Simultaneous determination of imperatorin and its 2 metabolites in dog plasma by using liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 640-646

  Wang, Lu ^a   Lu, Wen ^b   Shen, Qi ^a   Wang, Shengjia ^a   Zhou, Hui ^a   Yu, Lushan ^a   Wang, Sicen ^b   Jiang, Huidi ^a   He, Langchong ^b   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Imperatorin; LC MS MS; Metabolite; Pharmacokinetics

Indexed keywords

AMMONIUM ACETATE; IMPERATORIN EPOXIDE; IMPERATORIN HYDROXYLATE; METHANOL; PENTOSALEN; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; ELECTROSPRAY; EXPERIMENTAL DOG; FEMALE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MONITORING; NONHUMAN; PHASE SEPARATION; PHASE TRANSITION; PLASMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ACETATES; ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CALIBRATION; CHROMATOGRAPHY, LIQUID; DOGS; DRUGS, CHINESE HERBAL; EPOXY COMPOUNDS; FECES; FEMALE; HYDROXYLATION; INJECTIONS, INTRAVENOUS; LINEAR MODELS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METHANOL; MOLECULAR STRUCTURE; PSORALENS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SEX FACTORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84866257695     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.06.034     Document Type: Article

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