Structure elucidation and inhibitory effects on no production of clerodane diterpenes from Ajuga decumbens

Planta Medica

Volumn 78, Issue 14, 2012, Pages 1579-1583

  Sun, Zhanping ^a,b   Li, Yushan ^b   Jin, Da Qing ^a   Guo, Ping ^b   Xu, Jing ^a   Guo, Yuanqiang ^a   Zhang, Lei ^a  

^a NANKAI UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ajuga decumbens; clerodane diterpene inhibitory effects on NO production; Labiatae

Indexed keywords

18,19 DIACETOXY 4ALPHA,6ALPHA,12 TRIHYDROXY 1BETA TIGLOYLOXYNEOCLEROD 13 EN 15,16 OLIDE; 4ALPHA,6ALPHA DIHYDROXY 18 (4' METHOXY 4' OXOBUTYRYLOXY) 19 TIGLOYLOXYNEOCLEROD 13 EN 15,16 OLIDE; 6ALPHA,19 DIACETOXY 4ALPHA HYDROXY 1BETA TIGLOYLOXYNEOCLEROD 12 EN 15 OIC ACID METHYL ESTER 16 ALDEHYDE; AJUGACILIATIN J; AJUGACUMBIN A; AJUGACUMBIN A CHLOROHYDRIN; AJUGACUMBIN B; AJUGARIN I; CLERODANE DERIVATIVE; NITRIC OXIDE; UNCLASSIFIED DRUG;

AJUGA; AJUGA DECUMBENS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; NONHUMAN; STRUCTURE ANALYSIS;

AJUGA; ANIMALS; CELL LINE; DITERPENES, CLERODANE; MEDICINE, CHINESE TRADITIONAL; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE; PLANT EXTRACTS; POLYSACCHARIDES;

AJUGA DECUMBENS; LAMIACEAE;

EID: 84867081088     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1315215     Document Type: Article

References (16)

1. Nanjing University of Chinese Medicine Edita. Dictionary of Chinese Materia Medica. 2nd edition. Shanghai Shanghai Science and Technology Publishing House: 2006; 1035 1037
2. Huang X. C., Qin S., Guo Y. W., Krohn K. Four new neoclerodane diterpenoids from Ajuga decumbens. Helv Chim Acta: 2008; 91 628 634
3. Amano T., Nishida R., Kuwahara Y. Ajugatakasins A and B, new diterpenoids from Ajuga decumbens, and feeding stimulative activity of related neoclerodane analogs toward the turnip sawfly. Biosci Biotechnol Biochem: 1997; 61 1518 1522 (Pubitemid 127472974)
4. Min Z., Mizuno M., Wang S., Iinuma M., Tanaka T. Two new neo-clerodane diterpenes in Ajuga decumbens. Chem Pharm Bull: 1990; 38 3167 3168
5. Chen H. M., Min Z. D., Iinuma M., Tanaka T. Clerodane diterpenoids from Ajuga decumbe ns. Chem Pharm Bull: 1995; 43 2253 2255 (Pubitemid 26013565)
6. Shimomura H., Sashida Y., Ogawa K. Neo-clerodane diterpenes from Ajuga decumbens. Chem Pharm Bull: 1989; 37 996 998
7. Min Z., Wang S., Zheng Q., Wu B., Mizuno M., Tanaka T., Iinuma M. Four new insect antifeedant neo-clerodane diterpenoids, ajugacumbins A, B, C and D, from Ajuga decumbens. Chem Pharm Bull: 1989; 37 2505 2508
8. Takeda Y., Tsuchida S., Fujita T. Four new iridoid glucoside p -coumaroyl esters from Ajuga decumbens. Phytochemistry: 1987; 26 2303 2306
9. Guo P., Li Y., Xu J., Liu C., Ma Y., Guo Y. Bioactive neo -clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge. J Nat Prod: 2011; 74 1575 1583
10. Guo P., Li Y., Xu J., Guo Y., Jin D., Gao J., Hou W., Zhang T. neo -Clerodane diterpenes from Ajuga ciliata Bunge and their neuroprotective activities. Fitoterapia: 2011; 82 1123 1127
11. Xu J., Guo Y., Li Y., Zhao P., Liu C., Ma Y., Gao J., Hou W., Zhang T. Sesquiterpenoids from the resinous exudates of Commiphora myrrha and their neuroprotective effects. Planta Med: 2011; 77 2023 2028
12. Xu J., Jin D., Shi D., Ma Y., Yang B., Zhao P., Guo Y. Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production. Fitoterapia: 2011; 82 508 511
13. Cantrell C. L., Rajab M. S., Franzblau S. G., Fronczek F. R., Fischer N. H. Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota. Planta Med: 1999; 65 732 734
14. Guo Y., Li Y., Xu J., Watanabe R., Oshima Y., Yamakuni T., Ohizumi Y. Bioactive ent -clerodane diterpenoids from the aerial parts of Baccharis gaudichaudiana. J Nat Prod: 2006; 69 274 276
15. Urones J. G., Marcos I. S., Basabe P., Jimenez A., Gomez A., Lithgow A. M. 2alpha,3beta-Dihydroxy-4(18)-neo-cleroden-15-oic acid from Cistus populifolius. Phytochemistry: 1995; 38 443 445
16. Schmidt H. HHW, Kelm M. Determination of nitrite and nitrate by the Griess reaction. In: Feelish M., Stamler J. editors Methods in nitric oxide research. New York John Wiley & Sons Ltd.: 1996; 491 497