Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4882-4886

  Zhang, Liuqiang ^a   Feng, Li ^a   Jia, Qi ^a   Xu, Jinwen ^a   Wang, Rui ^a   Wang, Zhengtao ^a   Wu, Yingchun ^a   Li, Yiming ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Glucosidase; Anti inflammation; COX 2 inhibitors; Harpagide; Harpagoside; Iridoids

Indexed keywords

BETA GLUCOSIDASE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; HARPAGIDE; HARPAGOSIDE; HERBACEOUS AGENT; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; MEDICINAL PLANT; MOLECULAR MODEL; MOUSE; NONHUMAN; SCROPHULARIACEAE;

ANIMALS; BETA-GLUCOSIDASE; CELL SURVIVAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; GLYCOSIDES; HUMANS; HYDROGEN BONDING; HYDROLYSIS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MACROPHAGES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OSTEOARTHRITIS; PHYTOTHERAPY; PLANT PREPARATIONS; PYRANS; SODIUM NITRITE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79961167887     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.069     Document Type: Article

References (17)

1. Y. Li, S. Jiang, W. Gao, and D. Zhu Phytochemistry 50 1999 101
2. S. Lin, S. Jiang, Y. Li, J. Zeng, and D. Zhu Tetrahedron Lett. 41 2000 1069
3. J. Qi, J. Chen, Z. Cheng, J. Zhou, B. Yu, and S. Qiu Phytochemistry 67 2006 1372
4. Jiangsu New Medical College. The Dictionary of Chinese Herb; Shanghai Science and Technology Press: Shanghai, 1977; Vol. 1, p. 769.
5. M. Cameron, J.J. Gagnier, C.V. Little, T.J. Parsons, A. Blümle, and S. Chrubasik Phytother. Res. 23 2009 1647
6. P. Chantre, A. Cappelaere, D. Leblan, D. Guedon, J. Vandermander, and B. Fournie Phytomedicine 7 2000 177
7. J.E. Chrubasik, B.D. Roufogalis, and S. Chrubasik Phytother. Res. 21 2007 675
8. N.A. Ouitas, and C.M. Heard Int. J. Pharm. 376 2009 63
9. T.H. Huang, V.H. Tran, R.K. Duke, S. Tan, S. Chrubasik, B.D. Roufogalis, and C.C. Duke J. Ethnopharmacol. 104 2006 149
10. K. Inaba, K. Murata, S. Naruto, and H. Matsuda J. Nat. Med. 64 2010 219
11. B.L. Fiebich, M. Heinrich, K.O. Hiller, and N. Kammerer Phytomedicine 8 2001 28
12. N. Abdelouahab, and C. Heard J. Nat. Prod. 71 2008 746
13. Y. Li, Z. Han, S. Jiang, Y. Jiang, S. Yao, and D. Zhu Acta Pharmacol. Sin. 21 2000 1125
14. K.S. Park, B.H. Kim, and I.-M. Chang ECAM 7 2010 41
15. R.G. Kurumbail, A.M. Stevens, J.K. Gierse, J.J. McDonald, R.A. Stegeman, J.Y. Pak, D. Gildehaus, J.M. Miyashiro, T.D. Penning, K. Seibert, P.C. Isakson, and W.C. Stallings Nature 384 1996 644
16. W.E. Workman, and D.F. Day Appl. Environ. Microbiol. 44 1982 1289
17. K.J. Livak, and T.D. Schmittgen Methods 25 2001 402