A new neo-clerodane diterpene from Ajuga decumbens

Natural Product Research

Volumn 28, Issue 3, 2014, Pages 196-200

  Lv, Huawei ^a   Luo, Jianguang ^a   Kong, Lingyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ajuga decumbens; anti inflammatory activity; neo clerodane diterpene

Indexed keywords

1BETA,6ALPHA,19 TRIACETOXY 12 [2 METHYLBUTANOYLOXYL] 4,18 EPOXYNEO CLEROD 13(14) EN 15,16 OLIDE; AJUGACUMBIN A; AJUGACUMBIN B; AJUGACUMBIN C; AJUGACUMBIN D; AJUGACUMBIN J; AJUGALIDE B; AJUGALIDE D; AJUGAMARIN; AJUGANIPPONIN A; AJUGAPANTIN A; AJUGARIN I; AJUGARIN II; AURANTIAMIDE ACETATE; CLERODANE DERIVATIVE; DIPEPTIDE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AJUGA; AJUGA DECUMBENS; ANIMAL CELL; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MACROPHAGE; MEDICINAL PLANT; NONHUMAN;

AJUGA DECUMBENS;

AJUGA; ANIMALS; ANTI-INFLAMMATORY AGENTS; DITERPENES, CLERODANE; DRUGS, CHINESE HERBAL; INHIBITORY CONCENTRATION 50; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE;

EID: 84895465972     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786419.2013.866114     Document Type: Article

References (19)

1. Chan YY. 2005. Neoclerodane diterpenoids from Ajuga taiwanensis. Chem Pharm Bull. 53: 164-167.
2. Chinese Pharmacopoeia Commission. 2010. Chinese pharmacopoeia. Vol. 1. Beijing: The Medicine Science and Technology Press of China. p. 325.
3. Coll J. 2002. NMR shift data of neo-clerodane diterpenes from the genus Ajuga. Phytochem Anal. 13: 372-380.
4. Coll J, Tandrnón YA. 2006. Isolation and identification of neo-clerodane diterpenes from Ajuga nipponensis Makino. Nat Prod Commun. 1: 183-189.
5. Coll J, Tandrnón YA. 2008. Neo-clerodane diterpenoids from Ajuga: structural elucidation and biological activity. Phytochem Rev. 7: 25-49.
6. Guo P, Li Y, Xu J, Liu C, Ma Y, Guo Y. 2011. Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge. J Nat Prod. 74: 1575-1583.
7. Huang XC, Qin S, Guo YW, Krohn K. 2008. Four new neoclerodane diterpenoids from Ajuga decumbens. Helv Chim Acta. 91: 628-634.
8. Konoshima T, Takasaki M, Tokuda H, Nishino H. 2000. Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, from Ajuga decumbens. Cancer Lett. 157: 87-92.
9. Min Z, Mizuo M, Wang S, Munekazu I, Toshiyuki T. 1990. Two new neo-clerodane diterpenes in Ajuga decumbens. Chem Pharm Bull. 38: 3167-3168.
10. Min ZD, Wang SQ, Zheng QT, Wu B, Mizuo M, Toshiyuki T, Munekazu I. 1989. Four new insect antifeedant neo-clerodane diterpenoids, Ajugacumbins A, B, C and D, from Ajuga decumbens. Chem Pharm Bull. 37: 2505-2508.
11. Shimomura H, Sashida Y, Ogawa K. 1989. Neo-clerodane diterpenes from Ajuga ciliata var. Villosior. Chem Pharm Bull. 37: 988-992.
12. Shimomura H, Sashida Y, Ogawa K, Iitaka Y. 1983. The chemical constituents of Ajuga plants. I. neo-cleroanes from the leaves of Ajuga nipponensis Makino. Chem Pharm Bull. 31: 2192-2199.
13. Sun Z, Li Y, Jin D, Guo P, Xu J, Guo Y, Zhang L. 2012. Structure elucidation and inhibitory effects on NO production of clerodane diterpenes from Ajuga decumbens. Planta Med. 78: 1579-1583.
14. Takasaki M, Tokuda H, Nishino H, Konoshima T. 1999. Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. J Nat Prod. 62: 972-975.
15. Takasaki M, Yamauchi I, Haruna M, Konoshima T. 1998. New glycosides from Ajuga decumbens. J Nat Prod. 61: 1105-1109.
16. Takeda Y, Tsuchida S, Fujita T. 1987. Four new iridoid glucoside p-coumaroyl esters from Ajuga decumbens. Phytochemistry. 26: 2303-2306.
17. Wang B, Wang XN, Tao S, Wang SQ, Guo DX, Lou HX. 2012. Rearranged abietane diterpenoid hydroquinones from aerial parts of Ajuga decumbens Thunb. Phytochem Lett. 5: 271-275.
18. Wahidulla S, D'Souza L, Kamat SY. 1991. Dipeptides from the red alga Acantophora spicifera. Phytochemistry. 30: 3323-3325.
19. Yin H, Luo JG, Shan SM, Wang XB, Luo J, Yang MH, Kong LY. 2013. Amomaxins A and B, two unprecedented rearranged labdane norditerpenoids with a nine-membered ring from Amomum maximum. Org Lett. 15: 1572-1575.