Neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production

Fitoterapia

Volumn 83, Issue 8, 2012, Pages 1409-1414

  Sun, Zhanping ^a,b   Li, Yushan ^b   Jin, Da Qing ^a   Guo, Ping ^b   Song, Haibin ^a   Xu, Jing ^a   Guo, Yuanqiang ^a   Zhang, Lei ^a  

^a NANKAI UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ajuga decumbens; Inhibitory activities on NO production; neo Clerodane diterpenes

Indexed keywords

1ALPHA,19 EPOXY 6ALPHA,18 DIACETOXY 4ALPHA,12 DIHYDROXY NEO CLEROD 13 EN 15,16 OLIDE; 6ALPHA,19 DIACETOXY 18 CHLORO 4ALPHA HYDROXY 12 TIGLOYLOXY NEO CLEROD 13 EN 15,16 OLIDE; 6ALPHA,19 DIACETOXY 18 CHLORO 4ALPHA HYDROXY 12(2 METHYLBUTANOYLOXY) NEO CLEROD 13 EN 15,16 OLIDE; AJUGA DECUMBENS EXTRACT; AJUGAMARIN A1; AJUGAMARIN F4; AJUGANIPPONIN B; CLERODANE DERIVATIVE; LIPOPOLYSACCHARIDE; NEO CLERODANE DERIVATIVE; NITRIC OXIDE; PLANT EXTRACT; UNCLASSIFIED DRUG;

AJUGA; AJUGA DECUMBENS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; INFRARED SPECTROSCOPY; MICROGLIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYTOCHEMISTRY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AJUGA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; DITERPENES, CLERODANE; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MOLECULAR STRUCTURE; NITRIC OXIDE;

AJUGA DECUMBENS;

EID: 84870779901     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.08.003     Document Type: Article

References (14)

1. Nanjing University of Chinese Medicine Dictionary of Chinese Materia Medica Second ed. 2006 Shanghai Science and Technology Publishing House Shanghai 1035 1037
2. X.C. Huang, S. Qin, Y.W. Guo, and K. Krohn Four new neo-clerodane diterpenoids from Ajuga decumbens Helv Chim Acta 91 2008 628 634
3. T. Amano, R. Nishida, and Y. Kuwahara Ajugatakasins A and B, new diterpenoids from Ajuga decumbens, and feeding stimulative activity of related neoclerodane analogs toward the turnip sawfly Biosci Biotechnol Biochem 61 1997 1518 1522
4. Z. Min, M. Mizuno, S. Wang, M. Iinuma, and T. Tanaka Two new neo-clerodane diterpenes in Ajuga decumbens Chem Pharm Bull 38 1990 3167 3168
5. Z. Min, S. Wang, Q. Zheng, B. Wu, M. Mizuno, and T. Tanaka Four new insect antifeedant neo-clerodane diterpenoids, ajugacumbins A, B, C and D, from Ajuga decumbens Chem Pharm Bull 37 1989 2505 2508
6. H. Shimomura, Y. Sashida, and K. Ogawa neo-Clerodane diterpenes from Ajuga decumbens Chem Pharm Bull 37 1989 996 998
7. H.M. Chen, Z.D. Min, M. Iinuma, and T. Tanaka Clerodane diterpenoids from Ajuga decumbens Chem Pharm Bull 43 1995 2253 2255
8. Y. Takeda, S. Tsuchida, and T. Fujita Four new iridoid glucoside p-coumaroyl esters from Ajuga decumbens Phytochemistry 26 1987 2303 2306
9. P. Guo, Y. Li, J. Xu, C. Liu, Y. Ma, and Y. Guo Bioactive neo-Clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge J Nat Prod 74 2011 1575 1583
10. P. Guo, Y. Li, J. Xu, Y. Guo, D.Q. Jin, and J. Gao neo-Clerodane diterpenes from Ajuga ciliata Bunge and their neuroprotective activities Fitoterapia 82 2011 1123 1127
11. J. Xu, D. Jin, D. Shi, Y. Ma, B. Yang, and P. Zhao Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production Fitoterapia 82 2011 508 511
12. J. Xu, D.Q. Jin, P. Zhao, X. Song, Z. Sun, and Y. Guo Sesquiterpenes inhibiting NO production from Celastrus orbiculatus Fitoterapia 83 2012 1302 1305
13. Crystallographic data for compound 1 have been deposited in the Cambridge Crystallographic Data Centre (CCDC 880388). Copies of the data can be obtained, free of charge, on application to the director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: + 44-(0)1223-336033 or e-mail: deposit@ccdc.cam.ac.uk).
14. H.H.H.W. Schmidt, and M. Kelm M. Feelish, J. Stamler, Methods in nitric oxide research 1996 John Wiley & Sons Ltd. New York 491 497