M (2014) Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function? Redox Biol 2:251-258
    • (2014) Redox Biol , vol.2 , pp. 251-258
    • Cortese-Krott, M.M.1    Kelm, M.2
  • 29
    • 3042534143 scopus 로고
    • The kinetics of the reaction of selenium(IV) with 2,3-diaminonaphthalene
    • 1:CAS:528:DyaF2MXkslKlsro%3D
    • Cukor P, Lott PF (1965) The kinetics of the reaction of selenium(IV) with 2,3-diaminonaphthalene. J Phys Chem 69:3232-3239
    • (1965) J Phys Chem , vol.69 , pp. 3232-3239
    • Cukor, P.1    Lott, P.F.2
  • 30
    • 77952240774 scopus 로고    scopus 로고
    • NO synthase: Structures and mechanisms
    • 1:CAS:528:DC%2BC3cXmtFCgu7s%3D 20303412
    • Daff S (2010) NO synthase: structures and mechanisms. Nitric Oxide 23:1-11
    • (2010) Nitric Oxide , vol.23 , pp. 1-11
    • Daff, S.1
  • 32
    • 0242690438 scopus 로고    scopus 로고
    • Amp-activated protein kinase (ampk) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
    • 1:CAS:528:DC%2BD3sXptVynu7s%3D 14597982
    • Fleming I, Schulz C, Fichtlscherer B, Kemp BE, Fisslthaler B, Busse R (2003) Amp-activated protein kinase (ampk) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost 90:863-871
    • (2003) Thromb Haemost , vol.90 , pp. 863-871
    • Fleming, I.1    Schulz, C.2    Fichtlscherer, B.3    Kemp, B.E.4    Fisslthaler, B.5    Busse, R.6
  • 33
    • 84859487532 scopus 로고    scopus 로고
    • Nitric oxide synthases: Regaulation and function
    • 3345541 21890489
    • Förstermann U, Sessa WC (2012) Nitric oxide synthases: regaulation and function. Eur Heart J 33:829-837
    • (2012) Eur Heart J , vol.33 , pp. 829-837
    • Förstermann, U.1    Sessa, W.C.2
  • 35
    • 0034566857 scopus 로고    scopus 로고
    • Alpha-tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release
    • 1:CAS:528:DC%2BD3MXht1Sntro%3D 11024007
    • Freedman JE, Li L, Sauter R, Keaney JJ (2000) Alpha-tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. FASEB J 14:2377-2379
    • (2000) FASEB J , vol.14 , pp. 2377-2379
    • Freedman, J.E.1    Li, L.2    Sauter, R.3    Keaney, J.J.4
  • 36
    • 0043269271 scopus 로고    scopus 로고
    • Regulation of nitric oxide-sensitive guanylyl cyclase
    • 1:CAS:528:DC%2BD3sXlsVOntrw%3D 12881475
    • Friebe A, Koesling D (2003) Regulation of nitric oxide-sensitive guanylyl cyclase. Circ Res 93:96-105
    • (2003) Circ Res , vol.93 , pp. 96-105
    • Friebe, A.1    Koesling, D.2
  • 38
    • 1642411578 scopus 로고    scopus 로고
    • Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase
    • 1:CAS:528:DC%2BD2cXjtVaksrc%3D 14644996
    • Gambaryan S, Geiger J, Schwarz UR, Butt E, Begonja A, Obergfell A, Walter U (2004) Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase. Blood 103:2593-2600
    • (2004) Blood , vol.103 , pp. 2593-2600
    • Gambaryan, S.1    Geiger, J.2    Schwarz, U.R.3    Butt, E.4    Begonja, A.5    Obergfell, A.6    Walter, U.7
  • 40
    • 84877067925 scopus 로고    scopus 로고
    • Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets
    • 1:CAS:528:DC%2BC3sXot1Kiurk%3D 23467662
    • Gambaryan S, Subramanian H, Rukoyatkina N, Herterich S, Walter U (2013) Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets. Thromb Haemost 109:973-975
    • (2013) Thromb Haemost , vol.109 , pp. 973-975
    • Gambaryan, S.1    Subramanian, H.2    Rukoyatkina, N.3    Herterich, S.4    Walter, U.5
  • 41
    • 84973417766 scopus 로고    scopus 로고
    • Platelet nitric oxide signaling system in patients with coronary artery disease
    • Garelnabi M, Gupta V, Mallika V, Bhattacharjee J (2014) Platelet nitric oxide signaling system in patients with coronary artery disease. Ann Vasc Dis 4:99-105
    • (2014) Ann Vasc Dis , vol.4 , pp. 99-105
    • Garelnabi, M.1    Gupta, V.2    Mallika, V.3    Bhattacharjee, J.4
  • 42
    • 0027950792 scopus 로고
    • Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors
    • 1:CAS:528:DyaK2cXlslWhtLY%3D 8048483
    • Geiger J, Nolte C, Walter U (1994) Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors. Am J Physiol 267(1 Pt 1):C236-C244
    • (1994) Am J Physiol , vol.267 , Issue.1 , pp. C236-C244
    • Geiger, J.1    Nolte, C.2    Walter, U.3
  • 43
    • 27644534583 scopus 로고    scopus 로고
    • Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets
    • 1:CAS:528:DC%2BD2MXhtFahtLrM 16236600
    • Gende OA (2005) Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets. Platelets 16:392-397
    • (2005) Platelets , vol.16 , pp. 392-397
    • Gende, O.A.1
  • 44
    • 34848894877 scopus 로고    scopus 로고
    • Platelet-derived nitric oxide signaling and regulation
    • 1:CAS:528:DC%2BD2sXhtVOrsL%2FL 17901370
    • Gkaliagkousi E, Ritter J, Ferro A (2007) Platelet-derived nitric oxide signaling and regulation. Circ Res 101:654-662
    • (2007) Circ Res , vol.101 , pp. 654-662
    • Gkaliagkousi, E.1    Ritter, J.2    Ferro, A.3
  • 45
    • 72649083963 scopus 로고    scopus 로고
    • Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension
    • 1:CAS:528:DC%2BD1MXhsFyrsr%2FF 19687162
    • Gkaliagkousi E, Corrigall V, Becker S, de Winter P, Shah A, Zamboulis C, Ritter J, Ferro A (2009) Decreased platelet nitric oxide contributes to increased circulating monocyte-platelet aggregates in hypertension. Eur Heart J 30:3048-3054
    • (2009) Eur Heart J , vol.30 , pp. 3048-3054
    • Gkaliagkousi, E.1    Corrigall, V.2    Becker, S.3    De Winter, P.4    Shah, A.5    Zamboulis, C.6    Ritter, J.7    Ferro, A.8
  • 46
    • 0017342850 scopus 로고
    • Stimulation of human platelet guanylate cyclase by fatty acids
    • 1:CAS:528:DyaE2sXhtFKltLc%3D 14150
    • Glass DB, Frey W 2nd, Carr DW, Goldberg ND (1977a) Stimulation of human platelet guanylate cyclase by fatty acids. J Biol Chem 252:1279-1285
    • (1977) J Biol Chem , vol.252 , pp. 1279-1285
    • Glass, D.B.1    Frey, W.2    Carr, D.W.3    Goldberg, N.D.4
  • 47
    • 0017340269 scopus 로고
    • The involvement of prostaglandin endoperoxide formation in the elevation of cyclic gmp levels during platelet aggregation
    • 1:CAS:528:DyaE2sXhvVemsLc%3D 191476
    • Glass DB, Gerrard JM, Townsend D, Carr DW, White JG, Goldberg ND (1977b) The involvement of prostaglandin endoperoxide formation in the elevation of cyclic gmp levels during platelet aggregation. J Cyclic Nucleotide Res 3:37-44
    • (1977) J Cyclic Nucleotide Res , vol.3 , pp. 37-44
    • Glass, D.B.1    Gerrard, J.M.2    Townsend, D.3    Carr, D.W.4    White, J.G.5    Goldberg, N.D.6
  • 48
    • 68149169007 scopus 로고    scopus 로고
    • What is the real physiological NO concentration in vivo?
    • 2779337 1:CAS:528:DC%2BD1MXps1Wlurw%3D 19602444
    • Hall CN, Garthwaite J (2009) What is the real physiological NO concentration in vivo? Nitric Oxide 21:92-103
    • (2009) Nitric Oxide , vol.21 , pp. 92-103
    • Hall, C.N.1    Garthwaite, J.2
  • 49
    • 0032725027 scopus 로고    scopus 로고
    • Cyclic nucleotides and phosphodiesterases in platelets
    • 1:CAS:528:DyaK1MXnsVWms7w%3D 10605732
    • Haslam RJ, Dickinson NT, Jang EK (1999) Cyclic nucleotides and phosphodiesterases in platelets. Thromb Haemost 82:412-423
    • (1999) Thromb Haemost , vol.82 , pp. 412-423
    • Haslam, R.J.1    Dickinson, N.T.2    Jang, E.K.3
  • 51
    • 34250790336 scopus 로고    scopus 로고
    • Mechanics of proplatelet elaboration
    • 1:CAS:528:DC%2BD2sXovFGltrY%3D 17635704
    • Italiano JE Jr, Patel-Hett S, Hartwig JH (2007) Mechanics of proplatelet elaboration. J Thromb Haemost 5(Suppl 1):18-23
    • (2007) J Thromb Haemost , vol.5 , pp. 18-23
    • Italiano, J.E.1    Patel-Hett, S.2    Hartwig, J.H.3
  • 52
    • 84926519247 scopus 로고    scopus 로고
    • Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric oxide synthesis in platelets
    • Jana P, Maiti S, Kahn NN, Sinha AK (2014) Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric oxide synthesis in platelets. Blood Coagul Fibrinolysis. doi: 10.1097/MBC.0000000000000085
    • (2014) Blood Coagul Fibrinolysis
    • Jana, P.1    Maiti, S.2    Kahn, N.N.3    Sinha, A.K.4
  • 54
    • 34248216537 scopus 로고    scopus 로고
    • Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography
    • 1:CAS:528:DC%2BD2sXlt1aktbY%3D
    • Jobgen WS, Jobgen SC, Li H, Meininger CJ, Wu G (2007) Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography. J Chromatogr B 851:71-82
    • (2007) J Chromatogr B , vol.851 , pp. 71-82
    • Jobgen, W.S.1    Jobgen, S.C.2    Li, H.3    Meininger, C.J.4    Wu, G.5
  • 55
    • 84939520249 scopus 로고    scopus 로고
    • Analysis of platelet function and dysfunction
    • 1:STN:280:DC%2BC2MzlvF2htA%3D%3D 25482925
    • Jurk K (2015) Analysis of platelet function and dysfunction. Hamostaseologie 35:60-72
    • (2015) Hamostaseologie , vol.35 , pp. 60-72
    • Jurk, K.1
  • 56
    • 0033806952 scopus 로고    scopus 로고
    • Normal circulating adult human red blood cells contain inactive NOS proteins
    • 1:CAS:528:DC%2BD3cXks1SjtLs%3D 10850643
    • Kang ES, Ford K, Grokulsky G, Wang YB, Chiang TM, Acchiardo SR (2000) Normal circulating adult human red blood cells contain inactive NOS proteins. J Lab Clin Med 135:444-451
    • (2000) J Lab Clin Med , vol.135 , pp. 444-451
    • Kang, E.S.1    Ford, K.2    Grokulsky, G.3    Wang, Y.B.4    Chiang, T.M.5    Acchiardo, S.R.6
  • 58
    • 0037309121 scopus 로고    scopus 로고
    • Lack of oxidaative stress during sustained therapy with issorbide dinitrate and pentaerythrityl tertranitate in healthy humans: A randomized, double-blind crossover study
    • 1:CAS:528:DC%2BD3sXlvFSisQ%3D%3D 12548090
    • Keimer R, Stutzer FK, Tsikas D, Troost R, Gutzki FM, Frölich JC (2003) Lack of oxidaative stress during sustained therapy with issorbide dinitrate and pentaerythrityl tertranitate in healthy humans: a randomized, double-blind crossover study. J Cardiovasc Pharmacol 41:284-292
    • (2003) J Cardiovasc Pharmacol , vol.41 , pp. 284-292
    • Keimer, R.1    Stutzer, F.K.2    Tsikas, D.3    Troost, R.4    Gutzki, F.M.5    Frölich, J.C.6
  • 60
    • 84857743572 scopus 로고    scopus 로고
    • The thrombin inhibitors hirudin and refludan((r)) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets
    • 1:CAS:528:DC%2BC38XlsVSgtb4%3D 22234363
    • Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U (2012) The thrombin inhibitors hirudin and refludan((r)) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets. Thromb Haemost 107:521-529
    • (2012) Thromb Haemost , vol.107 , pp. 521-529
    • Kobsar, A.1    Koessler, J.2    Kehrer, L.3    Gambaryan, S.4    Walter, U.5
  • 61
    • 33344456589 scopus 로고    scopus 로고
    • The synthesis and metabolism of asymmetric dimethylarginine (ADMA)
    • Leiper JM, Vallance P (2006) The synthesis and metabolism of asymmetric dimethylarginine (ADMA). Eur J Clin Pharmacol 26:33-38
    • (2006) Eur J Clin Pharmacol , vol.26 , pp. 33-38
    • Leiper, J.M.1    Vallance, P.2
  • 62
    • 0037428145 scopus 로고    scopus 로고
    • A stimulatory role for cGMP-dependent protein kinase in platelet activation
    • 1:CAS:528:DC%2BD3sXmtFGgtg%3D%3D 12526795
    • Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X (2003) A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell 112:77-86
    • (2003) Cell , vol.112 , pp. 77-86
    • Li, Z.1    Xi, X.2    Gu, M.3    Feil, R.4    Ye, R.D.5    Eigenthaler, M.6    Hofmann, F.7    Du, X.8
  • 63
    • 33645304173 scopus 로고    scopus 로고
    • Tracking functions of cGMP-dependent protein kinases (CGK)
    • 1:CAS:528:DC%2BD2MXisVektbY%3D 15769627
    • Lohmann SM, Walter U (2005) Tracking functions of cGMP-dependent protein kinases (CGK). Front Biosci 10:1313-1328
    • (2005) Front Biosci , vol.10 , pp. 1313-1328
    • Lohmann, S.M.1    Walter, U.2
  • 64
    • 84655169528 scopus 로고    scopus 로고
    • A novel role of andrographolide, an NF-kappa b inhibitor, on inhibition of platelet activation: The pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP
    • 1:CAS:528:DC%2BC3MXhsFSisrnE
    • Lu WJ, Lee JJ, Chou DS, Jayakumar T, Fong TH, Hsiao G, Sheu JR (2011) A novel role of andrographolide, an NF-kappa b inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP. J Mol Med (Berl) 89:1261-1273
    • (2011) J Mol Med (Berl) , vol.89 , pp. 1261-1273
    • Lu, W.J.1    Lee, J.J.2    Chou, D.S.3    Jayakumar, T.4    Fong, T.H.5    Hsiao, G.6    Sheu, J.R.7
  • 65
    • 84880010050 scopus 로고    scopus 로고
    • The incredible journey: From megakaryocyte development to platelet formation
    • 3678154 1:CAS:528:DC%2BC3sXpsVaqsbc%3D 23751492
    • Machlus KR, Italiano JE Jr (2013) The incredible journey: from megakaryocyte development to platelet formation. J Cell Biol 201:785-796
    • (2013) J Cell Biol , vol.201 , pp. 785-796
    • Machlus, K.R.1    Italiano, J.E.2
  • 66
    • 0027325255 scopus 로고
    • Nitric oxide synthase structure and mechanism
    • 1:CAS:528:DyaK3sXksVersbo%3D 7685338
    • Marletta MA (1993) Nitric oxide synthase structure and mechanism. J Biol Chem 268:12231-12234
    • (1993) J Biol Chem , vol.268 , pp. 12231-12234
    • Marletta, M.A.1
  • 67
    • 1642278417 scopus 로고    scopus 로고
    • Gpib-dependent platelet activation is dependent on src kinases but not map kinase or cGMP-dependent kinase
    • 1:CAS:528:DC%2BD2cXjtVaks74%3D 14684423
    • Marshall SJ, Senis YA, Auger JM, Feil R, Hofmann F, Salmon G, Peterson JT, Burslem F, Watson SP (2004) Gpib-dependent platelet activation is dependent on src kinases but not map kinase or cGMP-dependent kinase. Blood 103:2601-2609
    • (2004) Blood , vol.103 , pp. 2601-2609
    • Marshall, S.J.1    Senis, Y.A.2    Auger, J.M.3    Feil, R.4    Hofmann, F.5    Salmon, G.6    Peterson, J.T.7    Burslem, F.8    Watson, S.P.9
  • 68
    • 15344351366 scopus 로고    scopus 로고
    • High glucose rapidly activates the nitric oxide/cyclic nucleotide pathway in human platelets via an osmotic mechanism
    • 1:CAS:528:DC%2BD2MXivVGmsLs%3D 15735804
    • Massucco P, Mattiello L, Russo I, Traversa M, Doronzo G, Anfossi G, Trovati M (2005) High glucose rapidly activates the nitric oxide/cyclic nucleotide pathway in human platelets via an osmotic mechanism. Thromb Haemost 93:517-526
    • (2005) Thromb Haemost , vol.93 , pp. 517-526
    • Massucco, P.1    Mattiello, L.2    Russo, I.3    Traversa, M.4    Doronzo, G.5    Anfossi, G.6    Trovati, M.7
  • 69
    • 0028924952 scopus 로고
    • Kinetics and mechanism of tetrahydrobiopterin-induced oxidation of nitric oxide
    • 1:CAS:528:DyaK2MXjtFKktbg%3D 7529763
    • Mayer B, Klatt P, Werner ER, Schmidt K (1995) Kinetics and mechanism of tetrahydrobiopterin-induced oxidation of nitric oxide. J Biol Chem 270:655-659
    • (1995) J Biol Chem , vol.270 , pp. 655-659
    • Mayer, B.1    Klatt, P.2    Werner, E.R.3    Schmidt, K.4
  • 70
    • 0029257415 scopus 로고
    • Identification of constitutive and inducible forms of nitric oxide synthase in human platelets
    • 1:CAS:528:DyaK2MXkvVGjsb0%3D 7534807
    • Mehta JL, Chen LY, Kone BC, Mehta P, Turner P (1995) Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J Lab Clin Med 125:370-377
    • (1995) J Lab Clin Med , vol.125 , pp. 370-377
    • Mehta, J.L.1    Chen, L.Y.2    Kone, B.C.3    Mehta, P.4    Turner, P.5
  • 71
    • 25844439569 scopus 로고    scopus 로고
    • Reactive oxygen species induce tyrosine phosphorylation of and src kinase recruitment to no-sensitive guanylyl cyclase
    • 1:CAS:528:DC%2BD2MXhtVens7fM 16079134
    • Meurer S, Pioch S, Gross S, Muller-Esterl W (2005) Reactive oxygen species induce tyrosine phosphorylation of and src kinase recruitment to no-sensitive guanylyl cyclase. J Biol Chem 280:33149-33156
    • (2005) J Biol Chem , vol.280 , pp. 33149-33156
    • Meurer, S.1    Pioch, S.2    Gross, S.3    Muller-Esterl, W.4
  • 74
    • 84863784135 scopus 로고    scopus 로고
    • Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the pkc/enos/no pathway
    • 1:CAS:528:DC%2BC38XhsVGitrzM 22517552
    • Munoz YC, Gomez GI, Moreno M, Solis CL, Valladares LE, Velarde V (2012) Dehydroepiandrosterone prevents the aggregation of platelets obtained from postmenopausal women with type 2 diabetes mellitus through the activation of the pkc/enos/no pathway. Horm Metab Res 44:625-631
    • (2012) Horm Metab Res , vol.44 , pp. 625-631
    • Munoz, Y.C.1    Gomez, G.I.2    Moreno, M.3    Solis, C.L.4    Valladares, L.E.5    Velarde, V.6
  • 75
    • 0028217686 scopus 로고
    • Isolation of nitric oxide synthase from human platelets
    • 1:CAS:528:DyaK2cXlsFWrurw%3D 7514442
    • Muruganandam A, Mutus B (1994) Isolation of nitric oxide synthase from human platelets. Biochim Biophys Acta 1200:1-6
    • (1994) Biochim Biophys Acta , vol.1200 , pp. 1-6
    • Muruganandam, A.1    Mutus, B.2
  • 76
    • 47649122497 scopus 로고    scopus 로고
    • ENOS, iNOS or no NOS, that is the question!
    • 1:CAS:528:DC%2BD1cXhtVOgtbzJ 18503634
    • Naseem KM (2008) eNOS, iNOS or no NOS, that is the question! J Thromb Haemost 6:1373-1375
    • (2008) J Thromb Haemost , vol.6 , pp. 1373-1375
    • Naseem, K.M.1
  • 77
    • 37549032754 scopus 로고    scopus 로고
    • Unresolved roles of platelet nitric oxide synthase
    • 1:CAS:528:DC%2BD1cXhslOrtrk%3D 17944990
    • Naseem KM, Riba R (2008) Unresolved roles of platelet nitric oxide synthase. J Thromb Haemost 6:10-19
    • (2008) J Thromb Haemost , vol.6 , pp. 10-19
    • Naseem, K.M.1    Riba, R.2
  • 78
    • 67649327409 scopus 로고    scopus 로고
    • Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity
    • 19377066
    • O'Kane P, Xie L, Liu Z, Queen L, Jackson G, Ji Y, Ferro A (2009) Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity. Cardiovasc Res 83:123-130
    • (2009) Cardiovasc Res , vol.83 , pp. 123-130
    • O'Kane, P.1    Xie, L.2    Liu, Z.3    Queen, L.4    Jackson, G.5    Ji, Y.6    Ferro, A.7
  • 79
    • 20444471138 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase plays a minor role in inhibition of arterial thrombus formation
    • 15968403
    • Özuyaman B, Godecke A, Kusters S, Kirchhoff E, Scharf RE, Schrader J (2005) Endothelial nitric oxide synthase plays a minor role in inhibition of arterial thrombus formation. Thromb Haemost 93:1161-1167
    • (2005) Thromb Haemost , vol.93 , pp. 1161-1167
    • Özuyaman, B.1    Godecke, A.2    Kusters, S.3    Kirchhoff, E.4    Scharf, R.E.5    Schrader, J.6
  • 80
    • 84902304016 scopus 로고    scopus 로고
    • Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography
    • 1:CAS:528:DC%2BC2cXht1yntbbO 24858214
    • Park JW, Piknova B, Nghiem K, Lozier JN, Schechter AN (2014) Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide 40:45-51
    • (2014) Nitric Oxide , vol.40 , pp. 45-51
    • Park, J.W.1    Piknova, B.2    Nghiem, K.3    Lozier, J.N.4    Schechter, A.N.5
  • 81
    • 33750053256 scopus 로고    scopus 로고
    • Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: Possible role for shp-1 phosphatase
    • 1:CAS:528:DC%2BD28Xht1yjtbbN 16898954
    • Patel B, Sharifi M, Milward AD, Oberprieler NG, Gibbins JM, Parkin S, Naseem KM (2006) Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for shp-1 phosphatase. J Thromb Haemost 4:2423-2432
    • (2006) J Thromb Haemost , vol.4 , pp. 2423-2432
    • Patel, B.1    Sharifi, M.2    Milward, A.D.3    Oberprieler, N.G.4    Gibbins, J.M.5    Parkin, S.6    Naseem, K.M.7
  • 82
    • 33846463633 scopus 로고    scopus 로고
    • Nitric oxide production in plants: Facts and fictions
    • 2633878 19521475
    • Planchet E, Kaiser WM (2006) Nitric oxide production in plants: facts and fictions. Plant Signal Behav 1:46-51
    • (2006) Plant Signal Behav , vol.1 , pp. 46-51
    • Planchet, E.1    Kaiser, W.M.2
  • 83
    • 0034617072 scopus 로고    scopus 로고
    • Beta(2)-adrenoceptors activate nitric oxide synthase in human platelets
    • 1:CAS:528:DC%2BD3cXkvFWju74%3D 10884370
    • Queen LR, Xu B, Horinouchi K, Fisher I, Ferro A (2000) Beta(2)-adrenoceptors activate nitric oxide synthase in human platelets. Circ Res 87:39-44
    • (2000) Circ Res , vol.87 , pp. 39-44
    • Queen, L.R.1    Xu, B.2    Horinouchi, K.3    Fisher, I.4    Ferro, A.5
  • 84
    • 0025131570 scopus 로고
    • Characterization of the l-arginine: Nitric oxide pathway in human platelets
    • 1917694 1:CAS:528:DyaK3cXmtVyqsrw%3D 1701676
    • Radomski MW, Palmer RM, Moncada S (1990a) Characterization of the l-arginine: nitric oxide pathway in human platelets. Br J Pharmacol 101:325-328
    • (1990) Br J Pharmacol , vol.101 , pp. 325-328
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 85
    • 0025366847 scopus 로고
    • An l-arginine/nitric oxide pathway present in human platelets regulates aggregation
    • 54288 1:CAS:528:DyaK3cXkslGmt7k%3D 1695013
    • Radomski MW, Palmer RM, Moncada S (1990b) An l-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87:5193-5197
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5193-5197
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 86
    • 0025196302 scopus 로고
    • Paradoxical effect of bicarbonate on cytoplasmic pH
    • 1:STN:280:DyaK3c3lvVGntw%3D%3D 1971322
    • Ritter JM, Doktor HS, Benjamin N (1990) Paradoxical effect of bicarbonate on cytoplasmic pH. Lancet 335:1243-1246
    • (1990) Lancet , vol.335 , pp. 1243-1246
    • Ritter, J.M.1    Doktor, H.S.2    Benjamin, N.3
  • 88
    • 34249889864 scopus 로고    scopus 로고
    • The role of von Willebrand factor in thrombus formation
    • 2702526 1:CAS:528:DC%2BD2sXmtlSku70%3D 17493665
    • Ruggeri ZM (2007) The role of von Willebrand factor in thrombus formation. Thromb Res 120(Suppl 1):S5-S9
    • (2007) Thromb Res , vol.120 , pp. S5-S9
    • Ruggeri, Z.M.1
  • 89
    • 84863090308 scopus 로고    scopus 로고
    • DAF-fluorescence without NO: Elicitor treated tobacco cells produce fluorescing DAF-derivatives not related to DAF-2 triazol
    • 22683597
    • Rümer S, Krischke M, Fekete A, Mueller MJ, Kaiser WM (2012) DAF-fluorescence without NO: elicitor treated tobacco cells produce fluorescing DAF-derivatives not related to DAF-2 triazol. Nitric Oxide 27:123-135
    • (2012) Nitric Oxide , vol.27 , pp. 123-135
    • Rümer, S.1    Krischke, M.2    Fekete, A.3    Mueller, M.J.4    Kaiser, W.M.5
  • 90
    • 4644269783 scopus 로고    scopus 로고
    • The activity of constitutive nitric oxide synthase is increased by the pathway camp/camp-activated protein kinase in human platelets. New insights into the antiaggregating effects of camp-elevating agents
    • 1:CAS:528:DC%2BD2cXnslKhu7c%3D 15381390
    • Russo I, Doronzo G, Mattiello L, De Salve A, Trovati M, Anfossi G (2004) The activity of constitutive nitric oxide synthase is increased by the pathway camp/camp-activated protein kinase in human platelets. New insights into the antiaggregating effects of camp-elevating agents. Thromb Res 114:265-273
    • (2004) Thromb Res , vol.114 , pp. 265-273
    • Russo, I.1    Doronzo, G.2    Mattiello, L.3    De Salve, A.4    Trovati, M.5    Anfossi, G.6
  • 91
    • 39049133431 scopus 로고    scopus 로고
    • Sodium azide, a bacteriostatic preservative contained in commercially available laboratory reagents, influences the responses of human platelets via the cGMP/pkg/vasp pathway
    • 1:CAS:528:DC%2BD1cXitVWrsbk%3D 18022387
    • Russo I, Del Mese P, Viretto M, Doronzo G, Mattiello L, Trovati M, Anfossi G (2008) Sodium azide, a bacteriostatic preservative contained in commercially available laboratory reagents, influences the responses of human platelets via the cGMP/pkg/vasp pathway. Clin Biochem 41:343-349
    • (2008) Clin Biochem , vol.41 , pp. 343-349
    • Russo, I.1    Del Mese, P.2    Viretto, M.3    Doronzo, G.4    Mattiello, L.5    Trovati, M.6    Anfossi, G.7
  • 92
    • 84868007942 scopus 로고    scopus 로고
    • High glucose inhibits the aspirin-induced activation of the nitric oxide/cGMP/cGMP-dependent protein kinase pathway and does not affect the aspirin-induced inhibition of thromboxane synthesis in human platelets
    • 3478557 1:CAS:528:DC%2BC38Xhsl2it7vL 22837307
    • Russo I, Viretto M, Barale C, Mattiello L, Doronzo G, Pagliarino A, Cavalot F, Trovati M, Anfossi G (2012) High glucose inhibits the aspirin-induced activation of the nitric oxide/cGMP/cGMP-dependent protein kinase pathway and does not affect the aspirin-induced inhibition of thromboxane synthesis in human platelets. Diabetes 61:2913-2921
    • (2012) Diabetes , vol.61 , pp. 2913-2921
    • Russo, I.1    Viretto, M.2    Barale, C.3    Mattiello, L.4    Doronzo, G.5    Pagliarino, A.6    Cavalot, F.7    Trovati, M.8    Anfossi, G.9
  • 93
    • 0001612446 scopus 로고
    • Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor
    • 297832 1:CAS:528:DyaL1MXlsFWisr4%3D 2548208
    • Salvemini D, de Nucci G, Gryglewski RJ, Vane JR (1989) Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc Natl Acad Sci USA 86:6328-6332
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6328-6332
    • Salvemini, D.1    De Nucci, G.2    Gryglewski, R.J.3    Vane, J.R.4
  • 94
    • 0035504605 scopus 로고    scopus 로고
    • Taming platelets with cyclic nucleotides
    • 1:CAS:528:DC%2BD3MXot1Omu7Y%3D 11705448
    • Schwarz UR, Walter U, Eigenthaler M (2001) Taming platelets with cyclic nucleotides. Biochem Pharmacol 62:1153-1161
    • (2001) Biochem Pharmacol , vol.62 , pp. 1153-1161
    • Schwarz, U.R.1    Walter, U.2    Eigenthaler, M.3
  • 95
    • 80052015789 scopus 로고    scopus 로고
    • Platelet nitric oxide signalling in heart failure: Role of oxidative stress
    • 1:CAS:528:DC%2BC3MXhtVOgu7bI 21502370
    • Shah A, Passacquale G, Gkaliagkousi E, Ritter J, Ferro A (2011) Platelet nitric oxide signalling in heart failure: role of oxidative stress. Cardiovasc Res 91:625-631
    • (2011) Cardiovasc Res , vol.91 , pp. 625-631
    • Shah, A.1    Passacquale, G.2    Gkaliagkousi, E.3    Ritter, J.4    Ferro, A.5
  • 97
    • 0021368279 scopus 로고
    • Carbonic anhydrase in human platelets
    • 1153275 1:CAS:528:DyaL2cXotFyqsg%3D%3D 6424649
    • Siffert W, Gros G (1984) Carbonic anhydrase in human platelets. Biochem J 217:727-730
    • (1984) Biochem J , vol.217 , pp. 727-730
    • Siffert, W.1    Gros, G.2
  • 98
    • 0021645707 scopus 로고
    • Carbonic anhydrase in human platelets: Effects of carbonic anhydrase inhibition on platelet aggregation
    • 1:CAS:528:DyaL2cXlvVyrtb0%3D 6430160
    • Siffert W, Fox G, Gros G (1984a) Carbonic anhydrase in human platelets: effects of carbonic anhydrase inhibition on platelet aggregation. Ann N Y Acad Sci 429:207-209
    • (1984) Ann N y Acad Sci , vol.429 , pp. 207-209
    • Siffert, W.1    Fox, G.2    Gros, G.3
  • 99
    • 0021248750 scopus 로고
    • The effect of carbonic anhydrase inhibition on the velocity of thrombin-stimulated platelet aggregation under physiological conditions
    • 1:CAS:528:DyaL2cXkt1WhsrY%3D 6428406
    • Siffert W, Fox G, Gros G (1984b) The effect of carbonic anhydrase inhibition on the velocity of thrombin-stimulated platelet aggregation under physiological conditions. Biochem Biophys Res Commun 121:266-270
    • (1984) Biochem Biophys Res Commun , vol.121 , pp. 266-270
    • Siffert, W.1    Fox, G.2    Gros, G.3
  • 100
    • 59049085356 scopus 로고    scopus 로고
    • Homocysteine decreases platelet NO level via protein kinase c activation
    • 1:CAS:528:DC%2BD1MXhsFKnt7s%3D 19100855
    • Signorello MG, Segantin A, Passalacqua M, Leoncini G (2009) Homocysteine decreases platelet NO level via protein kinase c activation. Nitric Oxide 20:104-113
    • (2009) Nitric Oxide , vol.20 , pp. 104-113
    • Signorello, M.G.1    Segantin, A.2    Passalacqua, M.3    Leoncini, G.4
  • 101
    • 79951798879 scopus 로고    scopus 로고
    • Leoncini G (2011a) the anandamide effect on no/cGMP pathway in human platelets
    • 1:CAS:528:DC%2BC3MXhvFelurg%3D 21328466
    • Signorello MG, Giacobbe E, Passalacqua M (2011a) Leoncini G (2011a) The anandamide effect on no/cGMP pathway in human platelets. J Cell Biochem 112:924-932
    • (2011) J Cell Biochem , vol.112 , pp. 924-932
    • Signorello, M.G.1    Giacobbe, E.2    Passalacqua, M.3
  • 103
    • 84856512481 scopus 로고    scopus 로고
    • Novel roles of camp/cGMP-dependent signaling in platelets
    • 1:CAS:528:DC%2BC38XksVantLw%3D 22136590
    • Smolenski A (2012) Novel roles of camp/cGMP-dependent signaling in platelets. J Thromb Haemost 10:167-176
    • (2012) J Thromb Haemost , vol.10 , pp. 167-176
    • Smolenski, A.1
  • 105
    • 84881591283 scopus 로고    scopus 로고
    • Phosphorylation of caldag-gefi by protein kinase a prevents rap1b activation
    • 1:CAS:528:DC%2BC3sXhtlGmtb7N 23611601
    • Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S (2013) Phosphorylation of caldag-gefi by protein kinase a prevents rap1b activation. J Thromb Haemost 11:1574-1582
    • (2013) J Thromb Haemost , vol.11 , pp. 1574-1582
    • Subramanian, H.1    Zahedi, R.P.2    Sickmann, A.3    Walter, U.4    Gambaryan, S.5
  • 106
    • 0346996706 scopus 로고    scopus 로고
    • Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line
    • 1:CAS:528:DC%2BD3sXpvVentLk%3D 14675775
    • Thum T, Tsikas D, Frölich JC, Borlak J (2003) Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line. FEBS Lett 555:567-571
    • (2003) FEBS Lett , vol.555 , pp. 567-571
    • Thum, T.1    Tsikas, D.2    Frölich, J.C.3    Borlak, J.4
  • 107
    • 0029950985 scopus 로고    scopus 로고
    • The insulin-induced increase of guanosine-3′,5′-cyclic monophosphate in human platelets is mediated by nitric oxide
    • 1:CAS:528:DyaK28Xjs1Oisr0%3D 8635651
    • Trovati M, Massucco P, Mattiello L, Piretto V, Cavalot F, Mularoni E, Anfossi G (1996) The insulin-induced increase of guanosine-3′,5′-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes 45:768-770
    • (1996) Diabetes , vol.45 , pp. 768-770
    • Trovati, M.1    Massucco, P.2    Mattiello, L.3    Piretto, V.4    Cavalot, F.5    Mularoni, E.6    Anfossi, G.7
  • 108
    • 4444375898 scopus 로고    scopus 로고
    • Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD2cXmsVOjurY%3D 15199238
    • Tsikas D (2004) Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry. Methods Mol Biol 279:81-103
    • (2004) Methods Mol Biol , vol.279 , pp. 81-103
    • Tsikas, D.1
  • 109
    • 22144495985 scopus 로고    scopus 로고
    • Analysis of the l-arginine/nitric oxide pathway: The unique role of mass spectrometry
    • 1:CAS:528:DC%2BD2MXhsVWkuro%3D
    • Tsikas D (2005a) Analysis of the l-arginine/nitric oxide pathway: the unique role of mass spectrometry. Curr Pharm Anal 1:15-30
    • (2005) Curr Pharm Anal , vol.1 , pp. 15-30
    • Tsikas, D.1
  • 110
    • 22144457461 scopus 로고    scopus 로고
    • Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids
    • 1:CAS:528:DC%2BD2MXmt1Gls7o%3D
    • Tsikas D (2005b) Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. Free Rad Res 39:797-815
    • (2005) Free Rad Res , vol.39 , pp. 797-815
    • Tsikas, D.1
  • 111
    • 45849096877 scopus 로고    scopus 로고
    • A critical review and discussion of analytical methods in the l-arginine/nitric oxide area of basic and clinical research
    • 1:CAS:528:DC%2BD1cXnvVKjt7k%3D 18510938
    • Tsikas D (2008) A critical review and discussion of analytical methods in the l-arginine/nitric oxide area of basic and clinical research. Anal Biochem 379:139-163
    • (2008) Anal Biochem , vol.379 , pp. 139-163
    • Tsikas, D.1
  • 112
    • 67650105423 scopus 로고    scopus 로고
    • A proposal for comparing methods of quantitative analysis of endogenous compounds in biological systems by using the relative lower limit of quantification (rLLOQ)
    • 1:CAS:528:DC%2BD1MXoslehur4%3D
    • Tsikas D (2009) A proposal for comparing methods of quantitative analysis of endogenous compounds in biological systems by using the relative lower limit of quantification (rLLOQ). J Chromatogr B 877:2244-2251
    • (2009) J Chromatogr B , vol.877 , pp. 2244-2251
    • Tsikas, D.1
  • 113
    • 84926476143 scopus 로고    scopus 로고
    • Pitfalls with nitric synthase activity assays and their avoidance by gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BC2MXlsFersLw%3D 25826550
    • Tsikas D (2015a) Pitfalls with nitric synthase activity assays and their avoidance by gas chromatography-mass spectrometry. Kidney Int 87:860-861
    • (2015) Kidney Int , vol.87 , pp. 860-861
    • Tsikas, D.1
  • 114
    • 84951966080 scopus 로고    scopus 로고
    • Can nitric oxide synthase activity be unequivocally measured in red blood cells and platelets? if yes, by which assay?
    • Tsikas D (2015b) Can nitric oxide synthase activity be unequivocally measured in red blood cells and platelets? If yes, by which assay? Redox Biol. doi: 10.1016/j.redox.2015.01.004
    • (2015) Redox Biol
    • Tsikas, D.1
  • 116
    • 0032955272 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: Evidence of inhibition of thromboxane A2 synthesis in human blood platelets
    • 1:CAS:528:DyaK1MXosleksQ%3D%3D 9928994
    • Tsikas D, Ikic M, Tewes KS, Raida M, Frölich JC (1999) Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets. FEBS Lett 442:162-166
    • (1999) FEBS Lett , vol.442 , pp. 162-166
    • Tsikas, D.1    Ikic, M.2    Tewes, K.S.3    Raida, M.4    Frölich, J.C.5
  • 117
    • 0342757751 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthase inhibitors are responsible for the l-arginine paradox
    • Tsikas D, Böger RH, Sandmann J, Bode-Böger SM, Frölich JC (2000a) Endogenous nitric oxide synthase inhibitors are responsible for the l-arginine paradox. FEBS Lett 28(478):1-3
    • (2000) FEBS Lett , vol.28 , Issue.478 , pp. 1-3
    • Tsikas, D.1    Böger, R.H.2    Sandmann, J.3    Bode-Böger, S.M.4    Frölich, J.C.5
  • 118
    • 0034716974 scopus 로고    scopus 로고
    • Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry
    • 1:CAS:528:DC%2BD3cXksVGlu7k%3D
    • Tsikas D, Sandmann J, Savva A, Luessen P, Böger RH, Gutzki FM, Mayer B, Frölich JC (2000b) Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry. J Chromatogr B 742:143-153
    • (2000) J Chromatogr B , vol.742 , pp. 143-153
    • Tsikas, D.1    Sandmann, J.2    Savva, A.3    Luessen, P.4    Böger, R.H.5    Gutzki, F.M.6    Mayer, B.7    Frölich, J.C.8
  • 119
    • 78650426618 scopus 로고    scopus 로고
    • Analysis of NO and its metabolites by mass spectrometry. Comment on 'detection of nitric oxide in tissue samples by ESI-MS' by Z. Shen, A. Webster, K. J. Welham, C. E. Dyer, J. Greenman and S. J. Haswell
    • 1:CAS:528:DC%2BC3cXhsF2is73J 20936207 (discussion 411)
    • Tsikas D, Sandmann J, Beckmann B (2011) Analysis of NO and its metabolites by mass spectrometry. Comment on 'detection of nitric oxide in tissue samples by ESI-MS' by Z. Shen, A. Webster, K. J. Welham, C. E. Dyer, J. Greenman and S. J. Haswell. Analyst 136:407-410 (discussion 411)
    • (2011) Analyst , vol.136 , pp. 407-410
    • Tsikas, D.1    Sandmann, J.2    Beckmann, B.3
  • 120
    • 71249084005 scopus 로고    scopus 로고
    • Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase
    • 2801214 1:CAS:528:DC%2BD1MXhs1Whtr%2FI 19912226
    • Tymvios C, Moore C, Jones S, Solomon A, Sanz-Rosa D, Emerson M (2009) Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase. Br J Pharmacol 158:1735-1742
    • (2009) Br J Pharmacol , vol.158 , pp. 1735-1742
    • Tymvios, C.1    Moore, C.2    Jones, S.3    Solomon, A.4    Sanz-Rosa, D.5    Emerson, M.6
  • 121
    • 84861608352 scopus 로고    scopus 로고
    • Pitfalls and limitations in using 4,5-diaminofluorescein or evaluating the influence of polyphenols on nitric oxide release from endothelial cells
    • 1:CAS:528:DC%2BC38XosFertLg%3D 22565032
    • Uhlenhut K, Högger P (2012) Pitfalls and limitations in using 4,5-diaminofluorescein or evaluating the influence of polyphenols on nitric oxide release from endothelial cells. Free Radic Biol Med 52:2266-2275
    • (2012) Free Radic Biol Med , vol.52 , pp. 2266-2275
    • Uhlenhut, K.1    Högger, P.2
  • 122
    • 0019251598 scopus 로고
    • Human platelet arginase
    • 1:CAS:528:DyaL3MXmtVCqsA%3D%3D 7207468
    • Villanueva VR, Giret M (1980) Human platelet arginase. Mol Cell Biochem 33:97-100
    • (1980) Mol Cell Biochem , vol.33 , pp. 97-100
    • Villanueva, V.R.1    Giret, M.2
  • 123
    • 61749092420 scopus 로고    scopus 로고
    • CGMP and cGMP-dependent protein kinase in platelets and blood cells
    • 1:CAS:528:DC%2BD1MXitlaitro%3D
    • Walter U, Gambaryan S (2009) cGMP and cGMP-dependent protein kinase in platelets and blood cells. Handbook Exper Pharmacol 191:533-548
    • (2009) Handbook Exper Pharmacol , vol.191 , pp. 533-548
    • Walter, U.1    Gambaryan, S.2
  • 125
    • 78049246328 scopus 로고    scopus 로고
    • Inhibitory signaling of 17beta-estradiol in platelet activation: The pivotal role of cyclic amp-mediated nitric oxide synthase activation
    • 1:CAS:528:DC%2BC3cXhtlKktb%2FF 20883689
    • Wu GJ, Lee JJ, Chou DS, Jayakumar T, Hsiao G, Chen WF, Sheu JR (2010) Inhibitory signaling of 17beta-estradiol in platelet activation: the pivotal role of cyclic amp-mediated nitric oxide synthase activation. Eur J Pharmacol 649:140-149
    • (2010) Eur J Pharmacol , vol.649 , pp. 140-149
    • Wu, G.J.1    Lee, J.J.2    Chou, D.S.3    Jayakumar, T.4    Hsiao, G.5    Chen, W.F.6    Sheu, J.R.7
  • 127
    • 67649204120 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via tlr4/myd88 and the cGMP-dependent protein kinase pathway
    • 2787095 1:CAS:528:DC%2BD1MXmslCntb4%3D 19494325
    • Zhang G, Han J, Welch EJ, Ye RD, Voyno-Yasenetskaya TA, Malik AB, Du X, Li Z (2009) Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via tlr4/myd88 and the cGMP-dependent protein kinase pathway. J Immunol 182:7997-8004
    • (2009) J Immunol , vol.182 , pp. 7997-8004
    • Zhang, G.1    Han, J.2    Welch, E.J.3    Ye, R.D.4    Voyno-Yasenetskaya, T.A.5    Malik, A.B.6    Du, X.7    Li, Z.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.